FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6308, 280 aa
  1>>>pF1KB6308 280 - 280 aa - 280 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3079+/-0.000439; mu= 15.2488+/- 0.027
 mean_var=66.9641+/-13.173, 0's: 0 Z-trim(110.2): 36  B-trim: 0 in 0/53
 Lambda= 0.156730
 statistics sampled from 18503 (18510) to 18503 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.217), width:  16
 Scan time:  6.850

The best scores are:                                      opt bits E(85289)
NP_004498 (OMIM: 603760) checkpoint protein HUS1 [ ( 280) 1825 421.7 7.4e-118
XP_016867604 (OMIM: 603760) PREDICTED: checkpoint  ( 259) 1683 389.6 3.2e-108
NP_683762 (OMIM: 609713) checkpoint protein HUS1B  ( 278)  938 221.2 1.7e-57


>>NP_004498 (OMIM: 603760) checkpoint protein HUS1 [Homo  (280 aa)
 initn: 1825 init1: 1825 opt: 1825  Z-score: 2236.9  bits: 421.7 E(85289): 7.4e-118
Smith-Waterman score: 1825; 100.0% identity (100.0% similar) in 280 aa overlap (1-280:1-280)

               10        20        30        40        50        60
pF1KB6 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 ENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 SMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 VIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF
              190       200       210       220       230       240

              250       260       270       280
pF1KB6 LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
       ::::::::::::::::::::::::::::::::::::::::
NP_004 LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
              250       260       270       280

>>XP_016867604 (OMIM: 603760) PREDICTED: checkpoint prot  (259 aa)
 initn: 1683 init1: 1683 opt: 1683  Z-score: 2063.9  bits: 389.6 E(85289): 3.2e-108
Smith-Waterman score: 1683; 100.0% identity (100.0% similar) in 259 aa overlap (22-280:1-259)

               10        20        30        40        50        60
pF1KB6 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQ
                            :::::::::::::::::::::::::::::::::::::::
XP_016                      MIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQ
                                    10        20        30         

               70        80        90       100       110       120
pF1KB6 ENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELL
      40        50        60        70        80        90         

              130       140       150       160       170       180
pF1KB6 SMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHL
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KB6 VIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF
     160       170       180       190       200       210         

              250       260       270       280
pF1KB6 LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
       ::::::::::::::::::::::::::::::::::::::::
XP_016 LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
     220       230       240       250         

>>NP_683762 (OMIM: 609713) checkpoint protein HUS1B [Hom  (278 aa)
 initn: 771 init1: 771 opt: 938  Z-score: 1153.0  bits: 221.2 E(85289): 1.7e-57
Smith-Waterman score: 938; 49.3% identity (81.2% similar) in 282 aa overlap (1-279:1-278)

               10        20        30        40        50          
pF1KB6 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE
       :::::::.  .::. : ..:. .:.:::.:.::. ::.: :      ..::.    .:::
NP_683 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE
               10        20        30        40           50       

        60        70        80        90       100       110       
pF1KB6 LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV
       ..: . :..:.::::: . .::.::::.:.:::: ..: .: .::..::.:. : :::.:
NP_683 VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV
        60         70        80        90       100       110      

       120       130       140       150       160       170       
pF1KB6 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS
       ::.:  . .: :.::.:..:.::..:.:   : .   :.:: ::  .:..:.::.: :..
NP_683 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG
        120       130       140       150       160       170      

       180       190       200       210       220       230       
pF1KB6 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL
       .:...::::.:...:.::::.: . ..::.::::: .. .. :.:..: :..:..: :::
NP_683 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL
        180       190       200       210       220       230      

       240       250       260       270       280
pF1KB6 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
       :::: :::..:: ::::: .: .... :..:::::::::::: 
NP_683 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL 
        240       250       260       270         




280 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 20:29:19 2016 done: Fri Nov  4 20:29:20 2016
 Total Scan time:  6.850 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]