Result of FASTA (omim) for
pF1KB7650
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7650, 392 aa
1>>>pF1KB7650 392 - 392 aa - 392 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.4782+/-0.00038; mu= 22.2310+/- 0.024
mean_var=83.1644+/-18.175, 0's: 0 Z-trim(113.0): 74 B-trim: 66 in 1/53
Lambda= 0.140639
statistics sampled from 22138 (22212) to 22138 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.26), width: 16
Scan time: 8.350
The best scores are: opt bits E(85289)
NP_671723 (OMIM: 615335) ceramide synthase 5 isofo ( 392) 2746 567.2 2.3e-161
XP_005269277 (OMIM: 615335) PREDICTED: ceramide sy ( 409) 2431 503.3 4.1e-142
NP_001318000 (OMIM: 615335) ceramide synthase 5 is ( 381) 2424 501.9 1.1e-141
NP_001317999 (OMIM: 615335) ceramide synthase 5 is ( 392) 2424 501.9 1.1e-141
NP_001268660 (OMIM: 615335) ceramide synthase 5 is ( 334) 2276 471.8 1.1e-132
XP_016875693 (OMIM: 615335) PREDICTED: ceramide sy ( 290) 2058 427.5 2e-119
NP_001317998 (OMIM: 615335) ceramide synthase 5 is ( 323) 1954 406.4 4.9e-113
XP_016875691 (OMIM: 615335) PREDICTED: ceramide sy ( 334) 1954 406.4 5e-113
NP_982288 (OMIM: 615336) ceramide synthase 6 isofo ( 384) 1802 375.7 1e-103
NP_001243055 (OMIM: 615336) ceramide synthase 6 is ( 392) 1776 370.4 4.1e-102
NP_001318001 (OMIM: 615335) ceramide synthase 5 is ( 248) 1730 360.8 2e-99
XP_016875694 (OMIM: 615335) PREDICTED: ceramide sy ( 237) 1408 295.5 8.9e-80
NP_001318002 (OMIM: 615335) ceramide synthase 5 is ( 237) 1408 295.5 8.9e-80
XP_016882792 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526597 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526593 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526592 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526594 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526595 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_016882794 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_016882793 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
XP_011526596 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1111 235.5 1.7e-61
NP_078828 (OMIM: 615334) ceramide synthase 4 [Homo ( 394) 1111 235.5 1.7e-61
NP_071358 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1094 232.0 1.8e-60
NP_859530 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1094 232.0 1.8e-60
XP_011507754 (OMIM: 606920) PREDICTED: ceramide sy ( 380) 1094 232.0 1.8e-60
XP_011507753 (OMIM: 606920) PREDICTED: ceramide sy ( 400) 1094 232.0 1.9e-60
XP_016859238 (OMIM: 615336) PREDICTED: ceramide sy ( 251) 1065 225.9 8.2e-59
XP_016877491 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1056 224.3 3.9e-58
XP_011519659 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1056 224.3 3.9e-58
XP_011519660 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1056 224.3 3.9e-58
NP_001277270 (OMIM: 615023,615276) ceramide syntha ( 394) 1056 224.3 3.9e-58
XP_011519657 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1056 224.3 3.9e-58
XP_016877493 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1051 223.3 7.7e-58
XP_016877492 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1051 223.3 7.7e-58
NP_849164 (OMIM: 615023,615276) ceramide synthase ( 383) 1051 223.3 7.7e-58
NP_001277272 (OMIM: 615023,615276) ceramide syntha ( 383) 1051 223.3 7.7e-58
NP_001277271 (OMIM: 615023,615276) ceramide syntha ( 383) 1051 223.3 7.7e-58
XP_005246497 (OMIM: 615336) PREDICTED: ceramide sy ( 200) 843 180.8 2.6e-45
NP_937850 (OMIM: 606919,616230) ceramide synthase ( 337) 251 60.9 5.2e-09
NP_067090 (OMIM: 606919,616230) ceramide synthase ( 350) 251 60.9 5.3e-09
NP_001277194 (OMIM: 606919,616230) ceramide syntha ( 239) 242 58.9 1.5e-08
XP_016868755 (OMIM: 605190) PREDICTED: translocati ( 278) 187 47.8 3.7e-05
XP_016868756 (OMIM: 605190) PREDICTED: translocati ( 278) 187 47.8 3.7e-05
NP_001304734 (OMIM: 605190) translocating chain-as ( 288) 187 47.8 3.8e-05
NP_001304733 (OMIM: 605190) translocating chain-as ( 343) 187 47.9 4.3e-05
NP_055109 (OMIM: 605190) translocating chain-assoc ( 374) 187 48.0 4.5e-05
XP_011513307 (OMIM: 608485) PREDICTED: translocati ( 333) 180 46.5 0.00011
NP_036420 (OMIM: 608485) translocating chain-assoc ( 370) 180 46.6 0.00012
>>NP_671723 (OMIM: 615335) ceramide synthase 5 isoform 1 (392 aa)
initn: 2746 init1: 2746 opt: 2746 Z-score: 3017.9 bits: 567.2 E(85289): 2.3e-161
Smith-Waterman score: 2746; 99.7% identity (99.7% similar) in 392 aa overlap (1-392:1-392)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_671 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
310 320 330 340 350 360
370 380 390
pF1KB7 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
::::::::::::::::::::::::::::::::
NP_671 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
370 380 390
>>XP_005269277 (OMIM: 615335) PREDICTED: ceramide syntha (409 aa)
initn: 2468 init1: 2424 opt: 2431 Z-score: 2672.3 bits: 503.3 E(85289): 4.1e-142
Smith-Waterman score: 2431; 92.6% identity (95.0% similar) in 379 aa overlap (1-379:1-378)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
:::::::::::::::::::::::::::::::::::::::::::: : . . :..:
XP_005 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVRMKD-GFFLLGMEDRD
310 320 330 340 350
370 380 390
pF1KB7 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
.: . :: . : ..:
XP_005 YSTDVLSPSNLVSPIYSSRPSKKPRAPKSSPLRYRRMIAVMWRAAQRKKM
360 370 380 390 400
>>NP_001318000 (OMIM: 615335) ceramide synthase 5 isofor (381 aa)
initn: 2466 init1: 2422 opt: 2424 Z-score: 2665.0 bits: 501.9 E(85289): 1.1e-141
Smith-Waterman score: 2424; 98.6% identity (98.9% similar) in 349 aa overlap (1-349:1-349)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
::::::::::::::::::::::::::::::::::::::::::::. :
NP_001 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVTCPGRIRPCTLHSFLT
310 320 330 340 350 360
370 380 390
pF1KB7 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
NP_001 SFLFSMPGGSWTVSSLACIEG
370 380
>>NP_001317999 (OMIM: 615335) ceramide synthase 5 isofor (392 aa)
initn: 2460 init1: 2416 opt: 2424 Z-score: 2664.8 bits: 501.9 E(85289): 1.1e-141
Smith-Waterman score: 2424; 94.0% identity (97.0% similar) in 368 aa overlap (1-368:1-366)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
:::::::::::::::::::::::::::::::::::::::::::. ..:: .... . .:
NP_001 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKM--ESRSVAQAGVQCHD
310 320 330 340 350
370 380 390
pF1KB7 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
. . :
NP_001 LGSPQPPPPGFKRFSCLSLPSSWDYRRMPPGIEG
360 370 380 390
>>NP_001268660 (OMIM: 615335) ceramide synthase 5 isofor (334 aa)
initn: 2276 init1: 2276 opt: 2276 Z-score: 2503.3 bits: 471.8 E(85289): 1.1e-132
Smith-Waterman score: 2276; 99.4% identity (99.7% similar) in 328 aa overlap (65-392:7-334)
40 50 60 70 80 90
pF1KB7 PADGYGYPRGRHILSVFPLAAGIFFVRLLFERFIAKPCALRIGIEDSGPYQAQPNAILEK
.::::::::: :::::::::::::::::::
NP_001 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
100 110 120 130 140 150
pF1KB7 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB7 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB7 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB7 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB7 ALKALIRGKVSKDDRSDVESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALKALIRGKVSKDDRSDVESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
280 290 300 310 320 330
>>XP_016875693 (OMIM: 615335) PREDICTED: ceramide syntha (290 aa)
initn: 2058 init1: 2058 opt: 2058 Z-score: 2265.0 bits: 427.5 E(85289): 2e-119
Smith-Waterman score: 2058; 99.7% identity (99.7% similar) in 290 aa overlap (1-290:1-290)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPF
250 260 270 280 290
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
>>NP_001317998 (OMIM: 615335) ceramide synthase 5 isofor (323 aa)
initn: 1995 init1: 1951 opt: 1954 Z-score: 2150.4 bits: 406.4 E(85289): 4.9e-113
Smith-Waterman score: 1954; 97.9% identity (98.6% similar) in 285 aa overlap (65-349:7-291)
40 50 60 70 80 90
pF1KB7 PADGYGYPRGRHILSVFPLAAGIFFVRLLFERFIAKPCALRIGIEDSGPYQAQPNAILEK
.::::::::: :::::::::::::::::::
NP_001 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
100 110 120 130 140 150
pF1KB7 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB7 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB7 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB7 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB7 ALKALIRGKVSKDDRSDVESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
::::::::::. :
NP_001 ALKALIRGKVTCPGRIRPCTLHSFLTSFLFSMPGGSWTVSSLACIEG
280 290 300 310 320
>>XP_016875691 (OMIM: 615335) PREDICTED: ceramide syntha (334 aa)
initn: 1989 init1: 1945 opt: 1954 Z-score: 2150.2 bits: 406.4 E(85289): 5e-113
Smith-Waterman score: 1954; 92.4% identity (96.4% similar) in 304 aa overlap (65-368:7-308)
40 50 60 70 80 90
pF1KB7 PADGYGYPRGRHILSVFPLAAGIFFVRLLFERFIAKPCALRIGIEDSGPYQAQPNAILEK
.::::::::: :::::::::::::::::::
XP_016 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
100 110 120 130 140 150
pF1KB7 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB7 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB7 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB7 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB7 ALKALIRGKVSKDDRSDVESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
:::::::::. ..:: .... . .:. . :
XP_016 ALKALIRGKM--ESRSVAQAGVQCHDLGSPQPPPPGFKRFSCLSLPSSWDYRRMPPGIEG
280 290 300 310 320 330
>>NP_982288 (OMIM: 615336) ceramide synthase 6 isoform 2 (384 aa)
initn: 1783 init1: 1673 opt: 1802 Z-score: 1982.9 bits: 375.7 E(85289): 1e-103
Smith-Waterman score: 1802; 65.1% identity (88.6% similar) in 370 aa overlap (15-384:7-375)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
NP_982 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
NP_982 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
NP_982 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
NP_982 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
NP_982 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED
:::.::: :::..: ::: .: :. .:::::..:: ::. :::::::::::.::::.:::
NP_982 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEED
300 310 320 330 340 350
370 380 390
pF1KB7 VTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
:.: ....::.. .::..
NP_982 SEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
360 370 380
>>NP_001243055 (OMIM: 615336) ceramide synthase 6 isofor (392 aa)
initn: 1775 init1: 1537 opt: 1776 Z-score: 1954.3 bits: 370.4 E(85289): 4.1e-102
Smith-Waterman score: 1776; 63.8% identity (86.8% similar) in 378 aa overlap (15-384:7-383)
10 20 30 40 50 60
pF1KB7 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
NP_001 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 RLLFERFIAKPCALRIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
NP_001 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
NP_001 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB7 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
NP_001 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB7 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
NP_001 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
240 250 260 270 280 290
310 320 330 340 350
pF1KB7 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGK--------VSKDDRSDV
:::.::: :::..: ::: .: :. .:::::..:: ::. ::: ::::::::.
NP_001 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDI
300 310 320 330 340 350
360 370 380 390
pF1KB7 ESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
::::.::: :.: ....::.. .::..
NP_001 ESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
360 370 380 390
392 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:03:04 2016 done: Sat Nov 5 10:03:05 2016
Total Scan time: 8.350 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]