Result of FASTA (omim) for
pF1KB6462
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6462, 352 aa
1>>>pF1KB6462 352 - 352 aa - 352 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.1233+/-0.00047; mu= -1.6051+/- 0.029
mean_var=272.3778+/-58.874, 0's: 0 Z-trim(117.4): 308 B-trim: 47 in 1/55
Lambda= 0.077712
statistics sampled from 28870 (29285) to 28870 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.343), width: 16
Scan time: 6.560
The best scores are: opt bits E(85289)
NP_003017 (OMIM: 604465) endophilin-A1 [Homo sapie ( 352) 2330 274.7 2.1e-73
XP_011516307 (OMIM: 604465) PREDICTED: endophilin- ( 386) 2235 264.1 3.7e-70
NP_003018 (OMIM: 603362) endophilin-A3 isoform a [ ( 347) 1617 194.8 2.5e-49
XP_011520191 (OMIM: 603362) PREDICTED: endophilin- ( 355) 1532 185.2 1.8e-46
NP_001288038 (OMIM: 603362) endophilin-A3 isoform ( 355) 1532 185.2 1.8e-46
NP_001311112 (OMIM: 603362) endophilin-A3 isoform ( 355) 1532 185.2 1.8e-46
NP_001311115 (OMIM: 603362) endophilin-A3 isoform ( 312) 1440 174.9 2.1e-43
NP_001311113 (OMIM: 603362) endophilin-A3 isoform ( 312) 1440 174.9 2.1e-43
NP_003016 (OMIM: 601768) endophilin-A2 isoform 1 [ ( 368) 1390 169.3 1.2e-41
XP_016882635 (OMIM: 601768) PREDICTED: endophilin- ( 358) 1318 161.3 3.1e-39
NP_001311114 (OMIM: 603362) endophilin-A3 isoform ( 278) 1279 156.8 5.4e-38
NP_001288037 (OMIM: 603362) endophilin-A3 isoform ( 278) 1279 156.8 5.4e-38
XP_016877975 (OMIM: 603362) PREDICTED: endophilin- ( 278) 1279 156.8 5.4e-38
NP_001311116 (OMIM: 603362) endophilin-A3 isoform ( 278) 1279 156.8 5.4e-38
NP_001311111 (OMIM: 603362) endophilin-A3 isoform ( 360) 1217 149.9 8e-36
XP_011526485 (OMIM: 601768) PREDICTED: endophilin- ( 333) 1187 146.5 7.7e-35
XP_011520194 (OMIM: 603362) PREDICTED: endophilin- ( 217) 930 117.5 2.7e-26
XP_011520193 (OMIM: 603362) PREDICTED: endophilin- ( 237) 929 117.5 3.1e-26
NP_001186872 (OMIM: 601768) endophilin-A2 isoform ( 320) 830 106.5 8.4e-23
NP_001186873 (OMIM: 601768) endophilin-A2 isoform ( 304) 666 88.1 2.8e-17
NP_057093 (OMIM: 609287) endophilin-B1 isoform 1 [ ( 365) 312 48.5 2.8e-05
NP_001273975 (OMIM: 609288) endophilin-B2 isoform ( 395) 285 45.5 0.00024
NP_064530 (OMIM: 609288) endophilin-B2 isoform b [ ( 395) 285 45.5 0.00024
XP_005252155 (OMIM: 609288) PREDICTED: endophilin- ( 400) 285 45.5 0.00024
XP_006717254 (OMIM: 609288) PREDICTED: endophilin- ( 399) 281 45.0 0.00033
NP_001273974 (OMIM: 609288) endophilin-B2 isoform ( 404) 281 45.0 0.00034
NP_001193580 (OMIM: 609287) endophilin-B1 isoform ( 394) 277 44.6 0.00045
XP_006710735 (OMIM: 609287) PREDICTED: endophilin- ( 402) 274 44.3 0.00058
XP_016856898 (OMIM: 609287) PREDICTED: endophilin- ( 235) 268 43.4 0.00063
XP_016856899 (OMIM: 609287) PREDICTED: endophilin- ( 219) 265 43.0 0.00075
XP_005252157 (OMIM: 609288) PREDICTED: endophilin- ( 379) 268 43.6 0.00088
NP_001193581 (OMIM: 609287) endophilin-B1 isoform ( 386) 268 43.6 0.00089
XP_011539840 (OMIM: 609287) PREDICTED: endophilin- ( 378) 265 43.2 0.0011
XP_006717252 (OMIM: 609288) PREDICTED: endophilin- ( 424) 265 43.3 0.0012
XP_006717253 (OMIM: 609288) PREDICTED: endophilin- ( 423) 263 43.0 0.0014
XP_006717251 (OMIM: 609288) PREDICTED: endophilin- ( 428) 263 43.0 0.0014
>>NP_003017 (OMIM: 604465) endophilin-A1 [Homo sapiens] (352 aa)
initn: 2330 init1: 2330 opt: 2330 Z-score: 1438.7 bits: 274.7 E(85289): 2.1e-73
Smith-Waterman score: 2330; 100.0% identity (100.0% similar) in 352 aa overlap (1-352:1-352)
10 20 30 40 50 60
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD
250 260 270 280 290 300
310 320 330 340 350
pF1KB6 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
310 320 330 340 350
>>XP_011516307 (OMIM: 604465) PREDICTED: endophilin-A1 i (386 aa)
initn: 2235 init1: 2235 opt: 2235 Z-score: 1380.6 bits: 264.1 E(85289): 3.7e-70
Smith-Waterman score: 2235; 100.0% identity (100.0% similar) in 337 aa overlap (16-352:50-386)
10 20 30 40
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSR
::::::::::::::::::::::::::::::
XP_011 DDFAFLLKGMFGNVWRHFWLPRLERCYQHLKVSEKVGGAEGTKLDDDFKEMERKVDVTSR
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB6 AVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELG
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB6 DDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRR
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB6 LDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEY
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB6 HKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKP
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB6 SGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE
320 330 340 350 360 370
350
pF1KB6 ILVALPH
:::::::
XP_011 ILVALPH
380
>>NP_003018 (OMIM: 603362) endophilin-A3 isoform a [Homo (347 aa)
initn: 1642 init1: 1212 opt: 1617 Z-score: 1006.7 bits: 194.8 E(85289): 2.5e-49
Smith-Waterman score: 1617; 68.1% identity (87.6% similar) in 354 aa overlap (1-352:1-347)
10 20 30 40 50 60
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
:::::::::::::.: :::..:::::::::.: .::::.:::...: ::..:: :::::
NP_003 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .:: :: ::::.
NP_003 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
:. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.:::::: :::::
NP_003 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:::.. .:
NP_003 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL
190 200 210 220 230 240
250 260 270 280 290
pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRAL
. :: ::: :::::.:.: . :.. .:.: :.. : .: . :::::::.:
NP_003 QMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGL
250 260 270 280 290
300 310 320 330 340 350
pF1KB6 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
:::::::.:::::::::::::::::::::::::.::.::::::::::..: ::.
NP_003 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ
300 310 320 330 340
>>XP_011520191 (OMIM: 603362) PREDICTED: endophilin-A3 i (355 aa)
initn: 1554 init1: 1124 opt: 1532 Z-score: 955.1 bits: 185.2 E(85289): 1.8e-46
Smith-Waterman score: 1532; 67.1% identity (87.1% similar) in 340 aa overlap (15-352:23-355)
10 20 30 40 50
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMT
: :::..:::::::::.: .::::.:::...: ::..
XP_011 MDGIFAGIICNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 KTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGP
:: :::::::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .::
XP_011 KTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 ALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKK
:: ::::.:. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.::::
XP_011 ALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB6 KRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQI
:: :::::::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:
XP_011 KRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 LQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQM
::.. .:. :: ::: :::::.:.: . :.. .:.: :.. : .: . :
XP_011 LQELQSKLQMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPM
250 260 270 280 290
300 310 320 330 340 350
pF1KB6 DQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL
::::::.::::::::.:::::::::::::::::::::::::.::.::::::::::..: :
XP_011 DQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL
300 310 320 330 340 350
pF1KB6 PH
:.
XP_011 PQ
>>NP_001288038 (OMIM: 603362) endophilin-A3 isoform c [H (355 aa)
initn: 1554 init1: 1124 opt: 1532 Z-score: 955.1 bits: 185.2 E(85289): 1.8e-46
Smith-Waterman score: 1532; 67.1% identity (87.1% similar) in 340 aa overlap (15-352:23-355)
10 20 30 40 50
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMT
: :::..:::::::::.: .::::.:::...: ::..
NP_001 MDGIFAGIICNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 KTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGP
:: :::::::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .::
NP_001 KTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 ALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKK
:: ::::.:. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.::::
NP_001 ALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB6 KRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQI
:: :::::::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:
NP_001 KRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 LQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQM
::.. .:. :: ::: :::::.:.: . :.. .:.: :.. : .: . :
NP_001 LQELQSKLQMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPM
250 260 270 280 290
300 310 320 330 340 350
pF1KB6 DQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL
::::::.::::::::.:::::::::::::::::::::::::.::.::::::::::..: :
NP_001 DQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL
300 310 320 330 340 350
pF1KB6 PH
:.
NP_001 PQ
>>NP_001311112 (OMIM: 603362) endophilin-A3 isoform c [H (355 aa)
initn: 1554 init1: 1124 opt: 1532 Z-score: 955.1 bits: 185.2 E(85289): 1.8e-46
Smith-Waterman score: 1532; 67.1% identity (87.1% similar) in 340 aa overlap (15-352:23-355)
10 20 30 40 50
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMT
: :::..:::::::::.: .::::.:::...: ::..
NP_001 MDGIFAGIICNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 KTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGP
:: :::::::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .::
NP_001 KTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 ALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKK
:: ::::.:. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.::::
NP_001 ALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB6 KRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQI
:: :::::::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:
NP_001 KRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 LQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQM
::.. .:. :: ::: :::::.:.: . :.. .:.: :.. : .: . :
NP_001 LQELQSKLQMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPM
250 260 270 280 290
300 310 320 330 340 350
pF1KB6 DQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL
::::::.::::::::.:::::::::::::::::::::::::.::.::::::::::..: :
NP_001 DQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL
300 310 320 330 340 350
pF1KB6 PH
:.
NP_001 PQ
>>NP_001311115 (OMIM: 603362) endophilin-A3 isoform e [H (312 aa)
initn: 1465 init1: 1035 opt: 1440 Z-score: 900.1 bits: 174.9 E(85289): 2.1e-43
Smith-Waterman score: 1440; 67.1% identity (87.1% similar) in 319 aa overlap (36-352:1-312)
10 20 30 40 50 60
pF1KB6 LKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASR
::::.:::...: ::..:: :::::::: :
NP_001 MERKIDVTNKVVAEILSKTTEYLQPNPAYR
10 20 30
70 80 90 100 110 120
pF1KB6 AKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELS
:::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .:: :: ::::.:. ..
NP_001 AKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 EVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQ
::::::::.:::.:::::: :.::::.:: ::::::::::::.:::::: :::::::.::
NP_001 EVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 ALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIR
:.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:::.. .:. ::
NP_001 AVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRIS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB6 QASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRALYDFEP
::: :::::.:.: . :.. .:.: :.. : .: . :::::::.::::::
NP_001 AASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEP
220 230 240 250 260
310 320 330 340 350
pF1KB6 ENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
::.:::::::::::::::::::::::::.::.::::::::::..: ::.
NP_001 ENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ
270 280 290 300 310
>>NP_001311113 (OMIM: 603362) endophilin-A3 isoform e [H (312 aa)
initn: 1465 init1: 1035 opt: 1440 Z-score: 900.1 bits: 174.9 E(85289): 2.1e-43
Smith-Waterman score: 1440; 67.1% identity (87.1% similar) in 319 aa overlap (36-352:1-312)
10 20 30 40 50 60
pF1KB6 LKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASR
::::.:::...: ::..:: :::::::: :
NP_001 MERKIDVTNKVVAEILSKTTEYLQPNPAYR
10 20 30
70 80 90 100 110 120
pF1KB6 AKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELS
:::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .:: :: ::::.:. ..
NP_001 AKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 EVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQ
::::::::.:::.:::::: :.::::.:: ::::::::::::.:::::: :::::::.::
NP_001 EVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 ALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIR
:.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:::.. .:. ::
NP_001 AVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRIS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB6 QASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRALYDFEP
::: :::::.:.: . :.. .:.: :.. : .: . :::::::.::::::
NP_001 AASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEP
220 230 240 250 260
310 320 330 340 350
pF1KB6 ENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
::.:::::::::::::::::::::::::.::.::::::::::..: ::.
NP_001 ENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ
270 280 290 300 310
>>NP_003016 (OMIM: 601768) endophilin-A2 isoform 1 [Homo (368 aa)
initn: 1721 init1: 1349 opt: 1390 Z-score: 868.9 bits: 169.3 E(85289): 1.2e-41
Smith-Waterman score: 1720; 71.1% identity (87.0% similar) in 370 aa overlap (1-352:1-368)
10 20 30 40 50 60
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
::::::::::.::.: :::::::::::::::::::::.::::::.:: :....:::::::
NP_003 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
::::::::.:.::.:::::: :.:::::.:.::.: :.. :.::: . ::: :: ..::.
NP_003 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
:..:.::::::::::::::::::::: .:::.::::::::::::::::::::::::::::
NP_003 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .:
NP_003 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
190 200 210 220 230 240
250 260 270 280
pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK----------------
..:.:.:::.:.:::.:::: : :. : :::. : .::
NP_003 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT
250 260 270 280 290
290 300 310 320 330 340
pF1KB6 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN
:: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::..
NP_003 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS
300 310 320 330 340 350
350
pF1KB6 YVEILVALPH
:::.:: ::.
NP_003 YVEVLVPLPQ
360
>>XP_016882635 (OMIM: 601768) PREDICTED: endophilin-A2 i (358 aa)
initn: 1649 init1: 1277 opt: 1318 Z-score: 825.4 bits: 161.3 E(85289): 3.1e-39
Smith-Waterman score: 1648; 70.6% identity (86.6% similar) in 357 aa overlap (14-352:4-358)
10 20 30 40 50 60
pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
:: :::::::::::::::::::::.::::::.:: :....:::::::
XP_016 MGVTQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
::::::::.:.::.:::::: :.:::::.:.::.: :.. :.::: . ::: :: ..::.
XP_016 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
:..:.::::::::::::::::::::: .:::.::::::::::::::::::::::::::::
XP_016 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .:
XP_016 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
180 190 200 210 220 230
250 260 270 280
pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK----------------
..:.:.:::.:.:::.:::: : :. : :::. : .::
XP_016 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT
240 250 260 270 280
290 300 310 320 330 340
pF1KB6 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN
:: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::..
XP_016 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS
290 300 310 320 330 340
350
pF1KB6 YVEILVALPH
:::.:: ::.
XP_016 YVEVLVPLPQ
350
352 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:56:01 2016 done: Fri Nov 4 20:56:02 2016
Total Scan time: 6.560 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]