Result of FASTA (omim) for pF1KB9630
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9630, 237 aa
  1>>>pF1KB9630 237 - 237 aa - 237 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.0663+/-0.000262; mu= 9.6306+/- 0.017
 mean_var=158.3319+/-32.058, 0's: 0 Z-trim(125.1): 61  B-trim: 1967 in 1/59
 Lambda= 0.101927
 statistics sampled from 47910 (47978) to 47910 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.843), E-opt: 0.2 (0.563), width:  16
 Scan time:  7.020

The best scores are:                                      opt bits E(85289)
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 1621 248.7 6.5e-66
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214)  472 79.7 4.4e-15
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214)  472 79.7 4.4e-15
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272)  437 74.7 1.8e-13
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331)  312 56.4 7.3e-08
NP_002491 (OMIM: 125853,601724,606394) neurogenic  ( 356)  292 53.4 5.9e-07
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382)  286 52.6 1.1e-06
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337)  281 51.8 1.7e-06
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323)  244 46.3 7.3e-05
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323)  244 46.3 7.3e-05
NP_005163 (OMIM: 601461) protein atonal homolog 1  ( 354)  242 46.1 9.6e-05
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328)  241 45.9  0.0001
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241)  237 45.2 0.00012
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189)  219 42.5 0.00063
XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206)  215 41.9   0.001
NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280)  215 42.0  0.0013
XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302)  215 42.1  0.0013
XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351)  215 42.1  0.0015
NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193)  201 39.8   0.004
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201)  200 39.7  0.0046
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201)  200 39.7  0.0046
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272)  195 39.1  0.0095


>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens]    (237 aa)
 initn: 1621 init1: 1621 opt: 1621  Z-score: 1304.4  bits: 248.7 E(85289): 6.5e-66
Smith-Waterman score: 1621; 100.0% identity (100.0% similar) in 237 aa overlap (1-237:1-237)

               10        20        30        40        50        60
pF1KB9 MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 VPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 SFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPA
              130       140       150       160       170       180

              190       200       210       220       230       
pF1KB9 SDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
              190       200       210       220       230       

>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen  (214 aa)
 initn: 453 init1: 412 opt: 472  Z-score: 391.8  bits: 79.7 E(85289): 4.4e-15
Smith-Waterman score: 489; 53.7% identity (70.9% similar) in 175 aa overlap (42-213:34-193)

              20        30        40         50        60        70
pF1KB9 LDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-RGAPNISRASEVPGAQDDEQE
                                     :.::.:.: ::  : ..: :       .. 
XP_016 QPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG--NCAEAEEGGCRGAPRKL
            10        20        30        40          50        60 

               80        90       100       110       120       130
pF1KB9 RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTK
       : :: ::.: .::  : . ::::: ::::::::::::::.::::::.:::.::::.::::
XP_016 RARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
              70        80        90       100       110       120 

              140       150       160       170       180       190
pF1KB9 IETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGA
       :::::::.::::::..:::.::..: .      : ::  .:      ::...  .:::  
XP_016 IETLRFAHNYIWALTQTLRIADHSLYA------LEPP--APHCGELGSPGGSPGDWGS--
             130       140             150         160       170   

              200         210       220       230       
pF1KB9 AAASPLSDPSS--PAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
          ::.:. .:  ::::  .  :::                        
XP_016 -LYSPVSQAGSLSPAAS--LEERPGLLGATFSACLSPGSLAFSDFL   
              180         190       200       210       

>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap  (214 aa)
 initn: 453 init1: 412 opt: 472  Z-score: 391.8  bits: 79.7 E(85289): 4.4e-15
Smith-Waterman score: 489; 53.7% identity (70.9% similar) in 175 aa overlap (42-213:34-193)

              20        30        40         50        60        70
pF1KB9 LDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-RGAPNISRASEVPGAQDDEQE
                                     :.::.:.: ::  : ..: :       .. 
NP_066 QPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG--NCAEAEEGGCRGAPRKL
            10        20        30        40          50        60 

               80        90       100       110       120       130
pF1KB9 RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTK
       : :: ::.: .::  : . ::::: ::::::::::::::.::::::.:::.::::.::::
NP_066 RARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
              70        80        90       100       110       120 

              140       150       160       170       180       190
pF1KB9 IETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGA
       :::::::.::::::..:::.::..: .      : ::  .:      ::...  .:::  
NP_066 IETLRFAHNYIWALTQTLRIADHSLYA------LEPP--APHCGELGSPGGSPGDWGS--
             130       140             150         160       170   

              200         210       220       230       
pF1KB9 AAASPLSDPSS--PAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
          ::.:. .:  ::::  .  :::                        
NP_066 -LYSPVSQAGSLSPAAS--LEERPGLLGATFSACLSPGSLAFSDFL   
              180         190       200       210       

>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens]    (272 aa)
 initn: 519 init1: 373 opt: 437  Z-score: 362.6  bits: 74.7 E(85289): 1.8e-13
Smith-Waterman score: 437; 46.2% identity (67.2% similar) in 186 aa overlap (33-215:51-233)

             10        20        30        40         50        60 
pF1KB9 ARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASAS-GPPAPARRGAPNISRASEV
                                     :: :..: :. :  . .  :: .  : ...
NP_076 GSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CRPARL
               30        40        50        60        70          

              70          80        90       100       110         
pF1KB9 PGAQDDEQER-RRRRGRTR-VRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVL
        :   : ..:  : :. .: ...   .. ....::.:::.::::::::::::::::: ::
NP_076 LGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVL
      80        90       100       110       120       130         

     120       130       140       150       160       170         
pF1KB9 PSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSP
       :.::.:.:::::::::::.::::::.:::::::.   :::.    :  . :   ::  : 
NP_076 PTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASA
     140       150       160       170       180       190         

     180       190       200       210       220       230         
pF1KB9 ASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH  
       :    : :.. . ::  :  .::: : . .    .:                        
NP_076 A--LSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPD
     200         210       220       230       240       250       

NP_076 KHRYAPHLPIARDCI
       260       270  

>>NP_067014 (OMIM: 611635) neurogenic differentiation fa  (331 aa)
 initn: 296 init1: 268 opt: 312  Z-score: 262.2  bits: 56.4 E(85289): 7.3e-08
Smith-Waterman score: 312; 39.0% identity (57.6% similar) in 177 aa overlap (65-231:60-226)

           40        50        60        70         80        90   
pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRG-RTRVRSEALLHSLRRSR
                                     .... :. .::: . .  ..: :. .: .:
NP_067 EVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFR-AR
      30        40        50        60        70        80         

           100       110       120       130       140       150   
pF1KB9 RVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQ
       ::::: :::.:::.:: ::: :: :.: .    ::.::::::.: ::::::.:.:. . :
NP_067 RVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLE-TGQ
       90       100       110       120       130       140        

           160       170               180       190       200     
pF1KB9 GLPGGGARERLLPPQCVP-------CLP-GPPSPASDAESWGSGAAAASPLSDPSSPAAS
          : :  : :      :       ::  :: :   . .         ::. :  :  . 
NP_067 TPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHE------DKSPICD--SAISV
       150       160       170       180             190           

         210        220       230                                  
pF1KB9 EDFTYR-PGDPVFSFPSLPKDLLHTTPCFIPYH                           
       ..:.:. :: :   .  .   :::  :                                 
NP_067 HNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSI
     200       210       220       230       240       250         

>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff  (356 aa)
 initn: 336 init1: 278 opt: 292  Z-score: 245.9  bits: 53.4 E(85289): 5.9e-07
Smith-Waterman score: 292; 55.3% identity (77.6% similar) in 85 aa overlap (65-149:75-158)

           40        50        60        70        80        90    
pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRR
                                     .::.:. .::  . .  ..: :. ..  ::
NP_002 AMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKL-RR
           50        60        70        80        90       100    

          100       110       120       130       140       150    
pF1KB9 VKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQG
       .::: :::::::.:::::: ::.:.: .    ::.::::::.: ::::::.: ::     
NP_002 MKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSP
           110       120       130       140       150       160   

          160       170       180       190       200       210    
pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGD
                                                                   
NP_002 DLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQS
           170       180       190       200       210       220   

>>NP_006151 (OMIM: 601725) neurogenic differentiation fa  (382 aa)
 initn: 341 init1: 280 opt: 286  Z-score: 240.7  bits: 52.6 E(85289): 1.1e-06
Smith-Waterman score: 286; 54.9% identity (72.5% similar) in 91 aa overlap (60-149:89-178)

      30        40        50        60        70         80        
pF1KB9 EDCARLQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRG-RTRVRSEALLHS
                                     :  : .. : :: ..:: . :  ..: :. 
NP_006 PLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLER
       60        70        80        90       100       110        

       90       100       110       120       130       140        
pF1KB9 LRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETL
         . :: ::: :::::::.:::::: ::.:.: .    ::.::::::.: ::::::.: :
NP_006 -SKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEIL
       120       130       140       150       160       170       

      150       160       170       180       190       200        
pF1KB9 RLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDF
       :                                                           
NP_006 RSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMH
       180       190       200       210       220       230       

>>NP_073565 (OMIM: 611513) neurogenic differentiation fa  (337 aa)
 initn: 297 init1: 268 opt: 281  Z-score: 237.5  bits: 51.8 E(85289): 1.7e-06
Smith-Waterman score: 284; 40.2% identity (56.1% similar) in 164 aa overlap (65-213:67-221)

           40        50        60        70        80        90    
pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRR
                                     ..::.   ::::  . ..  :     . ::
NP_073 FSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRR
         40        50        60        70        80        90      

          100       110       120       130       140       150    
pF1KB9 VKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQG
        .:: :::::::.:: ::: ::.:.: .    ::.::::::.: ::::::.: ::.    
NP_073 QEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRI----
        100       110       120       130       140       150      

          160       170       180                  190             
pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASD---------AESW--GSGAAAA----SPLSDP
           : :  ::      :  :  .:...         :.:.  :.:. ::    :: :  
NP_073 ----GKRPDLLTFVQNLC-KGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTF
                160        170       180       190       200       

     200       210       220       230                             
pF1KB9 SSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH                      
         :  : ..:  ::                                              
NP_073 YPPYHSPELTTPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINY
       210       220       230       240       250       260       

>>NP_005797 (OMIM: 606386) oligodendrocyte transcription  (323 aa)
 initn: 212 init1: 122 opt: 244  Z-score: 208.3  bits: 46.3 E(85289): 7.3e-05
Smith-Waterman score: 244; 29.2% identity (53.0% similar) in 236 aa overlap (17-237:29-258)

                           10        20           30             40
pF1KB9             MPARLETCISDLDCASSSGSDLSGFL---TDEEDC-----ARLQQAAS
                                   :::: ..:     .   ::     :.:. : .
NP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
               10        20        30        40        50        60

               50        60        70        80        90       100
pF1KB9 ASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDR
       ..:     . :. ... .:   ... .       .   .  .:  :..::    .: :.:
NP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLR----LKINSR
               70        80        90       100       110          

              110       120         130       140           150    
pF1KB9 ERNRMHNLNAALDALRSVLPSF--PDDTKLTKIETLRFAYNYIWALAETL----RLADQG
       ::.:::.:: :.:.:: :.:    :.  ::.:: :: .: :::  :...:    ::... 
NP_005 ERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEI
        120       130       140       150       160       170      

          160       170       180       190        200       210   
pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASP-LSDPSSPAASEDFTYRPG
          :: .  . :  :     . : ::. :.  ... ::  : .  :  : :.   .   .
NP_005 Y--GGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAA
          180       190       200       210       220       230    

           220       230                                           
pF1KB9 DPVFSFPSLPKDLLHTTPCFIPYH                                    
         . :  ::: . : ..  . : :                                    
NP_005 AAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCP
          240       250       260       270       280       290    

>>XP_005260965 (OMIM: 606386) PREDICTED: oligodendrocyte  (323 aa)
 initn: 212 init1: 122 opt: 244  Z-score: 208.3  bits: 46.3 E(85289): 7.3e-05
Smith-Waterman score: 244; 29.2% identity (53.0% similar) in 236 aa overlap (17-237:29-258)

                           10        20           30             40
pF1KB9             MPARLETCISDLDCASSSGSDLSGFL---TDEEDC-----ARLQQAAS
                                   :::: ..:     .   ::     :.:. : .
XP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
               10        20        30        40        50        60

               50        60        70        80        90       100
pF1KB9 ASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDR
       ..:     . :. ... .:   ... .       .   .  .:  :..::    .: :.:
XP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLR----LKINSR
               70        80        90       100       110          

              110       120         130       140           150    
pF1KB9 ERNRMHNLNAALDALRSVLPSF--PDDTKLTKIETLRFAYNYIWALAETL----RLADQG
       ::.:::.:: :.:.:: :.:    :.  ::.:: :: .: :::  :...:    ::... 
XP_005 ERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEI
        120       130       140       150       160       170      

          160       170       180       190        200       210   
pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASP-LSDPSSPAASEDFTYRPG
          :: .  . :  :     . : ::. :.  ... ::  : .  :  : :.   .   .
XP_005 Y--GGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAA
          180       190       200       210       220       230    

           220       230                                           
pF1KB9 DPVFSFPSLPKDLLHTTPCFIPYH                                    
         . :  ::: . : ..  . : :                                    
XP_005 AAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCP
          240       250       260       270       280       290    




237 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 17:49:44 2016 done: Fri Nov  4 17:49:45 2016
 Total Scan time:  7.020 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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