Result of FASTA (omim) for
pF1KB8877
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8877, 168 aa
1>>>pF1KB8877 168 - 168 aa - 168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3775+/-0.000517; mu= 5.8609+/- 0.031
mean_var=170.3860+/-37.100, 0's: 0 Z-trim(113.0): 703 B-trim: 650 in 1/51
Lambda= 0.098256
statistics sampled from 21193 (22130) to 21193 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.259), width: 16
Scan time: 4.270
The best scores are: opt bits E(85289)
NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 1092 166.9 1.4e-41
NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 1092 166.9 1.4e-41
NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 437 74.0 1.2e-13
NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 437 74.0 1.2e-13
NP_001182061 (OMIM: 155601,155755,600160,606719) c ( 167) 314 56.6 2.2e-08
NP_000068 (OMIM: 155601,155755,600160,606719) cycl ( 156) 311 56.1 2.8e-08
XP_011515978 (OMIM: 155601,155755,600160,606719) P ( 172) 311 56.2 3e-08
XP_011515977 (OMIM: 155601,155755,600160,606719) P ( 184) 311 56.2 3.1e-08
NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 ( 138) 298 54.2 9.3e-08
NP_065082 (OMIM: 610734) ankyrin repeat domain-con ( 360) 257 48.9 9.5e-06
NP_001278147 (OMIM: 610734) ankyrin repeat domain- ( 446) 257 49.1 1.1e-05
NP_065815 (OMIM: 612184) caskin-1 [Homo sapiens] (1431) 259 50.0 1.9e-05
NP_002805 (OMIM: 300880) 26S proteasome non-ATPase ( 226) 239 46.1 4.2e-05
NP_001123453 (OMIM: 610734) ankyrin repeat domain- ( 327) 240 46.5 4.8e-05
NP_001278148 (OMIM: 610734) ankyrin repeat domain- ( 413) 240 46.6 5.5e-05
XP_006719577 (OMIM: 607815) PREDICTED: ankyrin rep (1184) 245 47.9 6.5e-05
XP_016875147 (OMIM: 607815) PREDICTED: ankyrin rep (1188) 245 47.9 6.6e-05
XP_006719576 (OMIM: 607815) PREDICTED: ankyrin rep (1199) 245 47.9 6.6e-05
XP_006719575 (OMIM: 607815) PREDICTED: ankyrin rep (1200) 245 47.9 6.6e-05
XP_016875146 (OMIM: 607815) PREDICTED: ankyrin rep (1226) 245 47.9 6.7e-05
XP_006719573 (OMIM: 607815) PREDICTED: ankyrin rep (1235) 245 47.9 6.7e-05
NP_690001 (OMIM: 607815) ankyrin repeat and steril (1248) 245 47.9 6.8e-05
XP_016875145 (OMIM: 607815) PREDICTED: ankyrin rep (1250) 245 47.9 6.8e-05
XP_011536873 (OMIM: 607815) PREDICTED: ankyrin rep (1251) 245 47.9 6.8e-05
XP_005269086 (OMIM: 607815) PREDICTED: ankyrin rep (1256) 245 47.9 6.8e-05
XP_016875144 (OMIM: 607815) PREDICTED: ankyrin rep (1259) 245 47.9 6.8e-05
XP_006719572 (OMIM: 607815) PREDICTED: ankyrin rep (1259) 245 47.9 6.8e-05
XP_005269085 (OMIM: 607815) PREDICTED: ankyrin rep (1260) 245 47.9 6.8e-05
XP_006719571 (OMIM: 607815) PREDICTED: ankyrin rep (1260) 245 47.9 6.8e-05
XP_016875143 (OMIM: 607815) PREDICTED: ankyrin rep (1268) 245 47.9 6.8e-05
XP_016875142 (OMIM: 607815) PREDICTED: ankyrin rep (1272) 245 47.9 6.8e-05
XP_006719570 (OMIM: 607815) PREDICTED: ankyrin rep (1273) 245 47.9 6.8e-05
XP_016875141 (OMIM: 607815) PREDICTED: ankyrin rep (1281) 245 47.9 6.9e-05
XP_006719569 (OMIM: 607815) PREDICTED: ankyrin rep (1283) 245 47.9 6.9e-05
XP_006719567 (OMIM: 607815) PREDICTED: ankyrin rep (1284) 245 47.9 6.9e-05
XP_006719568 (OMIM: 607815) PREDICTED: ankyrin rep (1284) 245 47.9 6.9e-05
XP_016875140 (OMIM: 607815) PREDICTED: ankyrin rep (1285) 245 47.9 6.9e-05
NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835) 238 46.7 0.0001
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 242 47.7 0.00011
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725) 242 47.7 0.00011
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735) 242 47.7 0.00011
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737) 242 47.7 0.00011
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738) 242 47.7 0.00011
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741) 242 47.7 0.00011
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742) 242 47.7 0.00011
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747) 242 47.7 0.00011
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751) 242 47.7 0.00011
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763) 242 47.7 0.00011
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764) 242 47.7 0.00011
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785) 242 47.7 0.00011
>>NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 inh (168 aa)
initn: 1092 init1: 1092 opt: 1092 Z-score: 867.6 bits: 166.9 E(85289): 1.4e-41
Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
70 80 90 100 110 120
130 140 150 160
pF1KB8 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
130 140 150 160
>>NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 inh (168 aa)
initn: 1092 init1: 1092 opt: 1092 Z-score: 867.6 bits: 166.9 E(85289): 1.4e-41
Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
70 80 90 100 110 120
130 140 150 160
pF1KB8 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
130 140 150 160
>>NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 494 init1: 330 opt: 437 Z-score: 365.8 bits: 74.0 E(85289): 1.2e-13
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (6-159:9-161)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
:..:..::::::.... ::. . :. .: : ::.:::::: .:. :: .:
NP_524 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
: .::.:...: .: . .:::::.::::::..:.: ::::. :. : ::.:::..:::
NP_524 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: ::. . :.. .:. .: : .:: : ...:...:..
NP_524 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
130 140 150 160
>>NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 494 init1: 330 opt: 437 Z-score: 365.8 bits: 74.0 E(85289): 1.2e-13
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (6-159:9-161)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
:..:..::::::.... ::. . :. .: : ::.:::::: .:. :: .:
NP_001 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
: .::.:...: .: . .:::::.::::::..:.: ::::. :. : ::.:::..:::
NP_001 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: ::. . :.. .:. .: : .:: : ...:...:..
NP_001 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
130 140 150 160
>>NP_001182061 (OMIM: 155601,155755,600160,606719) cycli (167 aa)
initn: 312 init1: 181 opt: 314 Z-score: 271.6 bits: 56.6 E(85289): 2.2e-08
Smith-Waterman score: 314; 38.1% identity (69.4% similar) in 147 aa overlap (3-148:10-156)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
:: .. ::.::::: .:.. .::. .. :: :..:: .::: .:. ..:
NP_001 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
. :::.::.:. : . .. .::::: :::::: .: . : ....: : ::. :: .
NP_001 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: :...: .... : . . :.: ... :
NP_001 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSEMIGNHLWVCRSRHA
130 140 150 160
>>NP_000068 (OMIM: 155601,155755,600160,606719) cyclin-d (156 aa)
initn: 312 init1: 181 opt: 311 Z-score: 269.6 bits: 56.1 E(85289): 2.8e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
:: .. ::.::::: .:.. .::. .. :: :..:: .::: .:. ..:
NP_000 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
. :::.::.:. : . .. .::::: :::::: .: . : ....: : ::. :: .
NP_000 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: :...: .... : . . :.:
NP_000 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
130 140 150
>>XP_011515978 (OMIM: 155601,155755,600160,606719) PREDI (172 aa)
initn: 312 init1: 181 opt: 311 Z-score: 269.1 bits: 56.2 E(85289): 3e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
:: .. ::.::::: .:.. .::. .. :: :..:: .::: .:. ..:
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
. :::.::.:. : . .. .::::: :::::: .: . : ....: : ::. :: .
XP_011 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: :...: .... : . . :.:
XP_011 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSVTASIQVPGGEEGDFGSSYS
130 140 150 160 170
>>XP_011515977 (OMIM: 155601,155755,600160,606719) PREDI (184 aa)
initn: 299 init1: 181 opt: 311 Z-score: 268.8 bits: 56.2 E(85289): 3.1e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
:: .. ::.::::: .:.. .::. .. :: :..:: .::: .:. ..:
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
. :::.::.:. : . .. .::::: :::::: .: . : ....: : ::. :: .
XP_011 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
:: :...: .... : . . :.:
XP_011 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSAGWTNLRISKPNCAWHHLEISRSRLFCT
130 140 150 160 170 180
>>NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 inh (138 aa)
initn: 310 init1: 176 opt: 298 Z-score: 260.3 bits: 54.2 E(85289): 9.3e-08
Smith-Waterman score: 298; 45.2% identity (73.9% similar) in 115 aa overlap (9-122:18-132)
10 20 30 40 50
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPE
:::::::: .:.. .::. ... :. : ::: :.::: .:. .
NP_004 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 IARRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLA
.:. :::.::.:. : . .. .::::: :::::: .: . : ....: : ::. ::
NP_004 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
70 80 90 100 110 120
120 130 140 150 160
pF1KB8 AKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
..:: :. .:
NP_004 EERGHRDVAGYLRTATGD
130
>>NP_065082 (OMIM: 610734) ankyrin repeat domain-contain (360 aa)
initn: 239 init1: 172 opt: 257 Z-score: 224.2 bits: 48.9 E(85289): 9.5e-06
Smith-Waterman score: 257; 32.2% identity (71.7% similar) in 152 aa overlap (12-161:155-304)
10 20 30 40
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTA
::..: .. . ..: .. .... . : :::
NP_065 KKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTA
130 140 150 160 170 180
50 60 70 80 90 100
pF1KB8 LQVMKL-GNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED
:. .: :. :: ..:: ::. :..:: ...: : :.: :.... : ::.:..:
NP_065 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD
190 200 210 220 230 240
110 120 130 140 150
pF1KB8 NEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTAC-DLARLYGRNEVVSLMQAN
. . :::.:.. :....:: ... . ... :...:::: : .:: .: ....:. .
NP_065 KLLSTPLHVAVRTGQVEIVEHFLS-LGLEINARDREGDTALHDAVRL-NRYKIIKLLLLH
250 260 270 280 290 300
160
pF1KB8 GAGGATNLQ
::
NP_065 GADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
310 320 330 340 350 360
168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:57:21 2016 done: Sat Nov 5 19:57:21 2016
Total Scan time: 4.270 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]