Result of FASTA (omim) for
pF1KB9404
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9404, 794 aa
1>>>pF1KB9404 794 - 794 aa - 794 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6565+/-0.000431; mu= 4.1891+/- 0.027
mean_var=176.4063+/-38.263, 0's: 0 Z-trim(116.0): 423 B-trim: 251 in 1/49
Lambda= 0.096564
statistics sampled from 26405 (26849) to 26405 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.315), width: 16
Scan time: 10.230
The best scores are: opt bits E(85289)
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 5284 749.3 1.5e-215
XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase- ( 794) 5284 749.3 1.5e-215
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 5264 746.5 1.1e-214
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 3170 454.8 7.2e-127
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 3157 453.0 2.5e-126
XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase- ( 772) 2942 423.0 2.4e-117
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 2616 377.6 1.1e-103
XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase- ( 742) 2548 368.1 7.9e-101
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 2533 366.0 3.6e-100
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 1376 204.7 8.7e-52
XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 1376 204.8 1e-51
XP_006721808 (OMIM: 610591) PREDICTED: rho GTPase- ( 889) 1376 204.9 1.3e-51
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 1376 204.9 1.3e-51
XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 1318 196.7 2.8e-49
XP_006721810 (OMIM: 610591) PREDICTED: rho GTPase- ( 867) 1318 196.8 3.4e-49
XP_011522771 (OMIM: 610591) PREDICTED: rho GTPase- ( 900) 1041 158.2 1.5e-37
XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 1023 155.5 4.2e-37
XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 1023 155.5 4.5e-37
XP_011509781 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 1023 155.5 4.9e-37
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 1023 155.5 4.9e-37
XP_016859988 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 1023 155.5 4.9e-37
XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 1001 152.5 4.8e-36
XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 1002 152.7 5.3e-36
XP_011522770 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 1002 152.8 6.5e-36
XP_016879800 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 1002 152.8 6.5e-36
XP_011522773 (OMIM: 610591) PREDICTED: rho GTPase- ( 865) 1001 152.6 6.8e-36
XP_011509783 (OMIM: 610578) PREDICTED: rho GTPase- ( 435) 801 124.6 9.3e-28
XP_011509784 (OMIM: 610578) PREDICTED: rho GTPase- ( 416) 794 123.6 1.8e-27
XP_016875293 (OMIM: 610576) PREDICTED: rho GTPase- ( 425) 677 107.3 1.4e-22
XP_016875291 (OMIM: 610576) PREDICTED: rho GTPase- ( 516) 677 107.3 1.7e-22
XP_011536960 (OMIM: 610576) PREDICTED: rho GTPase- ( 700) 677 107.4 2.2e-22
XP_016875292 (OMIM: 610576) PREDICTED: rho GTPase- ( 456) 669 106.2 3.3e-22
XP_016875290 (OMIM: 610576) PREDICTED: rho GTPase- ( 547) 669 106.2 3.9e-22
NP_001073625 (OMIM: 610576) rho GTPase-activating ( 547) 669 106.2 3.9e-22
XP_011536961 (OMIM: 610576) PREDICTED: rho GTPase- ( 640) 669 106.3 4.4e-22
NP_001073626 (OMIM: 610576) rho GTPase-activating ( 640) 669 106.3 4.4e-22
XP_011536958 (OMIM: 610576) PREDICTED: rho GTPase- ( 731) 669 106.3 4.9e-22
NP_115885 (OMIM: 610576) rho GTPase-activating pro ( 731) 669 106.3 4.9e-22
XP_011522772 (OMIM: 610591) PREDICTED: rho GTPase- ( 870) 668 106.2 6.3e-22
XP_011517909 (OMIM: 609870) PREDICTED: rho GTPase- (1491) 501 83.1 9.9e-15
XP_011517908 (OMIM: 609870) PREDICTED: rho GTPase- (1924) 501 83.1 1.2e-14
XP_016871949 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 501 83.1 1.2e-14
XP_005252601 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 501 83.1 1.2e-14
XP_016871950 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 501 83.1 1.2e-14
NP_065875 (OMIM: 609870) rho GTPase-activating pro (1958) 501 83.1 1.2e-14
XP_016871948 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 501 83.1 1.2e-14
XP_005252599 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 501 83.1 1.2e-14
XP_011517907 (OMIM: 609870) PREDICTED: rho GTPase- (1982) 501 83.1 1.3e-14
XP_011517906 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 501 83.1 1.3e-14
XP_011517904 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 501 83.1 1.3e-14
>>NP_001257628 (OMIM: 610577) rho GTPase-activating prot (794 aa)
initn: 5284 init1: 5284 opt: 5284 Z-score: 3990.7 bits: 749.3 E(85289): 1.5e-215
Smith-Waterman score: 5284; 100.0% identity (100.0% similar) in 794 aa overlap (1-794:1-794)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
730 740 750 760 770 780
790
pF1KB9 VELILLELSSIFGR
::::::::::::::
NP_001 VELILLELSSIFGR
790
>>XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase-acti (794 aa)
initn: 5284 init1: 5284 opt: 5284 Z-score: 3990.7 bits: 749.3 E(85289): 1.5e-215
Smith-Waterman score: 5284; 100.0% identity (100.0% similar) in 794 aa overlap (1-794:1-794)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
730 740 750 760 770 780
790
pF1KB9 VELILLELSSIFGR
::::::::::::::
XP_005 VELILLELSSIFGR
790
>>NP_001257626 (OMIM: 610577) rho GTPase-activating prot (799 aa)
initn: 5270 init1: 2792 opt: 5264 Z-score: 3975.6 bits: 746.5 E(85289): 1.1e-214
Smith-Waterman score: 5264; 99.4% identity (99.4% similar) in 799 aa overlap (1-794:1-799)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
310 320 330 340 350 360
370 380 390 400 410
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDT-----DQEKY
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_001 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKY
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB9 GLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGA
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB9 TIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB9 EIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB9 YIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB9 NHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKD
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB9 LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTV
730 740 750 760 770 780
780 790
pF1KB9 YQNQIVELILLELSSIFGR
:::::::::::::::::::
NP_001 YQNQIVELILLELSSIFGR
790
>>NP_001257624 (OMIM: 610577) rho GTPase-activating prot (841 aa)
initn: 3145 init1: 3145 opt: 3170 Z-score: 2398.7 bits: 454.8 E(85289): 7.2e-127
Smith-Waterman score: 5081; 94.3% identity (94.3% similar) in 826 aa overlap (16-794:16-841)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310
pF1KB9 DASISKGDFQNPGDQE--------------------------------------------
::::::::::::::::
NP_001 DASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYT
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB9 ---WLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB9 RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNVTKIAENGKKVRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNVTKIAENGKKVRKN
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB9 WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFEL
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB9 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQK
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB9 DPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB9 NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHV
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB9 ITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KB9 HLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFG
790 800 810 820 830 840
pF1KB9 R
:
NP_001 R
>>NP_060757 (OMIM: 610577) rho GTPase-activating protein (846 aa)
initn: 4632 init1: 2492 opt: 3157 Z-score: 2388.9 bits: 453.0 E(85289): 2.5e-126
Smith-Waterman score: 5031; 93.7% identity (93.7% similar) in 826 aa overlap (21-794:21-846)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::
NP_060 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310
pF1KB9 DASISKGDFQNPGDQE--------------------------------------------
::::::::::::::::
NP_060 DASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYT
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB9 ---WLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
370 380 390 400 410 420
380 390 400 410 420
pF1KB9 RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDT-----DQEKYGLLNVTKIAENGK
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
NP_060 RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGK
430 440 450 460 470 480
430 440 450 460 470 480
pF1KB9 KVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKK
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB9 NVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDK
550 560 570 580 590 600
550 560 570 580 590 600
pF1KB9 EKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLAN
610 620 630 640 650 660
610 620 630 640 650 660
pF1KB9 LCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKW
670 680 690 700 710 720
670 680 690 700 710 720
pF1KB9 EDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTM
730 740 750 760 770 780
730 740 750 760 770 780
pF1KB9 QILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLEL
790 800 810 820 830 840
790
pF1KB9 SSIFGR
::::::
NP_060 SSIFGR
>>XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase-acti (772 aa)
initn: 4624 init1: 2492 opt: 2942 Z-score: 2227.6 bits: 423.0 E(85289): 2.4e-117
Smith-Waterman score: 4999; 96.0% identity (96.0% similar) in 799 aa overlap (1-794:1-772)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
:::::::::::::::: :::::::::::::::::
XP_011 DASISKGDFQNPGDQE---------------------------YNASSQQQREIIKSRSL
310 320 330
370 380 390 400 410
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDT-----DQEKY
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKY
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB9 GLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KB9 TIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KB9 EIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKG
520 530 540 550 560 570
600 610 620 630 640 650
pF1KB9 YIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAV
580 590 600 610 620 630
660 670 680 690 700 710
pF1KB9 NHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKD
640 650 660 670 680 690
720 730 740 750 760 770
pF1KB9 LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTV
700 710 720 730 740 750
780 790
pF1KB9 YQNQIVELILLELSSIFGR
:::::::::::::::::::
XP_011 YQNQIVELILLELSSIFGR
760 770
>>NP_001257627 (OMIM: 610577) rho GTPase-activating prot (769 aa)
initn: 2616 init1: 2616 opt: 2616 Z-score: 1982.2 bits: 377.6 E(85289): 1.1e-103
Smith-Waterman score: 5046; 96.9% identity (96.9% similar) in 794 aa overlap (1-794:1-769)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
::::::::::::::::::::::::: ::::::::::
NP_001 DRRLQEPIVLTKWRHSTIVLDTNDK-------------------------DQEKYGLLNV
370 380 390
430 440 450 460 470 480
pF1KB9 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
700 710 720 730 740 750
790
pF1KB9 VELILLELSSIFGR
::::::::::::::
NP_001 VELILLELSSIFGR
760
>>XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase-acti (742 aa)
initn: 4631 init1: 2499 opt: 2548 Z-score: 1931.2 bits: 368.1 E(85289): 7.9e-101
Smith-Waterman score: 4781; 93.5% identity (93.5% similar) in 794 aa overlap (1-794:1-742)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSL
:::::::::::::::: :::::::::::::::::
XP_016 DASISKGDFQNPGDQE---------------------------YNASSQQQREIIKSRSL
310 320 330
370 380 390 400 410 420
pF1KB9 DRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNV
::::::::::::::::::::::::: ::::::::::
XP_016 DRRLQEPIVLTKWRHSTIVLDTNDK-------------------------DQEKYGLLNV
340 350 360
430 440 450 460 470 480
pF1KB9 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMA
370 380 390 400 410 420
490 500 510 520 530 540
pF1KB9 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDS
430 440 450 460 470 480
550 560 570 580 590 600
pF1KB9 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ
490 500 510 520 530 540
610 620 630 640 650 660
pF1KB9 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEK
550 560 570 580 590 600
670 680 690 700 710 720
pF1KB9 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQL
610 620 630 640 650 660
730 740 750 760 770 780
pF1KB9 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQI
670 680 690 700 710 720
790
pF1KB9 VELILLELSSIFGR
::::::::::::::
XP_016 VELILLELSSIFGR
730 740
>>NP_001257625 (OMIM: 610577) rho GTPase-activating prot (816 aa)
initn: 4639 init1: 2499 opt: 2533 Z-score: 1919.3 bits: 366.0 E(85289): 3.6e-100
Smith-Waterman score: 4942; 91.4% identity (91.4% similar) in 841 aa overlap (1-794:1-816)
10 20 30 40 50 60
pF1KB9 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
250 260 270 280 290 300
310
pF1KB9 DASISKGDFQNPGDQE--------------------------------------------
::::::::::::::::
NP_001 DASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYT
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB9 ---WLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB9 RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNVTKIAENGKKVRKN
:::::::::::: :::::::::::::::::::::::
NP_001 RHSTIVLDTNDK-------------------------DQEKYGLLNVTKIAENGKKVRKN
430 440 450
440 450 460 470 480 490
pF1KB9 WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFEL
460 470 480 490 500 510
500 510 520 530 540 550
pF1KB9 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQK
520 530 540 550 560 570
560 570 580 590 600 610
pF1KB9 DPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE
580 590 600 610 620 630
620 630 640 650 660 670
pF1KB9 NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHV
640 650 660 670 680 690
680 690 700 710 720 730
pF1KB9 ITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFR
700 710 720 730 740 750
740 750 760 770 780 790
pF1KB9 HLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFG
760 770 780 790 800 810
pF1KB9 R
:
NP_001 R
>>NP_954976 (OMIM: 610591) rho GTPase-activating protein (548 aa)
initn: 1269 init1: 645 opt: 1376 Z-score: 1050.8 bits: 204.7 E(85289): 8.7e-52
Smith-Waterman score: 1377; 43.7% identity (66.5% similar) in 556 aa overlap (258-792:13-545)
230 240 250 260 270 280
pF1KB9 RATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETH--KDSSGRCYYYN
: : .: . .. .: : . .
NP_954 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGE
10 20 30 40
290 300 310 320 330 340
pF1KB9 RGTQERTWKPPRWTRDASISKGD-FQNPGDQE-WLKHVDDQGRQYYYSADGSRSEWELPK
: :: :. .: .: . : :: :.. : .:. :.:. . : .::::
NP_954 PGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELP-
50 60 70 80 90 100
350 360 370 380 390
pF1KB9 YNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASK-PC-FPE----
: . ::. . :. :: . :: : : . :
NP_954 -------QVPVPAPRSIHKSSQDG-------------DTPAQASPPEEKVPAELDEVGSW
110 120 130 140
400 410 420 430 440 450
pF1KB9 NESSPSSPKHQDTDQEKYGLLNVTKIAENGKKVRK-NWLSSWAVLQGSSLLFTKTQGSST
.: ::.. . .: :.:. :: :..::..:: .: .::.::.:. : : : :.:
NP_954 EEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFK--DSKT
150 160 170 180 190
460 470 480 490 500 510
pF1KB9 SWFG-----SNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVI
: : :. : ::.::.:.:::. : :::::.:::.::..:.:.: ::: :....:
NP_954 SAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAII
200 210 220 230 240 250
520 530 540 550 560
pF1KB9 NDWFKVLSSTINNQAVETD-EGIEEEIPDSPGIEKHD--KEKEQKDPKKLRSFKVSSID-
. : :.... :.. ..: : : : . :. .:::. . . .. .
NP_954 STWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL
260 270 280 290 300 310
570 580 590 600 610 620
pF1KB9 SSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEH
:. .:....:.::: ::::::..:::::::::::: :: ::.:: . ::.::. ::.
NP_954 ESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRA
320 330 340 350 360 370
630 640 650 660 670 680
pF1KB9 VEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPE
:: .::::::.::.:::::.:::::. :.:::.:::.:..:::.::::::::.:::::::
NP_954 VEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPE
380 390 400 410 420 430
690 700 710 720 730 740
pF1KB9 PLFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNR
::: :.:: .:. ::: :. .: :.::.:.:: ::.::...::.:: ::::.::.::
NP_954 PLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNR
440 450 460 470 480 490
750 760 770 780 790
pF1KB9 MTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR
:. ::.:::::::::.:: : .. . :.:::.::::: . ..::
NP_954 MSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
500 510 520 530 540
794 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:47:22 2016 done: Thu Nov 3 08:47:24 2016
Total Scan time: 10.230 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]