Result of FASTA (omim) for
pF1KB6981
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6981, 218 aa
1>>>pF1KB6981 218 - 218 aa - 218 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2347+/-0.000465; mu= 14.0357+/- 0.029
mean_var=67.1420+/-13.821, 0's: 0 Z-trim(109.2): 61 B-trim: 883 in 1/49
Lambda= 0.156523
statistics sampled from 17265 (17315) to 17265 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.566), E-opt: 0.2 (0.203), width: 16
Scan time: 5.110
The best scores are: opt bits E(85289)
NP_001028 (OMIM: 600235,604233,612838,615377) sodi ( 218) 1403 326.0 3.1e-89
NP_001308534 (OMIM: 600235,604233,612838,615377) s ( 185) 1194 278.7 4.3e-75
NP_950238 (OMIM: 600235,604233,612838,615377) sodi ( 268) 985 231.6 9.4e-61
NP_001035241 (OMIM: 608214,613120) sodium channel ( 215) 604 145.5 6.2e-35
XP_011541199 (OMIM: 608214,613120) PREDICTED: sodi ( 215) 604 145.5 6.2e-35
NP_060870 (OMIM: 608214,613120) sodium channel sub ( 215) 604 145.5 6.2e-35
NP_658911 (OMIM: 604873) myelin protein zero-like ( 215) 141 41.0 0.0019
NP_005788 (OMIM: 604873) myelin protein zero-like ( 215) 141 41.0 0.0019
>>NP_001028 (OMIM: 600235,604233,612838,615377) sodium c (218 aa)
initn: 1403 init1: 1403 opt: 1403 Z-score: 1723.1 bits: 326.0 E(85289): 3.1e-89
Smith-Waterman score: 1403; 100.0% identity (100.0% similar) in 218 aa overlap (1-218:1-218)
10 20 30 40 50 60
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
130 140 150 160 170 180
190 200 210
pF1KB6 CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
::::::::::::::::::::::::::::::::::::::
NP_001 CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
190 200 210
>>NP_001308534 (OMIM: 600235,604233,612838,615377) sodiu (185 aa)
initn: 1194 init1: 1194 opt: 1194 Z-score: 1469.1 bits: 278.7 E(85289): 4.3e-75
Smith-Waterman score: 1194; 100.0% identity (100.0% similar) in 185 aa overlap (34-218:1-185)
10 20 30 40 50 60
pF1KB6 LLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKG
::::::::::::::::::::::::::::::
NP_001 MTFKILCISCKRRSETNAETFTEWTFRQKG
10 20 30
70 80 90 100 110 120
pF1KB6 TEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 YRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYK
100 110 120 130 140 150
190 200 210
pF1KB6 KIAAATETAAQENASEYLAITSESKENCTGVQVAE
:::::::::::::::::::::::::::::::::::
NP_001 KIAAATETAAQENASEYLAITSESKENCTGVQVAE
160 170 180
>>NP_950238 (OMIM: 600235,604233,612838,615377) sodium c (268 aa)
initn: 985 init1: 985 opt: 985 Z-score: 1211.7 bits: 231.6 E(85289): 9.4e-61
Smith-Waterman score: 985; 96.8% identity (98.1% similar) in 155 aa overlap (1-155:1-155)
10 20 30 40 50 60
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_950 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_950 QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
:::::::::::::::::::::::::::::.. :
NP_950 CHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWL
130 140 150 160 170 180
190 200 210
pF1KB6 CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
NP_950 CAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTS
190 200 210 220 230 240
>>NP_001035241 (OMIM: 608214,613120) sodium channel subu (215 aa)
initn: 553 init1: 313 opt: 604 Z-score: 748.1 bits: 145.5 E(85289): 6.2e-35
Smith-Waterman score: 604; 49.5% identity (72.9% similar) in 214 aa overlap (5-218:10-215)
10 20 30 40 50
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFT
:: .: :: :::: :::::: : .:. :::: .: :..: : .
NP_001 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 EWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNH
:: .: .: ..:. : .:.: ..: :.::. :::: :::::.:: . ::: :
NP_001 EWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLND
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 SGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLV
:: : :.: : . :: .. ..... : ..:...:..:..:.:::::::.:.: ::.::.
NP_001 SGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLL
120 130 140 150 160 170
180 190 200 210
pF1KB6 AEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
::::::.:.. : : :::::::.:::: ::.::: ..: : :
NP_001 IEMIYCYRKVSKA-EEAAQENASDYLAIPSENKEN-SAVPVEE
180 190 200 210
>>XP_011541199 (OMIM: 608214,613120) PREDICTED: sodium c (215 aa)
initn: 553 init1: 313 opt: 604 Z-score: 748.1 bits: 145.5 E(85289): 6.2e-35
Smith-Waterman score: 604; 49.5% identity (72.9% similar) in 214 aa overlap (5-218:10-215)
10 20 30 40 50
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFT
:: .: :: :::: :::::: : .:. :::: .: :..: : .
XP_011 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 EWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNH
:: .: .: ..:. : .:.: ..: :.::. :::: :::::.:: . ::: :
XP_011 EWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLND
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 SGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLV
:: : :.: : . :: .. ..... : ..:...:..:..:.:::::::.:.: ::.::.
XP_011 SGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLL
120 130 140 150 160 170
180 190 200 210
pF1KB6 AEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
::::::.:.. : : :::::::.:::: ::.::: ..: : :
XP_011 IEMIYCYRKVSKA-EEAAQENASDYLAIPSENKEN-SAVPVEE
180 190 200 210
>>NP_060870 (OMIM: 608214,613120) sodium channel subunit (215 aa)
initn: 553 init1: 313 opt: 604 Z-score: 748.1 bits: 145.5 E(85289): 6.2e-35
Smith-Waterman score: 604; 49.5% identity (72.9% similar) in 214 aa overlap (5-218:10-215)
10 20 30 40 50
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFT
:: .: :: :::: :::::: : .:. :::: .: :..: : .
NP_060 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 EWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNH
:: .: .: ..:. : .:.: ..: :.::. :::: :::::.:: . ::: :
NP_060 EWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLND
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 SGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLV
:: : :.: : . :: .. ..... : ..:...:..:..:.:::::::.:.: ::.::.
NP_060 SGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLL
120 130 140 150 160 170
180 190 200 210
pF1KB6 AEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
::::::.:.. : : :::::::.:::: ::.::: ..: : :
NP_060 IEMIYCYRKVSKA-EEAAQENASDYLAIPSENKEN-SAVPVEE
180 190 200 210
>>NP_658911 (OMIM: 604873) myelin protein zero-like prot (215 aa)
initn: 51 init1: 51 opt: 141 Z-score: 183.1 bits: 41.0 E(85289): 0.0019
Smith-Waterman score: 142; 23.6% identity (54.2% similar) in 212 aa overlap (3-208:8-206)
10 20 30 40 50
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSET--EAVYGMTFKILCISCKRRSETNAET
: . :..: :.. . ::. . ::: : .. : . .: :
NP_658 MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 FTEWTFR--QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNV
: :.:: . : :.:: . :. . .: . ::. :: :.:. . : ::.. ..
NP_658 VT-WNFRPLDGGPEQFV--FYYHIDPFQ-PMSGRFKDRVSWDGN---PERYDASILLWKL
70 80 90 100 110
120 130 140 150 160
pF1KB6 TYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIM--MYVLIVV
.. .: : :.: .: .:. .:.. :: . . ... . .:...
NP_658 QFDDNGTYTCQV------KNPPDVDGVIGEIRLSVVHTVRFSEIHFLALAIGSACALMII
120 130 140 150 160
170 180 190 200 210
pF1KB6 LTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
..: .: . : :. : .. ... ...: ...:.:
NP_658 IVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVYLEDTD
170 180 190 200 210
>>NP_005788 (OMIM: 604873) myelin protein zero-like prot (215 aa)
initn: 51 init1: 51 opt: 141 Z-score: 183.1 bits: 41.0 E(85289): 0.0019
Smith-Waterman score: 142; 23.6% identity (54.2% similar) in 212 aa overlap (3-208:8-206)
10 20 30 40 50
pF1KB6 MGRLLALVVGAALVSSACGGCVEVDSET--EAVYGMTFKILCISCKRRSETNAET
: . :..: :.. . ::. . ::: : .. : . .: :
NP_005 MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 FTEWTFR--QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNV
: :.:: . : :.:: . :. . .: . ::. :: :.:. . : ::.. ..
NP_005 VT-WNFRPLDGGPEQFV--FYYHIDPFQ-PMSGRFKDRVSWDGN---PERYDASILLWKL
70 80 90 100 110
120 130 140 150 160
pF1KB6 TYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIM--MYVLIVV
.. .: : :.: .: .:. .:.. :: . . ... . .:...
NP_005 QFDDNGTYTCQV------KNPPDVDGVIGEIRLSVVHTVRFSEIHFLALAIGSACALMII
120 130 140 150 160
170 180 190 200 210
pF1KB6 LTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
..: .: . : :. : .. ... ...: ...:.:
NP_005 IVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVYLEDTD
170 180 190 200 210
218 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:46:07 2016 done: Fri Nov 4 10:46:08 2016
Total Scan time: 5.110 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]