Result of FASTA (omim) for
pF1KB7178
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7178, 426 aa
1>>>pF1KB7178 426 - 426 aa - 426 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1087+/-0.000619; mu= 7.1534+/- 0.037
mean_var=193.6395+/-42.006, 0's: 0 Z-trim(110.9): 438 B-trim: 192 in 1/50
Lambda= 0.092167
statistics sampled from 18760 (19306) to 18760 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.226), width: 16
Scan time: 7.990
The best scores are: opt bits E(85289)
NP_057200 (OMIM: 605761) ankyrin repeat and SOCS b ( 426) 2925 402.7 9.2e-112
XP_016867792 (OMIM: 605761) PREDICTED: ankyrin rep ( 368) 2486 344.3 3.1e-94
NP_665879 (OMIM: 605761) ankyrin repeat and SOCS b ( 349) 2218 308.6 1.6e-83
NP_543147 (OMIM: 603383,615054) ankyrin repeat and ( 452) 741 112.3 2.5e-24
NP_001135931 (OMIM: 603383,615054) ankyrin repeat ( 467) 726 110.4 1e-23
NP_543139 (OMIM: 615056) ankyrin repeat and SOCS b ( 453) 564 88.8 3.1e-17
NP_001135932 (OMIM: 603383,615054) ankyrin repeat ( 429) 496 79.7 1.6e-14
NP_001306226 (OMIM: 615053) ankyrin repeat and SOC ( 288) 249 46.7 9.2e-05
NP_001306225 (OMIM: 615053) ankyrin repeat and SOC ( 288) 249 46.7 9.2e-05
NP_077000 (OMIM: 615053) ankyrin repeat and SOCS b ( 288) 249 46.7 9.2e-05
XP_016884774 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 245 46.2 0.00015
XP_016884775 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 245 46.2 0.00015
XP_016884772 (OMIM: 300890) PREDICTED: ankyrin rep ( 377) 245 46.3 0.00016
NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 232 44.4 0.00042
NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 232 44.4 0.00042
NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 232 44.4 0.00045
XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 232 44.4 0.00045
XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689) 242 46.6 0.00056
XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 242 46.7 0.00058
NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 232 45.3 0.0014
XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 232 45.3 0.0014
XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 232 45.3 0.0014
XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 232 45.3 0.0014
XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 232 45.3 0.0015
XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 232 45.3 0.0015
XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 232 45.3 0.0015
NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 232 45.4 0.0015
NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 232 45.4 0.0015
NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 232 45.4 0.0015
XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 232 45.4 0.0015
XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 232 45.4 0.0015
NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 232 45.4 0.0015
XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 232 45.4 0.0015
XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 232 45.4 0.0015
XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 232 45.4 0.0015
XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 232 45.4 0.0015
XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 232 45.4 0.0015
XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 232 45.4 0.0015
XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 232 45.4 0.0015
XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 232 45.4 0.0015
NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835) 226 44.2 0.0015
XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 232 45.4 0.0015
XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 232 45.4 0.0015
XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 232 45.4 0.0016
XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 232 45.4 0.0016
XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 232 45.4 0.0016
XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 232 45.4 0.0016
XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 232 45.4 0.0016
XP_016872878 (OMIM: 603290,613436) PREDICTED: SH3 (1840) 229 44.9 0.002
XP_016872876 (OMIM: 603290,613436) PREDICTED: SH3 (1849) 229 45.0 0.002
>>NP_057200 (OMIM: 605761) ankyrin repeat and SOCS box p (426 aa)
initn: 2925 init1: 2925 opt: 2925 Z-score: 2127.5 bits: 402.7 E(85289): 9.2e-112
Smith-Waterman score: 2925; 100.0% identity (100.0% similar) in 426 aa overlap (1-426:1-426)
10 20 30 40 50 60
pF1KB7 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE
370 380 390 400 410 420
pF1KB7 PEGIIY
::::::
NP_057 PEGIIY
>>XP_016867792 (OMIM: 605761) PREDICTED: ankyrin repeat (368 aa)
initn: 2486 init1: 2486 opt: 2486 Z-score: 1812.8 bits: 344.3 E(85289): 3.1e-94
Smith-Waterman score: 2486; 100.0% identity (100.0% similar) in 364 aa overlap (1-364:1-364)
10 20 30 40 50 60
pF1KB7 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE
::::
XP_016 DDLEGIRK
>>NP_665879 (OMIM: 605761) ankyrin repeat and SOCS box p (349 aa)
initn: 2216 init1: 2216 opt: 2218 Z-score: 1620.4 bits: 308.6 E(85289): 1.6e-83
Smith-Waterman score: 2218; 98.2% identity (98.5% similar) in 335 aa overlap (1-335:1-331)
10 20 30 40 50 60
pF1KB7 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
::::::::::::::::::::::::::: . ::
NP_665 AAQPEICYQLLLNHGAARIYPPQFHKV----RLCPVVSRLRKIQMAALSEISK
310 320 330 340
370 380 390 400 410 420
pF1KB7 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE
>>NP_543147 (OMIM: 603383,615054) ankyrin repeat and SOC (452 aa)
initn: 624 init1: 265 opt: 741 Z-score: 557.7 bits: 112.3 E(85289): 2.5e-24
Smith-Waterman score: 741; 33.6% identity (64.2% similar) in 405 aa overlap (24-426:53-452)
10 20 30 40 50
pF1KB7 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE
:: ..:...:. .. .. .: ..: .
NP_543 ACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPHST-ADLLLESRAA
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB7 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV
. .:...: : .:. . . : ::... ::.: : .:: . : . :.:.: ::
NP_543 EPRWSSHQRGLWSLTYEEELT--TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHE
90 100 110 120 130
120 130 140 150 160 170
pF1KB7 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ
:: ... ::..: :: : . .:. ::.: :... ::. :. :: :. ... .
NP_543 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSE-E
140 150 160 170 180 190
180 190 200 210 220 230
pF1KB7 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHH
.::::::.::..: ::. . ...:: :. ::. ::: : . . : .: .
NP_543 EEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB7 L-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQY
: .: .::. :...: :.: . ::: : ......: :. :: :: .: . ..
NP_543 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB7 VLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWN
.:. .. : .:: . ::::::.:..: . ::.. .::..:::..:.: ..
NP_543 ALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLP
320 330 340 350 360 370
360 370 380 390 400 410
pF1KB7 TKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPL
. . . :.:. :: :::.. .::.:.::::::.: :.. .:.: : ::
NP_543 EEAVGLVTPETLQKHQRFYSSLFALV-RQPRSLQHLSRCALRSHLEGSLPQALPRLPLPP
380 390 400 410 420 430
420
pF1KB7 SLKKYLLLEPEGIIY
: .:: :. ::..:
NP_543 RLLRYLQLDFEGVLY
440 450
>>NP_001135931 (OMIM: 603383,615054) ankyrin repeat and (467 aa)
initn: 624 init1: 265 opt: 726 Z-score: 546.8 bits: 110.4 E(85289): 1e-23
Smith-Waterman score: 731; 33.1% identity (61.8% similar) in 432 aa overlap (10-426:40-467)
10 20 30
pF1KB7 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK
::: . .: :. : .:. ..: :
NP_001 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC
10 20 30 40 50 60
40 50 60 70 80
pF1KB7 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG
.. :: . . . :.::.. : ... . : .:. . . : ::... :
NP_001 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB7 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF
:.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::.
NP_001 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB7 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA
: :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. ::
NP_001 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB7 HMETPLAIAA-YWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD
. ::: : . . : .: . : .: .::. :...: :.: . ::: :
NP_001 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB7 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: .
NP_001 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB7 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTL
::.. .::..:::..:.: .. . . . :.:. :: :::.. .::.:
NP_001 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALV-RQPRSL
370 380 390 400 410 420
390 400 410 420
pF1KB7 MHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY
.::::::.: :.. .:.: : :: : .:: :. ::..:
NP_001 QHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
430 440 450 460
>>NP_543139 (OMIM: 615056) ankyrin repeat and SOCS box p (453 aa)
initn: 599 init1: 221 opt: 564 Z-score: 430.5 bits: 88.8 E(85289): 3.1e-17
Smith-Waterman score: 689; 33.8% identity (62.7% similar) in 405 aa overlap (23-425:63-452)
10 20 30 40 50
pF1KB7 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVED
.:: :... ...: :.: . .. . :. .
NP_543 AQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQA-LFQDEEAANMIVETVS
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB7 ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLH
:.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. ::
NP_543 -NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALH
100 110 120 130 140
120 130 140 150 160 170
pF1KB7 VACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNN
:: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. ..
NP_543 EACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-
150 160 170 180 190 200
180 190 200 210 220 230
pF1KB7 QDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTE-H
...:::::.:: :: . ::.:.:::: : ... :: : : : : : . :
NP_543 ESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA----EGPGSCRRH
210 220 230 240 250 260
240 250 260 270 280 290
pF1KB7 HLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQY
. . : ::. :.. : ..:::.: : : ...:. ::.:.. . : . ..
NP_543 QAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDC
270 280 290 300 310 320
300 310 320 330 340 350
pF1KB7 VLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWN
.:.... : .::. . ::..:: . : .... : . :.:.::..::: .
NP_543 ALQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFPRALEVLLNAYPCVPSC
330 340 350 360 370
360 370 380 390 400 410
pF1KB7 TKWRRAIPDDDLEKYWDFYHSLFTVC-CNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLP
: .:. . ... :: : ..: :.:: :.::.: :.: : .::... : ::
NP_543 ETWVEAVLPELWKEHEAFYSS--ALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLP
380 390 400 410 420 430
420
pF1KB7 LSLKKYLLLEPEGIIY
:. ::::. :: :
NP_543 PLLRDYLLLRVEGCIQ
440 450
>>NP_001135932 (OMIM: 603383,615054) ankyrin repeat and (429 aa)
initn: 665 init1: 218 opt: 496 Z-score: 381.9 bits: 79.7 E(85289): 1.6e-14
Smith-Waterman score: 592; 31.2% identity (56.9% similar) in 432 aa overlap (10-426:40-429)
10 20 30
pF1KB7 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK
::: . .: :. : .:. ..: :
NP_001 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC
10 20 30 40 50 60
40 50 60 70 80
pF1KB7 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG
.. :: . . . :.::.. : ... . : .:. . . : ::... :
NP_001 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB7 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF
:.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::.
NP_001 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB7 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA
: :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. ::
NP_001 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB7 HMETPLAIAA-YWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD
. ::: : . . : .: . : .: .::. :...: :.: . ::: :
NP_001 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB7 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..:
NP_001 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPG--
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB7 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTL
:.: .:. :: :::.. .::.:
NP_001 --------------------------------ALP----KKHQRFYSSLFALV-RQPRSL
370 380
390 400 410 420
pF1KB7 MHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY
.::::::.: :.. .:.: : :: : .:: :. ::..:
NP_001 QHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
390 400 410 420
>>NP_001306226 (OMIM: 615053) ankyrin repeat and SOCS bo (288 aa)
initn: 276 init1: 135 opt: 249 Z-score: 206.5 bits: 46.7 E(85289): 9.2e-05
Smith-Waterman score: 264; 29.1% identity (57.7% similar) in 220 aa overlap (94-310:40-240)
70 80 90 100 110 120
pF1KB7 YWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCV
:. .: .:: . ::: :: ....:::
NP_001 QSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCV
10 20 30 40 50 60
130 140 150 160 170 180
pF1KB7 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAA
..: ..::..: . ..::::. . . :.. :. ::: : .:.: :::: ::
NP_001 ELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRD--TPLHWAA
70 80 90 100 110 120
190 200 210 220 230 240
pF1KB7 HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKA
. .: : .: :: :.... . .:::. :: . : . .:::: :
NP_001 FKNNAECVRALLESGASVNALDYNNDTPLS----WAAMKGNLESVS-------ILLDYGA
130 140 150 160 170
250 260 270 280 290 300
pF1KB7 EVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP---
:: . . ..:. . . .:. : . : . ... :. .. :. ... :
NP_001 EVRVINLIGQTPISRLV-----ALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREV
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
: .:..: .:
NP_001 ARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
240 250 260 270 280
>>NP_001306225 (OMIM: 615053) ankyrin repeat and SOCS bo (288 aa)
initn: 276 init1: 135 opt: 249 Z-score: 206.5 bits: 46.7 E(85289): 9.2e-05
Smith-Waterman score: 264; 29.1% identity (57.7% similar) in 220 aa overlap (94-310:40-240)
70 80 90 100 110 120
pF1KB7 YWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCV
:. .: .:: . ::: :: ....:::
NP_001 QSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCV
10 20 30 40 50 60
130 140 150 160 170 180
pF1KB7 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAA
..: ..::..: . ..::::. . . :.. :. ::: : .:.: :::: ::
NP_001 ELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRD--TPLHWAA
70 80 90 100 110 120
190 200 210 220 230 240
pF1KB7 HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKA
. .: : .: :: :.... . .:::. :: . : . .:::: :
NP_001 FKNNAECVRALLESGASVNALDYNNDTPLS----WAAMKGNLESVS-------ILLDYGA
130 140 150 160 170
250 260 270 280 290 300
pF1KB7 EVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP---
:: . . ..:. . . .:. : . : . ... :. .. :. ... :
NP_001 EVRVINLIGQTPISRLV-----ALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREV
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
: .:..: .:
NP_001 ARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
240 250 260 270 280
>>NP_077000 (OMIM: 615053) ankyrin repeat and SOCS box p (288 aa)
initn: 276 init1: 135 opt: 249 Z-score: 206.5 bits: 46.7 E(85289): 9.2e-05
Smith-Waterman score: 264; 29.1% identity (57.7% similar) in 220 aa overlap (94-310:40-240)
70 80 90 100 110 120
pF1KB7 YWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCV
:. .: .:: . ::: :: ....:::
NP_077 QSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCV
10 20 30 40 50 60
130 140 150 160 170 180
pF1KB7 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAA
..: ..::..: . ..::::. . . :.. :. ::: : .:.: :::: ::
NP_077 ELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRD--TPLHWAA
70 80 90 100 110 120
190 200 210 220 230 240
pF1KB7 HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKA
. .: : .: :: :.... . .:::. :: . : . .:::: :
NP_077 FKNNAECVRALLESGASVNALDYNNDTPLS----WAAMKGNLESVS-------ILLDYGA
130 140 150 160 170
250 260 270 280 290 300
pF1KB7 EVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP---
:: . . ..:. . . .:. : . : . ... :. .. :. ... :
NP_077 EVRVINLIGQTPISRLV-----ALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREV
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB7 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
: .:..: .:
NP_077 ARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
240 250 260 270 280
426 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 05:38:49 2016 done: Fri Nov 4 05:38:51 2016
Total Scan time: 7.990 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]