Result of FASTA (omim) for
pF1KB8182
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8182, 232 aa
1>>>pF1KB8182 232 - 232 aa - 232 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6185+/-0.000498; mu= -4.7620+/- 0.031
mean_var=247.4161+/-50.512, 0's: 0 Z-trim(117.0): 22 B-trim: 1568 in 2/55
Lambda= 0.081538
statistics sampled from 28522 (28544) to 28522 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.335), width: 16
Scan time: 5.500
The best scores are: opt bits E(85289)
NP_001304106 (OMIM: 613748) MICOS complex subunit ( 232) 1473 185.8 5.4e-47
NP_060282 (OMIM: 613748) MICOS complex subunit MIC ( 227) 1420 179.6 4e-45
NP_001304107 (OMIM: 613748) MICOS complex subunit ( 138) 755 101.2 9.5e-22
NP_001307539 (OMIM: 615634) MICOS complex subunit ( 236) 443 64.6 1.6e-10
NP_115719 (OMIM: 615634) MICOS complex subunit MIC ( 235) 437 63.9 2.6e-10
XP_011511536 (OMIM: 615634) PREDICTED: MICOS compl ( 199) 333 51.6 1.1e-06
XP_016862810 (OMIM: 615634) PREDICTED: MICOS compl ( 207) 307 48.6 9.6e-06
XP_016862809 (OMIM: 615634) PREDICTED: MICOS compl ( 228) 298 47.6 2.2e-05
XP_016862811 (OMIM: 615634) PREDICTED: MICOS compl ( 187) 258 42.8 0.00048
>>NP_001304106 (OMIM: 613748) MICOS complex subunit MIC1 (232 aa)
initn: 1473 init1: 1473 opt: 1473 Z-score: 964.7 bits: 185.8 E(85289): 5.4e-47
Smith-Waterman score: 1473; 100.0% identity (100.0% similar) in 232 aa overlap (1-232:1-232)
10 20 30 40 50 60
pF1KB8 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
190 200 210 220 230
>>NP_060282 (OMIM: 613748) MICOS complex subunit MIC19 i (227 aa)
initn: 1426 init1: 755 opt: 1420 Z-score: 931.2 bits: 179.6 E(85289): 4e-45
Smith-Waterman score: 1420; 97.8% identity (97.8% similar) in 232 aa overlap (1-232:1-227)
10 20 30 40 50 60
pF1KB8 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KHL-----ARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
130 140 150 160 170
190 200 210 220 230
pF1KB8 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
180 190 200 210 220
>>NP_001304107 (OMIM: 613748) MICOS complex subunit MIC1 (138 aa)
initn: 755 init1: 755 opt: 755 Z-score: 511.4 bits: 101.2 E(85289): 9.5e-22
Smith-Waterman score: 755; 100.0% identity (100.0% similar) in 123 aa overlap (1-123:1-123)
10 20 30 40 50 60
pF1KB8 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
:::
NP_001 KHLIKVELLWVKPGVLTA
130
>>NP_001307539 (OMIM: 615634) MICOS complex subunit MIC2 (236 aa)
initn: 514 init1: 312 opt: 443 Z-score: 309.8 bits: 64.6 E(85289): 1.6e-10
Smith-Waterman score: 463; 34.7% identity (71.5% similar) in 239 aa overlap (1-225:1-235)
10 20 30 40 50
pF1KB8 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVS
::.: :. :::.: .::.: . :..:.::::::..:::: ::. :...: ..
NP_001 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKE--PSSPPPAPTSSTFG--LQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DEELKRRVAEELALEQAKKESEDQKRLKQA-KELDRERAAANEQLTRAILRER-ICSEEE
: .:. : ..... ... . .:.. :. ..:.:: ...: .. ::: ...
NP_001 DGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHS
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 RAK-------AKHLD---IEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTE
.:. .: . .. .::.:: .. :...:.:::::: :.:....:.:....:
NP_001 KASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 QYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQS
:...:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :..
NP_001 QFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
180 190 200 210 220 230
230
pF1KB8 MLEKGG
>>NP_115719 (OMIM: 615634) MICOS complex subunit MIC25 i (235 aa)
initn: 495 init1: 312 opt: 437 Z-score: 306.0 bits: 63.9 E(85289): 2.6e-10
Smith-Waterman score: 459; 35.1% identity (71.5% similar) in 239 aa overlap (1-225:1-234)
10 20 30 40 50
pF1KB8 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVS
::.: :. :::.: .::.: . :..:.::::::..:::: ::. :...: ..
NP_115 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKE--PSSPPPAPTSSTFG--LQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DEELKRRVAEELALEQAKKESEDQKRLKQA-KELDRERAAANEQLTRAILRERICSEEER
: .:. : ..... ... . .:.. :. ..:.:: ...: .. ::: . ..
NP_115 DGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKRER-EAATKH
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 AKAK------HLDIEDK-----ARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTE
.::. .. :.. ::.:: .. :...:.:::::: :.:....:.:....:
NP_115 SKASLPTGEGSISHEEQKSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 QYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQS
:...:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :..
NP_115 QFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
180 190 200 210 220 230
230
pF1KB8 MLEKGG
>>XP_011511536 (OMIM: 615634) PREDICTED: MICOS complex s (199 aa)
initn: 385 init1: 312 opt: 333 Z-score: 240.9 bits: 51.6 E(85289): 1.1e-06
Smith-Waterman score: 338; 33.9% identity (64.6% similar) in 189 aa overlap (37-225:28-198)
10 20 30 40 50 60
pF1KB8 TRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRV
:::. : : ::. : : .::
XP_011 MKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGS---SGGQQPSGMKEGVKRYE
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 AEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLDIE
:. :. : .: :. . .:: :. . . . . : ::... ..
XP_011 QEHAAI---------QDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKS------VR
60 70 80 90
130 140 150 160 170 180
pF1KB8 DKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHP
.::.:: .. :...:.:::::: :.:....:.:....::...:: ..:. .: . .:
XP_011 LQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEP
100 110 120 130 140 150
190 200 210 220 230
pF1KB8 VCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
::. :::.::.:::. :..: :: :. :..::. :..
XP_011 VCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
160 170 180 190
>>XP_016862810 (OMIM: 615634) PREDICTED: MICOS complex s (207 aa)
initn: 329 init1: 167 opt: 307 Z-score: 224.1 bits: 48.6 E(85289): 9.6e-06
Smith-Waterman score: 327; 32.0% identity (69.5% similar) in 203 aa overlap (1-188:1-199)
10 20 30 40 50
pF1KB8 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVS
::.: :. :::.: .::.: . :..:.::::::..:::: ::. :...: ..
XP_016 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKE--PSSPPPAPTSSTFG--LQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DEELKRRVAEELALEQAKKESEDQKRLKQA-KELDRERAAANEQLTRAILRER-ICSEEE
: .:. : ..... ... . .:.. :. ..:.:: ...: .. ::: ...
XP_016 DGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHS
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 RAK-------AKHLD---IEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTE
.:. .: . .. .::.:: .. :...:.:::::: :.:....:.:....:
XP_016 KASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 QYQKAAEEVEAKFK-RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQ
:...:: ..:. .: : . .:
XP_016 QFHEAASKMESTIKPRVPASDICQLLVEETP
180 190 200
>>XP_016862809 (OMIM: 615634) PREDICTED: MICOS complex s (228 aa)
initn: 329 init1: 167 opt: 298 Z-score: 217.8 bits: 47.6 E(85289): 2.2e-05
Smith-Waterman score: 318; 32.5% identity (70.6% similar) in 194 aa overlap (1-180:1-190)
10 20 30 40 50
pF1KB8 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVS
::.: :. :::.: .::.: . :..:.::::::..:::: ::. :...: ..
XP_016 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKE--PSSPPPAPTSSTFG--LQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DEELKRRVAEELALEQAKKESEDQKRLKQA-KELDRERAAANEQLTRAILRER-ICSEEE
: .:. : ..... ... . .:.. :. ..:.:: ...: .. ::: ...
XP_016 DGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHS
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 RAK-------AKHLD---IEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTE
.:. .: . .. .::.:: .. :...:.:::::: :.:....:.:....:
XP_016 KASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 QYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQS
:...:: ..:. .:
XP_016 QFHEAASKMESTIKMSWNFLMAEWSSCGGAESKSYGAEHTPLFLSRAPLTAL
180 190 200 210 220
>>XP_016862811 (OMIM: 615634) PREDICTED: MICOS complex s (187 aa)
initn: 269 init1: 139 opt: 258 Z-score: 193.6 bits: 42.8 E(85289): 0.00048
Smith-Waterman score: 258; 32.6% identity (68.0% similar) in 172 aa overlap (1-158:1-168)
10 20 30 40 50
pF1KB8 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVS
::.: :. :::.: .::.: . :..:.::::::..:::: ::. :...: ..
XP_016 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKE--PSSPPPAPTSSTFG--LQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DEELKRRVAEELALEQAKKESEDQKRLKQA-KELDRERAAANEQLTRAILRER-ICSEEE
: .:. : ..... ... . .:.. :. ..:.:: ...: .. ::: ...
XP_016 DGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHS
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 RAK-------AKHLD---IEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTE
.:. .: . .. .::.:: .. :...:.:::::: :.:...:
XP_016 KASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKASSICELVHL
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 QYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQS
XP_016 CVSPSSVSCAN
180
232 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:18:52 2016 done: Sat Nov 5 02:18:53 2016
Total Scan time: 5.500 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]