FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9630, 237 aa 1>>>pF1KB9630 237 - 237 aa - 237 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0663+/-0.000262; mu= 9.6306+/- 0.017 mean_var=158.3319+/-32.058, 0's: 0 Z-trim(125.1): 61 B-trim: 1967 in 1/59 Lambda= 0.101927 statistics sampled from 47910 (47978) to 47910 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.843), E-opt: 0.2 (0.563), width: 16 Scan time: 7.020 The best scores are: opt bits E(85289) NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 1621 248.7 6.5e-66 XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 472 79.7 4.4e-15 NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 472 79.7 4.4e-15 NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 437 74.7 1.8e-13 NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 312 56.4 7.3e-08 NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 292 53.4 5.9e-07 NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 286 52.6 1.1e-06 NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 281 51.8 1.7e-06 NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 244 46.3 7.3e-05 XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 244 46.3 7.3e-05 NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 242 46.1 9.6e-05 NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 241 45.9 0.0001 NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 237 45.2 0.00012 NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 219 42.5 0.00063 XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206) 215 41.9 0.001 NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280) 215 42.0 0.0013 XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302) 215 42.1 0.0013 XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351) 215 42.1 0.0015 NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193) 201 39.8 0.004 XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 200 39.7 0.0046 NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 200 39.7 0.0046 NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 195 39.1 0.0095 >>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa) initn: 1621 init1: 1621 opt: 1621 Z-score: 1304.4 bits: 248.7 E(85289): 6.5e-66 Smith-Waterman score: 1621; 100.0% identity (100.0% similar) in 237 aa overlap (1-237:1-237) 10 20 30 40 50 60 pF1KB9 MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPA 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 SDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH 190 200 210 220 230 >>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa) initn: 453 init1: 412 opt: 472 Z-score: 391.8 bits: 79.7 E(85289): 4.4e-15 Smith-Waterman score: 489; 53.7% identity (70.9% similar) in 175 aa overlap (42-213:34-193) 20 30 40 50 60 70 pF1KB9 LDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-RGAPNISRASEVPGAQDDEQE :.::.:.: :: : ..: : .. XP_016 QPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG--NCAEAEEGGCRGAPRKL 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB9 RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTK : :: ::.: .:: : . ::::: ::::::::::::::.::::::.:::.::::.:::: XP_016 RARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB9 IETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGA :::::::.::::::..:::.::..: . : :: .: ::... .::: XP_016 IETLRFAHNYIWALTQTLRIADHSLYA------LEPP--APHCGELGSPGGSPGDWGS-- 130 140 150 160 170 200 210 220 230 pF1KB9 AAASPLSDPSS--PAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH ::.:. .: :::: . ::: XP_016 -LYSPVSQAGSLSPAAS--LEERPGLLGATFSACLSPGSLAFSDFL 180 190 200 210 >>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa) initn: 453 init1: 412 opt: 472 Z-score: 391.8 bits: 79.7 E(85289): 4.4e-15 Smith-Waterman score: 489; 53.7% identity (70.9% similar) in 175 aa overlap (42-213:34-193) 20 30 40 50 60 70 pF1KB9 LDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-RGAPNISRASEVPGAQDDEQE :.::.:.: :: : ..: : .. NP_066 QPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG--NCAEAEEGGCRGAPRKL 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB9 RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTK : :: ::.: .:: : . ::::: ::::::::::::::.::::::.:::.::::.:::: NP_066 RARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB9 IETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGA :::::::.::::::..:::.::..: . : :: .: ::... .::: NP_066 IETLRFAHNYIWALTQTLRIADHSLYA------LEPP--APHCGELGSPGGSPGDWGS-- 130 140 150 160 170 200 210 220 230 pF1KB9 AAASPLSDPSS--PAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH ::.:. .: :::: . ::: NP_066 -LYSPVSQAGSLSPAAS--LEERPGLLGATFSACLSPGSLAFSDFL 180 190 200 210 >>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa) initn: 519 init1: 373 opt: 437 Z-score: 362.6 bits: 74.7 E(85289): 1.8e-13 Smith-Waterman score: 437; 46.2% identity (67.2% similar) in 186 aa overlap (33-215:51-233) 10 20 30 40 50 60 pF1KB9 ARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASAS-GPPAPARRGAPNISRASEV :: :..: :. : . . :: . : ... NP_076 GSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CRPARL 30 40 50 60 70 70 80 90 100 110 pF1KB9 PGAQDDEQER-RRRRGRTR-VRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVL : : ..: : :. .: ... .. ....::.:::.::::::::::::::::: :: NP_076 LGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVL 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB9 PSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSP :.::.:.:::::::::::.::::::.:::::::. :::. : . : :: : NP_076 PTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASA 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB9 ASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH : : :.. . :: : .::: : . . .: NP_076 A--LSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPD 200 210 220 230 240 250 NP_076 KHRYAPHLPIARDCI 260 270 >>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa) initn: 296 init1: 268 opt: 312 Z-score: 262.2 bits: 56.4 E(85289): 7.3e-08 Smith-Waterman score: 312; 39.0% identity (57.6% similar) in 177 aa overlap (65-231:60-226) 40 50 60 70 80 90 pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRG-RTRVRSEALLHSLRRSR .... :. .::: . . ..: :. .: .: NP_067 EVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFR-AR 30 40 50 60 70 80 100 110 120 130 140 150 pF1KB9 RVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQ ::::: :::.:::.:: ::: :: :.: . ::.::::::.: ::::::.:.:. . : NP_067 RVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLE-TGQ 90 100 110 120 130 140 160 170 180 190 200 pF1KB9 GLPGGGARERLLPPQCVP-------CLP-GPPSPASDAESWGSGAAAASPLSDPSSPAAS : : : : : :: :: : . . ::. : : . NP_067 TPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHE------DKSPICD--SAISV 150 160 170 180 190 210 220 230 pF1KB9 EDFTYR-PGDPVFSFPSLPKDLLHTTPCFIPYH ..:.:. :: : . . ::: : NP_067 HNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSI 200 210 220 230 240 250 >>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa) initn: 336 init1: 278 opt: 292 Z-score: 245.9 bits: 53.4 E(85289): 5.9e-07 Smith-Waterman score: 292; 55.3% identity (77.6% similar) in 85 aa overlap (65-149:75-158) 40 50 60 70 80 90 pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRR .::.:. .:: . . ..: :. .. :: NP_002 AMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKL-RR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB9 VKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQG .::: :::::::.:::::: ::.:.: . ::.::::::.: ::::::.: :: NP_002 MKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSP 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGD NP_002 DLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQS 170 180 190 200 210 220 >>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa) initn: 341 init1: 280 opt: 286 Z-score: 240.7 bits: 52.6 E(85289): 1.1e-06 Smith-Waterman score: 286; 54.9% identity (72.5% similar) in 91 aa overlap (60-149:89-178) 30 40 50 60 70 80 pF1KB9 EDCARLQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRG-RTRVRSEALLHS : : .. : :: ..:: . : ..: :. NP_006 PLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLER 60 70 80 90 100 110 90 100 110 120 130 140 pF1KB9 LRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETL . :: ::: :::::::.:::::: ::.:.: . ::.::::::.: ::::::.: : NP_006 -SKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEIL 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 RLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDF : NP_006 RSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMH 180 190 200 210 220 230 >>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa) initn: 297 init1: 268 opt: 281 Z-score: 237.5 bits: 51.8 E(85289): 1.7e-06 Smith-Waterman score: 284; 40.2% identity (56.1% similar) in 164 aa overlap (65-213:67-221) 40 50 60 70 80 90 pF1KB9 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRR ..::. :::: . .. : . :: NP_073 FSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRR 40 50 60 70 80 90 100 110 120 130 140 150 pF1KB9 VKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQG .:: :::::::.:: ::: ::.:.: . ::.::::::.: ::::::.: ::. NP_073 QEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRI---- 100 110 120 130 140 150 160 170 180 190 pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASD---------AESW--GSGAAAA----SPLSDP : : :: : : .:... :.:. :.:. :: :: : NP_073 ----GKRPDLLTFVQNLC-KGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTF 160 170 180 190 200 200 210 220 230 pF1KB9 SSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH : : ..: :: NP_073 YPPYHSPELTTPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINY 210 220 230 240 250 260 >>NP_005797 (OMIM: 606386) oligodendrocyte transcription (323 aa) initn: 212 init1: 122 opt: 244 Z-score: 208.3 bits: 46.3 E(85289): 7.3e-05 Smith-Waterman score: 244; 29.2% identity (53.0% similar) in 236 aa overlap (17-237:29-258) 10 20 30 40 pF1KB9 MPARLETCISDLDCASSSGSDLSGFL---TDEEDC-----ARLQQAAS :::: ..: . :: :.:. : . NP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 ASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDR ..: . :. ... .: ... . . . .: :..:: .: :.: NP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLR----LKINSR 70 80 90 100 110 110 120 130 140 150 pF1KB9 ERNRMHNLNAALDALRSVLPSF--PDDTKLTKIETLRFAYNYIWALAETL----RLADQG ::.:::.:: :.:.:: :.: :. ::.:: :: .: ::: :...: ::... NP_005 ERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEI 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASP-LSDPSSPAASEDFTYRPG :: . . : : . : ::. :. ... :: : . : : :. . . NP_005 Y--GGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAA 180 190 200 210 220 230 220 230 pF1KB9 DPVFSFPSLPKDLLHTTPCFIPYH . : ::: . : .. . : : NP_005 AAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCP 240 250 260 270 280 290 >>XP_005260965 (OMIM: 606386) PREDICTED: oligodendrocyte (323 aa) initn: 212 init1: 122 opt: 244 Z-score: 208.3 bits: 46.3 E(85289): 7.3e-05 Smith-Waterman score: 244; 29.2% identity (53.0% similar) in 236 aa overlap (17-237:29-258) 10 20 30 40 pF1KB9 MPARLETCISDLDCASSSGSDLSGFL---TDEEDC-----ARLQQAAS :::: ..: . :: :.:. : . XP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 ASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDR ..: . :. ... .: ... . . . .: :..:: .: :.: XP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLR----LKINSR 70 80 90 100 110 110 120 130 140 150 pF1KB9 ERNRMHNLNAALDALRSVLPSF--PDDTKLTKIETLRFAYNYIWALAETL----RLADQG ::.:::.:: :.:.:: :.: :. ::.:: :: .: ::: :...: ::... XP_005 ERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEI 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 LPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASP-LSDPSSPAASEDFTYRPG :: . . : : . : ::. :. ... :: : . : : :. . . XP_005 Y--GGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAA 180 190 200 210 220 230 220 230 pF1KB9 DPVFSFPSLPKDLLHTTPCFIPYH . : ::: . : .. . : : XP_005 AAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCP 240 250 260 270 280 290 237 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:49:44 2016 done: Fri Nov 4 17:49:45 2016 Total Scan time: 7.020 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]