Result of FASTA (omim) for
pF1KB6680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6680, 456 aa
1>>>pF1KB6680 456 - 456 aa - 456 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4417+/-0.000574; mu= -6.1715+/- 0.036
mean_var=364.8222+/-73.184, 0's: 0 Z-trim(116.3): 181 B-trim: 266 in 1/53
Lambda= 0.067148
statistics sampled from 27116 (27298) to 27116 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.32), width: 16
Scan time: 10.350
The best scores are: opt bits E(85289)
NP_002266 (OMIM: 148030) keratin, type I cytoskele ( 456) 2926 298.0 3.5e-80
XP_011523086 (OMIM: 148030) PREDICTED: keratin, ty ( 463) 2894 294.9 3e-79
XP_016880103 (OMIM: 148030) PREDICTED: keratin, ty ( 437) 2699 276.0 1.4e-73
NP_705694 (OMIM: 148065,615785) keratin, type I cy ( 458) 2024 210.6 7e-54
NP_002265 (OMIM: 148065,615785) keratin, type I cy ( 420) 2006 208.8 2.2e-53
NP_000517 (OMIM: 125595,131760,131800,131900,14806 ( 472) 1871 195.8 2.1e-49
NP_005548 (OMIM: 148067,167200,613000) keratin, ty ( 473) 1844 193.2 1.3e-48
NP_000413 (OMIM: 148069,167210,184500) keratin, ty ( 432) 1709 180.1 1e-44
NP_000412 (OMIM: 113800,148080,607602,609165) kera ( 584) 1628 172.4 2.9e-42
XP_005257400 (OMIM: 113800,148080,607602,609165) P ( 624) 1624 172.0 4e-42
NP_002267 (OMIM: 148020) keratin, type I cytoskele ( 400) 1554 165.0 3.3e-40
NP_000214 (OMIM: 122100,601687) keratin, type I cy ( 494) 1509 160.8 7.7e-39
NP_000217 (OMIM: 144200,607606) keratin, type I cy ( 623) 1484 158.4 4.9e-38
NP_061889 (OMIM: 607742) keratin, type I cytoskele ( 525) 1413 151.5 5.1e-36
XP_016879788 (OMIM: 607742) PREDICTED: keratin, ty ( 494) 1402 150.4 1e-35
NP_853513 (OMIM: 616677) keratin, type I cytoskele ( 464) 1375 147.8 6e-35
NP_853515 (OMIM: 616676) keratin, type I cytoskele ( 459) 1374 147.7 6.4e-35
NP_003762 (OMIM: 604540) keratin, type I cuticular ( 467) 1321 142.5 2.3e-33
XP_011522716 (OMIM: 616646,616760) PREDICTED: kera ( 448) 1320 142.4 2.3e-33
NP_853512 (OMIM: 616646,616760) keratin, type I cy ( 450) 1320 142.4 2.4e-33
XP_011523096 (OMIM: 602764) PREDICTED: keratin, ty ( 455) 1270 137.6 6.8e-32
NP_002271 (OMIM: 602764) keratin, type I cuticular ( 455) 1270 137.6 6.8e-32
NP_853517 (OMIM: 616675) keratin, type I cytoskele ( 468) 1247 135.4 3.3e-31
NP_002269 (OMIM: 602760) keratin, type I cuticular ( 448) 1217 132.4 2.4e-30
NP_061883 (OMIM: 608218) keratin, type I cytoskele ( 424) 1203 131.1 5.8e-30
NP_004129 (OMIM: 602761) keratin, type I cuticular ( 404) 1178 128.6 3e-29
NP_002268 (OMIM: 601077) keratin, type I cuticular ( 416) 1178 128.6 3.1e-29
NP_002270 (OMIM: 602762) keratin, type I cuticular ( 404) 1167 127.5 6.3e-29
XP_011523095 (OMIM: 602763) PREDICTED: keratin, ty ( 412) 1156 126.5 1.3e-28
NP_066293 (OMIM: 602763) keratin, type I cuticular ( 436) 1156 126.5 1.4e-28
XP_006721802 (OMIM: 607742) PREDICTED: keratin, ty ( 427) 1138 124.8 4.6e-28
XP_011522762 (OMIM: 607742) PREDICTED: keratin, ty ( 422) 1134 124.4 6e-28
NP_954657 (OMIM: 148070) keratin, type I cytoskele ( 430) 1095 120.6 8.3e-27
NP_000215 (OMIM: 148070) keratin, type I cytoskele ( 430) 1095 120.6 8.3e-27
NP_056330 (OMIM: 606194) keratin, type I cytoskele ( 422) 1069 118.1 4.7e-26
NP_872303 (OMIM: 616679) keratin, type I cytoskele ( 431) 1057 116.9 1.1e-25
XP_016879678 (OMIM: 616679) PREDICTED: keratin, ty ( 484) 1057 117.0 1.2e-25
NP_998821 (OMIM: 616678) keratin, type I cytoskele ( 491) 1056 116.9 1.3e-25
NP_006762 (OMIM: 604542) keratin, type I cuticular ( 456) 1044 115.7 2.7e-25
NP_003761 (OMIM: 604541) keratin, type I cuticular ( 449) 1036 114.9 4.5e-25
NP_001269362 (OMIM: 606194) keratin, type I cytosk ( 285) 769 88.8 2e-17
XP_005257257 (OMIM: 606194) PREDICTED: keratin, ty ( 285) 769 88.8 2e-17
XP_011522897 (OMIM: 606194) PREDICTED: keratin, ty ( 285) 769 88.8 2e-17
NP_001918 (OMIM: 125660,181400,601419,602067,60476 ( 470) 667 79.2 2.7e-14
NP_001124491 (OMIM: 137780,203450) glial fibrillar ( 431) 663 78.8 3.3e-14
XP_016879940 (OMIM: 137780,203450) PREDICTED: glia ( 472) 663 78.8 3.5e-14
NP_002046 (OMIM: 137780,203450) glial fibrillary a ( 432) 661 78.6 3.8e-14
NP_001229305 (OMIM: 137780,203450) glial fibrillar ( 438) 661 78.6 3.8e-14
NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483) 651 77.6 8e-14
NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483) 651 77.6 8e-14
>>NP_002266 (OMIM: 148030) keratin, type I cytoskeletal (456 aa)
initn: 2926 init1: 2926 opt: 2926 Z-score: 1560.6 bits: 298.0 E(85289): 3.5e-80
Smith-Waterman score: 2926; 99.8% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 DKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRDKIMATTIDNSRVILE
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_002 DKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 KKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 TEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI
370 380 390 400 410 420
430 440 450
pF1KB6 GIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
::::::::::::::::::::::::::::::::::::
NP_002 GIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
430 440 450
>>XP_011523086 (OMIM: 148030) PREDICTED: keratin, type I (463 aa)
initn: 1613 init1: 1613 opt: 2894 Z-score: 1543.7 bits: 294.9 E(85289): 3e-79
Smith-Waterman score: 2894; 98.1% identity (98.5% similar) in 463 aa overlap (1-456:1-463)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 DKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRDKIMATTIDNSRVILE
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_011 DKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
190 200 210 220 230 240
250 260 270 280 290
pF1KB6 KKNHEE-------EMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDV
:::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKNHEEWVPPILQEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB6 EAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAET
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB6 ECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQ
370 380 390 400 410 420
420 430 440 450
pF1KB6 DAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
:::::::.:::::::::::::::::::::::::::::::::::
XP_011 DAKMAGIAIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
430 440 450 460
>>XP_016880103 (OMIM: 148030) PREDICTED: keratin, type I (437 aa)
initn: 2732 init1: 1613 opt: 2699 Z-score: 1441.9 bits: 276.0 E(85289): 1.4e-73
Smith-Waterman score: 2699; 97.7% identity (98.2% similar) in 434 aa overlap (1-427:1-434)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 DKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRDKIMATTIDNSRVILE
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_016 DKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
190 200 210 220 230 240
250 260 270 280 290
pF1KB6 KKNHEE-------EMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDV
:::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKNHEEWVPPILQEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB6 EAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAET
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB6 ECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQ
370 380 390 400 410 420
420 430 440 450
pF1KB6 DAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
:::::::.:::: :
XP_016 DAKMAGIAIREAYSFSL
430
>>NP_705694 (OMIM: 148065,615785) keratin, type I cytosk (458 aa)
initn: 2254 init1: 1881 opt: 2024 Z-score: 1088.3 bits: 210.6 E(85289): 7e-54
Smith-Waterman score: 2103; 75.9% identity (89.1% similar) in 440 aa overlap (27-451:13-446)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
:::::::: . ::: :..:. :.::::.::.:::
NP_705 MSLRLQSSSASYGGGFGGGSCQLGGG-RGVSTCSTRFVSGGSAGGY
10 20 30 40
70 80 90 100
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGG---------------DGGLLSGNE
:::. ::::::::: ::::.:::.:::.:::.::: :::::.:::
NP_705 GGGVS-CGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNE
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB6 KITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRD
:::::::::::::::.::::::::::::::::.::. ::.::::: ::: :.::::::::
NP_705 KITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRD
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB6 KIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTD
::...::.:.::::::::::::::::::::::::::::.:::::::::::::::::..::
NP_705 KILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTD
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB6 LEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAM
::::::.:::::::.::::::::::::.:..:::::::::.::.::::::::::::::::
NP_705 LEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAM
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB6 AEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAG
::.::::.: :: .:. ::::::..:: ::::::::::.::::.: ::::::::::::::
NP_705 AERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB6 LENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIAT
:::..:::::::: :::::::::...:::::::: ::: :::::::::::::::::::::
NP_705 LENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIAT
350 360 370 380 390 400
410 420 430 440 450
pF1KB6 YRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
:::::::::::: :. ::.:. : . ... :.. ..:.
NP_705 YRSLLEGQDAKMIGF----PSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
410 420 430 440 450
>>NP_002265 (OMIM: 148065,615785) keratin, type I cytosk (420 aa)
initn: 1867 init1: 1867 opt: 2006 Z-score: 1079.3 bits: 208.8 E(85289): 2.2e-53
Smith-Waterman score: 2085; 80.5% identity (91.9% similar) in 405 aa overlap (27-416:13-415)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
:::::::: . ::: :..:. :.::::.::.:::
NP_002 MSLRLQSSSASYGGGFGGGSCQLGGG-RGVSTCSTRFVSGGSAGGY
10 20 30 40
70 80 90 100
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGG---------------DGGLLSGNE
:::. ::::::::: ::::.:::.:::.:::.::: :::::.:::
NP_002 GGGVS-CGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNE
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB6 KITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRD
:::::::::::::::.::::::::::::::::.::. ::.::::: ::: :.::::::::
NP_002 KITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRD
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB6 KIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTD
::...::.:.::::::::::::::::::::::::::::.:::::::::::::::::..::
NP_002 KILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTD
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB6 LEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAM
::::::.:::::::.::::::::::::.:..:::::::::.::.::::::::::::::::
NP_002 LEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAM
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB6 AEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAG
::.::::.: :: .:. ::::::..:: ::::::::::.::::.: ::::::::::::::
NP_002 AERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB6 LENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIAT
:::..:::::::: :::::::::...:::::::: ::: :::::::::::::::::::::
NP_002 LENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIAT
350 360 370 380 390 400
410 420 430 440 450
pF1KB6 YRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
:::::::::::
NP_002 YRSLLEGQDAKKRQPP
410 420
>>NP_000517 (OMIM: 125595,131760,131800,131900,148066,16 (472 aa)
initn: 1823 init1: 1335 opt: 1871 Z-score: 1008.0 bits: 195.8 E(85289): 2.1e-49
Smith-Waterman score: 1871; 66.6% identity (86.9% similar) in 449 aa overlap (14-454:25-466)
10 20 30 40
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSA
::::.: .:.::::. . : ::: .:.::.
NP_000 MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGS-CRAPSTYGGG----LSVSSS
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 RFVSSGS---GGGYGGGMRVCG--FGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGN
:: :.:. :::::::. . ::.: :. .:::.:.:.::::::::.:::: :: :.
NP_000 RFSSGGAYGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDG-LLVGS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 EKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELR
::.::::::::::::::::::::::::::::::.::::.: :: . ::: ::::::.::
NP_000 EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIK-DYSPYFKTIEDLR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 DKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLART
.::...:.::. :.:.:::::::::::: :::.:: ::..:::::::::::::::::::.
NP_000 NKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 DLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEA
:::::::.:.::::::::::::::. . .:..:.:::::::::::::.:.: :::.:::
NP_000 DLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB6 MAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKA
::::::.:.: :::.::::::.:::.:.:..:..:.::..::::::.:::::::::::::
NP_000 MAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB6 GLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIA
.::::: ::. :: :: ::: .::..: ::..:::::: ::::::.:::.:::::::::
NP_000 SLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIA
360 370 380 390 400 410
410 420 430 440 450
pF1KB6 TYRSLLEGQDAKMAGIGIREASSGG---GGSSSNFHINVEESVDGQVVSSHKREI
::: ::::.::.... . .:... .:: ... .: . ::.:::.:..
NP_000 TYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN
420 430 440 450 460 470
>>NP_005548 (OMIM: 148067,167200,613000) keratin, type I (473 aa)
initn: 1786 init1: 1368 opt: 1844 Z-score: 993.9 bits: 193.2 E(85289): 1.3e-48
Smith-Waterman score: 1844; 69.6% identity (86.7% similar) in 428 aa overlap (14-433:25-440)
10 20 30 40
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSA
::::.: .:.::::. . : ::: .:.::
NP_005 MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGS-CRAPSTYGGG----LSVSS-
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 RFVSSGS---GGGYGGGMRVC-----GFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLL
:: :.:. :::::::. ::::: :. .:.:::::.:.::::::.:::: ::
NP_005 RFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDG-LL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 SGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIE
:.::.::::::::::::::::::::::::::::::.::::.: :. . ::: ::::::
NP_005 VGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIK-DYSPYFKTIE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 ELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTL
.::.::.:.::.:.. ::.:::::::::::: :::.:::::: ::::.::::::::::::
NP_005 DLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 ARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQ
::::::::::::.::::::.::::::: . .: .:.:::::::::::::.:.: :::.:
NP_005 ARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQ
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB6 YEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLS
:: ::::::::.:.::.:::::::::::::.:..:.:..:.:.:::..: ::::::::::
NP_005 YEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB6 MKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQ
:::.::::: ::. :: ::.:::::::..: ::..:::::: :.:::..:::.::::::
NP_005 MKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQ
360 370 380 390 400 410
410 420 430 440 450
pF1KB6 EIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
:::::: ::::.::.... . .:: . ::
NP_005 EIATYRRLLEGEDAHLSS----QQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFS
420 430 440 450 460
NP_005 QGQSS
470
>>NP_000413 (OMIM: 148069,167210,184500) keratin, type I (432 aa)
initn: 1626 init1: 1307 opt: 1709 Z-score: 923.7 bits: 180.1 E(85289): 1e-44
Smith-Waterman score: 1721; 62.1% identity (83.7% similar) in 454 aa overlap (1-454:1-426)
10 20 30 40 50 60
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
:::.. : .::. : .:.: :.::.. . :::: : :.: :. ::.::
NP_000 MTTSIRQFTSSS----SIKGSSGLGGGSSRTSCRLSGGLG-----AGSCRL---GSAGGL
10 20 30 40
70 80 90 100 110 120
pF1KB6 GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
:. . .:: ... .. : :::.:..::: :: ::.:.:: :::::::::::::
NP_000 GSTL--------GGSSYSSCYSFGSGGGYGSSFGGVDG-LLAGGEKATMQNLNDRLASYL
50 60 70 80 90
130 140 150 160 170 180
pF1KB6 DKVRALEEANADLEVKIHDWYQKQTPASPECDYSQYFKTIEELRDKIMATTIDNSRVILE
::::::::::..:::::.::::.:.:. : :::::..:::::..::...:.::. ..:.
NP_000 DKVRALEEANTELEVKIRDWYQRQAPG-PARDYSQYYRTIEELQNKILTATVDNANILLQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
:::::::::::: :.:.: ::: .:::::::::::::::::::.:::::::.:.::::::
NP_000 IDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB6 KKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSK
::::::::. . .:..:..::::::::::::.:.: :::.::: ::::::.:.: :::::
NP_000 KKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB6 TEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQ
:::::.:::.:.:..:..:.::..:::::: :::::::::::::.::..::::: :: .:
NP_000 TEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQ
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB6 LQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI
:.:::::::..: ::..:::::: ::::::.:::.:::::::::::: ::::.::...
NP_000 LSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQY
340 350 360 370 380 390
430 440 450
pF1KB6 GIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
. .. . . . ::: ::.:.::...
NP_000 KKEPVT------TRQVRTIVEEVQDGKVISSREQVHQTTR
400 410 420 430
>>NP_000412 (OMIM: 113800,148080,607602,609165) keratin, (584 aa)
initn: 1189 init1: 1189 opt: 1628 Z-score: 879.6 bits: 172.4 E(85289): 2.9e-42
Smith-Waterman score: 1628; 62.6% identity (83.3% similar) in 431 aa overlap (9-431:48-472)
10 20 30
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGG
::. :.::: :: .::: :::.: .:
NP_000 GGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGS--SGGGCFGGSS-GGY
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 GGSRSISASSAR--FVSSGSGGGYGGGMRVCGFGGGA---GSVFGGGFGGG-VGGGFGGG
:: .....: : . ::. ::.:::.. .::::. :: ::::::: :::::::
NP_000 GGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGG
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 FGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQ--TPASPE
::: ::::::::::.:::::::::::::::::::::.: .:: ::..::.:. . .
NP_000 FGG-DGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEP
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 CDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADIN
:::.:.:::..:...:. : ::. ..:.::::::::::::::::::.::::.::::::
NP_000 RDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADIN
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 GLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVD
:::::::::::...:::::::.:.:::::::::::::::.. . .:.:::::.::::::
NP_000 GLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVD
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 LTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQ
::..: .:: ::: .::.::.:.:::: :..::. :. .: :.:.. :.:::.:::..:
NP_000 LTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQ
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 ELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYK
:::::::::..: .:: :::::: :: .::.:::. :..:: ::...: : : :: ::.
NP_000 ALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQ
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 MLLDIKTRLEQEIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVS
.::::: :::.:: ::::::::. . .: : : ..: :::
NP_000 QLLDIKIRLENEIQTYRSLLEGEGS--SGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGH
440 450 460 470 480 490
pF1KB6 SHKREI
NP_000 GGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGS
500 510 520 530 540 550
>>XP_005257400 (OMIM: 113800,148080,607602,609165) PREDI (624 aa)
initn: 1185 init1: 1185 opt: 1624 Z-score: 877.2 bits: 172.0 E(85289): 4e-42
Smith-Waterman score: 1624; 62.6% identity (83.1% similar) in 431 aa overlap (9-431:48-472)
10 20 30
pF1KB6 MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGG
::. :.::: :: .::: :::.: .:
XP_005 GGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGS--SGGGCFGGSS-GGY
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 GGSRSISASSAR--FVSSGSGGGYGGGMRVCGFGGGA---GSVFGGGFGGG-VGGGFGGG
:: .....: : . ::. ::.::: . .::::. :: ::::::: :::::::
XP_005 GGLGGFGGGSFRGSYGSSSFGGSYGGIFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGG
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 FGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQ--TPASPE
::: ::::::::::.:::::::::::::::::::::.: .:: ::..::.:. . .
XP_005 FGG-DGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEP
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 CDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADIN
:::.:.:::..:...:. : ::. ..:.::::::::::::::::::.::::.::::::
XP_005 RDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADIN
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 GLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVD
:::::::::::...:::::::.:.:::::::::::::::.. . .:.:::::.::::::
XP_005 GLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVD
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 LTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQ
::..: .:: ::: .::.::.:.:::: :..::. :. .: :.:.. :.:::.:::..:
XP_005 LTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQ
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 ELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYK
:::::::::..: .:: :::::: :: .::.:::. :..:: ::...: : : :: ::.
XP_005 ALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQ
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 MLLDIKTRLEQEIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVS
.::::: :::.:: ::::::::. . .: : : ..: :::
XP_005 QLLDIKIRLENEIQTYRSLLEGEGS--SGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGH
440 450 460 470 480 490
pF1KB6 SHKREI
XP_005 GGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGS
500 510 520 530 540 550
456 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:44:43 2016 done: Sat Nov 5 11:44:44 2016
Total Scan time: 10.350 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]