FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9578, 237 aa
  1>>>pF1KB9578 237 - 237 aa - 237 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.1527+/-0.000316; mu= 3.3096+/- 0.020
 mean_var=212.7831+/-43.550, 0's: 0 Z-trim(123.3): 69  B-trim: 547 in 1/55
 Lambda= 0.087924
 statistics sampled from 42655 (42750) to 42655 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.802), E-opt: 0.2 (0.501), width:  16
 Scan time:  7.580

The best scores are:                                      opt bits E(85289)
NP_004307 (OMIM: 100790,209880) achaete-scute homo ( 236) 1549 208.0 1.1e-53
NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193)  423 65.1 9.8e-11
NP_982260 (OMIM: 609155) achaete-scute homolog 4 [ ( 173)  254 43.6 0.00026
NP_065697 (OMIM: 609154) achaete-scute homolog 3 [ ( 181)  222 39.6  0.0044
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217)  215 38.8  0.0094


>>NP_004307 (OMIM: 100790,209880) achaete-scute homolog   (236 aa)
 initn: 1309 init1: 1309 opt: 1549  Z-score: 1084.5  bits: 208.0 E(85289): 1.1e-53
Smith-Waterman score: 1549; 99.6% identity (99.6% similar) in 237 aa overlap (1-237:1-236)

               10        20        30        40        50        60
pF1KB9 MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 QQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAA
       :: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QQ-APQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAA
                70        80        90       100       110         

              130       140       150       160       170       180
pF1KB9 VARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDA
     120       130       140       150       160       170         

              190       200       210       220       230       
pF1KB9 VSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
     180       190       200       210       220       230      

>>NP_005161 (OMIM: 601886) achaete-scute homolog 2 [Homo  (193 aa)
 initn: 517 init1: 350 opt: 423  Z-score: 313.7  bits: 65.1 E(85289): 9.8e-11
Smith-Waterman score: 472; 52.0% identity (68.0% similar) in 175 aa overlap (89-237:23-190)

       60        70        80        90       100           110    
pF1KB9 QQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRR----LNFSGFGYSLP
                                     :.: .::::.::.::       .: :    
NP_005         MDGGTLPRSAPPAPPVPVGCAARRRPASPELLRCSRRRRPATAETGGG----
                       10        20        30        40            

          120       130       140       150       160       170    
pF1KB9 QQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQL
           ::::::::::::::::::::: .::.:::.:.:.::.:::::::::::::::::.:
NP_005 ---AAAVARRNERERNRVKLVNLGFQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRL
          50        60        70        80        90       100     

          180           190                   200            210   
pF1KB9 LDEHDAVSAAFQAGV----LSPTI------------SPNYSNDL-----NSMAGSPVSSY
       : :::::  :. .:.    . :.             ::. ...      .:  ::: :.:
NP_005 LAEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGSPRSAY
         110       120       130       140       150       160     

            220       230          
pF1KB9 SSDE-GSYDPLSPEEQELLDFTNWF   
       :::. :    ::: :.:::::..:.   
NP_005 SSDDSGCEGALSPAERELLDFSSWLGGY
         170       180       190   

>>NP_982260 (OMIM: 609155) achaete-scute homolog 4 [Homo  (173 aa)
 initn: 234 init1: 234 opt: 254  Z-score: 198.4  bits: 43.6 E(85289): 0.00026
Smith-Waterman score: 254; 38.9% identity (60.5% similar) in 162 aa overlap (67-218:17-171)

         40        50        60        70          80         90   
pF1KB9 AAAAAAAAAAAQSAQQQQQQQQQQQQQAPQLRPAADGQPSG--GGHKSAPKQVK-RQRSS
                                     :: :  : :.   :  .  : .:  :  ..
NP_982               MMETRKPAERLALPYSLRTAPLGVPGTLPGLPRRDPLRVALRLDAA
                             10        20        30        40      

             100       110           120       130       140       
pF1KB9 SPELMR--CKRRLNFSGFGY-SLPQQ---QPAAVARRNERERNRVKLVNLGFATLREHVP
         :  :  : :     :. :  .: .   .:: . .::::::.::. :: :.: ::.:.:
NP_982 CWEWARSGCAR-----GWQYLPVPLDSAFEPAFLRKRNERERQRVRCVNEGYARLRDHLP
         50             60        70        80        90       100 

       150       160       170       180       190       200       
pF1KB9 NGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAG
          :.:..:::::::.:..::. ::.:: :..: .    ::.. :    . ..: .: :.
NP_982 RELADKRLSKVETLRAAIDYIKHLQELL-ERQAWGLEGAAGAV-PQRRAECNSDGESKAS
             110       120        130       140        150         

        210       220       230       
pF1KB9 S-PVSSYSSDEGSYDPLSPEEQELLDFTNWF
       : :  :   .::                   
NP_982 SAPSPSSEPEEGGS                 
     160       170                    

>>NP_065697 (OMIM: 609154) achaete-scute homolog 3 [Homo  (181 aa)
 initn: 214 init1: 214 opt: 222  Z-score: 176.3  bits: 39.6 E(85289): 0.0044
Smith-Waterman score: 222; 43.3% identity (63.9% similar) in 97 aa overlap (105-201:82-175)

           80        90       100       110       120       130    
pF1KB9 PSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKL
                                     :. :  ::     :: . .::::::.::: 
NP_065 ELPRLPFPSDSLILGNYSEPCPFSFPMPYPNYRGCEYSY---GPAFTRKRNERERQRVKC
              60        70        80        90          100        

          140       150       160       170       180       190    
pF1KB9 VNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTI
       :: :.: ::.:.:.   .:..:::::::.:..::  ::.::    : .    . : :   
NP_065 VNEGYAQLRHHLPEEYLEKRLSKVETLRAAIKYINYLQSLLYPDKAETKNNPGKVSSMIA
      110       120       130       140       150       160        

          200       210       220       230       
pF1KB9 SPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
       . ..  :                                    
NP_065 TTSHHADPMFRIV                              
      170       180                               

>>NP_068808 (OMIM: 602407) heart- and neural crest deriv  (217 aa)
 initn: 219 init1: 158 opt: 215  Z-score: 170.4  bits: 38.8 E(85289): 0.0094
Smith-Waterman score: 244; 31.7% identity (56.1% similar) in 205 aa overlap (20-212:8-195)

               10        20        30        40        50        60
pF1KB9 MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQ
                          :..: .   .  ::.::::::::::.            . .
NP_068             MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAAS------------RCS
                           10        20        30                  

               70        80        90       100       110       120
pF1KB9 QQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAA
       ... : ..    :.:     . .: . .   : :::       :. : .:   :   : .
NP_068 HEENPYFHGWLIGHP-----EMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPG
         40        50             60        70        80        90 

                       130       140       150       160       170 
pF1KB9 ------VARR---NERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRAL
             : ::   :..:: :.. .: .:: ::: .::  :. :.::..::: :. ::  :
NP_068 LGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYL
             100       110       120       130       140       150 

               180       190        200       210       220        
pF1KB9 QQLL--DEHDAVSAAFQAGVLSPTISPN-YSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQ
       ..::  :.... . ::.: . .  .. .  ...:: .  : :::                
NP_068 MDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVW
             160       170       180       190       200       210 

      230       
pF1KB9 ELLDFTNWF
                
NP_068 ALELKQ   
                




237 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 17:27:28 2016 done: Fri Nov  4 17:27:29 2016
 Total Scan time:  7.580 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]