Result of FASTA (omim) for
pF1KB6678
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6678, 436 aa
1>>>pF1KB6678 436 - 436 aa - 436 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6090+/-0.00035; mu= 16.1398+/- 0.022
mean_var=71.9426+/-14.424, 0's: 0 Z-trim(114.3): 31 B-trim: 115 in 1/55
Lambda= 0.151210
statistics sampled from 24067 (24098) to 24067 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.283), width: 16
Scan time: 6.660
The best scores are: opt bits E(85289)
NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase ( ( 436) 2916 645.4 8.6e-185
XP_011509647 (OMIM: 602524) PREDICTED: pyruvate de ( 360) 2410 534.9 1.2e-151
XP_011509649 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 2021 450.1 4.6e-126
XP_011509645 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 2021 450.1 4.6e-126
XP_011509646 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 2021 450.1 4.6e-126
NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenas ( 456) 2021 450.1 5.3e-126
NP_002602 (OMIM: 602525) pyruvate dehydrogenase ki ( 407) 1959 436.6 5.7e-122
NP_005382 (OMIM: 300906) pyruvate dehydrogenase ki ( 406) 1912 426.3 7e-119
NP_001135858 (OMIM: 300906) pyruvate dehydrogenase ( 415) 1912 426.3 7.1e-119
NP_002603 (OMIM: 602527) pyruvate dehydrogenase ki ( 411) 1863 415.6 1.2e-115
NP_001186828 (OMIM: 602525) pyruvate dehydrogenase ( 343) 1682 376.1 7.7e-104
NP_001186827 (OMIM: 602525) pyruvate dehydrogenase ( 343) 1682 376.1 7.7e-104
XP_006712658 (OMIM: 602524) PREDICTED: pyruvate de ( 244) 1617 361.9 1.1e-99
XP_006712657 (OMIM: 602524) PREDICTED: pyruvate de ( 281) 889 203.1 7.7e-52
NP_001186829 (OMIM: 602525) pyruvate dehydrogenase ( 199) 821 188.2 1.7e-47
NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobut ( 412) 289 72.3 2.7e-12
NP_001258855 (OMIM: 614901,614923) [3-methyl-2-oxo ( 335) 210 55.0 3.5e-07
NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxo ( 365) 210 55.0 3.7e-07
XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-me ( 410) 210 55.0 4.1e-07
>>NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase (acet (436 aa)
initn: 2916 init1: 2916 opt: 2916 Z-score: 3438.5 bits: 645.4 E(85289): 8.6e-185
Smith-Waterman score: 2916; 100.0% identity (100.0% similar) in 436 aa overlap (1-436:1-436)
10 20 30 40 50 60
pF1KB6 MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 LDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 DLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 ISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW
370 380 390 400 410 420
430
pF1KB6 CVPSREPKDMTTFRSA
::::::::::::::::
NP_002 CVPSREPKDMTTFRSA
430
>>XP_011509647 (OMIM: 602524) PREDICTED: pyruvate dehydr (360 aa)
initn: 2410 init1: 2410 opt: 2410 Z-score: 2843.2 bits: 534.9 E(85289): 1.2e-151
Smith-Waterman score: 2410; 100.0% identity (100.0% similar) in 360 aa overlap (77-436:1-360)
50 60 70 80 90 100
pF1KB6 DFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPS
::::::::::::::::::::::::::::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPS
10 20 30
110 120 130 140 150 160
pF1KB6 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKES
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 FGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVL
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 EVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMR
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB6 ATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVET
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB6 SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKA
280 290 300 310 320 330
410 420 430
pF1KB6 AWKHYNTNHEADDWCVPSREPKDMTTFRSA
::::::::::::::::::::::::::::::
XP_011 AWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360
>>XP_011509649 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa)
initn: 2390 init1: 2021 opt: 2021 Z-score: 2384.3 bits: 450.1 E(85289): 4.6e-126
Smith-Waterman score: 2354; 94.5% identity (94.7% similar) in 380 aa overlap (77-436:1-380)
50 60 70 80 90 100
pF1KB6 DFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPS
::::::::::::::::::::::::::::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPS
10 20 30
110 120 130 140
pF1KB6 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYD--------------------FTDTVIRIR
::::::::::::::::::::::::::::::. :::::::::
XP_011 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIR
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
280 290 300 310 320 330
390 400 410 420 430
pF1KB6 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360 370 380
>>XP_011509645 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa)
initn: 2390 init1: 2021 opt: 2021 Z-score: 2384.3 bits: 450.1 E(85289): 4.6e-126
Smith-Waterman score: 2354; 94.5% identity (94.7% similar) in 380 aa overlap (77-436:1-380)
50 60 70 80 90 100
pF1KB6 DFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPS
::::::::::::::::::::::::::::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPS
10 20 30
110 120 130 140
pF1KB6 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYD--------------------FTDTVIRIR
::::::::::::::::::::::::::::::. :::::::::
XP_011 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIR
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
280 290 300 310 320 330
390 400 410 420 430
pF1KB6 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360 370 380
>>XP_011509646 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa)
initn: 2390 init1: 2021 opt: 2021 Z-score: 2384.3 bits: 450.1 E(85289): 4.6e-126
Smith-Waterman score: 2354; 94.5% identity (94.7% similar) in 380 aa overlap (77-436:1-380)
50 60 70 80 90 100
pF1KB6 DFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPS
::::::::::::::::::::::::::::::
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPS
10 20 30
110 120 130 140
pF1KB6 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYD--------------------FTDTVIRIR
::::::::::::::::::::::::::::::. :::::::::
XP_011 VQLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIR
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLR
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAV
280 290 300 310 320 330
390 400 410 420 430
pF1KB6 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
340 350 360 370 380
>>NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenase (a (456 aa)
initn: 2896 init1: 2021 opt: 2021 Z-score: 2383.1 bits: 450.1 E(85289): 5.3e-126
Smith-Waterman score: 2860; 95.4% identity (95.6% similar) in 456 aa overlap (1-436:1-456)
10 20 30 40 50 60
pF1KB6 MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
70 80 90 100 110 120
130 140 150 160
pF1KB6 LLDFKDKSAEDAKAIYD--------------------FTDTVIRIRNRHNDVIPTMAQGV
::::::::::::::::. :::::::::::::::::::::::
NP_001 LLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRNRHNDVIPTMAQGV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB6 IEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSIN
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB6 PNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFEL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB6 FKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB6 RPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERL
370 380 390 400 410 420
410 420 430
pF1KB6 PVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
::::::::::::::::::::::::::::::::::::
NP_001 PVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
430 440 450
>>NP_002602 (OMIM: 602525) pyruvate dehydrogenase kinase (407 aa)
initn: 1964 init1: 840 opt: 1959 Z-score: 2310.7 bits: 436.6 E(85289): 5.7e-122
Smith-Waterman score: 1959; 69.6% identity (89.2% similar) in 398 aa overlap (37-434:11-405)
10 20 30 40 50 60
pF1KB6 LRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFG
:: :.: .. ...:::::::::::::::
NP_002 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFG
10 20 30 40
70 80 90 100 110 120
pF1KB6 SVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKD
: :::::::: :::::::::::::::::.:::: .: :::::::::::.::: ....: :
NP_002 SSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 KSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYM
:. :: ... .:::... ::::::::.:::::::.:::...: :::..::.::::::::.
NP_002 KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 SRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYIN
::::::::.:::.:.: :. .:.: ::::::.::::: ::.::.:. :. ::: ::.
NP_002 SRISIRMLINQHTLIFDGST--NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMA
170 180 190 200 210
250 260 270 280 290 300
pF1KB6 SPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVT
::.::..:.:: . :::..::::::::::.:::::::::::.: : . . :::.: :.
NP_002 SPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB6 LGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYA
::.:::..::::::::::::::.:::.::::::: :. :. ..::::::::::::::::
NP_002 LGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB6 QYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSRE
.::::::.:.:.::.:::::::.:::::::.::::::::.::.::.: .:: :::::: :
NP_002 KYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTE
340 350 360 370 380 390
430
pF1KB6 PKDMTTFRSA
::. .:.:
NP_002 PKNTSTYRVS
400
>>NP_005382 (OMIM: 300906) pyruvate dehydrogenase kinase (406 aa)
initn: 1516 init1: 810 opt: 1912 Z-score: 2255.3 bits: 426.3 E(85289): 7e-119
Smith-Waterman score: 1912; 68.6% identity (88.4% similar) in 395 aa overlap (42-435:12-404)
20 30 40 50 60 70
pF1KB6 LAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC
:: :.. :.::::::::.::::::: :::
NP_005 MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNAC
10 20 30 40
80 90 100 110 120 130
pF1KB6 EKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAED
::::.::::.:::::::: :.:..::::::: ::: ::::::.::. :::....:: ::
NP_005 EKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPED
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB6 AKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISI
... .: ...:..:::::::.::::::::::::.:: :: : :.:::::::: .:::.
NP_005 PQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB6 RMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELE
:::.:::.::::: .: : ::::::.:.::: .:.::.::.:. ::. ::. .::::
NP_005 RMLINQHTLLFGGDT--NPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELE
170 180 190 200 210
260 270 280 290 300 310
pF1KB6 LEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGV-YPPIQVHVTLGNE
.::.:::.: .:::::::::::.::.::::::.::::.: . .: :: ... ::::.:
NP_005 VEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB6 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQ
::..:.:: ::::::::::::::::::::::: .: .::.::::::::::::::::.:::
NP_005 DLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQ
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB6 GDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM
:::::::.:: :::::::.::::..:.:::::.::.::.::.:. ::::: :: ::.:
NP_005 GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
340 350 360 370 380 390
pF1KB6 TTFRSA
. ...
NP_005 SKYKAKQ
400
>>NP_001135858 (OMIM: 300906) pyruvate dehydrogenase kin (415 aa)
initn: 1516 init1: 810 opt: 1912 Z-score: 2255.2 bits: 426.3 E(85289): 7.1e-119
Smith-Waterman score: 1912; 68.6% identity (88.4% similar) in 395 aa overlap (42-435:12-404)
20 30 40 50 60 70
pF1KB6 LAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC
:: :.. :.::::::::.::::::: :::
NP_001 MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNAC
10 20 30 40
80 90 100 110 120 130
pF1KB6 EKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAED
::::.::::.:::::::: :.:..::::::: ::: ::::::.::. :::....:: ::
NP_001 EKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPED
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB6 AKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISI
... .: ...:..:::::::.::::::::::::.:: :: : :.:::::::: .:::.
NP_001 PQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB6 RMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELE
:::.:::.::::: .: : ::::::.:.::: .:.::.::.:. ::. ::. .::::
NP_001 RMLINQHTLLFGGDT--NPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELE
170 180 190 200 210
260 270 280 290 300 310
pF1KB6 LEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGV-YPPIQVHVTLGNE
.::.:::.: .:::::::::::.::.::::::.::::.: . .: :: ... ::::.:
NP_001 VEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB6 DLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQ
::..:.:: ::::::::::::::::::::::: .: .::.::::::::::::::::.:::
NP_001 DLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQ
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB6 GDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM
:::::::.:: :::::::.::::..:.:::::.::.::.::.:. ::::: :: ::.:
NP_001 GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
340 350 360 370 380 390
pF1KB6 TTFRSA
. ...
NP_001 SKYKAKQDKIKTNRTF
400 410
>>NP_002603 (OMIM: 602527) pyruvate dehydrogenase kinase (411 aa)
initn: 1872 init1: 1076 opt: 1863 Z-score: 2197.5 bits: 415.6 E(85289): 1.2e-115
Smith-Waterman score: 1863; 65.4% identity (87.4% similar) in 413 aa overlap (19-430:1-405)
10 20 30 40 50
pF1KB6 MRLARLLRGAALAGPGPGLRAAGFS-RSFSSDSGSSPASERGVPGQVDFYARFSPSPLSM
..:: : :: .: .:.. :: .:. ..:.:::::::
NP_002 MKAARFVLRSAGSLNGAGL-----VPREVEHFSRYSPSPLSM
10 20 30
60 70 80 90 100 110
pF1KB6 KQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQ
::.::::: ::::.::: :::::::::::::.:::..:: .:. : :::::.:::::::.
NP_002 KQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLM
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB6 ELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQY
.:..:..:: .: ::. ::.::.:..::::..:.::::::.::::.. :::::.::.::
NP_002 DLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQY
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB6 FLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRL
:::::::.::: :::.::: :.:. . :.:: :::::.:::.:. :..:..: .: :
NP_002 FLDRFYMNRISTRMLMNQHILIFSDSQTGNPS---HIGSIDPNCDVVAVVQDAFECSRML
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB6 CDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYP
:: ::..::::.: ..:.: : :::..:::::::.::.:::::::::::.::. :.
NP_002 CDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB6 PIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGL
::.: :.::.::::.:.:::::::::: :::::.: ::::: : ...:: .:::::::::
NP_002 PIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGL
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB6 PISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADD
:::::::.::::::.:::: ::::::.::.::::..:::.:::.::.:.:::. . ::::
NP_002 PISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADD
340 350 360 370 380 390
420 430
pF1KB6 WCVPSREPKDMTTFRSA
::.::::::..
NP_002 WCIPSREPKNLAKEVAM
400 410
436 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:22:08 2016 done: Sat Nov 5 11:22:09 2016
Total Scan time: 6.660 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]