Result of FASTA (omim) for
pF1KB9171
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9171, 669 aa
1>>>pF1KB9171 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.0047+/-0.000364; mu= 8.2793+/- 0.023
mean_var=169.5634+/-35.174, 0's: 0 Z-trim(119.7): 96 B-trim: 1413 in 1/52
Lambda= 0.098494
statistics sampled from 33859 (33956) to 33859 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.738), E-opt: 0.2 (0.398), width: 16
Scan time: 11.280
The best scores are: opt bits E(85289)
NP_114408 (OMIM: 608544) histone deacetylase 10 is ( 669) 4519 654.5 3.6e-187
NP_001152758 (OMIM: 608544) histone deacetylase 10 ( 649) 2665 391.0 7.2e-108
XP_016884676 (OMIM: 300272,300863) PREDICTED: hist ( 622) 1378 208.1 7.8e-53
NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52
NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52
NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52
NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 1378 208.3 1.3e-52
NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52
NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 1378 208.4 1.3e-52
XP_011510532 (OMIM: 605314) PREDICTED: histone dea ( 673) 744 118.1 1.1e-25
XP_016860884 (OMIM: 605314) PREDICTED: histone dea ( 917) 744 118.2 1.4e-25
XP_011510529 (OMIM: 605314) PREDICTED: histone dea (1041) 744 118.2 1.5e-25
XP_006712942 (OMIM: 605314) PREDICTED: histone dea (1062) 744 118.2 1.6e-25
XP_006712943 (OMIM: 605314) PREDICTED: histone dea (1062) 744 118.2 1.6e-25
XP_011510528 (OMIM: 605314) PREDICTED: histone dea (1065) 744 118.2 1.6e-25
XP_016860883 (OMIM: 605314) PREDICTED: histone dea (1069) 744 118.2 1.6e-25
XP_011510527 (OMIM: 605314) PREDICTED: histone dea (1079) 744 118.2 1.6e-25
NP_006028 (OMIM: 605314) histone deacetylase 4 [Ho (1084) 744 118.2 1.6e-25
XP_011510526 (OMIM: 605314) PREDICTED: histone dea (1084) 744 118.2 1.6e-25
XP_011510523 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25
XP_006712941 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25
XP_011510524 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25
XP_011510525 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25
XP_011510522 (OMIM: 605314) PREDICTED: histone dea (1090) 744 118.2 1.6e-25
XP_011510521 (OMIM: 605314) PREDICTED: histone dea (1103) 744 118.2 1.6e-25
XP_011510520 (OMIM: 605314) PREDICTED: histone dea (1108) 744 118.2 1.6e-25
XP_006712940 (OMIM: 605314) PREDICTED: histone dea (1108) 744 118.2 1.6e-25
XP_011510519 (OMIM: 605314) PREDICTED: histone dea (1113) 744 118.2 1.6e-25
NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 726 115.6 9e-25
NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 726 115.6 9e-25
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 726 115.6 9e-25
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 726 115.7 9e-25
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 726 115.7 9.1e-25
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 726 115.7 9.1e-25
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 726 115.7 9.1e-25
NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 726 115.7 9.1e-25
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 726 115.7 9.3e-25
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 726 115.7 9.3e-25
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 726 115.7 9.3e-25
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 726 115.7 9.3e-25
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 726 115.7 9.3e-25
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 726 115.7 9.3e-25
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 726 115.7 9.3e-25
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 726 115.7 9.4e-25
>>NP_114408 (OMIM: 608544) histone deacetylase 10 isofor (669 aa)
initn: 4519 init1: 4519 opt: 4519 Z-score: 3481.2 bits: 654.5 E(85289): 3.6e-187
Smith-Waterman score: 4519; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669)
10 20 30 40 50 60
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
610 620 630 640 650 660
pF1KB9 LQCHPHLVA
:::::::::
NP_114 LQCHPHLVA
>>NP_001152758 (OMIM: 608544) histone deacetylase 10 iso (649 aa)
initn: 2665 init1: 2665 opt: 2665 Z-score: 2057.6 bits: 391.0 E(85289): 7.2e-108
Smith-Waterman score: 4336; 97.0% identity (97.0% similar) in 669 aa overlap (1-669:1-649)
10 20 30 40 50 60
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
::::::::::: :::::::::::::::::::::::::::::
NP_001 AFLHLLLPLAF--------------------EGQMQATPECFAHLTQLLQVLAGGRVCAV
250 260 270 280
310 320 330 340 350 360
pF1KB9 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB9 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB9 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB9 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB9 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB9 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
590 600 610 620 630 640
pF1KB9 LQCHPHLVA
:::::::::
NP_001 LQCHPHLVA
>>XP_016884676 (OMIM: 300272,300863) PREDICTED: histone (622 aa)
initn: 1375 init1: 1328 opt: 1378 Z-score: 1069.5 bits: 208.1 E(85289): 7.8e-53
Smith-Waterman score: 1378; 52.3% identity (78.1% similar) in 388 aa overlap (2-383:99-484)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
XP_016 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
70 80 90 100 110 120
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
XP_016 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
130 140 150 160 170 180
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
XP_016 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
190 200 210 220 230 240
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
XP_016 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
250 260 270 280 290 300
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
XP_016 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
310 320 330 340 350 360
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
XP_016 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
370 380 390 400 410 420
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLPGG
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
XP_016 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
430 440 450 460 470 480
390 400 410 420 430 440
pF1KB9 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWA
XP_016 TWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPAT
490 500 510 520 530 540
>--
initn: 344 init1: 258 opt: 314 Z-score: 252.4 bits: 57.0 E(85289): 2.5e-07
Smith-Waterman score: 314; 44.3% identity (67.9% similar) in 131 aa overlap (3-132:495-621)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLT
:.::: ..: :::. . :. :.:.
XP_016 EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEV--PQRIL
470 480 490 500 510 520
40 50 60 70 80 90
pF1KB9 AALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDA
. ::.. :: ::: :. : :.: :: :: :::. .: :. . .::. :..::.
XP_016 RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDS
530 540 550 560 570 580
100 110 120 130 140 150
pF1KB9 IYFHPSTFHCARLAAGAGLQLVDAVLTGAVQN-GLALVRPPGHHGQRAAANGFCVFNNVA
::. :::: ::.::.::. .::.:::.: . ::. ::
XP_016 IYICPSTFACAQLATGAACRLVEAVLSGEDPDCGLGC--PPR
590 600 610 620
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
>>NP_001308157 (OMIM: 300272,300863) histone deacetylase (1215 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
360 370 380 390 400 410
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
420 430 440 450 460 470
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
480 490 500 510 520
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
530 540 550 560 570 580
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
590 600 610 620 630 640
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
650 660 670 680 690 700
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
710 720 730 740 750 760
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
770 780 790 800 810 820
>>NP_001308155 (OMIM: 300272,300863) histone deacetylase (1215 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
360 370 380 390 400 410
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
420 430 440 450 460 470
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
480 490 500 510 520
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
530 540 550 560 570 580
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
590 600 610 620 630 640
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
650 660 670 680 690 700
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
710 720 730 740 750 760
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
770 780 790 800 810 820
>>NP_001308156 (OMIM: 300272,300863) histone deacetylase (1215 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
360 370 380 390 400 410
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
420 430 440 450 460 470
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
480 490 500 510 520
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
530 540 550 560 570 580
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
590 600 610 620 630 640
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
650 660 670 680 690 700
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
710 720 730 740 750 760
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
770 780 790 800 810 820
>>NP_006035 (OMIM: 300272,300863) histone deacetylase 6 (1215 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_006 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_006 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_006 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_006 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_006 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_006 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
360 370 380 390 400 410
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_006 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
420 430 440 450 460 470
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_006 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
480 490 500 510 520
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_006 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
530 540 550 560 570 580
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_006 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
590 600 610 620 630 640
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_006 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
650 660 670 680 690 700
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_006 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
710 720 730 740 750 760
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_006 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
770 780 790 800 810 820
>>NP_001308158 (OMIM: 300272,300863) histone deacetylase (1215 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
360 370 380 390 400 410
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
420 430 440 450 460 470
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
480 490 500 510 520
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
530 540 550 560 570 580
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
590 600 610 620 630 640
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
650 660 670 680 690 700
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
710 720 730 740 750 760
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
770 780 790 800 810 820
>>NP_001308154 (OMIM: 300272,300863) histone deacetylase (1229 aa)
initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.3 bits: 208.4 E(85289): 1.3e-52
Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:99-793)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL
::.:: :... . :::: : ::::
NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL
70 80 90 100 110 120
40 50 60 70 80 90
pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD
: ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .:
NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD
130 140 150 160 170 180
100 110 120 130 140 150
pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA
..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.::
NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA
190 200 210 220 230 240
160 170 180 190 200 210
pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA
.:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :.
NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW
250 260 270 280 290 300
220 230 240 250 260 270
pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP
...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. :::
NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP
310 320 330 340 350 360
280 290 300 310 320 330
pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG
.:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : .
NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES
370 380 390 400 410 420
340 350 360 370 380
pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP--
: :::.:: :.. : : : :. : .. :. . . .: : : ::.::
NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL
430 440 450 460 470 480
390 400 410 420
pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD
:: . : . . :: . : : .: : .. :.: :
NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR
490 500 510 520 530 540
430 440 450 460
pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY
:: : .. .. : :.. .: : : :
NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR
550 560 570 580 590 600
470 480 490 500 510
pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA-
:....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: :
NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW
610 620 630 640 650 660
520 530 540
pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P
. . . . .: : :..... : :.:. .. : :.. :
NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP
670 680 690 700 710 720
550 560 570 580 590
pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG
: . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: :
NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG
730 740 750 760 770 780
600 610 620 630 640 650
pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK
::.::.. .::
NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR
790 800 810 820 830 840
>>XP_011510532 (OMIM: 605314) PREDICTED: histone deacety (673 aa)
initn: 721 init1: 412 opt: 744 Z-score: 582.1 bits: 118.1 E(85289): 1.1e-25
Smith-Waterman score: 806; 37.6% identity (64.9% similar) in 388 aa overlap (3-364:243-627)
10 20 30
pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLT
:.::: : . . . :. :.
XP_011 HRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQ
220 230 240 250 260 270
40 50 60 70 80 90
pF1KB9 AALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQA--LSGQF
. .::.. ::. .: . .:.:. ::: ::: : .:. :. :....:.. : :..
XP_011 SIWSRLQETGLRGKCECIRGRKATLEELQTVHS-EAHTLLYGTNPLNRQKLDSKKLLGSL
280 290 300 310 320 330
100 110 120 130
pF1KB9 DAIYFH-P------------STFHCA---RLAAGAGLQLVDAVLTGAVQNGLALVRPPGH
... . : . : : :::.: ..:: : :: ..::.:.::::::
XP_011 ASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGH
340 350 360 370 380 390
140 150 160 170 180 190
pF1KB9 HGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSW
:..... ::: ::.::.:: .:. .. .::.::::::::.: : : .::::::.:
XP_011 HAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSL
400 410 420 430 440 450
200 210 220 230 240 250
pF1KB9 HRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWN---QVGMGNADYVAAFLHLLLPLAF
:::. : :.: . : :: : :.::.::. .. . ::.:.:.::: ...:.:
XP_011 HRYDDGNFFP--GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIAS
460 470 480 490 500
260 270 280 290 300
pF1KB9 EFDPELVLVSAGFDSAIGDPE--GQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLES
:: :..::::.:::.. : : : .. . .::..::. :. :::::. .::::. : .
XP_011 EFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTA
510 520 530 540 550 560
310 320 330 340 350 360
pF1KB9 LAESVCMTVQTLLG---DPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVP
. .. :..::: :: : . : .:..:.... .. .:. ::. ::
XP_011 ICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGR
570 580 590 600 610 620
370 380 390 400 410 420
pF1KB9 MSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLP
XP_011 SLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
630 640 650 660 670
669 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:00:42 2016 done: Fri Nov 4 17:00:44 2016
Total Scan time: 11.280 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]