FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7089, 152 aa
  1>>>pF1KB7089 152 - 152 aa - 152 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7379+/-0.00027; mu= 6.9457+/- 0.017
 mean_var=116.8988+/-23.516, 0's: 0 Z-trim(123.0): 3  B-trim: 334 in 1/53
 Lambda= 0.118623
 statistics sampled from 42115 (42119) to 42115 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.494), width:  16
 Scan time:  4.780

The best scores are:                                      opt bits E(85289)
NP_003302 (OMIM: 602131) pleckstrin homology-like  ( 152) 1020 183.9 8.5e-47
NP_036528 (OMIM: 607054) pleckstrin homology-like  ( 127)  368 72.3 2.8e-13
NP_031376 (OMIM: 605335) pleckstrin homology-like  ( 401)  293 59.8 5.2e-09


>>NP_003302 (OMIM: 602131) pleckstrin homology-like doma  (152 aa)
 initn: 1020 init1: 1020 opt: 1020  Z-score: 961.2  bits: 183.9 E(85289): 8.5e-47
Smith-Waterman score: 1020; 100.0% identity (100.0% similar) in 152 aa overlap (1-152:1-152)

               10        20        30        40        50        60
pF1KB7 MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 VERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPA
               70        80        90       100       110       120

              130       140       150  
pF1KB7 APAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP
       ::::::::::::::::::::::::::::::::
NP_003 APAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP
              130       140       150  

>>NP_036528 (OMIM: 607054) pleckstrin homology-like doma  (127 aa)
 initn: 369 init1: 165 opt: 368  Z-score: 359.3  bits: 72.3 E(85289): 2.8e-13
Smith-Waterman score: 368; 55.5% identity (74.5% similar) in 110 aa overlap (7-114:9-118)

                 10        20        30        40         50       
pF1KB7   MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRA-RPKELRFHSILK
               ::.:: ::::: .:.::::.:: :::   :.:: :.  . ::::: :  :  
NP_036 MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKA
               10        20        30        40        50        60

        60        70        80         90       100       110      
pF1KB7 VDCVERTGKYVYFTIVTTDHKEIDFRCAGES-CWNAAIALALIDFQNRRALQDFRSRQER
       :.::: ::...:::.::    ::::::  :.  ::: :.:.:. :.:..:.:  :.::  
NP_036 VECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSL
               70        80        90       100       110       120

        120       130       140       150  
pF1KB7 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP
                                           
NP_036 GTGTLVS                             
                                           

>>NP_031376 (OMIM: 605335) pleckstrin homology-like doma  (401 aa)
 initn: 581 init1: 287 opt: 293  Z-score: 282.7  bits: 59.8 E(85289): 5.2e-09
Smith-Waterman score: 337; 35.9% identity (55.2% similar) in 192 aa overlap (8-150:151-342)

                                      10        20        30       
pF1KB7                        MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLS
                                     :.:: ::::::.:.::::::  .:: . : 
NP_031 PARAAGNGEAEPSGGPSYAGRMLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLL
              130       140       150       160       170       180

        40                                               50        
pF1KB7 LFP-------------------------------------AS--PRARPKELRFHSILKV
       :.:                                     ::  : .. :::.: ..  :
NP_031 LIPPKQLQHQQQQQQQQQQQQQQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTV
              190       200       210       220       230       240

       60        70        80        90       100       110        
pF1KB7 DCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRS-RQ---
       ::::: :::.:::.: .. :::::::  .. ::: :.: .....::.:.   .: ::   
NP_031 DCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQ
              250       260       270       280       290       300

             120       130          140       150                  
pF1KB7 ---ERTAPAAPAEDAVAAAAAAPS---EPSEPSRPSPQPKPRTP                
          ..  :. :  .        :.   .:.  :.:.:::.:.                  
NP_031 HLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHS
              310       320       330       340       350       360

NP_031 HPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRLLRSTSNSA
              370       380       390       400 




152 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 04:36:39 2016 done: Fri Nov  4 04:36:39 2016
 Total Scan time:  4.780 Total Display time: -0.040

Function used was FASTA [36.3.4 Apr, 2011]