Result of FASTA (omim) for
pF1KB6683
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6683, 427 aa
1>>>pF1KB6683 427 - 427 aa - 427 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6327+/-0.000323; mu= 16.4002+/- 0.020
mean_var=86.3306+/-17.717, 0's: 0 Z-trim(117.5): 67 B-trim: 166 in 1/53
Lambda= 0.138036
statistics sampled from 29532 (29623) to 29532 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.347), width: 16
Scan time: 9.330
The best scores are: opt bits E(85289)
NP_001551 (OMIM: 300119) interleukin-13 receptor s ( 427) 2968 600.8 2.1e-171
XP_011529638 (OMIM: 300119) PREDICTED: interleukin ( 529) 2747 556.9 4.4e-158
XP_016884996 (OMIM: 300119) PREDICTED: interleukin ( 286) 1957 399.4 6.2e-111
XP_011529639 (OMIM: 300119) PREDICTED: interleukin ( 226) 583 125.7 1.2e-28
NP_000631 (OMIM: 300130) interleukin-13 receptor s ( 380) 328 75.1 3.5e-13
NP_786943 (OMIM: 600694) interleukin-6 receptor su ( 329) 195 48.5 3e-05
NP_001177910 (OMIM: 600694) interleukin-6 receptor ( 857) 195 48.8 6.2e-05
NP_002175 (OMIM: 600694) interleukin-6 receptor su ( 918) 195 48.9 6.6e-05
NP_000197 (OMIM: 300400,308380,312863) cytokine re ( 369) 189 47.4 7.4e-05
NP_783854 (OMIM: 147851) interleukin-5 receptor su ( 333) 181 45.7 0.00021
NP_783851 (OMIM: 147851) interleukin-5 receptor su ( 333) 181 45.7 0.00021
NP_783855 (OMIM: 147851) interleukin-5 receptor su ( 335) 181 45.7 0.00021
NP_783852 (OMIM: 147851) interleukin-5 receptor su ( 335) 181 45.7 0.00021
NP_001230028 (OMIM: 147851) interleukin-5 receptor ( 378) 181 45.8 0.00023
NP_783853 (OMIM: 147851) interleukin-5 receptor su ( 420) 181 45.8 0.00025
NP_000555 (OMIM: 147851) interleukin-5 receptor su ( 420) 181 45.8 0.00025
XP_011531980 (OMIM: 147851) PREDICTED: interleukin ( 439) 181 45.8 0.00026
XP_011531979 (OMIM: 147851) PREDICTED: interleukin ( 439) 181 45.8 0.00026
NP_758452 (OMIM: 306250,425000) granulocyte-macrop ( 233) 166 42.6 0.0012
NP_001155004 (OMIM: 306250,425000) granulocyte-mac ( 267) 159 41.3 0.0036
XP_011543921 (OMIM: 306250,425000) PREDICTED: gran ( 400) 159 41.4 0.005
NP_758448 (OMIM: 306250,425000) granulocyte-macrop ( 400) 159 41.4 0.005
NP_001155001 (OMIM: 306250,425000) granulocyte-mac ( 400) 159 41.4 0.005
XP_011544468 (OMIM: 306250,425000) PREDICTED: gran ( 400) 159 41.4 0.005
NP_006131 (OMIM: 306250,425000) granulocyte-macrop ( 400) 159 41.4 0.005
XP_005274488 (OMIM: 308385,430000) PREDICTED: inte ( 378) 158 41.2 0.0054
NP_002174 (OMIM: 308385,430000) interleukin-3 rece ( 378) 158 41.2 0.0054
XP_005274837 (OMIM: 308385,430000) PREDICTED: inte ( 378) 158 41.2 0.0054
NP_001254642 (OMIM: 308385,430000) interleukin-3 r ( 300) 156 40.7 0.006
XP_016884980 (OMIM: 308385,430000) PREDICTED: inte ( 377) 154 40.4 0.0094
XP_016885532 (OMIM: 308385,430000) PREDICTED: inte ( 377) 154 40.4 0.0094
XP_005274838 (OMIM: 308385,430000) PREDICTED: inte ( 377) 154 40.4 0.0094
XP_005274489 (OMIM: 308385,430000) PREDICTED: inte ( 377) 154 40.4 0.0094
>>NP_001551 (OMIM: 300119) interleukin-13 receptor subun (427 aa)
initn: 2968 init1: 2968 opt: 2968 Z-score: 3198.2 bits: 600.8 E(85289): 2.1e-171
Smith-Waterman score: 2968; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427)
10 20 30 40 50 60
pF1KB6 MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 PEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 QYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 GVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 IVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIE
370 380 390 400 410 420
pF1KB6 NLKKASQ
:::::::
NP_001 NLKKASQ
>>XP_011529638 (OMIM: 300119) PREDICTED: interleukin-13 (529 aa)
initn: 2745 init1: 2745 opt: 2747 Z-score: 2959.1 bits: 556.9 E(85289): 4.4e-158
Smith-Waterman score: 2748; 94.4% identity (95.3% similar) in 430 aa overlap (16-427:100-529)
10 20
pF1KB6 MEWPARLCGLWALLLCAGGGGGGGG-------AAPT---------
:::.: .:.. :::
XP_011 QTPRPRLFSADDSVLVSSRAQPLAPPRPRKCAGSGDAGSATRREEAQAAPGVGGDVVEEV
70 80 90 100 110 120
30 40 50 60 70 80
pF1KB6 --ETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIE
130 140 150 160 170 180
90 100 110 120 130 140
pF1KB6 VPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWL
190 200 210 220 230 240
150 160 170 180 190 200
pF1KB6 PGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVK
250 260 270 280 290 300
210 220 230 240 250 260
pF1KB6 DNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNS
310 320 330 340 350 360
270 280 290 300 310 320
pF1KB6 QTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLW
370 380 390 400 410 420
330 340 350 360 370 380
pF1KB6 SNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKE
430 440 450 460 470 480
390 400 410 420
pF1KB6 MFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ
::::::::::::::::::::::::::::::::::::::::
XP_011 MFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ
490 500 510 520
>>XP_016884996 (OMIM: 300119) PREDICTED: interleukin-13 (286 aa)
initn: 1957 init1: 1957 opt: 1957 Z-score: 2112.5 bits: 399.4 E(85289): 6.2e-111
Smith-Waterman score: 1957; 100.0% identity (100.0% similar) in 286 aa overlap (142-427:1-286)
120 130 140 150 160 170
pF1KB6 ILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIH
::::::::::::::::::::::::::::::
XP_016 MKCSWLPGRNTSPDTNYTLYYWHRSLEKIH
10 20 30
180 190 200 210 220 230
pF1KB6 QCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPP
40 50 60 70 80 90
240 250 260 270 280 290
pF1KB6 HIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNV
100 110 120 130 140 150
300 310 320 330 340 350
pF1KB6 ENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLI
160 170 180 190 200 210
360 370 380 390 400 410
pF1KB6 VPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKE
220 230 240 250 260 270
420
pF1KB6 ETDSVVLIENLKKASQ
::::::::::::::::
XP_016 ETDSVVLIENLKKASQ
280
>>XP_011529639 (OMIM: 300119) PREDICTED: interleukin-13 (226 aa)
initn: 583 init1: 583 opt: 583 Z-score: 635.2 bits: 125.7 E(85289): 1.2e-28
Smith-Waterman score: 583; 100.0% identity (100.0% similar) in 91 aa overlap (337-427:136-226)
310 320 330 340 350 360
pF1KB6 LNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLY
::::::::::::::::::::::::::::::
XP_011 PQAVRAHPPGQLLSWAAAVCLLCQHHLQLPGKKRNSTLYITMLLIVPVIVAGAIIVLLLY
110 120 130 140 150 160
370 380 390 400 410 420
pF1KB6 LKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKAS
170 180 190 200 210 220
pF1KB6 Q
:
XP_011 Q
>>NP_000631 (OMIM: 300130) interleukin-13 receptor subun (380 aa)
initn: 326 init1: 202 opt: 328 Z-score: 357.6 bits: 75.1 E(85289): 3.5e-13
Smith-Waterman score: 399; 26.1% identity (55.6% similar) in 403 aa overlap (8-391:10-379)
10 20 30 40 50
pF1KB6 MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGA
: :...:. . : ... . ...:: :. : . :.:: .
NP_000 MAFVCLAIGC-LYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSL
10 20 30 40 50
60 70 80 90 100
pF1KB6 S--SNCSLWY---FSHFGDKQDKKIAPETRRSIE-VPLNERICLQVGS----QCSTNESE
. ..:.. : . ..:.. : : .. . . ::. : .. . :: :: ::
NP_000 DHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQC-TNGSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 KPSILVEKC--ISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRS
: .: ::: .: ::. : ...:...: .:. ::: :: .. ::::.:.::...
NP_000 VQSSWAETTYWISP-QGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 LEKIHQCENIFR-EGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSR
:.. :: . .. .:: .:: : ...: ... . . ... :. :. : .
NP_000 LDHALQCVDYIKADGQNIGCRFPYLEASD--YKDFYICVNGSSENKPIRSSYFTFQLQNI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 VKPDPPHIKNLSFHND-DLYVQWENPQNFI-SRCLFYEVEVNNSQTETHNVFYVQEAKCE
::: :: ... ... .. ..: : . : .::. ::.:. ...: . : :
NP_000 VKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTT------LVTATVE
240 250 260 270 280
290 300 310 320 330
pF1KB6 NPEFERNVENTS---CFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSI-GKK
: . .. : . ::.: : :.: : :: .::.::... :.
NP_000 NETYTLKTTNETRQLCFVV-------------RSKVNIYC-SDDGIWSEWSDKQCWEGED
290 300 310 320 330
340 350 360 370 380 390
pF1KB6 RNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHW
.. . . : : : :..:.... : .. : : :.. :.: :
NP_000 LSKKTLLRFWL--PF---GFILILVIFVTGL--LLRKPNTYP-KMIPEFFCDT
340 350 360 370 380
400 410 420
pF1KB6 KKYDIYEKQTKEETDSVVLIENLKKASQ
>>NP_786943 (OMIM: 600694) interleukin-6 receptor subuni (329 aa)
initn: 178 init1: 89 opt: 195 Z-score: 215.3 bits: 48.5 E(85289): 3e-05
Smith-Waterman score: 236; 25.3% identity (50.6% similar) in 316 aa overlap (32-335:34-318)
10 20 30 40 50 60
pF1KB6 EWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSN
. ::..: . .:.. ...:
NP_786 LQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 CSLWYFSHFG-DKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCIS-
.: .:: :.. : .: :. . .:. . : . . .. ::
NP_786 YIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 -PPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYY-WHRSLEKIHQCENIF
::: :.. :.:: .. . :.: : ::.: .::.:: : . .:. .:.
NP_786 LPPE-KPKN----LSCIVNEGKKMRCEWDGGRETHLETNFTLKSEW--ATHKFADCKA--
130 140 150 160 170
180 190 200 210 220 230
pF1KB6 REGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPS-FNIVPLTSRVKPDPPHIKNL
.. .:. : . : : . : . ... ::. . .:. :. .:::.::: ::
NP_786 KRDTPTSCTVDYSTVY---FVNIEVWVEAENALGKVTSDHINFDPVY-KVKPNPPH--NL
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 SFHNDD-----LYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNV
: :.. : . : ::. :. .. . .. : .:... .. :. :
NP_786 SVINSEELSSILKLTWTNPS--IKSVIILKYNI---QYRTKDASTWSQIPPEDTASTR--
230 240 250 260 270 280
300 310 320 330 340
pF1KB6 ENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDK--LWSNWSQEMSIGKKRNSTLYITML
: : : . : : . ::: :...: ::.::.: :
NP_786 ---SSFTVQDLKPFTEYVFRIR------CMKEDGKGYWSDWSEEASGITYEDNIASF
290 300 310 320
350 360 370 380 390 400
pF1KB6 LIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQT
>>NP_001177910 (OMIM: 600694) interleukin-6 receptor sub (857 aa)
initn: 218 init1: 89 opt: 195 Z-score: 209.5 bits: 48.8 E(85289): 6.2e-05
Smith-Waterman score: 244; 25.2% identity (48.8% similar) in 385 aa overlap (32-402:34-376)
10 20 30 40 50 60
pF1KB6 EWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSN
. ::..: . .:.. ...:
NP_001 LQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 CSLWYFSHFG-DKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCIS-
.: .:: :.. : .: :. . .:. . : . . .. ::
NP_001 YIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 -PPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYY-WHRSLEKIHQCENIF
::: :.. :.:: .. . :.: : ::.: .::.:: : . .:. .:.
NP_001 LPPE-KPKN----LSCIVNEGKKMRCEWDGGRETHLETNFTLKSEW--ATHKFADCKA--
130 140 150 160 170
180 190 200 210 220 230
pF1KB6 REGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPS-FNIVPLTSRVKPDPPHIKNL
.. .:. : . : ..: : . ... ::. . .:. :. .:::.::: ::
NP_001 KRDTPTSCTVDYSTVYFVNIE---VWVEAENALGKVTSDHINFDPVY-KVKPNPPH--NL
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 SFHNDD-----LYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNV
: :.. : . : ::. :. .. . .. : .:... .. :. :
NP_001 SVINSEELSSILKLTWTNPS--IKSVIILKYNI---QYRTKDASTWSQIPPEDTASTR--
230 240 250 260 270 280
300 310 320 330 340
pF1KB6 ENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDK--LWSNWSQEMS--IGKKRNSTLYIT
: : : . : : . ::: :...: ::.::.: : . : :
NP_001 ---SSFTVQDLKPFTEYVFRIR------CMKEDGKGYWSDWSEEASGITYEDRPSKAPSF
290 300 310 320 330
350 360 370 380 390 400
pF1KB6 MLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEK
: : . : : :.. : : ::. :::. : . .::..
NP_001 WYKIDPSHTQGYRTVQLVW-KTL-----PPFEANGKIL-----DYEVTLTRWKSHLQNYT
340 350 360 370 380
410 420
pF1KB6 QTKEETDSVVLIENLKKASQ
NP_001 VNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQGNLAESKCYLITVTPVYAD
390 400 410 420 430 440
>>NP_002175 (OMIM: 600694) interleukin-6 receptor subuni (918 aa)
initn: 218 init1: 89 opt: 195 Z-score: 209.1 bits: 48.9 E(85289): 6.6e-05
Smith-Waterman score: 244; 25.2% identity (48.8% similar) in 385 aa overlap (32-402:34-376)
10 20 30 40 50 60
pF1KB6 EWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSN
. ::..: . .:.. ...:
NP_002 LQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 CSLWYFSHFG-DKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCIS-
.: .:: :.. : .: :. . .:. . : . . .. ::
NP_002 YIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 -PPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYY-WHRSLEKIHQCENIF
::: :.. :.:: .. . :.: : ::.: .::.:: : . .:. .:.
NP_002 LPPE-KPKN----LSCIVNEGKKMRCEWDGGRETHLETNFTLKSEW--ATHKFADCKA--
130 140 150 160 170
180 190 200 210 220 230
pF1KB6 REGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPS-FNIVPLTSRVKPDPPHIKNL
.. .:. : . : ..: : . ... ::. . .:. :. .:::.::: ::
NP_002 KRDTPTSCTVDYSTVYFVNIE---VWVEAENALGKVTSDHINFDPVY-KVKPNPPH--NL
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 SFHNDD-----LYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNV
: :.. : . : ::. :. .. . .. : .:... .. :. :
NP_002 SVINSEELSSILKLTWTNPS--IKSVIILKYNI---QYRTKDASTWSQIPPEDTASTR--
230 240 250 260 270 280
300 310 320 330 340
pF1KB6 ENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDK--LWSNWSQEMS--IGKKRNSTLYIT
: : : . : : . ::: :...: ::.::.: : . : :
NP_002 ---SSFTVQDLKPFTEYVFRIR------CMKEDGKGYWSDWSEEASGITYEDRPSKAPSF
290 300 310 320 330
350 360 370 380 390 400
pF1KB6 MLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEK
: : . : : :.. : : ::. :::. : . .::..
NP_002 WYKIDPSHTQGYRTVQLVW-KTL-----PPFEANGKIL-----DYEVTLTRWKSHLQNYT
340 350 360 370 380
410 420
pF1KB6 QTKEETDSVVLIENLKKASQ
NP_002 VNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWV
390 400 410 420 430 440
>>NP_000197 (OMIM: 300400,308380,312863) cytokine recept (369 aa)
initn: 151 init1: 75 opt: 189 Z-score: 208.2 bits: 47.4 E(85289): 7.4e-05
Smith-Waterman score: 267; 25.6% identity (53.7% similar) in 281 aa overlap (131-399:59-310)
110 120 130 140 150 160
pF1KB6 QCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTL
:.::. :. ::.:.: . . .: :: ::
NP_000 TPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQP-TNLTL
30 40 50 60 70 80
170 180 190 200 210
pF1KB6 YYWHRSLE--KIHQCEN-IFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSF
.::... . :...: . .: : ::. : : . .. ::. .: . .
NP_000 HYWYKNSDNDKVQKCSHYLFSEEITSGCQ--LQKKEIHLYQTFVVQL--QDPREPRRQAT
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB6 NIVPLTSRVKPDPPHIKNLSFHN---DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNV
... : . : : : .::..:. ..: ..:.: :...:: . :. .. .. .
NP_000 QMLKLQNLVIPWAP--ENLTLHKLSESQLELNWNN--RFLNHCLEHLVQYRTDWDHSWT-
150 160 170 180 190
280 290 300 310 320 330
pF1KB6 FYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEM
:..:. : .:.: . : :.: . : :: . . ::.::. .
NP_000 -------------EQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCG-SAQHWSEWSHPI
200 210 220 230 240
340 350 360 370 380
pF1KB6 SIGK---KRNSTLYITMLLIVPVIVAGAIIVLL---LYLKRLKIIIFPPIPDPGKIFKEM
:. :.: :. ... : : :: :: ..:.: .: :: : ....
NP_000 HWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLER----TMPRIPTL-KNLEDL
250 260 270 280 290
390 400 410 420
pF1KB6 FGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ
. . . :
NP_000 VTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWA
300 310 320 330 340 350
>>NP_783854 (OMIM: 147851) interleukin-5 receptor subuni (333 aa)
initn: 175 init1: 120 opt: 181 Z-score: 200.2 bits: 45.7 E(85289): 0.00021
Smith-Waterman score: 302; 23.6% identity (54.3% similar) in 322 aa overlap (33-338:32-333)
10 20 30 40 50 60
pF1KB6 WPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNP-PEGASSN
::: :....: .: :. :.: :. . :
NP_783 IIVAHVLLILLGATEILQADLLPDEKISLLPPV-NFTIKVTGLAQVLLQWKPNPDQEQRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 CSLWYFSHFGDKQDKKIAPETRRSIEVP-LNERICLQVGSQCSTNESEKPSILVEKCISP
.: : ... .. . .: : :.. . .: . ....: : . .
NP_783 VNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHA
70 80 90 100 110 120
130 140 150 160
pF1KB6 PEGDPESAVTELQCIWH----NLSYMK-------CSWLPGRNTSPDTNYTLYYWHRSLEK
: :.: .....: : . : : .. :.:: : .. ::.: ::: . : .
NP_783 PPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB6 IHQCENIFRE--GQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVK
.:.. .. :. ..: : : . ... . .: . ... . :.: .. : . .
NP_783 --ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQ
190 200 210 220 230
230 240 250 260 270 280
pF1KB6 PDPPHIKNLSFHNDDLYVQWENP-QNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPE
.:: . ... : .:::.: . : .:. :::...:... :.: : .
NP_783 INPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNG-----YLQIEKLMTNA
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB6 FERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYI
: ... : . :..:. ....: : :::.::: . .::
NP_783 FISIIDDLSKY-----------DVQVRAAVSSMCREAG-LWSEWSQPIYVGK
300 310 320 330
350 360 370 380 390 400
pF1KB6 TMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYE
427 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:22:46 2016 done: Sat Nov 5 11:22:47 2016
Total Scan time: 9.330 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]