Result of FASTA (omim) for
pF1KB8763
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8763, 211 aa
1>>>pF1KB8763 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8432+/-0.000273; mu= 9.6786+/- 0.017
mean_var=147.1309+/-29.938, 0's: 0 Z-trim(122.9): 61 B-trim: 0 in 0/61
Lambda= 0.105736
statistics sampled from 41652 (41713) to 41652 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.489), width: 16
Scan time: 6.650
The best scores are: opt bits E(85289)
NP_003736 (OMIM: 603597) suppressor of cytokine si ( 211) 1445 230.7 1.4e-60
NP_003946 (OMIM: 604176) suppressor of cytokine si ( 225) 284 53.6 3e-07
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198) 252 48.7 8e-06
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198) 252 48.7 8e-06
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198) 252 48.7 8e-06
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198) 252 48.7 8e-06
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198) 252 48.7 8e-06
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198) 252 48.7 8e-06
XP_016875645 (OMIM: 605117) PREDICTED: suppressor ( 198) 252 48.7 8e-06
XP_011537238 (OMIM: 605117) PREDICTED: suppressor ( 204) 252 48.7 8.2e-06
XP_011537237 (OMIM: 605117) PREDICTED: suppressor ( 212) 252 48.7 8.4e-06
XP_011537231 (OMIM: 605117) PREDICTED: suppressor ( 220) 252 48.7 8.6e-06
XP_016875644 (OMIM: 605117) PREDICTED: suppressor ( 222) 252 48.7 8.7e-06
XP_016875637 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875639 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875638 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875640 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875643 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875641 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875642 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
XP_016875636 (OMIM: 605117) PREDICTED: suppressor ( 243) 252 48.7 9.3e-06
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258) 227 45.0 0.00014
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264) 227 45.0 0.00014
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275) 227 45.0 0.00014
>>NP_003736 (OMIM: 603597) suppressor of cytokine signal (211 aa)
initn: 1445 init1: 1445 opt: 1445 Z-score: 1208.7 bits: 230.7 E(85289): 1.4e-60
Smith-Waterman score: 1445; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB8 MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ
130 140 150 160 170 180
190 200 210
pF1KB8 RIVATVGRENLARIPLNPVLRDYLSSFPFQI
:::::::::::::::::::::::::::::::
NP_003 RIVATVGRENLARIPLNPVLRDYLSSFPFQI
190 200 210
>>NP_003946 (OMIM: 604176) suppressor of cytokine signal (225 aa)
initn: 294 init1: 215 opt: 284 Z-score: 251.2 bits: 53.6 E(85289): 3e-07
Smith-Waterman score: 284; 38.9% identity (64.9% similar) in 131 aa overlap (43-165:8-134)
20 30 40 50 60 70
pF1KB8 VSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFR--TFRSHADYRRITRA
::. : :: .: :: :...:. .. :
NP_003 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNA
10 20 30
80 90 100 110 120 130
pF1KB8 SALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHF
:. ::::. .. :. : :::.::::.::: .. ::.:::: :: ..:..
NP_003 VRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQC
40 50 60 70 80 90
140 150 160 170 180
pF1KB8 QAGRFHLDGSRES------FDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVA
..: : :... .: :::...:..::. : :::
NP_003 EGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPP----GAPSFPSPPTEPSSEVPEQPSA
100 110 120 130 140 150
190 200 210
pF1KB8 TVGRENLARIPLNPVLRDYLSSFPFQI
NP_003 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP
160 170 180 190 200 210
>>NP_001257398 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_001 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_001 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_001 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_001 PLPTRLKDYLEEYKFQV
190
>>NP_001257400 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_001 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_001 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_001 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_001 PLPTRLKDYLEEYKFQV
190
>>NP_001257396 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_001 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_001 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_001 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_001 PLPTRLKDYLEEYKFQV
190
>>NP_003868 (OMIM: 605117) suppressor of cytokine signal (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_003 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_003 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_003 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_003 PLPTRLKDYLEEYKFQV
190
>>NP_001257399 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_001 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_001 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_001 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_001 PLPTRLKDYLEEYKFQV
190
>>NP_001257397 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
NP_001 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
NP_001 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
NP_001 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
NP_001 PLPTRLKDYLEEYKFQV
190
>>XP_016875645 (OMIM: 605117) PREDICTED: suppressor of c (198 aa)
initn: 318 init1: 223 opt: 252 Z-score: 225.5 bits: 48.7 E(85289): 8e-06
Smith-Waterman score: 299; 34.7% identity (61.1% similar) in 167 aa overlap (66-211:35-198)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
XP_016 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
XP_016 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
XP_016 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::.
XP_016 PLPTRLKDYLEEYKFQV
190
>>XP_011537238 (OMIM: 605117) PREDICTED: suppressor of c (204 aa)
initn: 316 init1: 223 opt: 252 Z-score: 225.3 bits: 48.7 E(85289): 8.2e-06
Smith-Waterman score: 295; 34.9% identity (60.8% similar) in 166 aa overlap (66-210:35-197)
40 50 60 70 80 90
pF1KB8 PARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRA
:...: : :.::: ..:. :.:.:.
XP_011 CLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE
10 20 30 40 50 60
100 110 120 130 140
pF1KB8 EPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG-----SR-ESFDCLFE
: ::::.::: . . ....::: ..:::..:...: :.:.::. :. ..:: . .
XP_011 APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVH
70 80 90 100 110 120
150 160 170 180 190
pF1KB8 LLEHYVA----------APRR-----MLGAPLRQRRVRPLQELCRQRIVATVGRENLARI
:...:: ::: .: :: . ::.::: : .: . .
XP_011 LIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTS-APSLQHLCRLTINKCTG--AIWGL
130 140 150 160 170 180
200 210
pF1KB8 PLNPVLRDYLSSFPFQI
:: :.::: . ::
XP_011 PLPTRLKDYLEEYKFQPAVFYPG
190 200
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 15:22:47 2016 done: Fri Nov 4 15:22:48 2016
Total Scan time: 6.650 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]