Result of FASTA (omim) for
pF1KB9569
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9569, 741 aa
1>>>pF1KB9569 741 - 741 aa - 741 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6424+/-0.000552; mu= -13.0018+/- 0.035
mean_var=470.2909+/-96.908, 0's: 0 Z-trim(120.0): 86 B-trim: 1374 in 1/57
Lambda= 0.059141
statistics sampled from 34598 (34697) to 34598 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.407), width: 16
Scan time: 15.430
The best scores are: opt bits E(85289)
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 4458 395.5 4e-109
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 4458 395.6 4e-109
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 4458 395.6 4.1e-109
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 4458 395.6 4.1e-109
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 3861 344.6 8e-94
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 3584 321.0 1.1e-86
XP_016856997 (OMIM: 164175) PREDICTED: POU domain, ( 381) 2131 196.8 1.4e-49
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 1344 129.8 3.7e-29
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 1344 129.8 3.7e-29
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 1344 129.8 3.7e-29
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 1317 127.5 1.8e-28
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 1308 126.7 2.7e-28
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 1276 124.0 1.8e-27
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 1276 124.0 1.8e-27
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 1275 123.9 2e-27
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 1249 121.6 8.3e-27
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 1240 120.8 1.3e-26
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 1239 120.8 1.4e-26
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 1232 120.1 2e-26
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 1115 110.2 2.4e-23
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 1108 109.6 3.8e-23
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 1079 107.1 1.7e-22
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 1072 106.5 2.7e-22
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 1020 102.0 5e-21
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 1000 100.3 1.7e-20
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 1000 100.3 1.7e-20
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 1000 100.3 1.8e-20
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 1000 100.3 1.8e-20
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 970 97.7 8.9e-20
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 692 74.0 1.2e-12
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 685 73.4 2.2e-12
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 684 73.4 2.5e-12
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 672 72.3 4.8e-12
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 570 63.5 1.7e-09
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 551 61.8 4.1e-09
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 553 62.1 4.6e-09
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 504 58.1 1.3e-07
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 460 54.2 1.2e-06
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 450 53.3 1.9e-06
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 443 52.8 3.5e-06
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 425 50.9 5.5e-06
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 425 50.9 5.5e-06
>>XP_011507956 (OMIM: 164175) PREDICTED: POU domain, cla (743 aa)
initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.2 bits: 395.5 E(85289): 4e-109
Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:21-743)
10 20 30 40 50
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
::::::::::::::::::::::::::::::::::::::::
XP_011 MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB9 PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB9 KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB9 SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB9 EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB9 VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB9 SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB9 SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB9 FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ
670 680 690 700 710 720
720 730 740
pF1KB9 NSLFTVASASGAASTTTTASKAQ
:::::::::::::::::::::::
XP_011 NSLFTVASASGAASTTTTASKAQ
730 740
>>NP_001185712 (OMIM: 164175) POU domain, class 2, trans (755 aa)
initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.1 bits: 395.6 E(85289): 4e-109
Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:33-755)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
NP_001 DCSDYVLDSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
670 680 690 700 710 720
710 720 730 740
pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
:::::::::::::::::::::::::::::::::
NP_001 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
730 740 750
>>NP_002688 (OMIM: 164175) POU domain, class 2, transcri (766 aa)
initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.0 bits: 395.6 E(85289): 4.1e-109
Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:44-766)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
NP_002 AAAAAAADSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
440 450 460 470 480 490
470 480 490 500 510 520
pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
500 510 520 530 540 550
530 540 550 560 570 580
pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
560 570 580 590 600 610
590 600 610 620 630 640
pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
620 630 640 650 660 670
650 660 670 680 690 700
pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
680 690 700 710 720 730
710 720 730 740
pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
:::::::::::::::::::::::::::::::::
NP_002 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
740 750 760
>>XP_011507955 (OMIM: 164175) PREDICTED: POU domain, cla (769 aa)
initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.0 bits: 395.6 E(85289): 4.1e-109
Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:47-769)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
XP_011 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
440 450 460 470 480 490
470 480 490 500 510 520
pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
500 510 520 530 540 550
530 540 550 560 570 580
pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
560 570 580 590 600 610
590 600 610 620 630 640
pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
620 630 640 650 660 670
650 660 670 680 690 700
pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
680 690 700 710 720 730
710 720 730 740
pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
:::::::::::::::::::::::::::::::::
XP_011 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
740 750 760
>>XP_011507957 (OMIM: 164175) PREDICTED: POU domain, cla (671 aa)
initn: 4152 init1: 3861 opt: 3861 Z-score: 1805.5 bits: 344.6 E(85289): 8e-94
Smith-Waterman score: 3861; 99.5% identity (99.7% similar) in 625 aa overlap (19-643:47-671)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
XP_011 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
440 450 460 470 480 490
470 480 490 500 510 520
pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
500 510 520 530 540 550
530 540 550 560 570 580
pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
560 570 580 590 600 610
590 600 610 620 630 640
pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
::::::::::::::::::::::::::::::::::::::::::::::::::.: :
XP_011 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQVLLRG
620 630 640 650 660 670
650 660 670 680 690 700
pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
>>NP_001185715 (OMIM: 164175) POU domain, class 2, trans (703 aa)
initn: 3507 init1: 3507 opt: 3584 Z-score: 1677.5 bits: 321.0 E(85289): 1.1e-86
Smith-Waterman score: 3940; 91.3% identity (91.3% similar) in 723 aa overlap (19-741:44-703)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
NP_001 AAAAAAADSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
:
NP_001 G-----------------------------------------------------------
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----DLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
140 150 160 170 180 190
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
200 210 220 230 240 250
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
260 270 280 290 300 310
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
320 330 340 350 360 370
410 420 430 440 450 460
pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS
380 390 400 410 420 430
470 480 490 500 510 520
pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA
440 450 460 470 480 490
530 540 550 560 570 580
pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA
500 510 520 530 540 550
590 600 610 620 630 640
pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI
560 570 580 590 600 610
650 660 670 680 690 700
pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH
620 630 640 650 660 670
710 720 730 740
pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
:::::::::::::::::::::::::::::::::
NP_001 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ
680 690 700
>>XP_016856997 (OMIM: 164175) PREDICTED: POU domain, cla (381 aa)
initn: 2131 init1: 2131 opt: 2131 Z-score: 1011.0 bits: 196.8 E(85289): 1.4e-49
Smith-Waterman score: 2131; 100.0% identity (100.0% similar) in 334 aa overlap (19-352:47-380)
10 20 30 40
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
::::::::::::::::::::::::::::::
XP_016 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT
::::
XP_016 NDAEP
380
>>XP_016882381 (OMIM: 164176) PREDICTED: POU domain, cla (701 aa)
initn: 1441 init1: 556 opt: 1344 Z-score: 644.6 bits: 129.8 E(85289): 3.7e-29
Smith-Waterman score: 1700; 48.5% identity (66.2% similar) in 748 aa overlap (50-741:42-701)
20 30 40 50 60 70
pF1KB9 QTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS-LQAAAQSLNVQSKSNEESGD
:: :: .... . ... :... :::
XP_016 RMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB9 SQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT-LTPAQQQLLLQQAQAQAQLLAAAVQQ
: :. : .: .::.::::.:.:..::: : :::::::::::::: ::::::::
XP_016 SA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTALMPAQQQLLLQQAQAQ--LLAAAVQQ
80 90 100 110 120
140 150 160
pF1KB9 HSASQQHSAAGATISASAAT------------------------------PMTQIP----
::. .::.:. .:::.. : .: :
XP_016 SSAAAAANAAAAAAAASASSSTSSSSSSSASSSTSQPPASSGGGDLPPPQPASQPPGTPQ
130 140 150 160 170 180
170 180 190 200 210
pF1KB9 --LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVHPTTNLQP-AQFIISQTPQGQQGLLQA
::::::. :::.::: :::: .::: : .::: :::.. :. :.: ::: .
XP_016 LTLSQPIQLTAQDIQQLLQLQQ-------LVLV-PGHHLQPPAQFLLPQAQQSQPGLLPT
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 QNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSL-E
::. :::::.:. :: ::: : .: .: : : . :: :: .. :: :
XP_016 PNLF-QLPQQTQGALLTSQPRAGLPTQAVT--RPTLPDPHLSHPQP---PKCLEPPSHPE
250 260 270 280 290
280 290 300 310 320 330
pF1KB9 EPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMC
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB9 KLKPLLEKWLNDAENLSSDSSLSSPSALNSP--GIEGL-SRRRKKRTSIETNIRVALEKS
::::::::::::::..: :::: ::. :.:: :..:: .::::::::::::.: :::::
XP_016 KLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKS
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB9 FLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSP
:: ::::::::: .::.::.:::::::::::::::::::::: :..:. .:::
XP_016 FLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINP-----CSAAPM---LPSP
420 430 440 450 460
460 470 480 490 500 510
pF1KB9 TSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVTNLS-VTGT--SDTTSNNTATVISTAP
. .. .: .:: ...: :: .: . :..::.:: ..:: . :... . ..::
XP_016 GKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAP
470 480 490 500 510 520
520 530 540 550 560 570
pF1KB9 PASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAA
: .: ::..: : : : ....: :: :. .: ::
XP_016 PLNSI---PSVTPPPPA---------------TTNSTNP--SPQGSH----SAIGL----
530 540 550
580 590 600 610 620 630
pF1KB9 AAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSN
.::::: .:.....:. : ::::::::
XP_016 ----------------------SGLNPS--------TGSTMVGLSSG-----LSPALMSN
560 570 580
640 650 660 670 680
pF1KB9 STLATIQALASGGSLPITSLDATGNLVFANAG---GAPNIVTAPLFLNPQNLSLLTSNP-
. :::::::::::.::.::::..::::.. :: :.:..::.::::: .: ::.. :
XP_016 NPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPG
590 600 610 620 630 640
690 700 710 720 730 740
pF1KB9 VSLVSAAAASAGNS----APVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ
:.:::::::... : .: : ..:.:. : .. :.:.. :. . ..:: .
XP_016 VGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSSSTCSETAAQTPGGPGGPEAGSKPE
650 660 670 680 690 700
>>XP_016882378 (OMIM: 164176) PREDICTED: POU domain, cla (711 aa)
initn: 1434 init1: 556 opt: 1344 Z-score: 644.5 bits: 129.8 E(85289): 3.7e-29
Smith-Waterman score: 1705; 47.4% identity (65.7% similar) in 781 aa overlap (17-741:24-711)
10 20 30 40 50
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQ
:. .:: . :.. : ..: . .. .: : ..
XP_016 MSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPF--SVSPTGPSTKVGILSGLH
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 LAGTSLQAAAQSLNV-QSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT-
: .. . . :. : :... :::: :. : .: .::.::::.:.:..:::
XP_016 L---TFWGPGPCLSPPQIKAEDPSGDSA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTA
60 70 80 90 100 110
120 130 140 150
pF1KB9 LTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAAT--------------
: ::::::::::::: ::::::::: ::. .::.:. .:::..
XP_016 LMPAQQQLLLQQAQA--QLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSASSST
120 130 140 150 160 170
160 170 180 190
pF1KB9 ----------------PMTQIP------LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVH
: .: : ::::::. :::.::: :.:::.:::
XP_016 SQPPASSGGGDLPPPQPASQPPGTPQLTLSQPIQLTAQDIQQL-------LQLQQLVLV-
180 190 200 210 220
200 210 220 230 240 250
pF1KB9 PTTNLQP-AQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRT
: .::: :::.. :. :.: ::: . ::. :::::.:. :: ::: : .: . ::
XP_016 PGHHLQPPAQFLLPQAQQSQPGLLPTPNLF-QLPQQTQGALLTSQPRAGLPTQAV--TRP
230 240 250 260 270 280
260 270 280 290 300 310
pF1KB9 IAATPIQTLPQSQSTPKRIDTPSL-EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG
: . :: :: .. :: :::::::::::::.:::::::::::::::::::::
XP_016 TLPDPHLSHPQP---PKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMG
290 300 310 320 330
320 330 340 350 360 370
pF1KB9 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSP--G
::::::::::::::::::::::::::::::::::::::::..: :::: ::. :.:: :
XP_016 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLG
340 350 360 370 380 390
380 390 400 410 420
pF1KB9 IEGL-SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRR
..:: .::::::::::::.: ::::::: ::::::::: .::.::.::::::::::::::
XP_016 FDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRR
400 410 420 430 440 450
430 440 450 460 470 480
pF1KB9 QKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVT
:::::::: :..: ..::: . .. .: .:: ...: :: .: . :..::
XP_016 QKEKRINP-----CSAAP---MLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVT
460 470 480 490 500 510
490 500 510 520 530 540
pF1KB9 NLS-VTGT--SDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQ
.:: ..:: . :... . ..::: .: ::..: : : :
XP_016 TLSSAVGTLHPSRTAGGGGGGGGAAPPLNSI---PSVTPPPPA---------------TT
520 530 540 550
550 560 570 580 590 600
pF1KB9 TTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQ
....: :: :. .: :: .:::::
XP_016 NSTNP--SPQGSH----SAIGL--------------------------SGLNPS------
560 570
610 620 630 640 650 660
pF1KB9 FAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAG--
.:.....:. : ::::::::. :::::::::::.::.::::..::::.. ::
XP_016 --TGSTMVGLSSG-----LSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAA
580 590 600 610 620
670 680 690 700 710
pF1KB9 -GAPNIVTAPLFLNPQNLSLLTSNP-VSLVSAAAASAGNS----APVASLHATSTSAESI
:.:..::.::::: .: ::.. : :.:::::::... : .: : ..:.:. :
XP_016 PGSPGLVTSPLFLNHAGLPLLSTPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSS
630 640 650 660 670 680
720 730 740
pF1KB9 QNSLFTVASASGAASTTTTASKAQ
.. :.:.. :. . ..:: .
XP_016 STCSETAAQTPGGPGGPEAGSKPE
690 700 710
>>XP_016882376 (OMIM: 164176) PREDICTED: POU domain, cla (711 aa)
initn: 1434 init1: 556 opt: 1344 Z-score: 644.5 bits: 129.8 E(85289): 3.7e-29
Smith-Waterman score: 1705; 47.4% identity (65.7% similar) in 781 aa overlap (17-741:24-711)
10 20 30 40 50
pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQ
:. .:: . :.. : ..: . .. .: : ..
XP_016 MSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPF--SVSPTGPSTKVGILSGLH
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 LAGTSLQAAAQSLNV-QSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT-
: .. . . :. : :... :::: :. : .: .::.::::.:.:..:::
XP_016 L---TFWGPGPCLSPPQIKAEDPSGDSA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTA
60 70 80 90 100 110
120 130 140 150
pF1KB9 LTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAAT--------------
: ::::::::::::: ::::::::: ::. .::.:. .:::..
XP_016 LMPAQQQLLLQQAQA--QLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSASSST
120 130 140 150 160 170
160 170 180 190
pF1KB9 ----------------PMTQIP------LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVH
: .: : ::::::. :::.::: :.:::.:::
XP_016 SQPPASSGGGDLPPPQPASQPPGTPQLTLSQPIQLTAQDIQQL-------LQLQQLVLV-
180 190 200 210 220
200 210 220 230 240 250
pF1KB9 PTTNLQP-AQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRT
: .::: :::.. :. :.: ::: . ::. :::::.:. :: ::: : .: . ::
XP_016 PGHHLQPPAQFLLPQAQQSQPGLLPTPNLF-QLPQQTQGALLTSQPRAGLPTQAV--TRP
230 240 250 260 270 280
260 270 280 290 300 310
pF1KB9 IAATPIQTLPQSQSTPKRIDTPSL-EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG
: . :: :: .. :: :::::::::::::.:::::::::::::::::::::
XP_016 TLPDPHLSHPQP---PKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMG
290 300 310 320 330
320 330 340 350 360 370
pF1KB9 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSP--G
::::::::::::::::::::::::::::::::::::::::..: :::: ::. :.:: :
XP_016 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLG
340 350 360 370 380 390
380 390 400 410 420
pF1KB9 IEGL-SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRR
..:: .::::::::::::.: ::::::: ::::::::: .::.::.::::::::::::::
XP_016 FDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRR
400 410 420 430 440 450
430 440 450 460 470 480
pF1KB9 QKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVT
:::::::: :..: ..::: . .. .: .:: ...: :: .: . :..::
XP_016 QKEKRINP-----CSAAP---MLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVT
460 470 480 490 500 510
490 500 510 520 530 540
pF1KB9 NLS-VTGT--SDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQ
.:: ..:: . :... . ..::: .: ::..: : : :
XP_016 TLSSAVGTLHPSRTAGGGGGGGGAAPPLNSI---PSVTPPPPA---------------TT
520 530 540 550
550 560 570 580 590 600
pF1KB9 TTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQ
....: :: :. .: :: .:::::
XP_016 NSTNP--SPQGSH----SAIGL--------------------------SGLNPS------
560 570
610 620 630 640 650 660
pF1KB9 FAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAG--
.:.....:. : ::::::::. :::::::::::.::.::::..::::.. ::
XP_016 --TGSTMVGLSSG-----LSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAA
580 590 600 610 620
670 680 690 700 710
pF1KB9 -GAPNIVTAPLFLNPQNLSLLTSNP-VSLVSAAAASAGNS----APVASLHATSTSAESI
:.:..::.::::: .: ::.. : :.:::::::... : .: : ..:.:. :
XP_016 PGSPGLVTSPLFLNHAGLPLLSTPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSS
630 640 650 660 670 680
720 730 740
pF1KB9 QNSLFTVASASGAASTTTTASKAQ
.. :.:.. :. . ..:: .
XP_016 STCSETAAQTPGGPGGPEAGSKPE
690 700 710
741 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:22:59 2016 done: Fri Nov 4 17:23:01 2016
Total Scan time: 15.430 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]