Result of FASTA (omim) for
pF1KB8846
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8846, 535 aa
1>>>pF1KB8846 535 - 535 aa - 535 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1667+/-0.000363; mu= 16.0722+/- 0.023
mean_var=124.8732+/-26.461, 0's: 0 Z-trim(116.2): 162 B-trim: 1554 in 1/55
Lambda= 0.114773
statistics sampled from 27092 (27280) to 27092 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.32), width: 16
Scan time: 8.730
The best scores are: opt bits E(85289)
NP_004223 (OMIM: 605118) suppressor of cytokine si ( 535) 3590 606.0 9.4e-173
XP_016881576 (OMIM: 605118) PREDICTED: suppressor ( 535) 3590 606.0 9.4e-173
XP_005266840 (OMIM: 605118) PREDICTED: suppressor ( 535) 3590 606.0 9.4e-173
XP_016881575 (OMIM: 605118) PREDICTED: suppressor ( 535) 3590 606.0 9.4e-173
XP_016880041 (OMIM: 608788) PREDICTED: suppressor ( 576) 573 106.4 2.4e-22
NP_055413 (OMIM: 608788) suppressor of cytokine si ( 581) 573 106.4 2.4e-22
XP_016880040 (OMIM: 608788) PREDICTED: suppressor ( 611) 573 106.5 2.5e-22
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198) 339 67.2 5.2e-11
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198) 339 67.2 5.2e-11
XP_016875645 (OMIM: 605117) PREDICTED: suppressor ( 198) 339 67.2 5.2e-11
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198) 339 67.2 5.2e-11
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198) 339 67.2 5.2e-11
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198) 339 67.2 5.2e-11
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198) 339 67.2 5.2e-11
XP_011537238 (OMIM: 605117) PREDICTED: suppressor ( 204) 339 67.3 5.3e-11
XP_011537237 (OMIM: 605117) PREDICTED: suppressor ( 212) 339 67.3 5.4e-11
XP_011537231 (OMIM: 605117) PREDICTED: suppressor ( 220) 339 67.3 5.6e-11
XP_016875644 (OMIM: 605117) PREDICTED: suppressor ( 222) 339 67.3 5.6e-11
XP_016875639 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875640 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875638 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875636 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875637 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875642 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875641 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
XP_016875643 (OMIM: 605117) PREDICTED: suppressor ( 243) 339 67.3 6e-11
NP_659198 (OMIM: 607094) suppressor of cytokine si ( 536) 244 51.9 5.7e-06
NP_054730 (OMIM: 607094) suppressor of cytokine si ( 536) 244 51.9 5.7e-06
NP_543143 (OMIM: 616337) suppressor of cytokine si ( 440) 232 49.9 2e-05
NP_955453 (OMIM: 616337) suppressor of cytokine si ( 440) 232 49.9 2e-05
XP_011534727 (OMIM: 616337) PREDICTED: suppressor ( 440) 232 49.9 2e-05
XP_011534728 (OMIM: 616337) PREDICTED: suppressor ( 440) 232 49.9 2e-05
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258) 213 46.5 0.00012
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264) 213 46.5 0.00012
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275) 213 46.5 0.00012
NP_001290356 (OMIM: 606076) phosphatidylinositol 3 ( 507) 202 45.0 0.00068
NP_003946 (OMIM: 604176) suppressor of cytokine si ( 225) 194 43.3 0.00096
NP_005018 (OMIM: 603157,603387) phosphatidylinosit ( 728) 201 44.9 0.00098
NP_001290358 (OMIM: 606076) phosphatidylinositol 3 ( 402) 195 43.7 0.0013
NP_001315581 (OMIM: 606076) phosphatidylinositol 3 ( 404) 195 43.7 0.0013
NP_001107644 (OMIM: 606076) phosphatidylinositol 3 ( 461) 195 43.8 0.0014
NP_003620 (OMIM: 606076) phosphatidylinositol 3-ki ( 461) 195 43.8 0.0014
XP_016858103 (OMIM: 606076) PREDICTED: phosphatidy ( 461) 195 43.8 0.0014
NP_001290357 (OMIM: 606076) phosphatidylinositol 3 ( 478) 195 43.8 0.0015
NP_001315579 (OMIM: 606076) phosphatidylinositol 3 ( 417) 194 43.5 0.0015
NP_001315578 (OMIM: 606076) phosphatidylinositol 3 ( 417) 194 43.5 0.0015
NP_001315577 (OMIM: 606076) phosphatidylinositol 3 ( 417) 194 43.5 0.0015
NP_001315580 (OMIM: 606076) phosphatidylinositol 3 ( 417) 194 43.5 0.0015
NP_852556 (OMIM: 171833,269880,615214,616005) phos ( 454) 189 42.8 0.0028
NP_852665 (OMIM: 171833,269880,615214,616005) phos ( 424) 185 42.1 0.0042
>>NP_004223 (OMIM: 605118) suppressor of cytokine signal (535 aa)
initn: 3590 init1: 3590 opt: 3590 Z-score: 3222.5 bits: 606.0 E(85289): 9.4e-173
Smith-Waterman score: 3590; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KB8 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
430 440 450 460 470 480
490 500 510 520 530
pF1KB8 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
>>XP_016881576 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 3590 init1: 3590 opt: 3590 Z-score: 3222.5 bits: 606.0 E(85289): 9.4e-173
Smith-Waterman score: 3590; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KB8 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
430 440 450 460 470 480
490 500 510 520 530
pF1KB8 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
>>XP_005266840 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 3590 init1: 3590 opt: 3590 Z-score: 3222.5 bits: 606.0 E(85289): 9.4e-173
Smith-Waterman score: 3590; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KB8 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
430 440 450 460 470 480
490 500 510 520 530
pF1KB8 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
>>XP_016881575 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 3590 init1: 3590 opt: 3590 Z-score: 3222.5 bits: 606.0 E(85289): 9.4e-173
Smith-Waterman score: 3590; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KB8 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
430 440 450 460 470 480
490 500 510 520 530
pF1KB8 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
>>XP_016880041 (OMIM: 608788) PREDICTED: suppressor of c (576 aa)
initn: 552 init1: 317 opt: 573 Z-score: 522.2 bits: 106.4 E(85289): 2.4e-22
Smith-Waterman score: 585; 33.3% identity (58.3% similar) in 420 aa overlap (134-535:154-548)
110 120 130 140 150 160
pF1KB8 FSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSS
: : : :. . .. ::.
XP_016 LAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALL----
130 140 150 160 170
170 180 190 200 210 220
pF1KB8 PSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQY
.:.:.... ..:.... .:. .: ... .: : :. : : : .
XP_016 ---VLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQ-----PPGPELPPVPF---
180 190 200 210 220
230 240 250 260 270 280
pF1KB8 TVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFP-EDESQVDQDLVVAPEIFVD
::.. . :: : : .... .. :: : : :. . . ..:
XP_016 --PLQD-LVPL-GRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 QSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRC
.: :: : :. . : .: .. . : : ... :.... . ..:
XP_016 KSCNGGSGGGDGTG-KRP-SG--ELAASAASLTDM-GGSAGRELDAGRKPKLTRTQSAFS
290 300 310 320 330
350 360 370 380
pF1KB8 HLNFDP---NSAPGVA--RVYDSVQSSGPMVV---------TSLTEELKKLAKQGWYWGP
..:.: .. : .: :. .:..:. :. . .:.. :..: : ::::::
XP_016 PVSFSPLFTDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGP
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB8 ITRWE-AEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPD
.. :: :: :: . :::::::::::: ::.:::::::.: : :::.:: : ::.. .:
XP_016 MN-WEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPK
400 410 420 430 440 450
450 460 470 480 490 500
pF1KB8 VEGHT-SIVDLIEHSIRDSENGAFCYS-RSRLPGSATYPVRLTNPVSRFMQVRSLQYLCR
: . :.:..:...: :.:: : : :::.:: ::.: ::::: .:.:::.:::
XP_016 FEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCR
460 470 480 490 500 510
510 520 530
pF1KB8 FVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
: ::: .::: : ::::. . .:... .:
XP_016 FRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
520 530 540 550 560 570
>>NP_055413 (OMIM: 608788) suppressor of cytokine signal (581 aa)
initn: 527 init1: 317 opt: 573 Z-score: 522.1 bits: 106.4 E(85289): 2.4e-22
Smith-Waterman score: 612; 39.3% identity (61.6% similar) in 318 aa overlap (245-535:238-553)
220 230 240 250 260 270
pF1KB8 LMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVP-PQVGGRAFPEDESQVDQDL
:. . .::. ..:: : : .. :
NP_055 GSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKL
210 220 230 240 250 260
280 290 300 310 320 330
pF1KB8 VVAPEIFVDQSVNGLLIGTTGVMLQ---SPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLT
. . : : . :. : : ... : :. . :: .: :: .. .. ..::
NP_055 TRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPP-TPPPPPRRSLSLLDDISGTL
270 280 290 300 310 320
340 350 360 370
pF1KB8 GTEAHVAESMRCHLNFD---------PNSAPGVA--RVYDSVQSSGPMVV---------T
: . :: .: :.. : .: :. .:..:. :. . .
NP_055 PTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSS
330 340 350 360 370 380
380 390 400 410 420
pF1KB8 SLTEELKKLAKQGWYWGPITRWE-AEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTL
:.. :..: : ::::::.. :: :: :: . :::::::::::: ::.:::::::.: :
NP_055 SFAASLRELEKCGWYWGPMN-WEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITH
390 400 410 420 430 440
430 440 450 460 470 480
pF1KB8 HTRIEHSNGRFSFYEQPDVEGHT-SIVDLIEHSIRDSENGAFCYS-RSRLPGSATYPVRL
:::.:: : ::.. .: : . :.:..:...: :.:: : : :::.:: ::.:
NP_055 HTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQL
450 460 470 480 490 500
490 500 510 520 530
pF1KB8 TNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
::::: .:.:::.:::: ::: .::: : ::::. . .:... .:
NP_055 LYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLK
510 520 530 540 550 560
NP_055 EAQLISKQKQEVEPST
570 580
>>XP_016880040 (OMIM: 608788) PREDICTED: suppressor of c (611 aa)
initn: 552 init1: 317 opt: 573 Z-score: 521.9 bits: 106.5 E(85289): 2.5e-22
Smith-Waterman score: 586; 40.3% identity (61.7% similar) in 298 aa overlap (245-535:302-583)
220 230 240 250 260 270
pF1KB8 LMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVP-PQVGGRAFPEDESQVDQDL
:. . .::. ..:: : : .. :
XP_016 GSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKL
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB8 VVAPEIFVDQSVNGLLIGTTGVMLQ---SPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLT
. . : : . :. : : ... : :. . :: .: :: .. .. : ..
XP_016 TRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPP-TPPPPPRRSLSLLDAFPRIA
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB8 GTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPIT
.: :::.. . :. :: .:.. :..: : ::::::..
XP_016 PIRA--AESLHSQ---PPQHLQCPLYRPDS---------SSFAASLRELEKCGWYWGPMN
400 410 420 430
400 410 420 430 440
pF1KB8 RWE-AEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVE
:: :: :: . :::::::::::: ::.:::::::.: : :::.:: : ::.. .: :
XP_016 -WEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFE
440 450 460 470 480 490
450 460 470 480 490 500
pF1KB8 GHT-SIVDLIEHSIRDSENGAFCYS-RSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFV
. :.:..:...: :.:: : : :::.:: ::.: ::::: .:.:::.::::
XP_016 DRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFR
500 510 520 530 540 550
510 520 530
pF1KB8 IRQYTRIDLIQKLPLPNKMKDYLQEKHY
::: .::: : ::::. . .:... .:
XP_016 IRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
560 570 580 590 600 610
>>NP_003868 (OMIM: 605117) suppressor of cytokine signal (198 aa)
initn: 298 init1: 200 opt: 339 Z-score: 318.7 bits: 67.2 E(85289): 5.2e-11
Smith-Waterman score: 339; 31.9% identity (65.7% similar) in 207 aa overlap (339-535:2-196)
310 320 330 340 350 360
pF1KB8 PLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSS---G
..:: :. . :.. :. . .. :. .
NP_003 MTLRC-LEPSGNGGEGTRSQWGTAGSAEEPS
10 20 30
370 380 390 400 410 420
pF1KB8 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
:... :.. :..:.. ::::: .: ::. :: ..:.:.::.:::: . :::..: ..
NP_003 PQAAR-LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTS
40 50 60 70 80
430 440 450 460 470
pF1KB8 GKTLHTRIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLP
. . :::...:.: . . .. :.: ::.. . .:...: . :
NP_003 AGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGP------EAP
90 100 110 120 130 140
480 490 500 510 520 530
pF1KB8 GSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
..: . ::.:. . .. :::.:::..: . : : ::::...::::.: ..
NP_003 RNGTVHLYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQV
150 160 170 180 190
>>NP_001257400 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 298 init1: 200 opt: 339 Z-score: 318.7 bits: 67.2 E(85289): 5.2e-11
Smith-Waterman score: 339; 31.9% identity (65.7% similar) in 207 aa overlap (339-535:2-196)
310 320 330 340 350 360
pF1KB8 PLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSS---G
..:: :. . :.. :. . .. :. .
NP_001 MTLRC-LEPSGNGGEGTRSQWGTAGSAEEPS
10 20 30
370 380 390 400 410 420
pF1KB8 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
:... :.. :..:.. ::::: .: ::. :: ..:.:.::.:::: . :::..: ..
NP_001 PQAAR-LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTS
40 50 60 70 80
430 440 450 460 470
pF1KB8 GKTLHTRIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLP
. . :::...:.: . . .. :.: ::.. . .:...: . :
NP_001 AGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGP------EAP
90 100 110 120 130 140
480 490 500 510 520 530
pF1KB8 GSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
..: . ::.:. . .. :::.:::..: . : : ::::...::::.: ..
NP_001 RNGTVHLYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQV
150 160 170 180 190
>>XP_016875645 (OMIM: 605117) PREDICTED: suppressor of c (198 aa)
initn: 298 init1: 200 opt: 339 Z-score: 318.7 bits: 67.2 E(85289): 5.2e-11
Smith-Waterman score: 339; 31.9% identity (65.7% similar) in 207 aa overlap (339-535:2-196)
310 320 330 340 350 360
pF1KB8 PLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSS---G
..:: :. . :.. :. . .. :. .
XP_016 MTLRC-LEPSGNGGEGTRSQWGTAGSAEEPS
10 20 30
370 380 390 400 410 420
pF1KB8 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
:... :.. :..:.. ::::: .: ::. :: ..:.:.::.:::: . :::..: ..
XP_016 PQAAR-LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTS
40 50 60 70 80
430 440 450 460 470
pF1KB8 GKTLHTRIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLP
. . :::...:.: . . .. :.: ::.. . .:...: . :
XP_016 AGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGP------EAP
90 100 110 120 130 140
480 490 500 510 520 530
pF1KB8 GSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
..: . ::.:. . .. :::.:::..: . : : ::::...::::.: ..
XP_016 RNGTVHLYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQV
150 160 170 180 190
535 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:04:44 2016 done: Fri Nov 4 16:04:45 2016
Total Scan time: 8.730 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]