Result of FASTA (omim) for
pF1KB7223
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7223, 505 aa
1>>>pF1KB7223 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4925+/-0.000443; mu= 16.8105+/- 0.027
mean_var=73.1421+/-14.646, 0's: 0 Z-trim(111.0): 53 B-trim: 39 in 1/49
Lambda= 0.149965
statistics sampled from 19378 (19431) to 19378 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.228), width: 16
Scan time: 8.960
The best scores are: opt bits E(85289)
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 3416 749.0 7.6e-216
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 1843 408.6 2e-113
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 791 181.0 7e-45
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 753 172.8 2.3e-42
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 675 156.0 3.1e-37
NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 643 149.0 3.1e-35
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 635 147.3 1e-34
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 613 142.5 3e-33
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 578 135.0 5.6e-31
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 570 133.2 1.9e-30
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 542 127.2 1.3e-28
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 457 108.7 2.7e-23
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 440 105.1 5.3e-22
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 440 105.1 5.4e-22
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 440 105.1 5.4e-22
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 304 75.7 4.4e-13
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 304 75.7 4.4e-13
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 304 75.7 4.5e-13
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 304 75.7 4.5e-13
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 299 74.7 9.7e-13
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 299 74.7 1e-12
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 299 74.7 1e-12
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 288 72.3 4.8e-12
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 287 72.1 5.7e-12
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 269 68.2 8.5e-11
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 259 66.0 3.8e-10
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 259 66.0 3.8e-10
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 259 66.0 4e-10
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 259 66.0 4.1e-10
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 259 66.0 4.2e-10
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 259 66.0 4.2e-10
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 259 66.0 4.3e-10
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 259 66.0 4.3e-10
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 259 66.0 4.3e-10
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 259 66.0 4.4e-10
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 259 66.0 4.5e-10
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 259 66.0 4.5e-10
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 259 66.0 4.6e-10
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 259 66.1 4.6e-10
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 259 66.1 4.6e-10
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 259 66.1 4.7e-10
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 259 66.1 4.8e-10
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 259 66.1 4.8e-10
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 259 66.1 5e-10
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 259 66.1 5e-10
>>NP_059115 (OMIM: 616693) acid-sensing ion channel 5 [H (505 aa)
initn: 3416 init1: 3416 opt: 3416 Z-score: 3996.1 bits: 749.0 E(85289): 7.6e-216
Smith-Waterman score: 3416; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KB7 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
430 440 450 460 470 480
490 500
pF1KB7 KISEMTQWTPPPQNHLGNKNRIEEC
:::::::::::::::::::::::::
NP_059 KISEMTQWTPPPQNHLGNKNRIEEC
490 500
>>XP_016863780 (OMIM: 616693) PREDICTED: acid-sensing io (463 aa)
initn: 1843 init1: 1843 opt: 1843 Z-score: 2157.4 bits: 408.6 E(85289): 2e-113
Smith-Waterman score: 3041; 91.7% identity (91.7% similar) in 505 aa overlap (1-505:1-463)
10 20 30 40 50 60
pF1KB7 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
::::::::::::::: :::
XP_016 TLLDCEFFGKPCSPK------------------------------------------EAF
190
250 260 270 280 290 300
pF1KB7 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB7 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB7 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB7 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
380 390 400 410 420 430
490 500
pF1KB7 KISEMTQWTPPPQNHLGNKNRIEEC
:::::::::::::::::::::::::
XP_016 KISEMTQWTPPPQNHLGNKNRIEEC
440 450 460
>>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is (512 aa)
initn: 639 init1: 264 opt: 791 Z-score: 926.7 bits: 181.0 E(85289): 7e-45
Smith-Waterman score: 791; 32.1% identity (63.9% similar) in 446 aa overlap (41-468:20-455)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
:: ....::: : .: . :::::: :.
NP_001 MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAF
10 20 30 40
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLN-----RFQTDAVAK
.::..:. . :. ::.. .:... .... :::::.:::: :. :. . .
NP_001 VGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYH
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB7 FGVIFFLWHIVSKVL--HLQEITANSTGSREATDFAASH-QNFSIVEFIRNKGFYLNNST
: .. : . .. :: . .. . :. ..: . ..::..::.. : :..
NP_001 AGELLALLDVNLQIPDPHLADPSV-LEALRQKANFKHYKPKQFSMLEFLHRVGHDLKD-M
110 120 130 140 150 160
190 200 210 220 230
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGET---LQAKRKVSVSGRGLSLLFNVNQE
.: :.: :. :. .::. :::.::.:. :: :: : . : . .: :: ......:.
NP_001 MLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGG-TGNGLEIMLDIQQD
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 AFTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEY
. : : .. ::. ::: .. : .. ::. :... :. .. . ..
NP_001 EYL--PIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB7 PWGEC-NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVS
::::: . .. :. : :: ..: .:....: ..:.: .:: . : ... :.
NP_001 PWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB7 PVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIR
:.: . :: .. : . :. .: .:. ..::. . ::: ::.:.:.:::
NP_001 PALGLLAEKD-----SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS
350 360 370 380 390
420 430 440 450 460 470
pF1KB7 ENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFY
::.. ..: . :::. .:.:: :. ::.:.:::.::: :::..::.:...:..
NP_001 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK
400 410 420 430 440 450
480 490 500
pF1KB7 WICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
NP_001 EKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
460 470 480 490 500 510
>>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1 (562 aa)
initn: 683 init1: 250 opt: 753 Z-score: 881.7 bits: 172.8 E(85289): 2.3e-42
Smith-Waterman score: 753; 30.3% identity (62.4% similar) in 439 aa overlap (41-468:67-492)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNI-VQNRSKIRRVLWLVVV
:: : ..:: ..: :.. :.::: :.
NP_001 SESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAF
40 50 60 70 80 90
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
. ... :. :. :...: .: .. . .. :::::.:: : . . .. ...
NP_001 VLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLY
100 110 120 130 140 150
130 140 150 160 170 180
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFG
. . .: :.: .. : : . :.. .: :.. . .. :: : . :
NP_001 L-----APMLGLDESDDPGVPLAPPGPEAFSGEPFNLHRFY-NRSCHRLEDMLLYCSYQG
160 170 180 190 200 210
190 200 210 220 230 240
pF1KB7 KPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALG
::.:..:. :::.::.:.::: :. . . :. . .: :: ......:. . :. :
NP_001 GPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWG
220 230 240 250 260
250 260 270 280 290 300
pF1KB7 FVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP--
.: ::: ::: . : .: ::. :... :. .. . .. ::: :.
NP_001 ETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVT
270 280 290 300 310 320
310 320 330 340 350
pF1KB7 -NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIE
. :. :.::: ..: .:..... ..:.: .:: . : ..: :..:.:: .
NP_001 MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLV
330 340 350 360 370 380
360 370 380 390 400 410
pF1KB7 FKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIE
:: . : . :. .: .:. ..::. . :::.::.:.:..:: ::.. ..
NP_001 EKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLD
390 400 410 420 430 440
420 430 440 450 460 470
pF1KB7 INYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFL
: . :::. .:.:: .. ::.:.:::.::: :::..:..:...: .
NP_001 IFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRG
450 460 470 480 490 500
480 490 500
pF1KB7 LKISEMTQWTPPPQNHLGNKNRIEEC
NP_001 KCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
510 520 530 540 550 560
>>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is (666 aa)
initn: 492 init1: 276 opt: 675 Z-score: 789.4 bits: 156.0 E(85289): 3.1e-37
Smith-Waterman score: 675; 28.5% identity (60.9% similar) in 442 aa overlap (41-468:172-593)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIV-QNRSKIRRVLWLVVV
:: ....::. . .::.:: ...
NP_061 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL
150 160 170 180 190 200
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKME-FPAVTFCNLNRFQTDAVAKFGVI
: :.. .: .:.: : .... . :::::.::.:::. .:..
NP_061 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSD----
210 220 230 240 250
130 140 150 160 170 180
pF1KB7 FFLWHIVSKVLHLQEITANSTGSREATDFAA-SHQNFSIVEFIRNKGFYLNNSTLLDCEF
. ..:: ..:. .:.. :. . . ..:... : : . : .:.:
NP_061 -------ADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLAD-MLKSCNF
260 270 280 290 300
190 200 210 220 230 240
pF1KB7 FGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFT----DN
:. :: ..:. :.:.::.:.::: . ... : :: ......:: . ..
NP_061 SGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRET
310 320 330 340 350 360
250 260 270 280 290 300
pF1KB7 PALGFVDAGIIFVIHSPKKVPQFDGLGL-LSPVGMHARVTIRQVKTVHQEYPWGECNPNI
.: .::: ::: .. : . ::. .:: :... :. .. . .. :::.: .
NP_061 NETSF-EAGIRVQIHSQEEPPYIHQLGFGVSP-GFQTFVSCQEQRLTYLPQPWGNCRAES
370 380 390 400 410 420
310 320 330 340 350
pF1KB7 KL-----QNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH
.: :..:.::.:.: .:. . . ..: : .:: : . :. :.. .::
NP_061 ELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDS
430 440 450 460 470 480
360 370 380 390 400 410
pF1KB7 IEFKDLCTVGTHNSS-CPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLV
. : .. ::. :. .: ::. .:.. . .::..: :... :::::..
NP_061 L------GGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFL
490 500 510 520 530 540
420 430 440 450 460 470
pF1KB7 KIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICI
... . :. . .:. : ..: ::.:::::.::: :::..:..::..:..
NP_061 VLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLK
550 560 570 580 590 600
480 490 500
pF1KB7 FFLLKISEMTQWTPPPQNHLGNKNRIEEC
NP_061 RVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSRGRVEGGGVSSLLPNHHHPHGPPGGLF
610 620 630 640 650 660
>>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is (528 aa)
initn: 723 init1: 250 opt: 643 Z-score: 753.5 bits: 149.0 E(85289): 3.1e-35
Smith-Waterman score: 781; 30.6% identity (63.3% similar) in 447 aa overlap (41-468:21-458)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
:: :...::. : . .: ...:.:: .
NP_001 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
:::.... :. :: . .:... . .. :::::.::::.:. . :.: . ..
NP_001 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
60 70 80 90 100
130 140 150 160 170 180
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
.... . . :: .. .... .. .. :: .. :: : . .
NP_001 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
110 120 130 140 150 160
190 200 210 220 230
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEA
::.:.: :. :: .:: :::.::.:.::: :. . . :. . .: :: ......:.
NP_001 LLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 FTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYP
. :. : .: ::: ::: . : .: ::. :... :. .. . .. :
NP_001 YL--PVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB7 WGECNP---NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCV
:: :. . :. :.::: ..: .:..... ..:.: .:: . : ..: :.
NP_001 WGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB7 SPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYI
.:.:: . :: . : . :. .: .:. ..::. . :::.::.:.:..::
NP_001 DPALDFLVEKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYI
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB7 RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNF
::.. ..: . :::. .:.:: .. ::.:.:::.::: :::..:..:...: .
NP_001 GENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVI
410 420 430 440 450 460
480 490 500
pF1KB7 YWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
NP_001 KHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARG
470 480 490 500 510 520
>>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io (529 aa)
initn: 724 init1: 250 opt: 635 Z-score: 744.1 bits: 147.3 E(85289): 1e-34
Smith-Waterman score: 773; 30.8% identity (63.2% similar) in 448 aa overlap (41-468:21-459)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
:: :...::. : . .: ...:.:: .
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
:::.... :. :: . .:... . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
60 70 80 90 100
130 140 150 160 170 180
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
.... . . :: .. .... .. .. :: .. :: : . .
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
110 120 130 140 150 160
190 200 210 220 230
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEA
::.:.: :. :: .:: :::.::.:.::: :. . . :. . .: :: ......:.
XP_011 LLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 FTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIR-QVKTVHQEY
. :. : .: ::: ::: . : .: ::. :... :. . : . ..
XP_011 YL--PVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB7 PWGECNP---NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSC
::: :. . :. :.::: ..: .:..... ..:.: .:: . : ..: :
XP_011 PWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKEC
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB7 VSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKY
..:.:: . :: . : . :. .: .:. ..::. . :::.::.:.:..:
XP_011 ADPALDFLVEKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQY
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB7 IRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTN
: ::.. ..: . :::. .:.:: .. ::.:.:::.::: :::..:..:...: .
XP_011 IGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEV
410 420 430 440 450 460
480 490 500
pF1KB7 FYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
XP_011 IKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPAR
470 480 490 500 510 520
>>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is (563 aa)
initn: 611 init1: 264 opt: 613 Z-score: 718.0 bits: 142.5 E(85289): 3e-33
Smith-Waterman score: 714; 30.0% identity (61.0% similar) in 454 aa overlap (47-468:66-506)
20 30 40 50 60 70
pF1KB7 EKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI-----RRVLWLVVVLG
.::.... .:. ::.::...
NP_899 GQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCT
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB7 SVSLV-TWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFF
: .:. .:. ::: ....:. : .. .. ... ::::: :: : .. ..: : ...
NP_899 SFGLLLSWSSN-RLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSK-GDLYY
100 110 120 130 140 150
140 150 160 170
pF1KB7 LWH-------------IVSKVLHLQEITANSTGSREATDF----AASHQNFSIVEFIRNK
: .::..:. .: :. .:: : . . :.
NP_899 AGHWLGLLLPNRTARPLVSELLRGDE--PRRQWFRKLADFRLFLPPRHFEGISAAFMDRL
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB7 GFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGET---LQAKRKVSVSGRGLS
: :.. ::.:.. :. :.:..:. :::.::.:. :: :: : . : . .: ::
NP_899 GHQLED-MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGG-TGNGLE
220 230 240 250 260
240 250 260 270 280
pF1KB7 LLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQ
......:. . : : .. ::. ::: .. : .. ::. :... :. ..
NP_899 IMLDIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQE
270 280 290 300 310 320
290 300 310 320 330 340
pF1KB7 VKTVHQEYPWGEC-NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDL
. .. ::::: . .. :. : :: ..: .:....: ..:.: .:: . :
NP_899 QRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTP
330 340 350 360 370 380
350 360 370 380 390 400
pF1KB7 QKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL
... :. :.: . :: .. : . :. .: .:. ..::. . ::: ::.
NP_899 EQHKECAEPALGLLAEKD-----SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKF
390 400 410 420 430 440
410 420 430 440 450 460
pF1KB7 NQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEII
:.:.::: ::.. ..: . :::. .:.:: :. ::.:.:::.::: :::..::.:..
NP_899 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF
450 460 470 480 490 500
470 480 490 500
pF1KB7 EYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
.:..
NP_899 DYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIA
510 520 530 540 550 560
>>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io (559 aa)
initn: 721 init1: 250 opt: 578 Z-score: 677.1 bits: 135.0 E(85289): 5.6e-31
Smith-Waterman score: 714; 28.7% identity (59.4% similar) in 478 aa overlap (41-468:21-489)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
:: :...::. : . .: ...:.:: .
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
:::.... :. :: . .:... . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
60 70 80 90 100
130 140 150 160 170 180
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
.... . . :: .. .... .. .. :: .. :: : . .
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
110 120 130 140 150 160
190 200 210
pF1KB7 LLDCEFFGKPCSPKDFA-------------------------------HVFTEYGNCFTF
::.:.: :. :: .:: .:::.::.:.::
XP_011 LLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTF
170 180 190 200 210 220
220 230 240 250 260
pF1KB7 NHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV
: :. . . :. . .: :: ......:. . :. : .: ::: ::: .
XP_011 NSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEP
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB7 PQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKECK
: .: ::. :... :. .. . .. ::: :. . :. :.::: ..: .:.
XP_011 PFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCE
290 300 310 320 330 340
330 340 350 360 370 380
pF1KB7 AQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEI
.... ..:.: .:: . : ..: :..:.:: . :: . : . :.
XP_011 TRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNLT
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB7 EYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSE
.: .:. ..::. . :::.::.:.:..:: ::.. ..: . :::. .:.:: ..
XP_011 RYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAG
410 420 430 440 450 460
450 460 470 480 490 500
pF1KB7 LLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKN
::.:.:::.::: :::..:..:...: .
XP_011 LLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDD
470 480 490 500 510 520
>>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io (560 aa)
initn: 706 init1: 250 opt: 570 Z-score: 667.7 bits: 133.2 E(85289): 1.9e-30
Smith-Waterman score: 706; 28.8% identity (59.3% similar) in 479 aa overlap (41-468:21-490)
20 30 40 50 60
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
:: :...::. : . .: ...:.:: .
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
:::.... :. :: . .:... . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
60 70 80 90 100
130 140 150 160 170 180
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
.... . . :: .. .... .. .. :: .. :: : . .
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
110 120 130 140 150 160
190 200 210
pF1KB7 LLDCEFFGKPCSPKDFA-------------------------------HVFTEYGNCFTF
::.:.: :. :: .:: .:::.::.:.::
XP_011 LLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTF
170 180 190 200 210 220
220 230 240 250 260
pF1KB7 NHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV
: :. . . :. . .: :: ......:. . :. : .: ::: ::: .
XP_011 NSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEP
230 240 250 260 270 280
270 280 290 300 310
pF1KB7 PQFDGLGLLSPVGMHARVTIR-QVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKEC
: .: ::. :... :. . : . .. ::: :. . :. :.::: ..: .:
XP_011 PFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDC
290 300 310 320 330 340
320 330 340 350 360 370
pF1KB7 KAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEE
..... ..:.: .:: . : ..: :..:.:: . :: . : . :.
XP_011 ETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNL
350 360 370 380 390 400
380 390 400 410 420 430
pF1KB7 IEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVS
.: .:. ..::. . :::.::.:.:..:: ::.. ..: . :::. .:.:: ..
XP_011 TRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIA
410 420 430 440 450 460
440 450 460 470 480 490
pF1KB7 ELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNK
::.:.:::.::: :::..:..:...: .
XP_011 GLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLD
470 480 490 500 510 520
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 09:43:09 2016 done: Sat Nov 5 09:43:11 2016
Total Scan time: 8.960 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]