Result of FASTA (omim) for
pF1KB8622
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8622, 839 aa
1>>>pF1KB8622 839 - 839 aa - 839 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.9944+/-0.000587; mu= -1.4164+/- 0.036
mean_var=432.6432+/-94.189, 0's: 0 Z-trim(116.5): 229 B-trim: 0 in 0/54
Lambda= 0.061661
statistics sampled from 27421 (27653) to 27421 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.324), width: 16
Scan time: 13.820
The best scores are: opt bits E(85289)
NP_003362 (OMIM: 600428) guanine nucleotide exchan ( 839) 5729 525.7 3.5e-148
XP_016870601 (OMIM: 600428) PREDICTED: guanine nuc ( 844) 5709 523.9 1.2e-147
XP_005272270 (OMIM: 600428) PREDICTED: guanine nuc ( 868) 5269 484.8 7.3e-136
XP_016870599 (OMIM: 600428) PREDICTED: guanine nuc ( 873) 5249 483.0 2.5e-135
NP_001127870 (OMIM: 600428) guanine nucleotide exc ( 878) 3986 370.6 1.7e-101
XP_016870598 (OMIM: 600428) PREDICTED: guanine nuc ( 891) 3104 292.2 7.1e-78
XP_016870602 (OMIM: 600428) PREDICTED: guanine nuc ( 620) 3084 290.2 1.9e-77
NP_005419 (OMIM: 164875) proto-oncogene vav isofor ( 845) 2808 265.8 5.8e-70
XP_016870600 (OMIM: 600428) PREDICTED: guanine nuc ( 867) 2635 250.4 2.5e-65
XP_016855542 (OMIM: 605541) PREDICTED: guanine nuc ( 823) 2489 237.4 2e-61
XP_005259699 (OMIM: 164875) PREDICTED: proto-oncog ( 821) 2415 230.8 1.9e-59
XP_005270418 (OMIM: 605541) PREDICTED: guanine nuc ( 621) 2287 219.3 4.3e-56
XP_016855543 (OMIM: 605541) PREDICTED: guanine nuc ( 783) 2287 219.4 4.9e-56
NP_006104 (OMIM: 605541) guanine nucleotide exchan ( 847) 2287 219.5 5.2e-56
NP_001245135 (OMIM: 164875) proto-oncogene vav iso ( 823) 2235 214.8 1.3e-54
XP_016870597 (OMIM: 600428) PREDICTED: guanine nuc ( 896) 2175 209.5 5.3e-53
NP_001245136 (OMIM: 164875) proto-oncogene vav iso ( 813) 1924 187.2 2.7e-46
XP_016855544 (OMIM: 605541) PREDICTED: guanine nuc ( 751) 1715 168.5 1e-40
XP_005270417 (OMIM: 605541) PREDICTED: guanine nuc ( 753) 1709 168.0 1.4e-40
NP_001073343 (OMIM: 605541) guanine nucleotide exc ( 287) 792 85.9 2.9e-16
XP_016855545 (OMIM: 605541) PREDICTED: guanine nuc ( 407) 587 67.8 1.1e-10
NP_001273724 (OMIM: 613324) spermatogenesis-associ ( 574) 378 49.4 5.4e-05
NP_001273723 (OMIM: 613324) spermatogenesis-associ ( 596) 378 49.5 5.5e-05
NP_694568 (OMIM: 613324) spermatogenesis-associate ( 652) 378 49.5 5.8e-05
NP_001159743 (OMIM: 613324) spermatogenesis-associ (1277) 378 49.9 8.8e-05
NP_001273721 (OMIM: 613324) spermatogenesis-associ (1339) 378 49.9 9.1e-05
XP_005263746 (OMIM: 605216) PREDICTED: rho guanine ( 483) 367 48.4 9.5e-05
XP_011509579 (OMIM: 605216) PREDICTED: rho guanine ( 483) 367 48.4 9.5e-05
XP_011509578 (OMIM: 605216) PREDICTED: rho guanine ( 483) 367 48.4 9.5e-05
XP_005263745 (OMIM: 605216) PREDICTED: rho guanine ( 483) 367 48.4 9.5e-05
XP_011529194 (OMIM: 300429,300607) PREDICTED: rho ( 456) 365 48.2 0.0001
NP_001166950 (OMIM: 300429,300607) rho guanine nuc ( 463) 365 48.2 0.00011
XP_005263744 (OMIM: 605216) PREDICTED: rho guanine ( 567) 367 48.5 0.00011
NP_127462 (OMIM: 605216) rho guanine nucleotide ex ( 670) 367 48.5 0.00012
NP_056135 (OMIM: 605216) rho guanine nucleotide ex ( 690) 367 48.6 0.00012
XP_016884862 (OMIM: 300429,300607) PREDICTED: rho ( 414) 359 47.6 0.00014
NP_001166951 (OMIM: 300429,300607) rho guanine nuc ( 414) 359 47.6 0.00014
XP_011509576 (OMIM: 605216) PREDICTED: rho guanine (1870) 367 49.1 0.00022
XP_005263738 (OMIM: 605216) PREDICTED: rho guanine (1876) 367 49.1 0.00022
XP_006723397 (OMIM: 611893,616763) PREDICTED: plec (1327) 362 48.5 0.00024
XP_016882640 (OMIM: 611893,616763) PREDICTED: plec (1371) 362 48.5 0.00025
XP_016882639 (OMIM: 611893,616763) PREDICTED: plec (1374) 362 48.5 0.00025
NP_073746 (OMIM: 611893,616763) pleckstrin homolog (1386) 362 48.5 0.00025
XP_005259220 (OMIM: 611893,616763) PREDICTED: plec (1386) 362 48.5 0.00025
XP_011525534 (OMIM: 611893,616763) PREDICTED: plec (1387) 362 48.5 0.00025
XP_016884869 (OMIM: 300429,300607) PREDICTED: rho ( 305) 338 45.5 0.00043
XP_016884868 (OMIM: 300429,300607) PREDICTED: rho ( 344) 338 45.6 0.00046
XP_016884866 (OMIM: 300429,300607) PREDICTED: rho ( 365) 338 45.6 0.00048
XP_016884864 (OMIM: 300429,300607) PREDICTED: rho ( 385) 338 45.7 0.0005
NP_001273722 (OMIM: 613324) spermatogenesis-associ ( 512) 338 45.8 0.00059
>>NP_003362 (OMIM: 600428) guanine nucleotide exchange f (839 aa)
initn: 5729 init1: 5729 opt: 5729 Z-score: 2781.4 bits: 525.7 E(85289): 3.5e-148
Smith-Waterman score: 5729; 100.0% identity (100.0% similar) in 839 aa overlap (1-839:1-839)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIG
730 740 750 760 770 780
790 800 810 820 830
pF1KB8 TAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
790 800 810 820 830
>>XP_016870601 (OMIM: 600428) PREDICTED: guanine nucleot (844 aa)
initn: 4440 init1: 4440 opt: 5709 Z-score: 2771.8 bits: 523.9 E(85289): 1.2e-147
Smith-Waterman score: 5709; 99.4% identity (99.4% similar) in 844 aa overlap (1-839:1-844)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLR
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 GTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 KPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSRE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB8 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB8 DNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFT
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB8 PRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEE
790 800 810 820 830 840
pF1KB8 EGIQ
::::
XP_016 EGIQ
>>XP_005272270 (OMIM: 600428) PREDICTED: guanine nucleot (868 aa)
initn: 5715 init1: 5267 opt: 5269 Z-score: 2560.1 bits: 484.8 E(85289): 7.3e-136
Smith-Waterman score: 5661; 96.7% identity (96.7% similar) in 868 aa overlap (1-839:1-868)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH
670 680 690 700 710 720
730 740 750 760 770
pF1KB8 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSP--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNF
730 740 750 760 770 780
780 790 800 810
pF1KB8 ---------------------VFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG
:::::::::::::::::::::::::::::::::::::::
XP_005 SFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG
790 800 810 820 830 840
820 830
pF1KB8 GDQGWWKGETNGRIGWFPSTYVEEEGIQ
::::::::::::::::::::::::::::
XP_005 GDQGWWKGETNGRIGWFPSTYVEEEGIQ
850 860
>>XP_016870599 (OMIM: 600428) PREDICTED: guanine nucleot (873 aa)
initn: 4426 init1: 3978 opt: 5249 Z-score: 2550.5 bits: 483.0 E(85289): 2.5e-135
Smith-Waterman score: 5641; 96.1% identity (96.1% similar) in 873 aa overlap (1-839:1-873)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLR
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 GTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 KPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSRE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB8 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB8 DNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSP---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASC
730 740 750 760 770 780
780 790 800
pF1KB8 --------------------------VFTPRVIGTAVARYNFAARDMRELSLREGDVVRI
::::::::::::::::::::::::::::::::::
XP_016 ASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRI
790 800 810 820 830 840
810 820 830
pF1KB8 YSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
:::::::::::::::::::::::::::::::::
XP_016 YSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
850 860 870
>>NP_001127870 (OMIM: 600428) guanine nucleotide exchang (878 aa)
initn: 3897 init1: 2173 opt: 3986 Z-score: 1943.2 bits: 370.6 E(85289): 1.7e-101
Smith-Waterman score: 5621; 95.6% identity (95.6% similar) in 878 aa overlap (1-839:1-878)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK-----WSYGFY
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_001 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB8 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB8 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
730 740 750 760 770 780
780 790 800
pF1KB8 SP-----------------------------VFTPRVIGTAVARYNFAARDMRELSLREG
:: :::::::::::::::::::::::::::::
NP_001 SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG
790 800 810 820 830 840
810 820 830
pF1KB8 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
::::::::::::::::::::::::::::::::::::::
NP_001 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
850 860 870
>>XP_016870598 (OMIM: 600428) PREDICTED: guanine nucleot (891 aa)
initn: 3546 init1: 3098 opt: 3104 Z-score: 1519.1 bits: 292.2 E(85289): 7.1e-78
Smith-Waterman score: 5465; 94.0% identity (94.0% similar) in 871 aa overlap (1-819:1-871)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
370 380 390 400 410 420
430 440 450 460
pF1KB8 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK----------------
::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKQAGFPLPSHPAVLGGG
430 440 450 460 470 480
470 480 490 500 510
pF1KB8 -------WSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQ
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 MYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB8 GPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSV
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB8 KPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERF
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB8 AISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPY
730 740 750 760 770 780
760 770 780
pF1KB8 KSRERSASRASSRSP-----------------------------VFTPRVIGTAVARYNF
::::::::::::::: ::::::::::::::::
XP_016 KSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNF
790 800 810 820 830 840
790 800 810 820 830
pF1KB8 AARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
:::::::::::::::::::::::::::::::
XP_016 AARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
850 860 870 880 890
>>XP_016870602 (OMIM: 600428) PREDICTED: guanine nucleot (620 aa)
initn: 2568 init1: 1809 opt: 3084 Z-score: 1511.3 bits: 290.2 E(85289): 1.9e-77
Smith-Waterman score: 3777; 91.9% identity (93.4% similar) in 619 aa overlap (1-591:1-618)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
370 380 390 400 410 420
420 430 440 450 460
pF1KB8 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKQAGFPLPSHPA
430 440 450 460 470 480
470 480 490 500 510
pF1KB8 ------------WSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANAN
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLGGGLWSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANAN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 HHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDA
:::::::::::::::::::::::::::::::::::::::::::::::::::: :: . .
XP_016 HHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKF-SPMQPPS
550 560 570 580 590
580 590 600 610 620 630
pF1KB8 SGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYF
. :. :. ... .:
XP_016 CAQDPAAPGVSAGGFRRQPVA
600 610 620
>>NP_005419 (OMIM: 164875) proto-oncogene vav isoform 1 (845 aa)
initn: 2737 init1: 1235 opt: 2808 Z-score: 1377.1 bits: 265.8 E(85289): 5.8e-70
Smith-Waterman score: 2995; 52.0% identity (78.5% similar) in 856 aa overlap (1-836:1-840)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
:: :::: .:::.:.::::.:::.: .: : .:::::::::::::::.:: : .:.:...
NP_005 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
:.:::::::::::::::::..: .::::. ::::. ::::::.:::::: ..: :: :
NP_005 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSL-EELADEHDLGEDIYDCVPCEDG-GDDIYEDIIKV
:::.:: :::.:: . .:.:.: .: ... : . ::.:::: :.. ::.::::...
NP_005 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 E-VQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFI
: :..: :: :: ::: ::: :::.:: :: :: .:......::. :.: :. .::
NP_005 EPVSMPPKM--TEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFI
190 200 210 220 230
240 250 260 270 280 290
pF1KB8 NLEDLIKVHHSFLRAIDVSVMV-GGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLL
:.:::..:: ::. . .. . :...: .::. .:::.:.::.:::..: :.. :...
NP_005 NIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB8 ASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE
:.::: ..:.:::. ....:.: :.:::.:::::::::::::.::..:. : :...:.
NP_005 AAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB8 ALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHT
::.::.:::. .::::::.::::.:..:: :::::. .: ..::::::::::. :. ..
NP_005 ALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRS
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB8 KQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG
:.::: ::.::....:::.: ::.::....: .. :: ...: ::::. : ::. ::
NP_005 KMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQG
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB8 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRG
::...: ::...:.:::::::::.::: :..:.:: :.:::..:..::.::::.:.:::
NP_005 AQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRG
480 490 500 510 520 530
540 550 560 570 580
pF1KB8 TFYQGYMCTKCGVGAHKECLEVIPPCKFTS---PADL----------DASGAGPG-PKMV
:::::: : .: ..:::::: .::: . :. . : . : :::
NP_005 TFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKME
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB8 AMQNYHGNPAPPGK--PVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPC
..:.:.: : ::: : : .. ::..:: ... :. ::::: ..: . :.:: . :::
NP_005 VFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPY
600 610 620 630 640 650
650 660 670 680 690 700
pF1KB8 PVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAIS
: : ::. : ... :.:: ::: ....: ....::.:.:.: .: .::::
NP_005 -VHG------PPQ---DLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAIS
660 670 680 690 700
710 720 730 740 750 760
pF1KB8 IKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSR
::.: ::::::.. .. .::: : : .: ::::.:: .:::. ::.:::::..:.:
NP_005 IKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEP
710 720 730 740 750 760
770 780 790 800 810 820
pF1KB8 ERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGE
:. :. :: : . . .::: :::.: ::: ::::.:::...: .. :.::::.::
NP_005 EK---RTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGE
770 780 790 800 810 820
830
pF1KB8 TNGRIGWFPSTYVEEEGIQ
::.::::..::::.
NP_005 IYGRVGWFPANYVEEDYSEYC
830 840
>>XP_016870600 (OMIM: 600428) PREDICTED: guanine nucleot (867 aa)
initn: 3911 init1: 2635 opt: 2635 Z-score: 1293.8 bits: 250.4 E(85289): 2.5e-65
Smith-Waterman score: 5653; 96.8% identity (96.8% similar) in 867 aa overlap (1-839:1-867)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
370 380 390 400 410 420
420 430 440 450 460
pF1KB8 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKQAGFPLPSHPA
430 440 450 460 470 480
470 480 490 500 510
pF1KB8 ------------WSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANAN
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLGGGLWSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANAN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 HHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDA
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB8 SGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYF
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB8 PSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPA
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB8 EAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB8 LKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGG
790 800 810 820 830 840
820 830
pF1KB8 DQGWWKGETNGRIGWFPSTYVEEEGIQ
:::::::::::::::::::::::::::
XP_016 DQGWWKGETNGRIGWFPSTYVEEEGIQ
850 860
>>XP_016855542 (OMIM: 605541) PREDICTED: guanine nucleot (823 aa)
initn: 2524 init1: 1847 opt: 2489 Z-score: 1223.8 bits: 237.4 E(85289): 2e-61
Smith-Waterman score: 3191; 54.8% identity (81.3% similar) in 845 aa overlap (1-836:1-822)
10 20 30 40 50 60
pF1KB8 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
:: :.::..::: ::::: ::::.: :: ::::::.:::::::::::.:: ::.::.:
XP_016 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
:.::::::::::::::::: .: . ::.:.::::. ::::::::::::: ..:::: :
XP_016 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV
: ::::::.::. ::.:.:..: .: :: . ::.:::: :: : ..:::..:.
XP_016 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA
130 140 150 160 170
180 190 200 210 220 230
pF1KB8 E-VQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFI
: ..:: :.: :.::: ::..:: :: .:::.::: .:.::. :. :.. .:::
XP_016 EEAHQPK---CPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB8 NLEDLIKVHHSFLRAI-DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLL
:. .:.:.:..... : : : . ..: .::...::::.:::.::: .: : ..:. .
XP_016 NIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYIS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB8 ASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE
..:: . :.:::. ....::: :.:::::::::::::::::.::..:... :. .::
XP_016 KTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB8 ALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHT
::.::.:::.:.::::::.::::.:..:: :::::. . ::::. :::... .. .::
XP_016 ALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHT
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB8 KQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG
::.:..:::: .:::::::: .::.::::.: .:....: ..:. ::::::::::: ::
XP_016 KQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQG
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB8 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRG
..:..:.:::.:.:.::.::::::.:::.:: :..: :.:.:.:: ..:.::.:.:.:::
XP_016 QNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRG
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB8 TFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPG-
::::::.: :::. :::::: . : .. .: ::: ...:: :.: ::.
XP_016 TFYQGYLCFKCGARAHKECLGRVDNCGRVN--------SGGLPKMQVIRNYSGTP-PPAL
540 550 560 570 580
600 610 620 630 640 650
pF1KB8 --KPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPS
: : .:.::..:::.:: .: .:.:: . . . :.:::..::::: .:
XP_016 HEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKP-------
590 600 610 620 630 640
660 670 680 690 700 710
pF1KB8 REIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV
.::. ::.:: ::: :... : .....:::.:.: :. ..:::::.:.:.::::..
XP_016 --VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL
650 660 670 680 690
720 730 740 750 760 770
pF1KB8 EKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRS--
.:...::.: .:: ::.::::::. :::::.:. :::::..::: :.::.. ..:.
XP_016 TRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGN
700 710 720 730 740 750
780 790 800 810 820 830
pF1KB8 PVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPST
...:.:.: :.:::.: ::::::::: .::::.::...... :::.::.:::.::::::
XP_016 SLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPST
760 770 780 790 800 810
pF1KB8 YVEEEGIQ
::::.
XP_016 YVEEDE
820
839 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:47:09 2016 done: Sat Nov 5 19:47:12 2016
Total Scan time: 13.820 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]