Result of FASTA (omim) for
pF1KB7646
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7646, 390 aa
1>>>pF1KB7646 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4985+/-0.000412; mu= -2.6694+/- 0.026
mean_var=381.1587+/-77.058, 0's: 0 Z-trim(122.8): 10 B-trim: 0 in 0/61
Lambda= 0.065693
statistics sampled from 41538 (41561) to 41538 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.796), E-opt: 0.2 (0.487), width: 16
Scan time: 10.200
The best scores are: opt bits E(85289)
NP_006283 (OMIM: 114480,601387) tumor susceptibili ( 390) 2604 260.2 6.1e-69
XP_005253165 (OMIM: 114480,601387) PREDICTED: tumo ( 338) 2284 229.8 7.5e-60
NP_001284700 (OMIM: 610985) ubiquitin-conjugating ( 215) 566 66.8 5.7e-11
NP_060784 (OMIM: 610985) ubiquitin-conjugating enz ( 379) 566 67.0 8.4e-11
NP_001035787 (OMIM: 610985) ubiquitin-conjugating ( 471) 566 67.1 9.7e-11
NP_001248314 (OMIM: 610985) ubiquitin-conjugating ( 341) 481 58.9 2.1e-08
NP_001248312 (OMIM: 610985) ubiquitin-conjugating ( 357) 393 50.6 6.9e-06
NP_001248311 (OMIM: 610985) ubiquitin-conjugating ( 449) 393 50.7 8.1e-06
>>NP_006283 (OMIM: 114480,601387) tumor susceptibility g (390 aa)
initn: 2604 init1: 2604 opt: 2604 Z-score: 1358.7 bits: 260.2 E(85289): 6.1e-69
Smith-Waterman score: 2604; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 RMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFL
310 320 330 340 350 360
370 380 390
pF1KB7 KHVRLLSRKQFQLRALMQKARKTAGLSDLY
::::::::::::::::::::::::::::::
NP_006 KHVRLLSRKQFQLRALMQKARKTAGLSDLY
370 380 390
>>XP_005253165 (OMIM: 114480,601387) PREDICTED: tumor su (338 aa)
initn: 2284 init1: 2284 opt: 2284 Z-score: 1195.5 bits: 229.8 E(85289): 7.5e-60
Smith-Waterman score: 2284; 100.0% identity (100.0% similar) in 338 aa overlap (53-390:1-338)
30 40 50 60 70 80
pF1KB7 RETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPY
::::::::::::::::::::::::::::::
XP_005 MNLTGTIPVPYRGNTYNIPICLWLLDTYPY
10 20 30
90 100 110 120 130 140
pF1KB7 NPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB7 SRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB7 QYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEED
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB7 LKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTA
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB7 PLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARK
280 290 300 310 320 330
390
pF1KB7 TAGLSDLY
::::::::
XP_005 TAGLSDLY
>>NP_001284700 (OMIM: 610985) ubiquitin-conjugating enzy (215 aa)
initn: 565 init1: 565 opt: 566 Z-score: 318.0 bits: 66.8 E(85289): 5.7e-11
Smith-Waterman score: 566; 49.7% identity (80.0% similar) in 165 aa overlap (8-172:8-167)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
:.....:::.:::::.: :: ... .: .:.:::.:.:...:.:.:::::
NP_001 MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
: :.:::::::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::
NP_001 VMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
.: ..:::. ::. : .: :..: .:.: :. .:. . :.:
NP_001 KSVIVGLIKEMIAKFQEELPMYS--LSSSDEARQVDL---LAYIAKITEGVSDTNSKSWA
130 140 150 160 170
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
NP_001 NHENKTVNKITVVGGGELGIACTLAISAKVESRSVTQAGV
180 190 200 210
>>NP_060784 (OMIM: 610985) ubiquitin-conjugating enzyme (379 aa)
initn: 550 init1: 550 opt: 566 Z-score: 315.0 bits: 67.0 E(85289): 8.4e-11
Smith-Waterman score: 566; 49.7% identity (80.0% similar) in 165 aa overlap (8-172:8-167)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
:.....:::.:::::.: :: ... .: .:.:::.:.:...:.:.:::::
NP_060 MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
: :.:::::::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::
NP_060 VMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
.: ..:::. ::. : .: :..: .:.: :. .:. . :.:
NP_060 KSVIVGLIKEMIAKFQEELPMYS--LSSSDEARQVDL---LAYIAKITEGVSDTNSKSWA
130 140 150 160 170
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
NP_060 NHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVE
180 190 200 210 220 230
>>NP_001035787 (OMIM: 610985) ubiquitin-conjugating enzy (471 aa)
initn: 550 init1: 550 opt: 566 Z-score: 313.8 bits: 67.1 E(85289): 9.7e-11
Smith-Waterman score: 566; 49.7% identity (80.0% similar) in 165 aa overlap (8-172:8-167)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
:.....:::.:::::.: :: ... .: .:.:::.:.:...:.:.:::::
NP_001 MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
: :.:::::::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::
NP_001 VMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
.: ..:::. ::. : .: :..: .:.: :. .:. . :.:
NP_001 KSVIVGLIKEMIAKFQEELPMYS--LSSSDEARQVDL---LAYIAKITEGVSDTNSKSWA
130 140 150 160 170
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
NP_001 NHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVE
180 190 200 210 220 230
>>NP_001248314 (OMIM: 610985) ubiquitin-conjugating enzy (341 aa)
initn: 467 init1: 467 opt: 481 Z-score: 272.0 bits: 58.9 E(85289): 2.1e-08
Smith-Waterman score: 481; 51.5% identity (80.6% similar) in 134 aa overlap (39-172:1-129)
10 20 30 40 50 60
pF1KB7 KKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTY
.:.:::.:.:...:.:.:::::: :.::::
NP_001 MDTYVFKDSSQKDLLNFTGTIPVMYQGNTY
10 20 30
70 80 90 100 110 120
pF1KB7 NIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLI
:::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::.: ..:::
NP_001 NIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLI
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 QVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGC
. ::. : .: :..: .:.: :. .:. . :.:
NP_001 KEMIAKFQEELPMYS--LSSSDEARQVD---LLAYIAKITEGVSDTNSKSWANHENKTVN
100 110 120 130 140
190 200 210 220 230 240
pF1KB7 PYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDR
NP_001 KITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSAS
150 160 170 180 190 200
>>NP_001248312 (OMIM: 610985) ubiquitin-conjugating enzy (357 aa)
initn: 429 init1: 368 opt: 393 Z-score: 226.7 bits: 50.6 E(85289): 6.9e-06
Smith-Waterman score: 421; 41.8% identity (67.3% similar) in 165 aa overlap (8-172:8-145)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
:.....:::.:::::.: :: ... .: .:.:
NP_001 MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTY------------------
10 20 30 40
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
:::::::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::
NP_001 ----GNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
50 60 70 80 90
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
.: ..:::. ::. : .: :..: .:.: :. .:. . :.:
NP_001 KSVIVGLIKEMIAKFQEELPMYS--LSSSDEARQVDL---LAYIAKITEGVSDTNSKSWA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
NP_001 NHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVE
160 170 180 190 200 210
>>NP_001248311 (OMIM: 610985) ubiquitin-conjugating enzy (449 aa)
initn: 429 init1: 368 opt: 393 Z-score: 225.4 bits: 50.7 E(85289): 8.1e-06
Smith-Waterman score: 421; 41.8% identity (67.3% similar) in 165 aa overlap (8-172:8-145)
10 20 30 40 50 60
pF1KB7 MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
:.....:::.:::::.: :: ... .: .:.:
NP_001 MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTY------------------
10 20 30 40
70 80 90 100 110 120
pF1KB7 VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
:::::::: .:.::..:. :::::.:::..: : .::::::.:.::::::..:.::
NP_001 ----GNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
50 60 70 80 90
130 140 150 160 170 180
pF1KB7 QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
.: ..:::. ::. : .: :..: .:.: :. .:. . :.:
NP_001 KSVIVGLIKEMIAKFQEELPMYS--LSSSDEARQVDL---LAYIAKITEGVSDTNSKSWA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
NP_001 NHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVE
160 170 180 190 200 210
390 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:13:53 2016 done: Fri Nov 4 20:13:55 2016
Total Scan time: 10.200 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]