FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9476, 349 aa
  1>>>pF1KB9476 349 - 349 aa - 349 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2884+/-0.000367; mu= 11.4342+/- 0.023
 mean_var=81.3114+/-16.779, 0's: 0 Z-trim(114.8): 17  B-trim: 209 in 1/52
 Lambda= 0.142232
 statistics sampled from 24807 (24821) to 24807 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.291), width:  16
 Scan time:  8.140

The best scores are:                                      opt bits E(85289)
NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 2330 487.7 1.6e-137
NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Ho ( 350) 1615 341.0 2.3e-93
NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1  ( 357) 1591 336.1 7.2e-92


>>NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens]     (349 aa)
 initn: 2330 init1: 2330 opt: 2330  Z-score: 2590.0  bits: 487.7 E(85289): 1.6e-137
Smith-Waterman score: 2330; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)

               10        20        30        40        50        60
pF1KB9 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 PLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 PLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 YKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDG
              250       260       270       280       290       300

              310       320       330       340         
pF1KB9 AELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
       :::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 AELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
              310       320       330       340         

>>NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Homo s  (350 aa)
 initn: 1607 init1: 1607 opt: 1615  Z-score: 1797.1  bits: 341.0 E(85289): 2.3e-93
Smith-Waterman score: 1615; 65.4% identity (91.0% similar) in 344 aa overlap (1-344:1-344)

               10        20        30        40        50        60
pF1KB9 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
       :.:::::.:.:..::.::.:: :. ::.:. ::.::::.:. ..:   ::.:::  ::::
NP_002 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
       :. .::::.:.:::::::::.::.:.:::::.: :: ::::::::::.::::::::::::
NP_002 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAF
       .:::::.:.:. ::.:.: : ..:::::.::.::.::.::::.:...:..:::::::.::
NP_002 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 PLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFL
       :.. :: .::..:.....::.:...:.. : : :..:  :.. .::.:.:.:.:::::::
NP_002 PISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 YKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDG
       :::.:::: :::.::::::::: :::.:::::::::::::. ::....... .:::: .:
NP_002 YKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNG
              250       260       270       280       290       300

              310       320       330       340          
pF1KB9 AELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS 
        ::::.:::.:::::::: ::.:::::::.:::: .::::::.:      
NP_002 DELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
              310       320       330       340       350

>>NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 [Hom  (357 aa)
 initn: 1574 init1: 812 opt: 1591  Z-score: 1770.3  bits: 336.1 E(85289): 7.2e-92
Smith-Waterman score: 1591; 64.1% identity (89.2% similar) in 351 aa overlap (1-344:1-351)

               10        20        30        40        50        60
pF1KB9 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
       :.:::::.:.:..::.::.:: :. ::.:. ::.::::.:. ..:   ::.:::  ::::
NP_001 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
       :. .::::.:.:::::::::.::.:.:::::.: :: ::::::::::.::::::::::::
NP_001 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160              170   
pF1KB9 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINE-------VKTEISVESKHQ
       .:::::.:.:. ::.:.: : ..:::::.::.::.::.:::       :.:...:..:::
NP_001 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KB9 TLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDA
       ::::.:::.. :: .::..:.....::.:...:.. : : :..:  :.. .::.:.:.:.
NP_001 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
              190       200       210       220       230       240

           240       250       260       270       280       290   
pF1KB9 ARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAK
       ::::::::::.:::: :::.::::::::: :::.:::::::::::::. ::....... .
NP_001 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
              250       260       270       280       290       300

           300       310       320       330       340          
pF1KB9 KIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS 
       :::: .: ::::.:::.:::::::: ::.:::::::.:::: .::::::.:      
NP_001 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
              310       320       330       340       350       




349 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:45:36 2016 done: Thu Nov  3 23:45:37 2016
 Total Scan time:  8.140 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]