Result of FASTA (omim) for pF1KB7272
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7272, 442 aa
  1>>>pF1KB7272 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1183+/-0.000321; mu= 14.4978+/- 0.020
 mean_var=110.2892+/-22.045, 0's: 0 Z-trim(118.8): 81  B-trim: 0 in 0/55
 Lambda= 0.122126
 statistics sampled from 32077 (32172) to 32077 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.377), width:  16
 Scan time:  8.970

The best scores are:                                      opt bits E(85289)
NP_004589 (OMIM: 602264) testican-1 precursor [Hom ( 439) 3140 563.9 2.9e-160
XP_011530320 (OMIM: 607989) PREDICTED: testican-3  ( 436) 1679 306.5 8.8e-83
NP_058646 (OMIM: 607989) testican-3 isoform 2 prec ( 436) 1679 306.5 8.8e-83
XP_016863747 (OMIM: 607989) PREDICTED: testican-3  ( 433) 1646 300.7 4.9e-81
NP_001035249 (OMIM: 607989) testican-3 isoform 1 p ( 433) 1646 300.7 4.9e-81
XP_016863746 (OMIM: 607989) PREDICTED: testican-3  ( 445) 1646 300.7   5e-81
NP_001191281 (OMIM: 607989) testican-3 isoform 3 [ ( 385) 1471 269.8 8.7e-72
NP_055582 (OMIM: 607988) testican-2 isoform 2 prec ( 424) 1350 248.5 2.4e-65
NP_001231879 (OMIM: 607988) testican-2 isoform 2 p ( 424) 1350 248.5 2.4e-65
XP_011538706 (OMIM: 607988) PREDICTED: testican-2  ( 421) 1317 242.7 1.4e-63
NP_001191283 (OMIM: 607989) testican-3 isoform 5 [ ( 344) 1288 237.5   4e-62
NP_001191287 (OMIM: 607989) testican-3 isoform 9 p ( 313) 1265 233.4 6.3e-61
NP_001191282 (OMIM: 607989) testican-3 isoform 4 [ ( 316) 1163 215.5 1.6e-55
NP_001191284 (OMIM: 607989) testican-3 isoform 6 [ ( 340) 1163 215.5 1.7e-55
NP_001238896 (OMIM: 607989) testican-3 isoform 11  ( 338) 1021 190.5 5.8e-48
NP_001191285 (OMIM: 607989) testican-3 isoform 7 p ( 393)  814 154.1 6.2e-37
XP_016865578 (OMIM: 142790) PREDICTED: HLA class I ( 321)  207 47.0 8.3e-05
NP_001020330 (OMIM: 142790) HLA class II histocomp ( 296)  206 46.8 8.8e-05
NP_071420 (OMIM: 206920,608488) SPARC-related modu ( 434)  208 47.3 9.2e-05
NP_001030024 (OMIM: 206920,608488) SPARC-related m ( 435)  208 47.3 9.2e-05
XP_011542497 (OMIM: 131390) PREDICTED: nidogen-1 i (1205)  203 46.8 0.00036
NP_002499 (OMIM: 131390) nidogen-1 precursor [Homo (1247)  203 46.8 0.00037
NP_001013416 (OMIM: 146732) insulin-like growth fa ( 297)  194 44.7 0.00038
NP_000589 (OMIM: 146732) insulin-like growth facto ( 291)  191 44.2 0.00054
XP_016867641 (OMIM: 146732) PREDICTED: insulin-lik ( 291)  191 44.2 0.00054
NP_002169 (OMIM: 146735) insulin-like growth facto ( 240)  182 42.5  0.0014
NP_000590 (OMIM: 146734) insulin-like growth facto ( 272)  175 41.4  0.0037
XP_005268053 (OMIM: 206920,608488) PREDICTED: SPAR ( 445)  176 41.7  0.0047
XP_005268052 (OMIM: 206920,608488) PREDICTED: SPAR ( 446)  176 41.7  0.0047
NP_071421 (OMIM: 125400,607223) SPARC-related modu ( 457)  174 41.4  0.0061
XP_011534367 (OMIM: 125400,607223) PREDICTED: SPAR ( 475)  174 41.4  0.0063
XP_005267464 (OMIM: 605399) PREDICTED: nidogen-2 i (1327)  180 42.8  0.0065
XP_005267463 (OMIM: 605399) PREDICTED: nidogen-2 i (1354)  180 42.8  0.0066
NP_031387 (OMIM: 605399) nidogen-2 precursor [Homo (1375)  180 42.8  0.0067
XP_005267462 (OMIM: 605399) PREDICTED: nidogen-2 i (1402)  180 42.8  0.0068
NP_001159884 (OMIM: 125400,607223) SPARC-related m ( 446)  172 41.0  0.0076
XP_011534368 (OMIM: 125400,607223) PREDICTED: SPAR ( 464)  172 41.0  0.0079


>>NP_004589 (OMIM: 602264) testican-1 precursor [Homo sa  (439 aa)
 initn: 2719 init1: 2719 opt: 3140  Z-score: 2998.3  bits: 563.9 E(85289): 2.9e-160
Smith-Waterman score: 3140; 99.3% identity (99.3% similar) in 442 aa overlap (1-442:1-439)

               10        20        30        40        50        60
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQ
       ::   :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RD---DDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQ
                  70        80        90       100       110       

              130       140       150       160       170       180
pF1KB7 KKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCD
       120       130       140       150       160       170       

              190       200       210       220       230       240
pF1KB7 GPCPCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GPCPCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRF
       180       190       200       210       220       230       

              250       260       270       280       290       300
pF1KB7 DTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLS
       240       250       260       270       280       290       

              310       320       330       340       350       360
pF1KB7 NNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWC
       300       310       320       330       340       350       

              370       380       390       400       410       420
pF1KB7 VDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHT
       360       370       380       390       400       410       

              430       440  
pF1KB7 RAVTEDDEDEDDDKEDEVGYIW
       ::::::::::::::::::::::
NP_004 RAVTEDDEDEDDDKEDEVGYIW
       420       430         

>>XP_011530320 (OMIM: 607989) PREDICTED: testican-3 isof  (436 aa)
 initn: 1523 init1: 1113 opt: 1679  Z-score: 1607.2  bits: 306.5 E(85289): 8.8e-83
Smith-Waterman score: 1687; 54.4% identity (75.6% similar) in 434 aa overlap (5-435:6-427)

                10        20        30        40        50         
pF1KB7  MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
            ::: . :::::  .. .    : ::: . . :::::. :::.:.::::..   ::
XP_011 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
               10        20        30         40        50         

       60        70        80        90       100       110        
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
       .:::::::::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:  
XP_011 KFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
      60        70        80        90       100       110         

      120       130       140       150       160       170        
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
       :.:...: ...: ::  :  :: :::.  . :::::::.:. .::::..::  ::.... 
XP_011 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
     120       130        140       150       160       170        

      180       190        200       210       220       230       
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
       :.: ::: :  .: .  .  . ::.: :.:..:.::.::: ::::....  :  :     
XP_011 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
      180        190       200       210       220       230       

        240       250       260       270       280       290      
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
       ..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
XP_011 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
       240       250       260       270       280       290       

        300       310       320       330       340       350      
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
       . .::::::::::.    :::.:.. ::: .  :.::: .:: :.:.:::: ::::::.:
XP_011 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
       300       310       320       330       340       350       

        360       370       380       390       400       410      
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
       ::::::.::::. ::: .:...:  . : ::::.::      :: . : ..   . :   
XP_011 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
       360       370       380       390       400       410       

        420       430       440    
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW  
             . .::::: :: .         
XP_011 ------IEDDDEDEGDDDDGGDDHDVYI
                420       430      

>>NP_058646 (OMIM: 607989) testican-3 isoform 2 precurso  (436 aa)
 initn: 1523 init1: 1113 opt: 1679  Z-score: 1607.2  bits: 306.5 E(85289): 8.8e-83
Smith-Waterman score: 1687; 54.4% identity (75.6% similar) in 434 aa overlap (5-435:6-427)

                10        20        30        40        50         
pF1KB7  MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
            ::: . :::::  .. .    : ::: . . :::::. :::.:.::::..   ::
NP_058 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
               10        20        30         40        50         

       60        70        80        90       100       110        
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
       .:::::::::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:  
NP_058 KFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
      60        70        80        90       100       110         

      120       130       140       150       160       170        
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
       :.:...: ...: ::  :  :: :::.  . :::::::.:. .::::..::  ::.... 
NP_058 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
     120       130        140       150       160       170        

      180       190        200       210       220       230       
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
       :.: ::: :  .: .  .  . ::.: :.:..:.::.::: ::::....  :  :     
NP_058 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
      180        190       200       210       220       230       

        240       250       260       270       280       290      
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
       ..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
NP_058 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
       240       250       260       270       280       290       

        300       310       320       330       340       350      
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
       . .::::::::::.    :::.:.. ::: .  :.::: .:: :.:.:::: ::::::.:
NP_058 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
       300       310       320       330       340       350       

        360       370       380       390       400       410      
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
       ::::::.::::. ::: .:...:  . : ::::.::      :: . : ..   . :   
NP_058 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
       360       370       380       390       400       410       

        420       430       440    
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW  
             . .::::: :: .         
NP_058 ------IEDDDEDEGDDDDGGDDHDVYI
                420       430      

>>XP_016863747 (OMIM: 607989) PREDICTED: testican-3 isof  (433 aa)
 initn: 1581 init1: 1008 opt: 1646  Z-score: 1575.8  bits: 300.7 E(85289): 4.9e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:6-424)

                10        20        30        40        50         
pF1KB7  MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
            ::: . :::::  .. .    : ::: . . :::::. :::.:.::::..   ::
XP_016 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
               10        20        30         40        50         

       60        70        80        90       100       110        
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
       .:::   :::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:  
XP_016 KFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
      60           70        80        90       100       110      

      120       130       140       150       160       170        
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
       :.:...: ...: ::  :  :: :::.  . :::::::.:. .::::..::  ::.... 
XP_016 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
        120       130        140       150       160       170     

      180       190        200       210       220       230       
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
       :.: ::: :  .: .  .  . ::.: :.:..:.::.::: ::::....  :  :     
XP_016 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
         180        190       200       210       220       230    

        240       250       260       270       280       290      
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
       ..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
XP_016 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
          240       250       260       270       280       290    

        300       310       320       330       340       350      
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
       . .::::::::::.    :::.:.. ::: .  :.::: .:: :.:.:::: ::::::.:
XP_016 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
          300       310       320       330       340       350    

        360       370       380       390       400       410      
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
       ::::::.::::. ::: .:...:  . : ::::.::      :: . : ..   . :   
XP_016 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
          360       370       380       390       400       410    

        420       430       440    
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW  
             . .::::: :: .         
XP_016 ------IEDDDEDEGDDDDGGDDHDVYI
                   420       430   

>>NP_001035249 (OMIM: 607989) testican-3 isoform 1 precu  (433 aa)
 initn: 1581 init1: 1008 opt: 1646  Z-score: 1575.8  bits: 300.7 E(85289): 4.9e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:6-424)

                10        20        30        40        50         
pF1KB7  MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
            ::: . :::::  .. .    : ::: . . :::::. :::.:.::::..   ::
NP_001 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
               10        20        30         40        50         

       60        70        80        90       100       110        
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
       .:::   :::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:  
NP_001 KFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
      60           70        80        90       100       110      

      120       130       140       150       160       170        
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
       :.:...: ...: ::  :  :: :::.  . :::::::.:. .::::..::  ::.... 
NP_001 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
        120       130        140       150       160       170     

      180       190        200       210       220       230       
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
       :.: ::: :  .: .  .  . ::.: :.:..:.::.::: ::::....  :  :     
NP_001 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
         180        190       200       210       220       230    

        240       250       260       270       280       290      
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
       ..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
NP_001 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
          240       250       260       270       280       290    

        300       310       320       330       340       350      
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
       . .::::::::::.    :::.:.. ::: .  :.::: .:: :.:.:::: ::::::.:
NP_001 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
          300       310       320       330       340       350    

        360       370       380       390       400       410      
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
       ::::::.::::. ::: .:...:  . : ::::.::      :: . : ..   . :   
NP_001 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
          360       370       380       390       400       410    

        420       430       440    
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW  
             . .::::: :: .         
NP_001 ------IEDDDEDEGDDDDGGDDHDVYI
                   420       430   

>>XP_016863746 (OMIM: 607989) PREDICTED: testican-3 isof  (445 aa)
 initn: 1581 init1: 1008 opt: 1646  Z-score: 1575.6  bits: 300.7 E(85289): 5e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:18-436)

                            10        20        30        40       
pF1KB7              MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLST
                        ::: . :::::  .. .    : ::: . . :::::. :::.:
XP_016 MPPHPPLCLLSQMLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTT
               10        20        30        40         50         

        50         60        70        80        90       100      
pF1KB7 VSQYDRD-KYWNRFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQ
       .::::..   ::.:::   :::::.:.:.:::::::::.::::::.::: ::::..:: :
XP_016 ISQYDKEVGQWNKFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQ
      60        70           80        90       100       110      

        110       120       130       140       150       160      
pF1KB7 TALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEF
       ::.:.:...:  :.:...: ...: ::  :  :: :::.  . :::::::.:. .::::.
XP_016 TAVCISHRRLTHRMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEY
        120       130       140        150       160       170     

        170       180       190        200       210       220     
pF1KB7 HACSTGKSLATLCDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDAN
       .::  ::.... :.: ::: :  .: .  .  . ::.: :.:..:.::.::: ::::...
XP_016 QACVLGKQISVKCEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGS
         180       190        200       210       220       230    

         230        240       250       260       270       280    
pF1KB7 RVIKP-TSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCI
       .  :  :     ..:::::::::::::::::::.:: ::::::: ::. .::::: : : 
XP_016 QNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCT
          240       250       260       270       280       290    

          290       300       310       320       330       340    
pF1KB7 KPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEG
       : .:::::..::. .::::::::::.    :::.:.. ::: .  :.::: .:: :.:.:
XP_016 KAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
          300       310       320       330       340       350    

          350       360       370       380       390       400    
pF1KB7 YYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYE
       ::: ::::::.:::::::.::::. ::: .:...:  . : ::::.::      :: . :
XP_016 YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDE
          360       370       380       390       400       410    

          410       420       430       440    
pF1KB7 RELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW  
        ..   . :         . .::::: :: .         
XP_016 DDIMNDEDE---------IEDDDEDEGDDDDGGDDHDVYI
          420                430       440     

>>NP_001191281 (OMIM: 607989) testican-3 isoform 3 [Homo  (385 aa)
 initn: 1401 init1: 1003 opt: 1471  Z-score: 1409.8  bits: 269.8 E(85289): 8.7e-72
Smith-Waterman score: 1479; 54.4% identity (76.1% similar) in 373 aa overlap (65-435:15-376)

           40        50        60        70        80        90    
pF1KB7 HGNFLDNDQWLSTVSQYDRDKYWNRFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKC
                                     .:::::.:.:.:::::::::.::::::.::
NP_001                 MITQDHIHMSSGLSQDDYFRTWSPGKPFDQALDPAKDPCLKMKC
                               10        20        30        40    

          100       110       120       130       140       150    
pF1KB7 SPHKVCVTQDYQTALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSD
       : ::::..:: :::.:.:...:  :.:...: ...: ::  :  :: :::.  . :::::
NP_001 SRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSD
           50        60        70        80         90       100   

          160       170       180       190        200       210   
pF1KB7 GHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRL
       ::.:. .::::..::  ::.... :.: ::: :  .: .  .  . ::.: :.:..:.::
NP_001 GHTYSFQCKLEYQACVLGKQISVKCEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRL
           110       120       130        140       150       160  

           220       230        240       250       260       270  
pF1KB7 KDWFGALHEDANRVIKP-TSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEI
       .::: ::::....  :  :     ..:::::::::::::::::::.:: ::::::: ::.
NP_001 RDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSEL
            170       180       190       200       210       220  

            280       290       300       310       320       330  
pF1KB7 NAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSL
        .::::: : : : .:::::..::. .::::::::::.    :::.:.. ::: .  :.:
NP_001 RSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKL
            230       240       250       260       270       280  

            340       350       360       370       380       390  
pF1KB7 LGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSG
       :: .:: :.:.:::: ::::::.:::::::.::::. ::: .:...:  . : ::::.::
NP_001 LGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASG
            290       300       310       320       330       340  

            400       410       420       430       440    
pF1KB7 GSVVLLDDLEYERELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW  
             :: . : ..   . :         . .::::: :: .         
NP_001 DFHEWTDDEDDEDDIMNDEDE---------IEDDDEDEGDDDDGGDDHDVYI
            350       360                370       380     

>>NP_055582 (OMIM: 607988) testican-2 isoform 2 precurso  (424 aa)
 initn: 868 init1: 427 opt: 1350  Z-score: 1294.0  bits: 248.5 E(85289): 2.4e-65
Smith-Waterman score: 1366; 47.3% identity (71.1% similar) in 425 aa overlap (25-442:25-424)

               10        20        30        40        50          
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
                               :: .   : . :::....::::..:::. . :.:::
NP_055 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
       :::::::::...:. :.  :.::: .:::: ::::: ::::..: :: :.:.:::.:  :
NP_055 FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
        :. .: . :  : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
NP_055 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
                 130        140       150       160       170      

     180       190         200       210       220       230       
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
       .::::: :  .     :. .  .:: ..: .:..::.:::  :::....  . .:     
NP_055 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
        180        190       200       210       220       230     

       240       250       260       270       280       290       
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
       . .: :.   ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
NP_055 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
         240       250       260       270       280       290     

       300         310       320       330       340       350     
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
       ..:. :::.::  .::   ::  :..:::    .:.  : ::: :.:.:::.  ::  :.
NP_055 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
         300       310          320       330       340       350  

         360       370       380       390       400       410     
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
       :.:::::. : ::.:.: .:. .:..    :::::::              .: .:.: :
NP_055 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
            360       370       380                     390        

         420       430         440  
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
          .:. . :. :.:. .  . :. ::::
NP_055 ---ETEEAGEEAEEEEGEAGEADDGGYIW
         400       410       420    

>>NP_001231879 (OMIM: 607988) testican-2 isoform 2 precu  (424 aa)
 initn: 868 init1: 427 opt: 1350  Z-score: 1294.0  bits: 248.5 E(85289): 2.4e-65
Smith-Waterman score: 1366; 47.3% identity (71.1% similar) in 425 aa overlap (25-442:25-424)

               10        20        30        40        50          
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
                               :: .   : . :::....::::..:::. . :.:::
NP_001 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
       :::::::::...:. :.  :.::: .:::: ::::: ::::..: :: :.:.:::.:  :
NP_001 FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
        :. .: . :  : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
NP_001 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
                 130        140       150       160       170      

     180       190         200       210       220       230       
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
       .::::: :  .     :. .  .:: ..: .:..::.:::  :::....  . .:     
NP_001 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
        180        190       200       210       220       230     

       240       250       260       270       280       290       
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
       . .: :.   ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
NP_001 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
         240       250       260       270       280       290     

       300         310       320       330       340       350     
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
       ..:. :::.::  .::   ::  :..:::    .:.  : ::: :.:.:::.  ::  :.
NP_001 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
         300       310          320       330       340       350  

         360       370       380       390       400       410     
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
       :.:::::. : ::.:.: .:. .:..    :::::::              .: .:.: :
NP_001 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
            360       370       380                     390        

         420       430         440  
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
          .:. . :. :.:. .  . :. ::::
NP_001 ---ETEEAGEEAEEEEGEAGEADDGGYIW
         400       410       420    

>>XP_011538706 (OMIM: 607988) PREDICTED: testican-2 isof  (421 aa)
 initn: 793 init1: 427 opt: 1317  Z-score: 1262.7  bits: 242.7 E(85289): 1.4e-63
Smith-Waterman score: 1333; 46.6% identity (70.4% similar) in 425 aa overlap (25-442:25-421)

               10        20        30        40        50          
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
                               :: .   : . :::....::::..:::. . :.:::
XP_011 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
       :::   :::...:. :.  :.::: .:::: ::::: ::::..: :: :.:.:::.:  :
XP_011 FRD---DDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
                  70        80        90       100       110       

     120       130       140       150       160       170         
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
        :. .: . :  : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
XP_011 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
       120          130        140       150       160       170   

     180       190         200       210       220       230       
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
       .::::: :  .     :. .  .:: ..: .:..::.:::  :::....  . .:     
XP_011 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
            180       190       200       210       220       230  

       240       250       260       270       280       290       
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
       . .: :.   ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
XP_011 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
            240       250       260       270       280       290  

       300         310       320       330       340       350     
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
       ..:. :::.::  .::   ::  :..:::    .:.  : ::: :.:.:::.  ::  :.
XP_011 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
            300          310       320       330       340         

         360       370       380       390       400       410     
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
       :.:::::. : ::.:.: .:. .:..    :::::::              .: .:.: :
XP_011 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
     350       360       370       380                     390     

         420       430         440  
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
          .:. . :. :.:. .  . :. ::::
XP_011 ---ETEEAGEEAEEEEGEAGEADDGGYIW
            400       410       420 




442 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 06:32:26 2016 done: Fri Nov  4 06:32:27 2016
 Total Scan time:  8.970 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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