Result of FASTA (omim) for
pF1KB8999
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8999, 357 aa
1>>>pF1KB8999 357 - 357 aa - 357 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.4946+/-0.000403; mu= 21.3447+/- 0.025
mean_var=100.1885+/-26.396, 0's: 0 Z-trim(111.0): 449 B-trim: 1212 in 1/51
Lambda= 0.128134
statistics sampled from 18843 (19430) to 18843 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.228), width: 16
Scan time: 7.930
The best scores are: opt bits E(85289)
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 2392 453.3 3.9e-127
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 709 142.3 1.9e-33
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 709 142.3 2e-33
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 709 142.3 2.1e-33
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 675 136.0 1.5e-31
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 675 136.0 1.5e-31
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 675 136.0 1.6e-31
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 675 136.0 1.6e-31
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 675 136.1 1.6e-31
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 675 136.1 1.6e-31
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 675 136.1 1.6e-31
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 675 136.1 1.6e-31
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 652 131.9 3.2e-30
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 597 121.5 3e-27
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 585 119.1 1.3e-26
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 585 119.2 1.3e-26
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 585 119.2 1.3e-26
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 585 119.2 1.4e-26
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 585 119.3 1.4e-26
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 565 115.7 2e-25
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 561 114.9 3.2e-25
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 561 114.9 3.2e-25
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 561 115.1 3.9e-25
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 558 114.2 4.2e-25
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 554 113.5 7e-25
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 554 113.5 7.5e-25
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 544 111.9 3.5e-24
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 527 108.6 2.5e-23
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 523 107.9 4.6e-23
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 520 107.3 6.3e-23
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 502 103.9 5.9e-22
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 477 99.3 1.4e-20
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 477 99.3 1.4e-20
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 477 99.3 1.4e-20
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 477 99.3 1.4e-20
NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 477 99.3 1.4e-20
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 477 99.3 1.4e-20
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 474 98.7 2.1e-20
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 474 98.7 2.1e-20
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 456 95.6 2.4e-19
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 450 94.4 5.2e-19
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 446 93.5 7.6e-19
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 446 93.6 7.8e-19
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 446 93.6 7.9e-19
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 446 93.6 7.9e-19
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 446 93.6 8.2e-19
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 446 93.7 8.4e-19
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 446 93.7 8.6e-19
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 443 93.2 1.3e-18
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 423 89.3 1.5e-17
>>NP_076917 (OMIM: 601305) 5-hydroxytryptamine receptor (357 aa)
initn: 2392 init1: 2392 opt: 2392 Z-score: 2403.6 bits: 453.3 E(85289): 3.9e-127
Smith-Waterman score: 2392; 100.0% identity (100.0% similar) in 357 aa overlap (1-357:1-357)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
250 260 270 280 290 300
310 320 330 340 350
pF1KB8 FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
310 320 330 340 350
>>NP_062874 (OMIM: 182137) 5-hydroxytryptamine receptor (432 aa)
initn: 641 init1: 251 opt: 709 Z-score: 721.3 bits: 142.3 E(85289): 1.9e-33
Smith-Waterman score: 709; 37.1% identity (70.2% similar) in 329 aa overlap (41-357:82-403)
20 30 40 50 60 70
pF1KB8 SLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRT
:.: ..: ... :.: : ::. .. :.
NP_062 VTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKK
60 70 80 90 100 110
80 90 100 110 120
pF1KB8 FHRVPHN-LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASI
. : : : :..:.:..:. ::. :::. : .: : .: .:. .:...:: ::.::::::
NP_062 L-RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASI
120 130 140 150 160 170
130 140 150 160 170 180
pF1KB8 WNVTAIALDRYWSITRHMEYTLRTR-KCVSNVMIALTWALSAVISLAPLLFGWGETYSEG
.. .:..::: .::: . : .: ::... :: .: ::: :.: :: :::... ..
NP_062 MTLCVISIDRYLGITRPLTYPVRQNGKCMAK-MILSVWLLSASITLPPL-FGWAQNVND-
180 190 200 210 220
190 200 210 220 230 240
pF1KB8 SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNS---VSPISEA
.. : .:.. .:...::. :::.:. :.::.:..:::::. ....: . : : : .
NP_062 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDS-V
230 240 250 260 270 280
250 260 270 280 290 300
pF1KB8 VEVKDSAKQPQMVFTVRHATVTFQPEGDTWR-EQKEQRAALMVGILIGVFVLCWIPFFLT
. .. .: . : . . .. : . ..::.:: .::..:.:..::.::::
NP_062 IALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL
290 300 310 320 330 340
310 320 330 340 350
pF1KB8 ELISPL-----CSCDIPAIW-KSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
:. ::: :: .: . ::::::.::..::.::. ::.. ........ :.
NP_062 STARPFICGTSCSC-IP-LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR
350 360 370 380 390 400
NP_062 NINRKLSAAGMHEALKLAERPERPEFVL
410 420 430
>>NP_000863 (OMIM: 182137) 5-hydroxytryptamine receptor (445 aa)
initn: 641 init1: 251 opt: 709 Z-score: 721.2 bits: 142.3 E(85289): 2e-33
Smith-Waterman score: 709; 37.1% identity (70.2% similar) in 329 aa overlap (41-357:82-403)
20 30 40 50 60 70
pF1KB8 SLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRT
:.: ..: ... :.: : ::. .. :.
NP_000 VTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKK
60 70 80 90 100 110
80 90 100 110 120
pF1KB8 FHRVPHN-LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASI
. : : : :..:.:..:. ::. :::. : .: : .: .:. .:...:: ::.::::::
NP_000 L-RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASI
120 130 140 150 160 170
130 140 150 160 170 180
pF1KB8 WNVTAIALDRYWSITRHMEYTLRTR-KCVSNVMIALTWALSAVISLAPLLFGWGETYSEG
.. .:..::: .::: . : .: ::... :: .: ::: :.: :: :::... ..
NP_000 MTLCVISIDRYLGITRPLTYPVRQNGKCMAK-MILSVWLLSASITLPPL-FGWAQNVND-
180 190 200 210 220
190 200 210 220 230 240
pF1KB8 SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNS---VSPISEA
.. : .:.. .:...::. :::.:. :.::.:..:::::. ....: . : : : .
NP_000 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDS-V
230 240 250 260 270 280
250 260 270 280 290 300
pF1KB8 VEVKDSAKQPQMVFTVRHATVTFQPEGDTWR-EQKEQRAALMVGILIGVFVLCWIPFFLT
. .. .: . : . . .. : . ..::.:: .::..:.:..::.::::
NP_000 IALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL
290 300 310 320 330 340
310 320 330 340 350
pF1KB8 ELISPL-----CSCDIPAIW-KSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
:. ::: :: .: . ::::::.::..::.::. ::.. ........ :.
NP_000 STARPFICGTSCSC-IP-LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR
350 360 370 380 390 400
NP_000 NINRKLSAAGMHEALKLAERPERPEFVLQNADYCRKKGHDS
410 420 430 440
>>NP_062873 (OMIM: 182137) 5-hydroxytryptamine receptor (479 aa)
initn: 641 init1: 251 opt: 709 Z-score: 720.8 bits: 142.3 E(85289): 2.1e-33
Smith-Waterman score: 709; 37.1% identity (70.2% similar) in 329 aa overlap (41-357:82-403)
20 30 40 50 60 70
pF1KB8 SLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRT
:.: ..: ... :.: : ::. .. :.
NP_062 VTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKK
60 70 80 90 100 110
80 90 100 110 120
pF1KB8 FHRVPHN-LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASI
. : : : :..:.:..:. ::. :::. : .: : .: .:. .:...:: ::.::::::
NP_062 L-RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASI
120 130 140 150 160 170
130 140 150 160 170 180
pF1KB8 WNVTAIALDRYWSITRHMEYTLRTR-KCVSNVMIALTWALSAVISLAPLLFGWGETYSEG
.. .:..::: .::: . : .: ::... :: .: ::: :.: :: :::... ..
NP_062 MTLCVISIDRYLGITRPLTYPVRQNGKCMAK-MILSVWLLSASITLPPL-FGWAQNVND-
180 190 200 210 220
190 200 210 220 230 240
pF1KB8 SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNS---VSPISEA
.. : .:.. .:...::. :::.:. :.::.:..:::::. ....: . : : : .
NP_062 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDS-V
230 240 250 260 270 280
250 260 270 280 290 300
pF1KB8 VEVKDSAKQPQMVFTVRHATVTFQPEGDTWR-EQKEQRAALMVGILIGVFVLCWIPFFLT
. .. .: . : . . .. : . ..::.:: .::..:.:..::.::::
NP_062 IALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL
290 300 310 320 330 340
310 320 330 340 350
pF1KB8 ELISPL-----CSCDIPAIW-KSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
:. ::: :: .: . ::::::.::..::.::. ::.. ........ :.
NP_062 STARPFICGTSCSC-IP-LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR
350 360 370 380 390 400
NP_062 NINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLA
410 420 430 440 450 460
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 389 init1: 193 opt: 675 Z-score: 687.4 bits: 136.0 E(85289): 1.5e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
NP_150 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
NP_150 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
NP_150 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
NP_150 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 389 init1: 193 opt: 675 Z-score: 687.4 bits: 136.0 E(85289): 1.5e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
XP_006 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
XP_006 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
XP_006 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
XP_006 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
XP_006 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
XP_006 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 389 init1: 193 opt: 675 Z-score: 687.1 bits: 136.0 E(85289): 1.6e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
NP_150 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
NP_150 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
NP_150 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
NP_150 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa)
initn: 389 init1: 193 opt: 675 Z-score: 687.0 bits: 136.0 E(85289): 1.6e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
NP_000 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
NP_000 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
NP_000 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
NP_000 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
NP_000 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
NP_000 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 389 init1: 193 opt: 675 Z-score: 686.9 bits: 136.1 E(85289): 1.6e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
XP_006 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
XP_006 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
XP_006 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
XP_006 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
XP_006 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
XP_006 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
>>XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 389 init1: 193 opt: 675 Z-score: 686.9 bits: 136.1 E(85289): 1.6e-31
Smith-Waterman score: 675; 34.7% identity (65.0% similar) in 346 aa overlap (18-356:4-344)
10 20 30 40 50 60
pF1KB8 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
: : : ... .: .:. ..:. ..:: :. :.:
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNIL
10 20 30 40
70 80 90 100 110 120
pF1KB8 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
:. .. : .: : : ....::.:.:... :.:.: . :. : : .:: .:..: :
XP_016 VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAV
50 60 70 80 90 100
130 140 150 160 170
pF1KB8 DVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIAL-TWALSAVISLAPLL
::::::::: .. :..::: ... ..: :. :.. ..: : .:::: :::..::
XP_016 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR--RGLMALLCVWALSLVISIGPL-
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 FGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-
::: . : ::...::.:..::..:.::::: ..: .: ..: .:: . . :..
XP_016 FGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 -SVSPISEAVEVKDSAKQ-PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFV
. . :: : .. :. : . : . . . ..:..:: .::..: ::
XP_016 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 LCWIPFFLTELISPLCSCDIPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF
:::.::::. :. . :. ..: .: :::: :: .::.:: ......::.: .
XP_016 LCWLPFFLVMPIGSFFPDFKPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQNVL
290 300 310 320 330 340
pF1KB8 SRQH
:
XP_016 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS
350 360 370 380 390 400
357 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:56:37 2016 done: Fri Nov 4 16:56:38 2016
Total Scan time: 7.930 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]