FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9443, 307 aa
  1>>>pF1KB9443 307 - 307 aa - 307 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4566+/-0.000301; mu= 2.2566+/- 0.019
 mean_var=149.7478+/-29.981, 0's: 0 Z-trim(122.6): 4  B-trim: 0 in 0/57
 Lambda= 0.104808
 statistics sampled from 40956 (40960) to 40956 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.48), width:  16
 Scan time:  9.100

The best scores are:                                      opt bits E(85289)
XP_011523740 (OMIM: 603460) PREDICTED: cyclin-depe ( 307) 2038 318.9   8e-87
NP_003876 (OMIM: 603460) cyclin-dependent kinase 5 ( 307) 2038 318.9   8e-87
XP_016880770 (OMIM: 603460) PREDICTED: cyclin-depe ( 307) 2038 318.9   8e-87
NP_003927 (OMIM: 603764) cyclin-dependent kinase 5 ( 367)  820 134.8 2.6e-31


>>XP_011523740 (OMIM: 603460) PREDICTED: cyclin-dependen  (307 aa)
 initn: 2038 init1: 2038 opt: 2038  Z-score: 1679.7  bits: 318.9 E(85289): 8e-87
Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307)

               10        20        30        40        50        60
pF1KB9 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
              250       260       270       280       290       300

              
pF1KB9 LLLGLDR
       :::::::
XP_011 LLLGLDR
              

>>NP_003876 (OMIM: 603460) cyclin-dependent kinase 5 act  (307 aa)
 initn: 2038 init1: 2038 opt: 2038  Z-score: 1679.7  bits: 318.9 E(85289): 8e-87
Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307)

               10        20        30        40        50        60
pF1KB9 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
              250       260       270       280       290       300

              
pF1KB9 LLLGLDR
       :::::::
NP_003 LLLGLDR
              

>>XP_016880770 (OMIM: 603460) PREDICTED: cyclin-dependen  (307 aa)
 initn: 2038 init1: 2038 opt: 2038  Z-score: 1679.7  bits: 318.9 E(85289): 8e-87
Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307)

               10        20        30        40        50        60
pF1KB9 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
              250       260       270       280       290       300

              
pF1KB9 LLLGLDR
       :::::::
XP_016 LLLGLDR
              

>>NP_003927 (OMIM: 603764) cyclin-dependent kinase 5 act  (367 aa)
 initn: 917 init1: 419 opt: 820  Z-score: 683.2  bits: 134.8 E(85289): 2.6e-31
Smith-Waterman score: 936; 52.0% identity (72.6% similar) in 325 aa overlap (4-292:4-328)

               10                    20        30        40        
pF1KB9 MGTVLSLSPS-----YRKATLFED-------GAATVGHYTAVQNSKNAKDKN-LKRHSI-
          ::::::.      : . : :.       :  ..: : :   .:..: .. ::: :. 
NP_003 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL
               10        20        30        40        50        60

         50        60         70           80         90       100 
pF1KB9 ISVLPWKRIVAVSAKKKN-SKKVQPNSSYQNN---ITHLNNENL-KKSLSCANLSTFAQP
       ::.: :::.::.:::::. :::: :. .  .    . . : ::: .:. .  . .  :.:
NP_003 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP
               70        80        90       100       110       120

                      110       120       130              140     
pF1KB9 ---P-PAQPPA-----PPASQLSGSQTGGSSSVKKAPHPAVTS-------AGTPKRVIVQ
          : :. : :     ::..  ...:  ::.. :  : :  .        .:.:.:::::
NP_003 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ
              130       140       150       160       170       180

         150       160       170       180       190       200     
pF1KB9 ASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLY
       :::.:::::::.:.::::::::.::: . : :.:.:::::::::::::.::::::.::.:
NP_003 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY
              190       200       210       220       230       240

         210        220       230       240       250       260    
pF1KB9 MLCRDVI-SSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSV
       .:::. . ..:..:  ::::..::::::.::::::::::::::::::  :: ::.::: .
NP_003 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL
              250       260       270       280       290       300

          270       280       290       300                        
pF1KB9 INLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR                 
       :. .: .::..:::::.:::::.:::::                                
NP_003 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH
              310       320       330       340       350       360




307 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:24:17 2016 done: Thu Nov  3 23:24:18 2016
 Total Scan time:  9.100 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]