Result of FASTA (omim) for
pF1KB8538
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8538, 898 aa
1>>>pF1KB8538 898 - 898 aa - 898 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5995+/-0.000445; mu= 15.0678+/- 0.028
mean_var=109.0864+/-21.184, 0's: 0 Z-trim(111.8): 48 B-trim: 201 in 1/54
Lambda= 0.122797
statistics sampled from 20528 (20565) to 20528 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.241), width: 16
Scan time: 9.900
The best scores are: opt bits E(85289)
NP_002261 (OMIM: 602901) transportin-1 isoform 1 [ ( 898) 6065 1086.4 0
NP_694858 (OMIM: 602901) transportin-1 isoform 2 [ ( 890) 6005 1075.7 0
XP_005248557 (OMIM: 602901) PREDICTED: transportin ( 890) 6005 1075.7 0
NP_001129667 (OMIM: 603002) transportin-2 isoform ( 887) 5240 940.2 0
NP_038461 (OMIM: 603002) transportin-2 isoform 2 [ ( 887) 5240 940.2 0
XP_005248558 (OMIM: 602901) PREDICTED: transportin ( 866) 5019 901.0 0
XP_016864947 (OMIM: 602901) PREDICTED: transportin ( 858) 4959 890.4 0
NP_001129668 (OMIM: 603002) transportin-2 isoform ( 897) 4491 807.5 0
NP_001263382 (OMIM: 602738) importin subunit beta- ( 731) 310 66.7 4.5e-10
NP_002256 (OMIM: 602738) importin subunit beta-1 i ( 876) 310 66.8 5.2e-10
XP_011519390 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
XP_016876051 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
XP_011519391 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
XP_011519392 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
XP_011519389 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
NP_002262 (OMIM: 602008) importin-5 [Homo sapiens] (1115) 288 63.0 9.5e-09
XP_005254110 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
XP_005254109 (OMIM: 602008) PREDICTED: importin-5 (1115) 288 63.0 9.5e-09
>>NP_002261 (OMIM: 602901) transportin-1 isoform 1 [Homo (898 aa)
initn: 6065 init1: 6065 opt: 6065 Z-score: 5810.6 bits: 1086.4 E(85289): 0
Smith-Waterman score: 6065; 100.0% identity (100.0% similar) in 898 aa overlap (1-898:1-898)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
790 800 810 820 830 840
850 860 870 880 890
pF1KB8 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
850 860 870 880 890
>>NP_694858 (OMIM: 602901) transportin-1 isoform 2 [Homo (890 aa)
initn: 6005 init1: 6005 opt: 6005 Z-score: 5753.2 bits: 1075.7 E(85289): 0
Smith-Waterman score: 6005; 100.0% identity (100.0% similar) in 890 aa overlap (9-898:1-890)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB8 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB8 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB8 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB8 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB8 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB8 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB8 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB8 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
780 790 800 810 820 830
850 860 870 880 890
pF1KB8 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
840 850 860 870 880 890
>>XP_005248557 (OMIM: 602901) PREDICTED: transportin-1 i (890 aa)
initn: 6005 init1: 6005 opt: 6005 Z-score: 5753.2 bits: 1075.7 E(85289): 0
Smith-Waterman score: 6005; 100.0% identity (100.0% similar) in 890 aa overlap (9-898:1-890)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB8 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB8 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB8 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB8 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB8 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB8 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB8 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB8 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
780 790 800 810 820 830
850 860 870 880 890
pF1KB8 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
840 850 860 870 880 890
>>NP_001129667 (OMIM: 603002) transportin-2 isoform 2 [H (887 aa)
initn: 3274 init1: 3274 opt: 5240 Z-score: 5020.8 bits: 940.2 E(85289): 0
Smith-Waterman score: 5240; 85.5% identity (95.7% similar) in 890 aa overlap (12-898:2-887)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
.:.::::::::.:::::.::::.:. :: ::.::.::::.:::::::::
NP_001 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
:::.:::::::::::::::::::::::.:.:: :.::::.::::::::.: :::::.::
NP_001 VLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
:::::::::::: ::.:::.::.::.:::::::::::::::::::::.:.::::.:.:::
NP_001 LITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::: ::::::::.:::::::..:.:::: .::.:::.::::: :..::::
NP_001 NIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::.:::.::::.:..::::::::.::::::::::::::::::::::.:
NP_001 KNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEV
240 250 260 270 280 290
310 320 330 340 350
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDE-
:. :: .:::.::::::::.::::::::::::::..:::::::.::::.::::. :.
NP_001 LASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB8 --DGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHH
:: :. .:::: ::..:::::::::::::::::::.:.:::::.::::: ::::
NP_001 RPDGSEDAEDDDD----DDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHP
360 370 380 390 400
420 430 440 450 460 470
pF1KB8 EWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWV
:::::::::::::::::::::::.::::::::::::::::::::::::.:::::::::::
NP_001 EWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWV
410 420 430 440 450 460
480 490 500 510 520 530
pF1KB8 VSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFA
:::::: .::::::::::::::.:::::::::::::::::::::::::::.:::::::::
NP_001 VSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
470 480 490 500 510 520
540 550 560 570 580 590
pF1KB8 FSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLEC
:.::::::::::::::::::::::::::.::::: :::::::::: ::::::::::::::
NP_001 FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLEC
530 540 550 560 570 580
600 610 620 630 640 650
pF1KB8 LSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLS
::::::::::::::::::::::::.::::::::::. . .:.::::::::::::::::::
NP_001 LSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLS
590 600 610 620 630 640
660 670 680 690 700 710
pF1KB8 GLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADF
::::::::..:::::::::.::..:::::.:::::::::::::::::::: :::::::.:
NP_001 GLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEF
650 660 670 680 690 700
720 730 740 750 760 770
pF1KB8 MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLE
:::::::::::::::::::::::::: .::: :::::. :::..::::::::::::::::
NP_001 MPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLE
710 720 730 740 750 760
780 790 800 810 820 830
pF1KB8 NTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVI
::::::::::::::::::::::::::::::::::::::::::::::::: ::.:::.::.
NP_001 NTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVV
770 780 790 800 810 820
840 850 860 870 880 890
pF1KB8 QDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYG
:::::::::::::..::::::::: :::::::.:::..::..::.::: ::::::::::
NP_001 QDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYG
830 840 850 860 870 880
pF1KB8 V
:
NP_001 V
>>NP_038461 (OMIM: 603002) transportin-2 isoform 2 [Homo (887 aa)
initn: 3274 init1: 3274 opt: 5240 Z-score: 5020.8 bits: 940.2 E(85289): 0
Smith-Waterman score: 5240; 85.5% identity (95.7% similar) in 890 aa overlap (12-898:2-887)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
.:.::::::::.:::::.::::.:. :: ::.::.::::.:::::::::
NP_038 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
:::.:::::::::::::::::::::::.:.:: :.::::.::::::::.: :::::.::
NP_038 VLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
:::::::::::: ::.:::.::.::.:::::::::::::::::::::.:.::::.:.:::
NP_038 LITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::: ::::::::.:::::::..:.:::: .::.:::.::::: :..::::
NP_038 NIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::.:::.::::.:..::::::::.::::::::::::::::::::::.:
NP_038 KNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEV
240 250 260 270 280 290
310 320 330 340 350
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDE-
:. :: .:::.::::::::.::::::::::::::..:::::::.::::.::::. :.
NP_038 LASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB8 --DGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHH
:: :. .:::: ::..:::::::::::::::::::.:.:::::.::::: ::::
NP_038 RPDGSEDAEDDDD----DDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHP
360 370 380 390 400
420 430 440 450 460 470
pF1KB8 EWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWV
:::::::::::::::::::::::.::::::::::::::::::::::::.:::::::::::
NP_038 EWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWV
410 420 430 440 450 460
480 490 500 510 520 530
pF1KB8 VSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFA
:::::: .::::::::::::::.:::::::::::::::::::::::::::.:::::::::
NP_038 VSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
470 480 490 500 510 520
540 550 560 570 580 590
pF1KB8 FSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLEC
:.::::::::::::::::::::::::::.::::: :::::::::: ::::::::::::::
NP_038 FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLEC
530 540 550 560 570 580
600 610 620 630 640 650
pF1KB8 LSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLS
::::::::::::::::::::::::.::::::::::. . .:.::::::::::::::::::
NP_038 LSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLS
590 600 610 620 630 640
660 670 680 690 700 710
pF1KB8 GLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADF
::::::::..:::::::::.::..:::::.:::::::::::::::::::: :::::::.:
NP_038 GLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEF
650 660 670 680 690 700
720 730 740 750 760 770
pF1KB8 MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLE
:::::::::::::::::::::::::: .::: :::::. :::..::::::::::::::::
NP_038 MPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLE
710 720 730 740 750 760
780 790 800 810 820 830
pF1KB8 NTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVI
::::::::::::::::::::::::::::::::::::::::::::::::: ::.:::.::.
NP_038 NTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVV
770 780 790 800 810 820
840 850 860 870 880 890
pF1KB8 QDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYG
:::::::::::::..::::::::: :::::::.:::..::..::.::: ::::::::::
NP_038 QDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYG
830 840 850 860 870 880
pF1KB8 V
:
NP_038 V
>>XP_005248558 (OMIM: 602901) PREDICTED: transportin-1 i (866 aa)
initn: 5094 init1: 5013 opt: 5019 Z-score: 4809.4 bits: 901.0 E(85289): 0
Smith-Waterman score: 5780; 96.4% identity (96.4% similar) in 898 aa overlap (1-898:1-866)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
::::::::::::::::::::::::::: :
XP_005 LGTNLNPEFISVCNNATWAIGEISIQM--------------------------------A
730 740
790 800 810 820 830 840
pF1KB8 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
750 760 770 780 790 800
850 860 870 880 890
pF1KB8 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
810 820 830 840 850 860
>>XP_016864947 (OMIM: 602901) PREDICTED: transportin-1 i (858 aa)
initn: 5034 init1: 4953 opt: 4959 Z-score: 4752.0 bits: 890.4 E(85289): 0
Smith-Waterman score: 5720; 96.4% identity (96.4% similar) in 890 aa overlap (9-898:1-858)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB8 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB8 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB8 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB8 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB8 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB8 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB8 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
::::::::::::::::::::::::::: :
XP_016 LGTNLNPEFISVCNNATWAIGEISIQM--------------------------------A
720 730 740
790 800 810 820 830 840
pF1KB8 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
750 760 770 780 790 800
850 860 870 880 890
pF1KB8 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
810 820 830 840 850
>>NP_001129668 (OMIM: 603002) transportin-2 isoform 1 [H (897 aa)
initn: 3260 init1: 2523 opt: 4491 Z-score: 4303.6 bits: 807.5 E(85289): 0
Smith-Waterman score: 5210; 84.6% identity (94.7% similar) in 900 aa overlap (12-898:2-897)
10 20 30 40 50 60
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
.:.::::::::.:::::.::::.:. :: ::.::.::::.:::::::::
NP_001 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIF
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
:::.:::::::::::::::::::::::.:.:: :.::::.::::::::.: :::::.::
NP_001 VLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
:::::::::::: ::.:::.::.::.:::::::::::::::::::::.:.::::.:.:::
NP_001 LITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
::::::::::::: ::::::::.:::::::..:.:::: .::.:::.::::: :..::::
NP_001 NIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
::::::::::::::.:::.::::.:..::::::::.::::::::::::::::::::::.:
NP_001 KNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEV
240 250 260 270 280 290
310 320 330 340 350
pF1KB8 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDE-
:. :: .:::.::::::::.::::::::::::::..:::::::.::::.::::. :.
NP_001 LASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB8 --DGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHH
:: :. .:::: ::..:::::::::::::::::::.:.:::::.::::: ::::
NP_001 RPDGSEDAEDDDD----DDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHP
360 370 380 390 400
420 430 440 450 460 470
pF1KB8 EWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWV
:::::::::::::::::::::::.::::::::::::::::::::::::.:::::::::::
NP_001 EWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWV
410 420 430 440 450 460
480 490 500 510 520 530
pF1KB8 VSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFA
:::::: .::::::::::::::.:::::::::::::::::::::::::::.:::::::::
NP_001 VSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
470 480 490 500 510 520
540 550 560 570 580 590
pF1KB8 FSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLEC
:.::::::::::::::::::::::::::.::::: :::::::::: ::::::::::::::
NP_001 FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLEC
530 540 550 560 570 580
600 610 620 630 640 650
pF1KB8 LSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLS
::::::::::::::::::::::::.::::::::::. . .:.::::::::::::::::::
NP_001 LSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLS
590 600 610 620 630 640
660 670 680 690 700 710
pF1KB8 GLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADF
::::::::..:::::::::.::..:::::.:::::::::::::::::::: :::::::.:
NP_001 GLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEF
650 660 670 680 690 700
720 730 740 750 760 770
pF1KB8 MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLE
:::::::::::::::::::::::::: .::: :::::. :::..::::::::::::::::
NP_001 MPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLE
710 720 730 740 750 760
780 790 800 810 820
pF1KB8 NT----------AITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICT
:: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTGRLTSPSAIPAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICM
770 780 790 800 810 820
830 840 850 860 870 880
pF1KB8 MISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLP
::.:::.::.:::::::::::::..::::::::: :::::::.:::..::..::.:::
NP_001 MIGVNPGGVVQDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPL
830 840 850 860 870 880
890
pF1KB8 LKERLAAFYGV
:::::::::::
NP_001 LKERLAAFYGV
890
>>NP_001263382 (OMIM: 602738) importin subunit beta-1 is (731 aa)
initn: 279 init1: 168 opt: 310 Z-score: 301.8 bits: 66.7 E(85289): 4.5e-10
Smith-Waterman score: 404; 24.7% identity (52.7% similar) in 575 aa overlap (235-762:39-594)
210 220 230 240 250
pF1KB8 CVNQFIISRTQALMLHIDSFIENLFALAGDEEP--EVRKNVCRALVMLLE---VRMDRLL
::: .:. . ::. :: . .:.
NP_001 IGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKE-
10 20 30 40 50 60
260 270 280 290 300 310
pF1KB8 PHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHL-PKLIPVLVNGMKY
. : :.. . . :: : : . : . . . . . . . .. : :. . ...::
NP_001 SERHFIMQVVCEATQCPDTRVRVAALQNLVKI--MSLYYQYMETYMGPALFAITIEAMK-
70 80 90 100 110 120
320 330 340 350 360
pF1KB8 SDIDIILLKG--------DVEEDETIPDSE--QDIRPRFHRSRTVAQ---QHDEDGIEEE
:::: . :.: : : : .: :: .. :: : :. :. :. . .
NP_001 SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQT
130 140 150 160 170 180
370 380 390 400 410 420
pF1KB8 DDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESG
.:: :::: ::: : ... : .::. .:...::.::..:: . . .: ....
NP_001 LTKQDENDDDD---DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAA
190 200 210 220 230 240
430 440 450 460 470 480
pF1KB8 ILVLGAIAEGCMQGMI-PYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQP-PD
....: : :: ... : . . .: ::. ..: ...::. . ::..: . . :
NP_001 VMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAIND
250 260 270 280 290 300
490 500 510 520 530 540
pF1KB8 TYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQH
.:: ::. :.. :... :: .: ::..: : : : . . .. .:. .
NP_001 VYLAPLLQCLIEG-LSAEPRVASNVCWAFSSLAE-AAYEAADVADDQEEPATYCLSSSFE
310 320 330 340 350
550 560 570 580 590 600
pF1KB8 KNLLILYDAIGTLADSVGHHLN-KPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVA
::. . : ::. : . . :: ...:. :: .: .. . :
NP_001 ---LIVQKLLETTDRPDGHQNNLRSSAYESLM-------EIVKNSAKDCYPAVQKTTLVI
360 370 380 390 400
610 620 630 640 650
pF1KB8 TALQSGFLPYCEPVYQRC----VNLVQKTLAQAMLNNAQPDQYEAPDK--DFMIVALDLL
. : . . . : .:. : .. : . :.. . : ....: .
NP_001 MERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRM
410 420 430 440 450 460
660 670 680 690
pF1KB8 SGLAEGLGGNIEQ-LVARSNILTLM----YQCMQDKMP------------EVRQSSFALL
. : :: :. :.: :... .. . :. : .: .. .:.
NP_001 FQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLV
470 480 490 500 510 520
700 710 720 730 740 750
pF1KB8 GDLTKACFQHVKPCIADFMPILGTNLNPEFI--SVCNNATWAIGEISIQMGIEMQPYIPM
::: .: ... : . : .: ::. : . :: . ..:.:.. .: :.. :. .
NP_001 GDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEV
530 540 550 560 570 580
760 770 780 790 800 810
pF1KB8 VLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEE
::. :
NP_001 VLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRV
590 600 610 620 630 640
>>NP_002256 (OMIM: 602738) importin subunit beta-1 isofo (876 aa)
initn: 245 init1: 168 opt: 310 Z-score: 300.7 bits: 66.8 E(85289): 5.2e-10
Smith-Waterman score: 456; 22.6% identity (52.0% similar) in 800 aa overlap (22-762:2-739)
10 20 30 40 50
pF1KB8 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQ--LNQYPDFNNYL
... .:... ::: ...:. ::. ... : : :
NP_002 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVEL
10 20 30 40
60 70 80 90 100
pF1KB8 IFVLTKLKSEDEPTRSLSGLILKN-------NVKAHFQN----FPNGVTDFIKSECLNNI
::.. .... .: .:: .:: ..::..:. . .. .:. :...
NP_002 SRVLAN-PGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTL
50 60 70 80 90
110 120 130 140 150 160
pF1KB8 GDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDY--NTCEGAFGALQKICE
: . .. . .. ...::.:.:.: . . . . . :... :. ::.
NP_002 GTETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQ
100 110 120 130 140 150
170 180 190 200 210 220
pF1KB8 DSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFI
: .: . :. : .. ..: ... :. :. .. :.::. .. :
NP_002 D----IDPEQLQDKSNEILTAIIQGMRKEEPS---------NNVKLAATNALLNSLE-FT
160 170 180 190 200
230 240 250 260 270 280
pF1KB8 ENLFALAGDEEPE---VRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVAL
. : :.: : . . ::.: .. ..:. . ..:.:. : : .. ..
NP_002 KANF----DKESERHFIMQVVCEA-TQCPDTRVR--VAALQNLVKIMSLYYQYMETYMG-
210 220 230 240 250
290 300 310 320 330
pF1KB8 EACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKG--------DVEEDE
: :. . ...:: :::: . :.: : : :
NP_002 -----------------------PALFAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDL
260 270 280 290
340 350 360 370 380
pF1KB8 TIPDSE--QDIRPRFHRSRTVAQ---QHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAA
.: :: .. :: : :. :. :. . . .:: :::: ::: : ...
NP_002 AIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD---DWNPCKAAGV
300 310 320 330 340 350
390 400 410 420 430 440
pF1KB8 ALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMI-PYLPELI
: .::. .:...::.::..:: . . .: ........: : :: ... : . . .
NP_002 CLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAM
360 370 380 390 400 410
450 460 470 480 490 500
pF1KB8 PHLIQCLSDKKALVRSITCWTLSRYAHWVVSQP-PDTYLKPLMTELLKRILDSNKRVQEA
: ::. ..: ...::. . ::..: . . :.:: ::. :.. :... ::
NP_002 PTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEG-LSAEPRVASN
420 430 440 450 460
510 520 530 540 550 560
pF1KB8 ACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLN-K
.: ::..: : : : . . .. .:. . ::. . : ::. : .
NP_002 VCWAFSSLAE-AAYEAADVADDQEEPATYCLSSSFE---LIVQKLLETTDRPDGHQNNLR
470 480 490 500 510 520
570 580 590 600 610 620
pF1KB8 PEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRC----VN
. :: ...:. :: .: .. . : . : . . . :
NP_002 SSAYESLM-------EIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFN
530 540 550 560 570
630 640 650 660 670
pF1KB8 LVQKTLAQAMLNNAQPDQYEAPDK--DFMIVALDLLSGLAEGLGGNIEQ-LVARSNILTL
.:. : .. : . :.. . : ....: . . : :: :. :.: :... .
NP_002 DLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEV
580 590 600 610 620 630
680 690 700 710 720
pF1KB8 M----YQCMQDKMP------------EVRQSSFALLGDLTKACFQHVKPCIADFMPILGT
. . :. : .: .. .:.::: .: ... : . : .:
NP_002 LGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB8 NLNPEFI--SVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAI
::. : . :: . ..:.:.. .: :.. :. .::. :
NP_002 NLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYL
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB8 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFI
NP_002 NELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACA
760 770 780 790 800 810
898 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:37:54 2016 done: Sat Nov 5 16:37:55 2016
Total Scan time: 9.900 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]