Result of FASTA (omim) for
pF1KB6395
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6395, 276 aa
1>>>pF1KB6395 276 - 276 aa - 276 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1414+/-0.000333; mu= 16.6019+/- 0.021
mean_var=68.0852+/-13.584, 0's: 0 Z-trim(114.8): 34 B-trim: 0 in 0/51
Lambda= 0.155435
statistics sampled from 24760 (24791) to 24760 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.291), width: 16
Scan time: 7.240
The best scores are: opt bits E(85289)
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 1878 429.8 2.8e-120
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 1549 356.0 4.4e-98
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 1010 235.1 1e-61
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 797 187.4 2.8e-47
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 761 179.1 4.5e-45
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 622 148.0 1.1e-35
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 614 146.2 4.6e-35
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 337 84.1 2.4e-16
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 331 82.8 6.6e-16
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 288 73.2 5.9e-13
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 284 72.3 1.1e-12
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 266 68.2 1.5e-11
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 213 56.4 6.6e-08
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 188 50.7 2.6e-06
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 173 47.3 2.7e-05
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 172 47.1 2.8e-05
NP_002778 (OMIM: 176842) proteasome subunit alpha ( 234) 167 46.0 7.7e-05
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 149 42.0 0.0013
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 1878 init1: 1878 opt: 1878 Z-score: 2280.5 bits: 429.8 E(85289): 2.8e-120
Smith-Waterman score: 1878; 100.0% identity (100.0% similar) in 276 aa overlap (1-276:1-276)
10 20 30 40 50 60
pF1KB6 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
190 200 210 220 230 240
250 260 270
pF1KB6 YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
::::::::::::::::::::::::::::::::::::
NP_683 YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
250 260 270
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 1549 init1: 1549 opt: 1549 Z-score: 1881.8 bits: 356.0 E(85289): 4.4e-98
Smith-Waterman score: 1549; 99.1% identity (100.0% similar) in 230 aa overlap (47-276:43-272)
20 30 40 50 60 70
pF1KB6 SALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTL
:..:::::::::::::::::::::::::::
NP_004 PSSWLTSSLLVEAAPLDDTTLPTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTL
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB6 AFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECR
80 90 100 110 120 130
140 150 160 170 180 190
pF1KB6 LYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGN
140 150 160 170 180 190
200 210 220 230 240 250
pF1KB6 MFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGW
200 210 220 230 240 250
260 270
pF1KB6 VKVESTDVSDLLHQYREANQ
::::::::::::::::::::
NP_004 VKVESTDVSDLLHQYREANQ
260 270
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 1028 init1: 1009 opt: 1010 Z-score: 1228.8 bits: 235.1 E(85289): 1e-61
Smith-Waterman score: 1010; 62.4% identity (83.1% similar) in 242 aa overlap (31-271:17-258)
10 20 30 40 50 60
pF1KB6 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
: .... :. : : : . . :
NP_002 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGW
10 20 30 40
70 80 90 100 110
pF1KB6 G-ERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG
: .. ::: ::::::::::.::::.:.::::.::.::.. :.:::::::::::::.:
NP_002 GVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKK
::::..::::::..::.: ::: :::::.::::::.::. ::.:::::::.:::::::.
NP_002 GAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 GPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRD
:::::::: .:.:.:: ::.:::..::::::: :: .: :.::::.:::: ::.::
NP_002 GPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRD
170 180 190 200 210 220
240 250 260 270
pF1KB6 SYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
.::::.::.::..::::..: : .:.:: ..:
NP_002 AYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
230 240 250 260
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 857 init1: 769 opt: 797 Z-score: 969.9 bits: 187.4 E(85289): 2.8e-47
Smith-Waterman score: 817; 49.4% identity (69.4% similar) in 265 aa overlap (1-263:1-240)
10 20 30 40 50
pF1KB6 MALLDVCG--APRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLG
::: ::: .: : : :: ::. :.::: .: :.:
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGG-----------------WAVPRGCDPQTFLQI--
10 20 30 40
60 70 80 90 100 110
pF1KB6 GDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMS
: : .:::::::::.:.::::::.:.:.: :::.. ::: .. .:::: :
NP_001 -HGPR-----LAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTS
50 60 70 80 90
120 130 140 150 160 170
pF1KB6 GCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDK
: .::: : :.: .: :: ::.:. ::..:.:::: :: ::::. : ... .::::.
NP_001 GTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB6 KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHR
.:: :.:: ::::.:..::.:::. :::::.: ::: ..: .::: :.: :.:.::::
NP_001 SGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHR
160 170 180 190 200 210
240 250 260 270
pF1KB6 DSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
:.:::: :...:..:.:: .: .:
NP_001 DAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAE
220 230 240 250 260 270
>>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa)
initn: 763 init1: 748 opt: 761 Z-score: 930.2 bits: 179.1 E(85289): 4.5e-45
Smith-Waterman score: 761; 67.7% identity (89.0% similar) in 155 aa overlap (117-271:1-155)
90 100 110 120 130 140
pF1KB6 AVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERI
:.: ::::..::::::..::.: ::: :::
NP_001 MAGGAADCSFWERLLARQCRIYELRNKERI
10 20 30
150 160 170 180 190 200
pF1KB6 SVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTY
::.::::::.::. ::.:::::::.:::::::.:::::::: .:.:.:: ::.:::..:
NP_001 SVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVY
40 50 60 70 80 90
210 220 230 240 250 260
pF1KB6 AYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSD
:::::: :: .: :.::::.:::: ::.::.::::.::.::..::::..: : .:.:
NP_001 AYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVAD
100 110 120 130 140 150
270
pF1KB6 LLHQYREANQ
: ..:
NP_001 LHEKYSGSTP
160
>>XP_005267928 (OMIM: 600306) PREDICTED: proteasome subu (169 aa)
initn: 621 init1: 621 opt: 622 Z-score: 761.4 bits: 148.0 E(85289): 1.1e-35
Smith-Waterman score: 622; 62.7% identity (81.7% similar) in 153 aa overlap (31-182:17-169)
10 20 30 40 50 60
pF1KB6 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
: .... :. : : : . . :
XP_005 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGW
10 20 30 40
70 80 90 100 110
pF1KB6 G-ERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG
: .. ::: ::::::::::.::::.:.::::.::.::.. :.:::::::::::::.:
XP_005 GVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKK
::::..::::::..::.: ::: :::::.::::::.::. ::.:::::::.:::::::.
XP_005 GAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 GPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRD
:::
XP_005 GPG
>>NP_001138404 (OMIM: 600306) proteasome subunit beta ty (203 aa)
initn: 613 init1: 613 opt: 614 Z-score: 750.5 bits: 146.2 E(85289): 4.6e-35
Smith-Waterman score: 614; 62.5% identity (81.6% similar) in 152 aa overlap (31-181:17-168)
10 20 30 40 50 60
pF1KB6 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
: .... :. : : : . . :
NP_001 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGW
10 20 30 40
70 80 90 100 110
pF1KB6 G-ERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG
: .. ::: ::::::::::.::::.:.::::.::.::.. :.:::::::::::::.:
NP_001 GVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKK
::::..::::::..::.: ::: :::::.::::::.::. ::.:::::::.:::::::.
NP_001 GAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 GPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRD
::
NP_001 GPVSEVLCLKPKSFGMYLFCGCAERIGNMARPLLRGQ
170 180 190 200
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 354 init1: 197 opt: 337 Z-score: 414.4 bits: 84.1 E(85289): 2.4e-16
Smith-Waterman score: 337; 33.8% identity (58.1% similar) in 198 aa overlap (59-255:9-202)
30 40 50 60 70 80
pF1KB6 DPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAV
:: : ... ::: .: .:. ::. .
NP_002 MLRAGAPTGDLPRAGEVHT--GTTIMAVEFDGGVVMGS
10 20 30
90 100 110 120 130 140
pF1KB6 DSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISV
:::.::: . .:. .. . ..:: ::: : . : . .:. .. : :
NP_002 DSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLV
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 SAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTG-SGNTYA
::.... :. .:: :: :. :::.. : : : :. . :. : ::.:.
NP_002 LAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIGGSGSTFI
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 YGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDL
:: .:..:.:..:::: . ::: : ::. ::::. . . :
NP_002 YGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELP
160 170 180 190 200 210
270
pF1KB6 LHQYREANQ
NP_002 KFYDE
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 322 init1: 280 opt: 331 Z-score: 406.5 bits: 82.8 E(85289): 6.6e-16
Smith-Waterman score: 331; 32.8% identity (62.4% similar) in 189 aa overlap (68-255:30-217)
40 50 60 70 80 90
pF1KB6 RSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSY
:.. ::: .: .:. ::. ..:::...:::
NP_002 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSY
10 20 30 40 50
100 110 120 130 140 150
pF1KB6 ISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSN
:. ..:. :. .. :: ::: : .. . .. .. .: : .:..:...
NP_002 IANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKE
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB6 MMCQYRGMGLSMGSMICGWD-KKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYR
: .:: : : .: ::: ..: .: : : . .. :::..: :: .:. ::
NP_002 MCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYR
120 130 140 150 160 170
220 230 240 250 260 270
pF1KB6 PNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
... :: .. :.: : .::. ::::. . . :.:
NP_002 EGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPP
180 190 200 210 220 230
NP_002 A
>>NP_002792 (OMIM: 176847) proteasome subunit beta type- (273 aa)
initn: 269 init1: 162 opt: 288 Z-score: 353.6 bits: 73.2 E(85289): 5.9e-13
Smith-Waterman score: 288; 29.8% identity (58.2% similar) in 225 aa overlap (37-255:1-221)
10 20 30 40 50 60
pF1KB6 CGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQ
: .: : ::: : : ... :: .
NP_002 MLKPALE-PRGGFSFENCQR-NASLERVLP
10 20
70 80 90 100 110 120
pF1KB6 -IEMAH----GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCA
... : ::: .. :: ::: ..:.::. : .. .:. : : . .: :
NP_002 GLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KB6 ADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKG
:: .. :..:.. .:. : .:.. :......: . . .:.: .: :. .. : : :
NP_002 ADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLTG
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB6 PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
: :: : ::. . . :::. : .:... ..::.. : : : .:.. . :
NP_002 PQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDL
150 160 170 180 190 200
250 260 270
pF1KB6 YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
::: :. . . :
NP_002 GSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEET
210 220 230 240 250 260
276 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:48:07 2016 done: Fri Nov 4 20:48:08 2016
Total Scan time: 7.240 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]