Result of FASTA (omim) for
pF1KB6978
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6978, 245 aa
1>>>pF1KB6978 245 - 245 aa - 245 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8781+/-0.000419; mu= 8.8328+/- 0.026
mean_var=189.8478+/-41.334, 0's: 0 Z-trim(116.9): 120 B-trim: 0 in 0/51
Lambda= 0.093083
statistics sampled from 28363 (28499) to 28363 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.334), width: 16
Scan time: 4.960
The best scores are: opt bits E(85289)
NP_057355 (OMIM: 616319) E3 ubiquitin-protein liga ( 245) 1724 243.5 2.5e-64
NP_001178253 (OMIM: 616319) E3 ubiquitin-protein l ( 245) 1724 243.5 2.5e-64
XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 199) 1400 199.9 2.7e-51
NP_937761 (OMIM: 616319) E3 ubiquitin-protein liga ( 151) 791 118.0 9.5e-27
XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 151) 791 118.0 9.5e-27
NP_061153 (OMIM: 612451) E3 ubiquitin-protein liga ( 228) 288 50.7 2.7e-06
XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 u ( 191) 258 46.5 3.9e-05
XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 u ( 196) 258 46.6 4e-05
NP_064507 (OMIM: 614719) E3 ubiquitin-protein liga ( 381) 207 40.0 0.007
XP_006712115 (OMIM: 614719) PREDICTED: E3 ubiquiti ( 389) 204 39.7 0.0094
>>NP_057355 (OMIM: 616319) E3 ubiquitin-protein ligase R (245 aa)
initn: 1724 init1: 1724 opt: 1724 Z-score: 1275.9 bits: 243.5 E(85289): 2.5e-64
Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 245 aa overlap (1-245:1-245)
10 20 30 40 50 60
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
190 200 210 220 230 240
pF1KB6 FQVNI
:::::
NP_057 FQVNI
>>NP_001178253 (OMIM: 616319) E3 ubiquitin-protein ligas (245 aa)
initn: 1724 init1: 1724 opt: 1724 Z-score: 1275.9 bits: 243.5 E(85289): 2.5e-64
Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 245 aa overlap (1-245:1-245)
10 20 30 40 50 60
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
190 200 210 220 230 240
pF1KB6 FQVNI
:::::
NP_001 FQVNI
>>XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (199 aa)
initn: 1400 init1: 1400 opt: 1400 Z-score: 1041.8 bits: 199.9 E(85289): 2.7e-51
Smith-Waterman score: 1400; 100.0% identity (100.0% similar) in 199 aa overlap (47-245:1-199)
20 30 40 50 60 70
pF1KB6 YCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTRRERACPERALDLE
::::::::::::::::::::::::::::::
XP_005 MRESGAHCPLCRGNVTRRERACPERALDLE
10 20 30
80 90 100 110 120 130
pF1KB6 NIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSET
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB6 STSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLP
100 110 120 130 140 150
200 210 220 230 240
pF1KB6 WGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
160 170 180 190
>>NP_937761 (OMIM: 616319) E3 ubiquitin-protein ligase R (151 aa)
initn: 791 init1: 791 opt: 791 Z-score: 601.2 bits: 118.0 E(85289): 9.5e-27
Smith-Waterman score: 847; 61.6% identity (61.6% similar) in 245 aa overlap (1-245:1-151)
10 20 30 40 50 60
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
:::::::::::::::::::::::::::::::::::::
NP_937 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHV-----------------------
10 20 30
70 80 90 100 110 120
pF1KB6 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
NP_937 ------------------------------------------------------------
130 140 150 160 170 180
pF1KB6 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_937 -----------NRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
40 50 60 70 80
190 200 210 220 230 240
pF1KB6 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_937 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
90 100 110 120 130 140
pF1KB6 FQVNI
:::::
NP_937 FQVNI
150
>>XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (151 aa)
initn: 791 init1: 791 opt: 791 Z-score: 601.2 bits: 118.0 E(85289): 9.5e-27
Smith-Waterman score: 847; 61.6% identity (61.6% similar) in 245 aa overlap (1-245:1-151)
10 20 30 40 50 60
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
:::::::::::::::::::::::::::::::::::::
XP_005 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHV-----------------------
10 20 30
70 80 90 100 110 120
pF1KB6 VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
XP_005 ------------------------------------------------------------
130 140 150 160 170 180
pF1KB6 FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 -----------NRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
40 50 60 70 80
190 200 210 220 230 240
pF1KB6 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
90 100 110 120 130 140
pF1KB6 FQVNI
:::::
XP_005 FQVNI
150
>>NP_061153 (OMIM: 612451) E3 ubiquitin-protein ligase R (228 aa)
initn: 452 init1: 288 opt: 288 Z-score: 234.1 bits: 50.7 E(85289): 2.7e-06
Smith-Waterman score: 460; 32.6% identity (58.1% similar) in 227 aa overlap (16-240:27-224)
10 20 30 40
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRE
: :::: :: . ::.. : :::: :. ..
NP_061 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVP-CGHVFCSACLQECLKP
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 SGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQ
. : .::. . : ::..:: ... ::. : :.. . ..: : .:.:::
NP_061 KKPVCGVCRSAL-----APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 DEY--GVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNF
. ::.. : . ... .: : :: :: : :.::
NP_061 NYIMEGVKATIKDASLQPRNVPNRY-----------------------TFPCPYCPEKNF
120 130 140 150
170 180 190 200 210 220
pF1KB6 TRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQL
.. :..::. : . :.::::.:.:::::. . :: :...::.:.: ::. ..
NP_061 DQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDV
160 170 180 190 200 210
230 240
pF1KB6 DEETQYQTAVEESFQVNI
::: ... ....:
NP_061 DEEDMMNQVLQRSIIDQ
220
>>XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (191 aa)
initn: 250 init1: 116 opt: 258 Z-score: 213.2 bits: 46.5 E(85289): 3.9e-05
Smith-Waterman score: 264; 30.8% identity (52.9% similar) in 172 aa overlap (16-187:35-168)
10 20 30 40
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT
: : :: :::. :::: : :::::.:. :
XP_011 LSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTR-CGHVFCRSCIAT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC
..... :: ::. . .. : : :. . :.. .: : . . .:: : ..:
XP_011 SLKNNKWTCPYCRAYLPS--EGVP--ATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTC
70 80 90 100 110
110 120 130 140 150 160
pF1KB6 KKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQES
.:: :.:: : :: .... . ::.::.
XP_011 QKYIDKYG-----P-------------------------LQELEETAARCV--CPFCQR-
120 130 140
170 180 190 200 210 220
pF1KB6 NFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNL
.. .. ::::: ..: . ::
XP_011 ELYEDSLLDHCITHHRSERRPVDNNTKIHLSCCCPRPHFHPQVPQ
150 160 170 180 190
>>XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (196 aa)
initn: 250 init1: 116 opt: 258 Z-score: 213.0 bits: 46.6 E(85289): 4e-05
Smith-Waterman score: 264; 30.8% identity (52.9% similar) in 172 aa overlap (16-187:35-168)
10 20 30 40
pF1KB6 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT
: : :: :::. :::: : :::::.:. :
XP_011 LSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTR-CGHVFCRSCIAT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC
..... :: ::. . .. : : :. . :.. .: : . . .:: : ..:
XP_011 SLKNNKWTCPYCRAYLPS--EGVP--ATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTC
70 80 90 100 110
110 120 130 140 150 160
pF1KB6 KKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQES
.:: :.:: : :: .... . ::.::.
XP_011 QKYIDKYG-----P-------------------------LQELEETAARCV--CPFCQR-
120 130 140
170 180 190 200 210 220
pF1KB6 NFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNL
.. .. ::::: ..: . ::
XP_011 ELYEDSLLDHCITHHRSERRPVDFNIIEEALIRRVLDRSLLEYVNHSNTT
150 160 170 180 190
>>NP_064507 (OMIM: 614719) E3 ubiquitin-protein ligase K (381 aa)
initn: 215 init1: 186 opt: 207 Z-score: 172.7 bits: 40.0 E(85289): 0.007
Smith-Waterman score: 207; 28.6% identity (55.0% similar) in 140 aa overlap (79-216:1-137)
50 60 70 80 90 100
pF1KB6 ESGAHCPLCRGNVTRRERACPERALDLENIMRKFSG-SCRCCAKQIKFYRMRHHYKSCKK
: . : :: : : .: :. ::
NP_064 MSRHEGVSCDACLKGN--FRGRR-YKCLIC
10 20
110 120 130 140 150 160
pF1KB6 YQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHP-TFKCPLCQESN
:. . .: . .. .. . . . : : .. : .: .: :: : . .
NP_064 YDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMG
30 40 50 60 70 80
170 180 190 200 210 220
pF1KB6 FTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQ
.:. : .: .:.: . : ::::..:: :::...: .:..::. .:.
NP_064 YTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSG
90 100 110 120 130 140
230 240
pF1KB6 LDEETQYQTAVEESFQVNI
NP_064 VRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLS
150 160 170 180 190 200
>>XP_006712115 (OMIM: 614719) PREDICTED: E3 ubiquitin-pr (389 aa)
initn: 215 init1: 186 opt: 204 Z-score: 170.4 bits: 39.7 E(85289): 0.0094
Smith-Waterman score: 204; 28.6% identity (55.6% similar) in 133 aa overlap (85-216:16-145)
60 70 80 90 100 110
pF1KB6 PLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGV
:: : : .: :. :: :. . .
XP_006 MCCLPDQVLENDDGVSCDACLKGN--FRGRR-YKCLICYDYDLCA
10 20 30 40
120 130 140 150 160 170
pF1KB6 SSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHP-TFKCPLCQESNFTRQRLL
: . .. .. . . . : : .. : .: .: :: : . ..:. :
XP_006 SCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQ
50 60 70 80 90 100
180 190 200 210 220 230
pF1KB6 DHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQY
.: .:.: . : ::::..:: :::...: .:..::. .:.
XP_006 EHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRM
110 120 130 140 150 160
240
pF1KB6 QTAVEESFQVNI
XP_006 FHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAG
170 180 190 200 210 220
245 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:20:48 2016 done: Sat Nov 5 18:20:48 2016
Total Scan time: 4.960 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]