FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8347, 378 aa
  1>>>pF1KB8347 378 - 378 aa - 378 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4408+/-0.000409; mu= 3.4236+/- 0.025
 mean_var=212.6909+/-43.108, 0's: 0 Z-trim(119.0): 11  B-trim: 367 in 1/55
 Lambda= 0.087943
 statistics sampled from 32458 (32469) to 32458 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.381), width:  16
 Scan time:  9.440

The best scores are:                                      opt bits E(85289)
NP_008996 (OMIM: 605065) hsp90 co-chaperone Cdc37  ( 378) 2533 333.9 3.6e-91
XP_011525954 (OMIM: 605065) PREDICTED: hsp90 co-ch ( 429) 1688 226.8 7.5e-59
NP_060383 (OMIM: 610346) hsp90 co-chaperone Cdc37- ( 337)  747 107.3 5.5e-23


>>NP_008996 (OMIM: 605065) hsp90 co-chaperone Cdc37 [Hom  (378 aa)
 initn: 2533 init1: 2533 opt: 2533  Z-score: 1757.7  bits: 333.9 E(85289): 3.6e-91
Smith-Waterman score: 2533; 99.5% identity (99.5% similar) in 378 aa overlap (1-378:1-378)

               10        20        30        40        50        60
pF1KB8 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VAECQRKLKELEVAEGGKAELERQQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
       ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_008 VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDPGLWVPNSKASEAKEGEEAGPG
       :::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_008 LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPG
              310       320       330       340       350       360

              370        
pF1KB8 DPLLEAVPKTGDEKDVSV
       ::::::::::::::::::
NP_008 DPLLEAVPKTGDEKDVSV
              370        

>>XP_011525954 (OMIM: 605065) PREDICTED: hsp90 co-chaper  (429 aa)
 initn: 1710 init1: 1684 opt: 1688  Z-score: 1177.5  bits: 226.8 E(85289): 7.5e-59
Smith-Waterman score: 2288; 87.1% identity (87.1% similar) in 410 aa overlap (20-378:20-429)

               10        20        30        40        50        60
pF1KB8 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
                          :::::::::::::::::::::::::::::::::::::::::
XP_011 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VAECQRKLKELEVAEGGKAELERQQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
       ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_011 VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
               70        80        90       100       110       120

                                                                   
pF1KB8 KDGFSK---------------------------------------------------SMV
       ::::::                                                   :::
XP_011 KDGFSKAHAHAPATLMLMASSPPPPWMGWALRPRPARPRSRRSAALPQPTPPLTLPQSMV
              130       140       150       160       170       180

     130       140       150       160       170       180         
pF1KB8 NTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANY
              190       200       210       220       230       240

     190       200       210       220       230       240         
pF1KB8 LVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYM
              250       260       270       280       290       300

     250       260       270       280       290       300         
pF1KB8 EGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCF
              310       320       330       340       350       360

     310       320       330       340       350       360         
pF1KB8 DVKDVQMLQDAISKMDPTDAKYHMQRCIDPGLWVPNSKASEAKEGEEAGPGDPLLEAVPK
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 DVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPK
              370       380       390       400       410       420

     370        
pF1KB8 TGDEKDVSV
       :::::::::
XP_011 TGDEKDVSV
                

>>NP_060383 (OMIM: 610346) hsp90 co-chaperone Cdc37-like  (337 aa)
 initn: 608 init1: 554 opt: 747  Z-score: 533.7  bits: 107.3 E(85289): 5.5e-23
Smith-Waterman score: 747; 44.3% identity (73.7% similar) in 262 aa overlap (44-303:55-304)

            20        30        40        50        60        70   
pF1KB8 DDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEV
                                     ::.:: . ..   :: ..:: :.::  : .
NP_060 DFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFV-KSSVACKWNLAEAQQKLGSLAL
           30        40        50        60         70        80   

              80        90       100       110       120       130 
pF1KB8 --AEGGKAELERQQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNT
         .:.   :  . :. ...::..:. :.:: : . ..::   :..:..::: :.::..: 
NP_060 HNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQ
            90       100       110       120       130       140   

             140       150       160       170       180       190 
pF1KB8 KPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLV
         .:  ::     :.: ..:..:::..:.::::: ::::::..:::. .:::::::.::.
NP_060 DKRKDTED-----EDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLI
           150            160       170       180       190        

             200       210       220       230       240       250 
pF1KB8 IWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEG
       .::. ::.:.: :::::.:::..:::::.:.::. .::::.::: :: : :. .. :.:.
NP_060 LWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEA
      200       210       220       230       240       250        

             260       270       280       290       300       310 
pF1KB8 FNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDV
       :..:::::: :::      . .  . ..    ....  .:.  . . ::::.        
NP_060 FKNELEAFKSRVR------LYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYS
      260       270             280       290       300       310  

             320       330       340       350       360       370 
pF1KB8 KDVQMLQDAISKMDPTDAKYHMQRCIDPGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTG
                                                                   
NP_060 ISTALCSLNSVVHKEDDEPKMMDTV                                   
            320       330                                          




378 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 11:59:32 2016 done: Fri Nov  4 11:59:33 2016
 Total Scan time:  9.440 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]