Result of FASTA (omim) for
pF1KB9628
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9628, 331 aa
1>>>pF1KB9628 331 - 331 aa - 331 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4829+/-0.000285; mu= 8.4277+/- 0.018
mean_var=149.4641+/-31.272, 0's: 0 Z-trim(121.9): 57 B-trim: 1920 in 1/60
Lambda= 0.104907
statistics sampled from 39031 (39093) to 39031 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.787), E-opt: 0.2 (0.458), width: 16
Scan time: 8.950
The best scores are: opt bits E(85289)
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 2245 350.6 2.6e-96
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 1102 177.7 3.3e-44
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 827 136.0 1.1e-31
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 653 109.7 1e-23
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 312 58.0 2.4e-08
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 267 51.2 3e-06
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 260 50.1 5.1e-06
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 260 50.1 5.1e-06
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 246 48.1 3.3e-05
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 224 44.5 0.00017
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 227 45.1 0.00018
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 212 42.9 0.00095
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 201 41.1 0.0023
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 205 41.9 0.0023
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 205 41.9 0.0023
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 194 40.0 0.0041
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 194 40.0 0.0041
NP_001099039 (OMIM: 612209) mesogenin-1 [Homo sapi ( 193) 189 39.3 0.0081
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 193 40.1 0.0091
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 2245 init1: 2245 opt: 2245 Z-score: 1850.0 bits: 350.6 E(85289): 2.6e-96
Smith-Waterman score: 2245; 100.0% identity (100.0% similar) in 331 aa overlap (1-331:1-331)
10 20 30 40 50 60
pF1KB9 MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 EEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 EEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 QKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 QKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 VLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 VLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQA
250 260 270 280 290 300
310 320 330
pF1KB9 GTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE
:::::::::::::::::::::::::::::::
NP_067 GTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE
310 320 330
>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa)
initn: 1210 init1: 714 opt: 1102 Z-score: 914.6 bits: 177.7 E(85289): 3.3e-44
Smith-Waterman score: 1207; 53.4% identity (77.4% similar) in 358 aa overlap (1-329:1-354)
10 20 30 40 50
pF1KB9 MSKTFVKSKEMGELV--NTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSI----
:.:.. .: ::: . ::: :. :.::.: .: ... : ... :.::.
NP_002 MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDD---LEAMNAEEDSLRNGG
10 20 30 40 50
60 70 80 90 100
pF1KB9 -----------EEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGL
:::::::.: .::::::::::::::::::::. ::.:::::::.:::::
NP_002 EEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB9 NDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLS
: ::::::.:.::::::::::::::::::.::::::::.:..:..:. .::. ::::::
NP_002 NAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLS
120 130 140 150 160 170
170 180 190 200 210
pF1KB9 QPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSA---ISVHNFNYQSPGLPSPPYGHMET-
:::.:::::::::.:.. : :...: : .: . :: ..:::::::::::: :..
NP_002 QPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB9 HLLHLKP--QVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSY
:..:.:: ..... : : : : ::..: ..:::.:::::.::::.:.. : ..::.:
NP_002 HVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNY
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB9 SFMPHYPSSSLSSGHVHSTPFQAGT--PRYDVPID--MSYDSYPHHG--IGTQLNTVFTE
.: :::...:.... :.. : .:: :: ..::: ::.::. :: ...:::..:
NP_002 AFTMHYPAATLAGAQSHGSIF-SGTAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
300 310 320 330 340 350
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 737 init1: 737 opt: 827 Z-score: 690.0 bits: 136.0 E(85289): 1.1e-31
Smith-Waterman score: 827; 51.3% identity (72.3% similar) in 267 aa overlap (49-307:54-318)
20 30 40 50 60 70
pF1KB9 SWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEK--PKRRGPKKKK
:: .. ::::..::. :. :.::: .:::
NP_073 ECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKK
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB9 MTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYI
:: :::: . :: .::::::.:::::::::::::.:.::::::::::::::::::.:::
NP_073 TTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYI
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB9 WALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSA
:::::.:. :. :. ::. :::::::::.:::::::::. .: :. . . . :
NP_073 WALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSP
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB9 ISVHNFNYQSPGLPSPP-YGHMETHLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTP
:. :.:: : .:: .: ... .:: . : :: . : :.:..: .::::.:
NP_073 YSTFYPPYHSPELTTPPGHGTLDNSK-SMKPYNYCSAYESFYESTSPECASPQFEGPLSP
210 220 230 240 250 260
260 270 280 290 300 310
pF1KB9 P-LSISGNFSLKQDGSPDLEKSYSFMPHY----PSSSLSSGHVHSTPFQAGTPRYDVPID
: .. .: :::::. . : :.:.. :: : . :..: . : .. : ::.
NP_073 PPINYNGIFSLKQEETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFP-YDLHLR
270 280 290 300 310 320
320 330
pF1KB9 MSYDSYPHHGIGTQLNTVFTE
NP_073 SQSLTMQDELNAVFHN
330
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 926 init1: 642 opt: 653 Z-score: 546.9 bits: 109.7 E(85289): 1e-23
Smith-Waterman score: 849; 48.4% identity (67.7% similar) in 316 aa overlap (39-329:65-380)
10 20 30 40 50 60
pF1KB9 KEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHD-SIEEEEEEEED----
:: . :. . :: . . ::::::::.
NP_006 DAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLD
40 50 60 70 80 90
70 80 90 100 110 120
pF1KB9 ---GEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT
::.::.:::::.::::::::: . :: :::::::.::: :: ::::::.:.::::::
NP_006 EAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKT
100 110 120 130 140 150
130 140 150 160 170 180
pF1KB9 QKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQS
::::::::::::.::::::::.:..:. :. ..:. :::::::::.:::::::::. ..
NP_006 QKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRN
160 170 180 190 200 210
190 200 210 220
pF1KB9 VLLEKHEDKSPICDSA---ISVHNFNYQSPGLPSPP------YGHMETHLL--HLKPQVF
: :. : . .. ...: . : : . : .: : : ..
NP_006 FLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAY
220 230 240 250 260 270
230 240 250 260 270 280
pF1KB9 KSL-GESSFGSHLPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSL
..: . .. :. :: .. :::::.::: ..::::::::.::: :::: . :: .
NP_006 ETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPG
280 290 300 310 320 330
290 300 310 320 330
pF1KB9 SSGHVHSTPFQAGTPRYDVPID--MSYDSYPHHGIGT---QLNTVFTE
: :. : ... : : . .::: . :: : .::. :
NP_006 SRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN
340 350 360 370 380
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 296 init1: 268 opt: 312 Z-score: 270.9 bits: 58.0 E(85289): 2.4e-08
Smith-Waterman score: 312; 39.0% identity (57.6% similar) in 177 aa overlap (60-226:65-231)
30 40 50 60 70 80
pF1KB9 EVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFR-AR
.... :. .::: . . ..: :. .: .:
NP_006 LQQAASASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRG-RTRVRSEALLHSLRRSR
40 50 60 70 80 90
90 100 110 120 130 140
pF1KB9 RVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETG-Q
::::: :::.:::.:: ::: :: :.: . ::.::::::.: ::::::.:.:. . :
NP_006 RVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQ
100 110 120 130 140 150
150 160 170 180 190
pF1KB9 TPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHE------DKSPICD--SAISV
: : : : : :: :: : . . ::. : : .
NP_006 GLPGGGARERLLPPQCVP-------CLP-GPPSPASDAESWGSGAAAASPLSDPSSPAAS
160 170 180 190 200
200 210 220 230 240 250
pF1KB9 HNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSI
..:.:. :: : . . ::: :
NP_006 EDFTYR-PGDPVFSFPSLPKDLLHTTPCFIPYH
210 220 230
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 331 init1: 245 opt: 267 Z-score: 233.3 bits: 51.2 E(85289): 3e-06
Smith-Waterman score: 267; 33.3% identity (59.4% similar) in 192 aa overlap (66-244:89-271)
40 50 60 70 80 90
pF1KB9 SRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKR-RGPKKKKMTKARLERFR-ARRVKAN
.:.: :. .. : ..:.. .::.:::
NP_076 AGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKAN
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB9 ARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKG
:::.:::.:: ::: ::.:.: . . ::.::::::.:.::::::.:.:. .. : :
NP_076 NRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGG
120 130 140 150 160 170
160 170 180 190 200
pF1KB9 -------FVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQS
: : . . . .. : .. . .: :. .:: .:..: .. . :
NP_076 GGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTW---SCTNSPAPSSSVSSNSTSPYS
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB9 PGL-PSPPYGHMETHLLHLKPQVFKSLGESSFGSHLP---DCSTPPYEGPLTPPLSISGN
: :. : : . . . .: . .. ::: ::
NP_076 CTLSPASPAG---SDMDYWQP---PPPDKHRYAPHLPIARDCI
240 250 260 270
270 280 290 300 310 320
pF1KB9 FSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQAGTPRYDVPIDMSYDSYPHHGIG
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 281 init1: 233 opt: 260 Z-score: 229.0 bits: 50.1 E(85289): 5.1e-06
Smith-Waterman score: 260; 50.0% identity (71.7% similar) in 92 aa overlap (59-143:48-139)
30 40 50 60 70 80
pF1KB9 NEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEK--PK----RRGPKKKKMTKARL
: :: : . :. ::: ... .. :
XP_016 ERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELAL
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 ER-FRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSE
. :.:: ::: :::.:::.::.::: :: :.: . ::.::::::.:.::::::..
XP_016 SKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQ
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB9 VLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHN
.:
XP_016 TLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGA
140 150 160 170 180 190
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 281 init1: 233 opt: 260 Z-score: 229.0 bits: 50.1 E(85289): 5.1e-06
Smith-Waterman score: 260; 50.0% identity (71.7% similar) in 92 aa overlap (59-143:48-139)
30 40 50 60 70 80
pF1KB9 NEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEK--PK----RRGPKKKKMTKARL
: :: : . :. ::: ... .. :
NP_066 ERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELAL
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 ER-FRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSE
. :.:: ::: :::.:::.::.::: :: :.: . ::.::::::.:.::::::..
NP_066 SKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQ
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB9 VLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHN
.:
NP_066 TLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGA
140 150 160 170 180 190
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 275 init1: 231 opt: 246 Z-score: 214.5 bits: 48.1 E(85289): 3.3e-05
Smith-Waterman score: 246; 50.0% identity (77.4% similar) in 84 aa overlap (68-151:144-220)
40 50 60 70 80 90
pF1KB9 PGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARER
..:.:..:... .. . ::. ::::::
NP_005 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQ----KQRRLAANARER
120 130 140 150 160
100 110 120 130 140 150
pF1KB9 TRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEM
:::::: :.:.:: :.: ... .:::: :::..:. :: ::::.: ::: :
NP_005 RRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELL---QTPSGGEQPPP
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB9 LCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHM
NP_005 PPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYS
230 240 250 260 270 280
>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom (152 aa)
initn: 221 init1: 221 opt: 224 Z-score: 201.7 bits: 44.5 E(85289): 0.00017
Smith-Waterman score: 224; 48.1% identity (72.8% similar) in 81 aa overlap (81-160:34-114)
60 70 80 90 100 110
pF1KB9 HDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNL
::: ::. :::::: ::.::: :.: :
NP_660 CKPSGPPAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRL
10 20 30 40 50 60
120 130 140 150 160
pF1KB9 RRVMPCYSKTQKLSKIETLRLARNYIWALSEVL-ETGQTPEGKGFVEMLCKGLSQPTSNL
:::.: ... .:::: :::..: .:: ::...: :. . . .: . :.
NP_660 RRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLP
70 80 90 100 110 120
170 180 190 200 210 220
pF1KB9 VAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVF
NP_660 FPGAKLPGESELYSQRLFGFQPEPFQMAT
130 140 150
331 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:48:39 2016 done: Fri Nov 4 17:48:41 2016
Total Scan time: 8.950 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]