Result of FASTA (omim) for
pF1KB8664
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8664, 409 aa
1>>>pF1KB8664 409 - 409 aa - 409 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0899+/-0.000342; mu= 8.8255+/- 0.021
mean_var=117.8808+/-23.949, 0's: 0 Z-trim(117.6): 117 B-trim: 0 in 0/55
Lambda= 0.118128
statistics sampled from 29541 (29682) to 29541 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.348), width: 16
Scan time: 9.730
The best scores are: opt bits E(85289)
NP_073620 (OMIM: 612974) DEP domain-containing mTO ( 409) 2707 472.3 9.7e-133
NP_001269941 (OMIM: 612974) DEP domain-containing ( 308) 1772 312.9 7.1e-85
XP_016869224 (OMIM: 612974) PREDICTED: DEP domain- ( 266) 1756 310.1 4.2e-84
NP_079446 (OMIM: 612139) phosphatidylinositol 3,4, ( 979) 522 100.1 2.5e-20
XP_011515914 (OMIM: 612139) PREDICTED: phosphatidy (1157) 522 100.1 2.9e-20
NP_079146 (OMIM: 612139) phosphatidylinositol 3,4, (1606) 522 100.2 3.8e-20
XP_011527236 (OMIM: 606905) PREDICTED: phosphatidy (1259) 504 97.1 2.6e-19
NP_065871 (OMIM: 606905) phosphatidylinositol 3,4, (1659) 504 97.2 3.3e-19
NP_001269829 (OMIM: 606058) rap guanine nucleotide ( 840) 227 49.8 3e-05
XP_006712268 (OMIM: 606058) PREDICTED: rap guanine ( 840) 227 49.8 3e-05
XP_016858686 (OMIM: 606058) PREDICTED: rap guanine ( 849) 227 49.8 3e-05
NP_001269828 (OMIM: 606058) rap guanine nucleotide ( 858) 227 49.8 3.1e-05
NP_001093867 (OMIM: 606058) rap guanine nucleotide ( 867) 227 49.8 3.1e-05
XP_011508807 (OMIM: 606058) PREDICTED: rap guanine ( 881) 227 49.8 3.1e-05
XP_016858685 (OMIM: 606058) PREDICTED: rap guanine ( 960) 227 49.8 3.4e-05
XP_005246303 (OMIM: 606058) PREDICTED: rap guanine ( 993) 227 49.8 3.5e-05
NP_008954 (OMIM: 606058) rap guanine nucleotide ex (1011) 227 49.8 3.5e-05
NP_001269830 (OMIM: 606058) rap guanine nucleotide ( 791) 222 48.9 5.2e-05
>>NP_073620 (OMIM: 612974) DEP domain-containing mTOR-in (409 aa)
initn: 2707 init1: 2707 opt: 2707 Z-score: 2504.1 bits: 472.3 E(85289): 9.7e-133
Smith-Waterman score: 2707; 99.5% identity (99.8% similar) in 409 aa overlap (1-409:1-409)
10 20 30 40 50 60
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 TTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_073 TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 THDSPFCLGKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
310 320 330 340 350 360
370 380 390 400
pF1KB8 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
370 380 390 400
>>NP_001269941 (OMIM: 612974) DEP domain-containing mTOR (308 aa)
initn: 1764 init1: 1764 opt: 1772 Z-score: 1644.8 bits: 312.9 E(85289): 7.1e-85
Smith-Waterman score: 1803; 74.8% identity (75.1% similar) in 409 aa overlap (1-409:1-308)
10 20 30 40 50 60
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
::::::::::::::::::::::::::::::::::::::::::
NP_001 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRL------------------
10 20 30 40
70 80 90 100 110 120
pF1KB8 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
NP_001 ------------------------------------------------------------
130 140 150 160 170 180
pF1KB8 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
:::::::::::::::::::::::::::::::::::::
NP_001 -----------------------MSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
50 60 70
190 200 210 220 230 240
pF1KB8 TTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_001 TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
80 90 100 110 120 130
250 260 270 280 290 300
pF1KB8 THDSPFCLGKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
140 150 160 170 180 190
310 320 330 340 350 360
pF1KB8 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
200 210 220 230 240 250
370 380 390 400
pF1KB8 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
260 270 280 290 300
>>XP_016869224 (OMIM: 612974) PREDICTED: DEP domain-cont (266 aa)
initn: 1756 init1: 1756 opt: 1756 Z-score: 1631.0 bits: 310.1 E(85289): 4.2e-84
Smith-Waterman score: 1756; 99.2% identity (99.6% similar) in 266 aa overlap (144-409:1-266)
120 130 140 150 160 170
pF1KB8 FYRFRKDDGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDW
::::::::::::::::::::::::::::::
XP_016 MSPENTLLQPREEEGVKYERTFMASEFLDW
10 20 30
180 190 200 210 220 230
pF1KB8 LVQEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLNE
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 LVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNE
40 50 60 70 80 90
240 250 260 270 280 290
pF1KB8 KSPSSQETHDSPFCLGKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSS
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSS
100 110 120 130 140 150
300 310 320 330 340 350
pF1KB8 PTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQ
160 170 180 190 200 210
360 370 380 390 400
pF1KB8 AVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
220 230 240 250 260
>>NP_079446 (OMIM: 612139) phosphatidylinositol 3,4,5-tr (979 aa)
initn: 470 init1: 355 opt: 522 Z-score: 485.9 bits: 100.1 E(85289): 2.5e-20
Smith-Waterman score: 522; 32.0% identity (61.0% similar) in 372 aa overlap (27-380:370-727)
10 20 30 40 50
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVT--GEQL-RLRLHEEKVIKDR
.:. . :... ::.: .. .. ..::::
NP_079 VCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDR
340 350 360 370 380 390
60 70 80 90 100 110
pF1KB8 RHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKL
...: :.:.::...:...::.: : : ...: : : . :::::: :.:. :: ..
NP_079 KRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQ-FKPEQM
400 410 420 430 440 450
120 130 140 150 160 170
pF1KB8 FYRFRKDDGTFPLDNEVKAFM-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLD
.:::: ::::: ::.. . .: ::: .: : . ... .. . :. . ::....:
NP_079 LYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLID
460 470 480 490 500 510
180 190 200 210 220 230
pF1KB8 WLVQEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLN
::. .:. ::.:: . : ..:...:: : : : ::..: : .. :: :
NP_079 WLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRF---FSDEE--MEGSN
520 530 540 550 560 570
240 250 260 270 280
pF1KB8 EKSPSSQETHDSPFC---LGKQS--HDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGS-
: :: ..:. ..:. : .: .. .... :.. :...: . ..
NP_079 MK--HRLMKHDLKVVENVIAKSLLIKSNEGSYGF-GLEDKNKVPIIKLVEKGSNAEMAGM
580 590 600 610 620 630
290 300 310 320 330
pF1KB8 ---SGYFSSSPTLSSSPP---VLCNPKSVL--KRPVTSEELLTPGAPYARKTFTIVGDAV
. :. . : : : : :: : ..:. ..:. : :.: : .:
NP_079 EVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--RETVKIPDSAD
640 650 660 670 680
340 350 360 370 380 390
pF1KB8 GWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRT
: :: .:: : ..:: . :::::.. : ...:::.::
NP_079 GLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKY
690 700 710 720 730 740
400
pF1KB8 IVMEVMEELEC
NP_079 RRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKK
750 760 770 780 790 800
>>XP_011515914 (OMIM: 612139) PREDICTED: phosphatidylino (1157 aa)
initn: 470 init1: 355 opt: 522 Z-score: 484.8 bits: 100.1 E(85289): 2.9e-20
Smith-Waterman score: 522; 32.0% identity (61.0% similar) in 372 aa overlap (27-380:370-727)
10 20 30 40 50
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVT--GEQL-RLRLHEEKVIKDR
.:. . :... ::.: .. .. ..::::
XP_011 VCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDR
340 350 360 370 380 390
60 70 80 90 100 110
pF1KB8 RHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKL
...: :.:.::...:...::.: : : ...: : : . :::::: :.:. :: ..
XP_011 KRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQ-FKPEQM
400 410 420 430 440 450
120 130 140 150 160 170
pF1KB8 FYRFRKDDGTFPLDNEVKAFM-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLD
.:::: ::::: ::.. . .: ::: .: : . ... .. . :. . ::....:
XP_011 LYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLID
460 470 480 490 500 510
180 190 200 210 220 230
pF1KB8 WLVQEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLN
::. .:. ::.:: . : ..:...:: : : : ::..: : .. :: :
XP_011 WLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRF---FSDEE--MEGSN
520 530 540 550 560 570
240 250 260 270 280
pF1KB8 EKSPSSQETHDSPFC---LGKQS--HDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGS-
: :: ..:. ..:. : .: .. .... :.. :...: . ..
XP_011 MK--HRLMKHDLKVVENVIAKSLLIKSNEGSYGF-GLEDKNKVPIIKLVEKGSNAEMAGM
580 590 600 610 620 630
290 300 310 320 330
pF1KB8 ---SGYFSSSPTLSSSPP---VLCNPKSVL--KRPVTSEELLTPGAPYARKTFTIVGDAV
. :. . : : : : :: : ..:. ..:. : :.: : .:
XP_011 EVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--RETVKIPDSAD
640 650 660 670 680
340 350 360 370 380 390
pF1KB8 GWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRT
: :: .:: : ..:: . :::::.. : ...:::.::
XP_011 GLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKY
690 700 710 720 730 740
400
pF1KB8 IVMEVMEELEC
XP_011 RRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKK
750 760 770 780 790 800
>>NP_079146 (OMIM: 612139) phosphatidylinositol 3,4,5-tr (1606 aa)
initn: 470 init1: 355 opt: 522 Z-score: 482.7 bits: 100.2 E(85289): 3.8e-20
Smith-Waterman score: 522; 32.0% identity (61.0% similar) in 372 aa overlap (27-380:370-727)
10 20 30 40 50
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVT--GEQL-RLRLHEEKVIKDR
.:. . :... ::.: .. .. ..::::
NP_079 VCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDR
340 350 360 370 380 390
60 70 80 90 100 110
pF1KB8 RHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKL
...: :.:.::...:...::.: : : ...: : : . :::::: :.:. :: ..
NP_079 KRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQ-FKPEQM
400 410 420 430 440 450
120 130 140 150 160 170
pF1KB8 FYRFRKDDGTFPLDNEVKAFM-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLD
.:::: ::::: ::.. . .: ::: .: : . ... .. . :. . ::....:
NP_079 LYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLID
460 470 480 490 500 510
180 190 200 210 220 230
pF1KB8 WLVQEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLN
::. .:. ::.:: . : ..:...:: : : : ::..: : .. :: :
NP_079 WLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRF---FSDEE--MEGSN
520 530 540 550 560 570
240 250 260 270 280
pF1KB8 EKSPSSQETHDSPFC---LGKQS--HDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGS-
: :: ..:. ..:. : .: .. .... :.. :...: . ..
NP_079 MK--HRLMKHDLKVVENVIAKSLLIKSNEGSYGF-GLEDKNKVPIIKLVEKGSNAEMAGM
580 590 600 610 620 630
290 300 310 320 330
pF1KB8 ---SGYFSSSPTLSSSPP---VLCNPKSVL--KRPVTSEELLTPGAPYARKTFTIVGDAV
. :. . : : : : :: : ..:. ..:. : :.: : .:
NP_079 EVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--RETVKIPDSAD
640 650 660 670 680
340 350 360 370 380 390
pF1KB8 GWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRT
: :: .:: : ..:: . :::::.. : ...:::.::
NP_079 GLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKY
690 700 710 720 730 740
400
pF1KB8 IVMEVMEELEC
NP_079 RRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKK
750 760 770 780 790 800
>>XP_011527236 (OMIM: 606905) PREDICTED: phosphatidylino (1259 aa)
initn: 402 init1: 323 opt: 504 Z-score: 467.7 bits: 97.1 E(85289): 2.6e-19
Smith-Waterman score: 504; 30.0% identity (61.4% similar) in 370 aa overlap (27-382:1-361)
10 20 30 40 50
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVT--GEQLRLRLHEEKV--IKDRRHH
.:: : :... ::.: . ..:: :::::..
XP_011 MERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRK
10 20 30
60 70 80 90 100 110
pF1KB8 LKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYR
:.: :.::...:.. ::.: : : : ...: : : . :::::: :.:. ::. ...::
XP_011 LSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQ-FKNEQVMYR
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 FRKDDGTFPLDNEVKAFM-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLV
:: ::::. .:.. .: .: ::: .: : . ... :. . :. .. .:...:::.
XP_011 FRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLL
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB8 QEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLNEKS
.:. ::.:: : : ..:...:: : : : . ..:. . :. . .:
XP_011 AQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHAD-------EEMEGTSS
160 170 180 190 200
240 250 260 270 280
pF1KB8 PSSQETHDSPFC---LGKQSHDNRKSTSF-MSVSPSKEIKIVSAVRRSSMSSCGS----S
..: .: . :.:. . .. ... ... .:..:.:.:.. ..
XP_011 KNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGR
210 220 230 240 250 260
290 300 310 320 330 340
pF1KB8 GYFSSSPTLSSSPPVLCNPKSVLKRPVTSEE-LLTPGAPYARKTFTIVGDAVGWGFVVRG
.: . : : . . .:.:.. :.. : : :.. . : . : .::
XP_011 KIYSINEDLVFLRP-FSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRG
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB8 SKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEE
. : .. :: .. : :::. . : ...::: ::..
XP_011 AAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLY
330 340 350 360 370 380
pF1KB8 LEC
XP_011 QWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLT
390 400 410 420 430 440
>>NP_065871 (OMIM: 606905) phosphatidylinositol 3,4,5-tr (1659 aa)
initn: 402 init1: 323 opt: 504 Z-score: 465.9 bits: 97.2 E(85289): 3.3e-19
Smith-Waterman score: 506; 30.1% identity (60.9% similar) in 379 aa overlap (23-382:392-761)
10 20 30 40
pF1KB8 MEEGGSTGSAGSDSSTSGSGGAQQRE-----LERMAEVLVT--GEQLRLRLH
.::: .:: : :... ::.: .
NP_065 HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMM
370 380 390 400 410 420
50 60 70 80 90 100
pF1KB8 EEKV--IKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCD
..:: :::::..:.: :.::...:.. ::.: : : : ...: : : . :::::: :
NP_065 NKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSD
430 440 450 460 470 480
110 120 130 140 150 160
pF1KB8 EHKEFKDVKLFYRFRKDDGTFPLDNEVKAFM-RGQRLYEKLMSPENTLLQPREEEGVKYE
.:. ::. ...:::: ::::. .:.. .: .: ::: .: : . ... :. . :.
NP_065 KHQ-FKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK
490 500 510 520 530 540
170 180 190 200 210 220
pF1KB8 RTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFR
.. .:...:::. .:. ::.:: : : ..:...:: : : : . ..:. .
NP_065 SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHAD--
550 560 570 580 590
230 240 250 260 270
pF1KB8 RRRRLMELLNEKSPSSQETHDSPFC---LGKQSHDNRKSTSF-MSVSPSKEIKIVSAVRR
:. . .: ..: .: . :.:. . .. ... ... .:..:.:
NP_065 -----EEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQR
600 610 620 630 640 650
280 290 300 310 320 330
pF1KB8 SSMSSCGS----SGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEE-LLTPGAPYARKTFTI
.:.. .. .: . : : . . .:.:.. :.. : : :.. . :
NP_065 GSLAEVAGLQVGRKIYSINEDLVFLRP-FSEVESILNQSFCSRRPLRLLVATKAKEIIKI
660 670 680 690 700 710
340 350 360 370 380 390
pF1KB8 VGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLIL
. : .::. : .. :: .. : :::. . : ...::: ::..
NP_065 PDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQ
720 730 740 750 760 770
400
pF1KB8 TGPRTIVMEVMEELEC
NP_065 AFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPR
780 790 800 810 820 830
>>NP_001269829 (OMIM: 606058) rap guanine nucleotide exc (840 aa)
initn: 236 init1: 161 opt: 227 Z-score: 215.2 bits: 49.8 E(85289): 3e-05
Smith-Waterman score: 227; 36.8% identity (67.9% similar) in 106 aa overlap (32-131:31-135)
10 20 30 40 50
pF1KB8 EEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRL--HEEKVIKDRRHHLKT
..: .:. :: . . ..:.::..::::
NP_001 MAGLLAPPYGVMETGSNNDRIPDKENVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 YPNCFVAKELIDWLIEHKE-ASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFR
: .: :. ::.::.... . .: :. . : : . :...:: .::. :.: :::::
NP_001 YRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHH-FQDKYLFYRFL
70 80 90 100 110
120 130 140 150 160 170
pF1KB8 KD---DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLV
: :. .: ..: :
NP_001 DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEE
120 130 140 150 160 170
>>XP_006712268 (OMIM: 606058) PREDICTED: rap guanine nuc (840 aa)
initn: 236 init1: 161 opt: 227 Z-score: 215.2 bits: 49.8 E(85289): 3e-05
Smith-Waterman score: 227; 36.8% identity (67.9% similar) in 106 aa overlap (32-131:31-135)
10 20 30 40 50
pF1KB8 EEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRL--HEEKVIKDRRHHLKT
..: .:. :: . . ..:.::..::::
XP_006 MAGLLAPPYGVMETGSNNDRIPDKENVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 YPNCFVAKELIDWLIEHKE-ASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFR
: .: :. ::.::.... . .: :. . : : . :...:: .::. :.: :::::
XP_006 YRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHH-FQDKYLFYRFL
70 80 90 100 110
120 130 140 150 160 170
pF1KB8 KD---DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLV
: :. .: ..: :
XP_006 DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEE
120 130 140 150 160 170
409 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 19:43:49 2016 done: Fri Nov 4 19:43:50 2016
Total Scan time: 9.730 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]