FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8108, 478 aa 1>>>pF1KB8108 478 - 478 aa - 478 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8467+/-0.000981; mu= 6.9709+/- 0.059 mean_var=157.1655+/-31.235, 0's: 0 Z-trim(110.3): 24 B-trim: 0 in 0/50 Lambda= 0.102305 statistics sampled from 11490 (11498) to 11490 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.353), width: 16 Scan time: 2.780 The best scores are: opt bits E(32554) CCDS9052.1 METAP2 gene_id:10988|Hs108|chr12 ( 478) 3253 492.1 5.5e-139 CCDS81724.1 METAP2 gene_id:10988|Hs108|chr12 ( 477) 3236 489.6 3.1e-138 CCDS81725.1 METAP2 gene_id:10988|Hs108|chr12 ( 455) 2553 388.8 6.6e-108 CCDS81723.1 METAP2 gene_id:10988|Hs108|chr12 ( 455) 2374 362.3 6e-100 CCDS8902.1 PA2G4 gene_id:5036|Hs108|chr12 ( 394) 385 68.7 1.3e-11 >>CCDS9052.1 METAP2 gene_id:10988|Hs108|chr12 (478 aa) initn: 3253 init1: 3253 opt: 3253 Z-score: 2608.7 bits: 492.1 E(32554): 5.5e-139 Smith-Waterman score: 3253; 100.0% identity (100.0% similar) in 478 aa overlap (1-478:1-478) 10 20 30 40 50 60 pF1KB8 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 370 380 390 400 410 420 430 440 450 460 470 pF1KB8 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 430 440 450 460 470 >>CCDS81724.1 METAP2 gene_id:10988|Hs108|chr12 (477 aa) initn: 3001 init1: 3001 opt: 3236 Z-score: 2595.2 bits: 489.6 E(32554): 3.1e-138 Smith-Waterman score: 3236; 99.8% identity (99.8% similar) in 478 aa overlap (1-478:1-477) 10 20 30 40 50 60 pF1KB8 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: CCDS81 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA-GEQEPDKES 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB8 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB8 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB8 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 360 370 380 390 400 410 430 440 450 460 470 pF1KB8 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 420 430 440 450 460 470 >>CCDS81725.1 METAP2 gene_id:10988|Hs108|chr12 (455 aa) initn: 2904 init1: 2546 opt: 2553 Z-score: 2050.7 bits: 388.8 E(32554): 6.6e-108 Smith-Waterman score: 3020; 95.0% identity (95.0% similar) in 478 aa overlap (1-478:1-455) 10 20 30 40 50 60 pF1KB8 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: CCDS81 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA-GEQEPDKES 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI :::::::::::::::::::::::::: ::::::::::: CCDS81 GASVDEVARQLERSALEDKERDEDDE----------------------AKVQTDPPSVPI 60 70 80 90 130 140 150 160 170 180 pF1KB8 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 340 350 360 370 380 390 430 440 450 460 470 pF1KB8 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 400 410 420 430 440 450 >>CCDS81723.1 METAP2 gene_id:10988|Hs108|chr12 (455 aa) initn: 2374 init1: 2374 opt: 2374 Z-score: 1907.9 bits: 362.3 E(32554): 6e-100 Smith-Waterman score: 3012; 95.0% identity (95.0% similar) in 478 aa overlap (1-478:1-455) 10 20 30 40 50 60 pF1KB8 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI :::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGR----------- 70 80 90 100 130 140 150 160 170 180 pF1KB8 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR :::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 ------------QECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 340 350 360 370 380 390 430 440 450 460 470 pF1KB8 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 400 410 420 430 440 450 >>CCDS8902.1 PA2G4 gene_id:5036|Hs108|chr12 (394 aa) initn: 141 init1: 108 opt: 385 Z-score: 322.2 bits: 68.7 E(32554): 1.3e-11 Smith-Waterman score: 385; 23.8% identity (59.8% similar) in 336 aa overlap (153-475:5-336) 130 140 150 160 170 180 pF1KB8 LYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKY .:.. : . . . .. ... .: . CCDS89 MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRS 10 20 30 190 200 210 220 230 pF1KB8 VMSWIKPGMTMIEICEK-----LEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAG .. . :.... .::: .:. .. . ::. .. :.::::. :.:::. :..: . CCDS89 LVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKS 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB8 DTT-VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVK-DATNTGIKCAGIDV : .:. :. :::.:.:..: : . : : . . : . . : :. ... :: . CCDS89 DQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAAL 100 110 120 130 140 150 300 310 320 330 340 pF1KB8 RLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV---PI---VKG :: :. .: :... .. ..... ::... .:.. :. : . ::. : : CCDS89 RLVKPGNQNTQVTEAWN-KV-AHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKD 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 GEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINEN : ...: ::::.... :.:.: ..: . . .: . ... .. ... ... CCDS89 HEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERR 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB8 FGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCK : .. : : .. :.: :.. . ...:. : . .: ..:::. :.:: :. CCDS89 FDAMPFTLRAFE--DEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGP 280 290 300 310 320 330 470 pF1KB8 EVVSRGDDY .. : CCDS89 MRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEEN 340 350 360 370 380 390 478 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:33:54 2016 done: Fri Nov 4 09:33:55 2016 Total Scan time: 2.780 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]