Result of FASTA (omim) for
pF1KB8729
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8729, 841 aa
1>>>pF1KB8729 841 - 841 aa - 841 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4645+/-0.000371; mu= 20.0750+/- 0.023
mean_var=75.0642+/-14.926, 0's: 0 Z-trim(113.3): 27 B-trim: 0 in 0/55
Lambda= 0.148033
statistics sampled from 22579 (22605) to 22579 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.265), width: 16
Scan time: 13.540
The best scores are: opt bits E(85289)
NP_005472 (OMIM: 604062) mediator of RNA polymeras ( 877) 5596 1205.2 0
XP_016881610 (OMIM: 604062) PREDICTED: mediator of ( 702) 4354 939.9 0
XP_016881609 (OMIM: 604062) PREDICTED: mediator of ( 808) 3039 659.1 2.3e-188
>>NP_005472 (OMIM: 604062) mediator of RNA polymerase II (877 aa)
initn: 5596 init1: 5596 opt: 5596 Z-score: 6453.4 bits: 1205.2 E(85289): 0
Smith-Waterman score: 5596; 100.0% identity (100.0% similar) in 828 aa overlap (1-828:1-828)
10 20 30 40 50 60
pF1KB8 MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 CMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSY
::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVT
790 800 810 820 830 840
pF1KB8 P
NP_005 SRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
850 860 870
>>XP_016881610 (OMIM: 604062) PREDICTED: mediator of RNA (702 aa)
initn: 4354 init1: 4354 opt: 4354 Z-score: 5021.3 bits: 939.9 E(85289): 0
Smith-Waterman score: 4354; 100.0% identity (100.0% similar) in 653 aa overlap (176-828:1-653)
150 160 170 180 190 200
pF1KB8 HVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTES
::::::::::::::::::::::::::::::
XP_016 MEGWIAVTVSGLVTVSLLKPSGQVLTSTES
10 20 30
210 220 230 240 250 260
pF1KB8 LCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFM
40 50 60 70 80 90
270 280 290 300 310 320
pF1KB8 RCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQI
100 110 120 130 140 150
330 340 350 360 370 380
pF1KB8 SPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALA
160 170 180 190 200 210
390 400 410 420 430 440
pF1KB8 FHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVG
220 230 240 250 260 270
450 460 470 480 490 500
pF1KB8 IDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVE
280 290 300 310 320 330
510 520 530 540 550 560
pF1KB8 KLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLR
340 350 360 370 380 390
570 580 590 600 610 620
pF1KB8 PHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
400 410 420 430 440 450
630 640 650 660 670 680
pF1KB8 LYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDS
460 470 480 490 500 510
690 700 710 720 730 740
pF1KB8 MSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPK
520 530 540 550 560 570
750 760 770 780 790 800
pF1KB8 QPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVT
580 590 600 610 620 630
810 820 830 840
pF1KB8 MLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSYP
:::::::::::::::::::::::
XP_016 MLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTP
640 650 660 670 680 690
>>XP_016881609 (OMIM: 604062) PREDICTED: mediator of RNA (808 aa)
initn: 3039 init1: 3039 opt: 3039 Z-score: 3502.6 bits: 659.1 E(85289): 2.3e-188
Smith-Waterman score: 4985; 91.7% identity (91.7% similar) in 828 aa overlap (1-828:1-759)
10 20 30 40 50 60
pF1KB8 MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEY
:::::::::::::::::::::::::::::::
XP_016 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGK-----------------------------
430 440 450
490 500 510 520 530 540
pF1KB8 CMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCT
::::::::::::::::::::
XP_016 ----------------------------------------VLSTRILAMKASLCKLSPCT
460 470
550 560 570 580 590 600
pF1KB8 VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
480 490 500 510 520 530
610 620 630 640 650 660
pF1KB8 TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
540 550 560 570 580 590
670 680 690 700 710 720
pF1KB8 VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB8 PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
660 670 680 690 700 710
790 800 810 820 830 840
pF1KB8 HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSY
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVT
720 730 740 750 760 770
pF1KB8 P
XP_016 SRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
780 790 800
841 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 15:00:46 2016 done: Fri Nov 4 15:00:48 2016
Total Scan time: 13.540 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]