Result of FASTA (omim) for
pF1KB8365
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8365, 472 aa
1>>>pF1KB8365 472 - 472 aa - 472 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6905+/-0.000411; mu= -4.8131+/- 0.026
mean_var=333.7249+/-68.171, 0's: 0 Z-trim(121.9): 134 B-trim: 2243 in 1/55
Lambda= 0.070207
statistics sampled from 39140 (39280) to 39140 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.461), width: 16
Scan time: 8.040
The best scores are: opt bits E(85289)
NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 3216 339.3 1.4e-92
XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 2996 317.0 6.8e-86
NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 1249 140.0 1.3e-32
NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 1249 140.0 1.3e-32
NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 773 91.7 3.4e-18
NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 623 76.6 1.6e-13
NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 622 76.6 2e-13
NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 606 74.9 5.5e-13
NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 554 69.7 2.1e-11
NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 535 67.6 5.8e-11
NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 515 65.6 2.5e-10
NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 517 65.9 2.5e-10
NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 514 65.5 2.9e-10
NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 511 65.2 3.5e-10
NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 491 63.1 1.3e-09
NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 489 63.1 2e-09
NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 480 62.1 3.5e-09
NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 477 61.8 4.3e-09
NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 470 61.1 6.7e-09
NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 469 61.0 7.3e-09
NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 469 61.0 7.3e-09
NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 454 59.4 1.9e-08
NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 454 59.4 1.9e-08
NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 448 58.9 3.1e-08
NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 425 56.6 1.8e-07
NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 397 53.7 1.2e-06
NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 379 51.8 3.7e-06
XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 377 51.8 5.9e-06
NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 377 51.8 6e-06
XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 377 51.8 6.1e-06
XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 377 51.8 6.2e-06
XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 377 51.8 6.3e-06
NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 377 51.8 6.3e-06
NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 377 51.8 6.3e-06
NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 377 51.8 6.3e-06
XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 377 51.8 6.4e-06
NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 377 51.8 6.6e-06
XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 365 50.6 1.4e-05
NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 365 50.7 1.7e-05
NP_658982 (OMIM: 274600,600791,601093) forkhead bo ( 283) 319 45.7 0.0002
NP_963853 (OMIM: 602681) forkhead box protein O3 [ ( 673) 320 46.1 0.00037
NP_001446 (OMIM: 602681) forkhead box protein O3 [ ( 673) 320 46.1 0.00037
XP_005264339 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
XP_006712064 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
XP_016859447 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
XP_016859446 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
XP_016859445 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
NP_002149 (OMIM: 143089) forkhead box protein N2 [ ( 431) 308 44.7 0.00061
XP_011531110 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
XP_005264340 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 308 44.7 0.00061
>>NP_004487 (OMIM: 602294) hepatocyte nuclear factor 3-a (472 aa)
initn: 3216 init1: 3216 opt: 3216 Z-score: 1783.1 bits: 339.3 E(85289): 1.4e-92
Smith-Waterman score: 3216; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472)
10 20 30 40 50 60
pF1KB8 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAY
370 380 390 400 410 420
430 440 450 460 470
pF1KB8 EQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
430 440 450 460 470
>>XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte nucl (439 aa)
initn: 2996 init1: 2996 opt: 2996 Z-score: 1663.1 bits: 317.0 E(85289): 6.8e-86
Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 439 aa overlap (34-472:1-439)
10 20 30 40 50 60
pF1KB8 TVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPAS
::::::::::::::::::::::::::::::
XP_016 MNSGLGSMNSMNTYMTMNTMTTSGNMTPAS
10 20 30
70 80 90 100 110 120
pF1KB8 FNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAAS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 MNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAI
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 QQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB8 WTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGASNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGASNP
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB8 SADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPISSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPISSG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB8 PGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQA
340 350 360 370 380 390
430 440 450 460 470
pF1KB8 LQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
400 410 420 430
>>NP_710141 (OMIM: 600288) hepatocyte nuclear factor 3-b (457 aa)
initn: 1245 init1: 802 opt: 1249 Z-score: 706.5 bits: 140.0 E(85289): 1.3e-32
Smith-Waterman score: 1597; 55.9% identity (73.9% similar) in 499 aa overlap (1-472:1-457)
10 20 30 40 50
pF1KB8 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTM---TTSG
:::.::::::: :::.::::. :.:::: ::::.::: ::.:::::.:.. . ::
NP_710 MLGAVKMEGHEPSDWSSYYAEP-EGYSSV--SNMNAGLG-MNGMNTYMSMSAAAMGSGSG
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 NMTPASFNMS-YANPGLG---AGLSPGA--VAGMPGGSAGAMNSMTAAGVTAMGTALSPS
::. .:.::: :.. :.. ::.:::: .::: :::::: :::..:: ::::
NP_710 NMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGM-GGSAGA------AGVAGMGPHLSPS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 GMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKP
.. .:.: :..:.::.::: :: :::: :. ..:.:.: : ::..::: ::::
NP_710 -LSPLGGQAAGAMGGLAPYAN-MNS-MSPM-YGQAGLSRAR-----DPKTYRRSYTHAKP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 PYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKV
::::::::::::::.:.:::::::::::::::::.::::::::::::::::::::::.::
NP_710 PYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKV
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB8 ARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAG-GGGGSGSGGSGAKGG
::::::::::.:::::::::::::::::::::::::::: . ..:..::: ..: :.
NP_710 PRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGA
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB8 PESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELK
:. . . :..:....: :. .: .::: .:. :: .:::
NP_710 QASQAQLGEAAGPASETP------------AGTESPHSSASP-CQEHK----RGGLGELK
290 300 310 320
360 370 380 390 400
pF1KB8 -TPASSTAPP-ISSGPG----ALASV--PASHPAHGLAPHESQLHLKGDPHYSFNHPFSI
:::.. .:: . .:: : : . : :: :: : . ::: . ::.:::::::
NP_710 GTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHP--GLPP---EAHLKPEHHYAFNHPFSI
330 340 350 360 370
410 420 430 440 450
pF1KB8 NNLMSSSEQQH---------KLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEPS
:::::: .:.: :.:.:::::...: ::: .:.:: .: .. : :
NP_710 NNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASPL
380 390 400 410 420 430
460 470
pF1KB8 ALEPAYYQGVYSRPVLNTS
: . .:::::::::..:.:
NP_710 AADTSYYQGVYSRPIMNSS
440 450
>>NP_068556 (OMIM: 600288) hepatocyte nuclear factor 3-b (463 aa)
initn: 1245 init1: 802 opt: 1249 Z-score: 706.5 bits: 140.0 E(85289): 1.3e-32
Smith-Waterman score: 1597; 55.9% identity (73.9% similar) in 499 aa overlap (1-472:7-463)
10 20 30 40 50
pF1KB8 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTM-
:::.::::::: :::.::::. :.:::: ::::.::: ::.:::::.:..
NP_068 MHSASSMLGAVKMEGHEPSDWSSYYAEP-EGYSSV--SNMNAGLG-MNGMNTYMSMSAAA
10 20 30 40 50
60 70 80 90 100
pF1KB8 --TTSGNMTPASFNMS-YANPGLG---AGLSPGA--VAGMPGGSAGAMNSMTAAGVTAMG
. ::::. .:.::: :.. :.. ::.:::: .::: :::::: :::..::
NP_068 MGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGM-GGSAGA------AGVAGMG
60 70 80 90 100
110 120 130 140 150 160
pF1KB8 TALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRS
:::: .. .:.: :..:.::.::: :: :::: :. ..:.:.: : ::..::
NP_068 PHLSPS-LSPLGGQAAGAMGGLAPYAN-MNS-MSPM-YGQAGLSRAR-----DPKTYRRS
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB8 YPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFN
: ::::::::::::::::::.:.:::::::::::::::::.:::::::::::::::::::
NP_068 YTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFN
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 DCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAG-GGGGSGSGG
:::.:: ::::::::::.:::::::::::::::::::::::::::: . ..:..:::
NP_068 DCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGK
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 SGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATG
..: :. :. . . :..:....: :. .: .::: .:. :
NP_068 KAAAGAQASQAQLGEAAGPASETP------------AGTESPHSSASP-CQEHK----RG
290 300 310 320
350 360 370 380 390
pF1KB8 GASELK-TPASSTAPP-ISSGPG----ALASV--PASHPAHGLAPHESQLHLKGDPHYSF
: .::: :::.. .:: . .:: : : . : :: :: : . ::: . ::.:
NP_068 GLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHP--GLPP---EAHLKPEHHYAF
330 340 350 360 370
400 410 420 430 440
pF1KB8 NHPFSINNLMSSSEQQH---------KLDFKAYEQALQYSPYGSTLPASLPLGSASVTTR
:::::::::::: .:.: :.:.:::::...: ::: .:.:: .: .. :
NP_068 NHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTG
380 390 400 410 420 430
450 460 470
pF1KB8 SPIEPSALEPAYYQGVYSRPVLNTS
: : . .:::::::::..:.:
NP_068 LDASPLAADTSYYQGVYSRPIMNSS
440 450 460
>>NP_004488 (OMIM: 602295) hepatocyte nuclear factor 3-g (350 aa)
initn: 973 init1: 754 opt: 773 Z-score: 447.5 bits: 91.7 E(85289): 3.4e-18
Smith-Waterman score: 925; 42.9% identity (58.6% similar) in 473 aa overlap (1-472:1-350)
10 20 30 40 50 60
pF1KB8 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT
:::.::::.:. ..: ::: .. :.:: ::. . . : .:.:::.: .. .
NP_004 MLGSVKMEAHDLAEW-SYYPEAGEVYS--PVTPVPT----MAPLNSYMTLNPLS-----S
10 20 30 40
70 80 90 100 110 120
pF1KB8 PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQ
: : :: : :: .:.: . : .. .: .. : :.:. :.
NP_004 P------YPPGGLPA--SP-----LPSGPLAP-----PAPAAPLGPTF-P-GLGVSGG--
50 60 70 80
130 140 150 160 170 180
pF1KB8 AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT
.: .: : :: : . . : : ..: :::::::::::::
NP_004 -SSSSGYG---------------AP---GPGLVHGKEMPKGYRRPLAHAKPPYSYISLIT
90 100 110 120
190 200 210 220 230 240
pF1KB8 MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGK
:::::::.::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_004 MAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGK
130 140 150 160 170 180
250 260 270 280 290 300
pF1KB8 GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA
::::.:::.:::::::::::::::::: :.. ::.:.. . .:. :. : :..
NP_004 GSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGAATTTRNGT-GSAASTTTPAA-
190 200 210 220 230 240
310 320 330 340 350 360
pF1KB8 SNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPI
.. :: : : : : :. ..: . :: . .::::: :
NP_004 ---TVTSP---------------PQPPPPA-PEPEAQGGEDV--GALDCGSPASST--PY
250 260 270 280
370 380 390 400 410
pF1KB8 SSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMS-SSEQQHKLDFKA
.: .:. .:: : :.:::::::::::: .. :::
NP_004 FTG----LELPG--------------ELKLDAPYNFNHPFSINNLMSEQTPAPPKLD---
290 300 310 320
420 430 440 450 460 470
pF1KB8 YEQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
. .. ::. :. ::. .::::.::: .::.:
NP_004 ----VGFGGYGAE-------GG---------EPG----VYYQGLYSRSLLNAS
330 340 350
>>NP_004463 (OMIM: 601091) forkhead box protein D1 [Homo (465 aa)
initn: 504 init1: 504 opt: 623 Z-score: 363.8 bits: 76.6 E(85289): 1.6e-13
Smith-Waterman score: 629; 38.7% identity (60.2% similar) in 344 aa overlap (128-454:84-420)
100 110 120 130 140 150
pF1KB8 AAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGG
: : .: . : : .. : . :::::
NP_004 RRRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPGPAPAAGAGAGGGGGGGGAGGGG
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB8 DAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNS
.: . .. : .:::::::.:::::: :.:.: :::::: ..: :::::.. ::::
NP_004 SAGSGAKN-PLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNS
120 130 140 150 160 170
220 230 240 250 260 270
pF1KB8 IRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEK--QPGAG
:::.::.::::::. : : .::::.:::: :.:..::.:: .:::.:::: . :.:.
NP_004 IRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLLPPNAA
180 190 200 210 220 230
280 290 300 310 320 330
pF1KB8 GGGGSGSGGSGAKGGPESRKDPSGASN---PSADSPLHRGVHGKTGQLEGAPAPGPAASP
.. . :.:: :: ::..:. :. : : .: : : : : : :
NP_004 AAESLLLRGAGAAGGA---GDPAAAAALFPPAPPPPPHAYGYGPYGCGYGLQLP-PYAPP
240 250 260 270 280
340 350 360 370 380
pF1KB8 QTLDHSGATATGGASELKTPASSTAPPISSGPGA-LASVPASHPAHGLA-----PHESQL
..: ..:.:...:. .. : : :: : .: :: . .. : :. : ..
NP_004 SAL-FAAAAAAAAAAAFH-PHSPPPPPPPHGAAAELARTAFGYRPHPLGAALPGPLPASA
290 300 310 320 330 340
390 400 410 420 430 440
pF1KB8 HLKGDPHYSF--NHPFSINNLMSSSEQQHKLDFKAYEQAL--QYSPYGSTLPASLPLGSA
: : : ::::......: : . : : :: : . : ::.
NP_004 AKAGGPGASALARSPFSIESIIGGSLGPAAAAAAAAQAAAAAQASPSPSPVAAPPAPGSS
350 360 370 380 390 400
450 460 470
pF1KB8 S--VTTRSPIEPSALEPAYYQGVYSRPVLNTS
. .... . :.:
NP_004 GGGCAAQAAVGPAAALTRSLVAAAAAAASSVSSSAALGTLHQGTALSSVENFTARISNC
410 420 430 440 450 460
>>NP_001444 (OMIM: 601090,601631,602482) forkhead box pr (553 aa)
initn: 556 init1: 523 opt: 622 Z-score: 362.2 bits: 76.6 E(85289): 2e-13
Smith-Waterman score: 645; 37.5% identity (60.7% similar) in 392 aa overlap (109-472:9-369)
80 90 100 110 120 130
pF1KB8 PGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGA---MGAQQ----AASMNGLGPYA
::...:. .:..: ::. . : :.
NP_001 MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYT
10 20 30
140 150 160 170 180
pF1KB8 AAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPH------AKPPYSYISLITMAIQQ
: : :: ... :.. .. :: :... :. .:::::::.:::::::.
NP_001 AMPAP-MSVYSH-PAH---AEQYPGGMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQN
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB8 APSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWT
::.: .::. :::.::: ::.::.:.: :::::::.::.:.::::: :. :::::::::
NP_001 APDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWT
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB8 LHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA---SN
: ::: :::::: .:::..::: . : . . : .:. : . ..
NP_001 LDPDSYNMFENGSFLRRRRRFK---KKDAVKDKEEKDRLHLKEPPPPGRQPPPAPPEQAD
160 170 180 190 200 210
310 320 330 340 350
pF1KB8 PSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGAS---ELKTPASSTAPP
.: .: :. . . :.. :.: :: :. ..: ..:.:. ....: ::..
NP_001 GNAPGPQPPPVRIQDIKTENGTCPSP---PQPLSPAAALGSGSAAAVPKIESPDSSSSS-
220 230 240 250 260
360 370 380 390 400 410
pF1KB8 ISSG---PGALASV-PASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKL
.::: ::.: :. : : . :: ::.: . ::..:.:.:
NP_001 LSSGSSPPGSLPSARPLSLDGADSAP-PPPAPSAPPPHHS--QGFSVDNIMTS-------
270 280 290 300 310
420 430 440 450 460 470
pF1KB8 DFKAYEQALQYSPYGST--LPASLPLGSASVTTRSPIEPSALEPAYYQG---VYSRPVLN
:. :: ... : ..: :.::....:. : : :: : .:: : .
NP_001 --------LRGSPQSAAAELSSGL-LASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQ
320 330 340 350 360
pF1KB8 TS
::
NP_001 TSSAGSSGGGGGGAGAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDP
370 380 390 400 410 420
>>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa)
initn: 605 init1: 494 opt: 606 Z-score: 354.1 bits: 74.9 E(85289): 5.5e-13
Smith-Waterman score: 612; 42.9% identity (61.0% similar) in 282 aa overlap (110-381:82-345)
80 90 100 110 120 130
pF1KB8 GAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMS
: .... :: ::. .. :: ::: .
NP_004 LPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGA--AAAAGSPGPGAAAARGAAG
60 70 80 90 100
140 150 160 170 180 190
pF1KB8 PMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQW
: :: :: : :: : .:::::::.:::::: :.:.: :::::: ..
NP_004 PGPGPPS---------GGAAT---RS-PLVKPPYSYIALITMAILQSPKKRLTLSEICEF
110 120 130 140 150
200 210 220 230 240 250
pF1KB8 IMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCY
: :::::.. :::::::.::.::::::. : : .::::.:::: :.:..::.:: .
NP_004 ISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSF
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB8 LRRQKRFKCEKQPGAGGGGGSGSGGSGA-KGGPESRKDPSGASNPSADSPLHRGV-HGKT
:::.:::: .:: .:: . :: :: :. . : .: .
NP_004 LRRRKRFK--RQPLPPPHPHPHPHPELLLRGGAAAAGDP-GAFLPGFAAYGAYGYGYGLA
220 230 240 250 260 270
320 330 340 350 360
pF1KB8 GQLEGAPAPGPAASPQTLDHSGATATGGAS---ELKTPASSTA-----PPISSGPGALAS
::: :::: :. :. : :...:. .:..: . .: :: .: .. .:
NP_004 LPAYGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB8 VPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPY
.:: :: : .:
NP_004 APAPAPASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKT
340 350 360 370 380 390
>>NP_005242 (OMIM: 153400,602402) forkhead box protein C (501 aa)
initn: 600 init1: 513 opt: 554 Z-score: 325.6 bits: 69.7 E(85289): 2.1e-11
Smith-Waterman score: 589; 35.7% identity (58.1% similar) in 370 aa overlap (104-436:1-370)
80 90 100 110 120 130
pF1KB8 GAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAA
: . : : .:.:. : .. :..
NP_005 MQARYSVSDPNALGVVPYLSEQNYYRAAGS
10 20 30
140 150 160 170 180
pF1KB8 MNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHA-----KPPYSYISLITMAIQQAPS
.. :::. .. . :: : . ... : : :::::::.:::::::.::
NP_005 YGGMASPMGVYSGHPEQYSAGMGRSYAPYHHHQPAAPKDLVKPPYSYIALITMAIQNAPE
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB8 KMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHP
: .::. :::.::: ::.::.:.: :::::::.::.:.::::: :. :::::::::: :
NP_005 KKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDP
100 110 120 130 140 150
250 260 270 280 290
pF1KB8 DSGNMFENGCYLRRQKRFKCE------------KQPGAGGGGGSGSGGSGAKGGPESRKD
:: :::::: .:::..::: . :.: ... :. . : . :..:
NP_005 DSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEPPPAASKGAPATPHLADAPKEAEKK
160 170 180 190 200 210
300 310 320 330 340
pF1KB8 ---PSGASNPSADSPLHRGVHGKTGQLEGAP---APGPAASPQ-TL-DHSGATATG--GA
: :..:. . . . . :.:.: : ::.::. .: .: .:. .: :
NP_005 VVIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAGSPDGSLPEHHAAAPNGLPGF
220 230 240 250 260 270
350 360 370 380 390
pF1KB8 SELKTPASSTAPP---ISSGPG--ALASVPASHPAHGLAP----HESQLHLKGDPHYSFN
: . . :.:: .: : : .:. : . : . : . :.. ...
NP_005 SVENIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPAAYGQPCAQGLEAGAAGGYQ
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB8 HPFSINNLMSSSEQQ-HKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALE
. .:....:. : : ..::. : : : : :
NP_005 CSMRAMSLYTGAERPAHMCVPPALDEALSDHPSGPTSPLSALNLAAGQEGALAATGHHHQ
340 350 360 370 380 390
460 470
pF1KB8 PAYYQGVYSRPVLNTS
NP_005 HHGHHHPQAPPPPPAPQPQPTPQPGAAAAQAASWYLNHSGDLNHLPGHTFAAQQQTFPNV
400 410 420 430 440 450
>>NP_036318 (OMIM: 107250,601094,610256) forkhead box pr (319 aa)
initn: 536 init1: 462 opt: 535 Z-score: 317.8 bits: 67.6 E(85289): 5.8e-11
Smith-Waterman score: 535; 36.5% identity (60.2% similar) in 304 aa overlap (99-390:2-291)
70 80 90 100 110 120
pF1KB8 ANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLG
:: . : . ::. :. : : : .
NP_036 MAGRSDMDPPAAFSGFPALPAV-APSGPPPS
10 20 30
130 140 150 160 170 180
pF1KB8 PYAAAMNPCMSPMAYAPSNLGRSRAG---GGGDAKTFKRSYPHAKPPYSYISLITMAIQQ
: :.: .: : : ::..:. . : .. .: ..:::::::.::.::. .
NP_036 PLAGA-EPGREPEEAAA---GRGEAAPTPAPGPGRRRRRPLQRGKPPYSYIALIAMALAH
40 50 60 70 80
190 200 210 220 230 240
pF1KB8 APSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWT
::.. :::. ::..: . : .::.. ..:::::::.:..::::::: : : .::::.:::
NP_036 APGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWT
90 100 110 120 130 140
250 260 270 280 290
pF1KB8 LHPDSGNMFENGCYLRRQKRFKCEKQPG-AGGGGGSG-----SGGSGAKGGPESRKDPSG
: : ...::.:: .:::.:::: . :. :... : . . : : ::.
NP_036 LDPAAADMFDNGSFLRRRKRFKRAELPAHAAAAPGPPLPFPYAPYAPAPGPALLVPPPSA
150 160 170 180 190 200
300 310 320 330 340 350
pF1KB8 ASNPSADSPLHR--GVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTA
. .:: . : .. . .: : :: : :. ..:. . :....
NP_036 GPGPSPPARLFSVDSLVNLQPELAGLGAPEPPCC--------AAPDAAAAAFPPCAAAAS
210 220 230 240 250
360 370 380 390 400 410
pF1KB8 PPISSG-PGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLD
::. : : :. .::..:. : : : : : :
NP_036 PPLYSQVPDRLV-LPATRPGPGPLPAEPLLALAGPAAALGPLSPGEAYLRQPGFASGLER
260 270 280 290 300 310
420 430 440 450 460 470
pF1KB8 FKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
NP_036 YL
472 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:15:54 2016 done: Fri Nov 4 12:15:56 2016
Total Scan time: 8.040 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]