FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6143, 595 aa 1>>>pF1KB6143 595 - 595 aa - 595 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2159+/-0.000472; mu= 10.8470+/- 0.029 mean_var=164.3339+/-36.120, 0's: 0 Z-trim(114.1): 113 B-trim: 1431 in 1/54 Lambda= 0.100049 statistics sampled from 23703 (23825) to 23703 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.279), width: 16 Scan time: 10.360 The best scores are: opt bits E(85289) NP_057308 (OMIM: 605952) sorting nexin-9 [Homo sap ( 595) 4030 594.6 3.1e-169 XP_005267072 (OMIM: 605952) PREDICTED: sorting nex ( 588) 3990 588.8 1.7e-167 XP_011534188 (OMIM: 605952) PREDICTED: sorting nex ( 501) 3377 500.3 6.5e-141 XP_016867572 (OMIM: 614905) PREDICTED: sorting nex ( 412) 197 41.2 0.0084 XP_016867573 (OMIM: 614905) PREDICTED: sorting nex ( 412) 197 41.2 0.0084 XP_011513632 (OMIM: 614905) PREDICTED: sorting nex ( 451) 197 41.2 0.009 XP_011513631 (OMIM: 614905) PREDICTED: sorting nex ( 457) 197 41.2 0.0091 NP_037453 (OMIM: 614905) sorting nexin-8 [Homo sap ( 465) 197 41.2 0.0092 >>NP_057308 (OMIM: 605952) sorting nexin-9 [Homo sapiens (595 aa) initn: 4030 init1: 4030 opt: 4030 Z-score: 3159.2 bits: 594.6 E(85289): 3.1e-169 Smith-Waterman score: 4030; 100.0% identity (100.0% similar) in 595 aa overlap (1-595:1-595) 10 20 30 40 50 60 pF1KB6 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 FGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 EWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 QEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKR 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 VSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM 550 560 570 580 590 >>XP_005267072 (OMIM: 605952) PREDICTED: sorting nexin-9 (588 aa) initn: 3990 init1: 3990 opt: 3990 Z-score: 3128.1 bits: 588.8 E(85289): 1.7e-167 Smith-Waterman score: 3990; 100.0% identity (100.0% similar) in 588 aa overlap (8-595:1-588) 10 20 30 40 50 60 pF1KB6 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEIL ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEIL 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 PSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 SESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 PMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB6 FGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEK 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB6 EWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVG 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB6 QEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB6 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKR 480 490 500 510 520 530 550 560 570 580 590 pF1KB6 VSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM 540 550 560 570 580 >>XP_011534188 (OMIM: 605952) PREDICTED: sorting nexin-9 (501 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 2650.8 bits: 500.3 E(85289): 6.5e-141 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (101-595:7-501) 80 90 100 110 120 130 pF1KB6 GNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPE :::::::::::::::::::::::::::::: XP_011 MKHLSPVGSGNDPWSAWSASKSGNWESSEGWGAQPE 10 20 30 140 150 160 170 180 190 pF1KB6 GAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADAGGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADAGGAQ 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 RGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTF 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 DCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSL 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 PDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGKRKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGKRKAE 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 RDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGP 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 LPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLM 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 ECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSYALQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSYALQA 400 410 420 430 440 450 560 570 580 590 pF1KB6 EMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM ::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM 460 470 480 490 500 >>XP_016867572 (OMIM: 614905) PREDICTED: sorting nexin-8 (412 aa) initn: 142 init1: 90 opt: 197 Z-score: 171.3 bits: 41.2 E(85289): 0.0084 Smith-Waterman score: 200; 23.7% identity (52.6% similar) in 359 aa overlap (269-590:39-388) 240 250 260 270 280 290 pF1KB6 YGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLL ..::... . :: .::. : . : :: XP_016 LLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLL 10 20 30 40 50 60 300 310 320 330 340 350 pF1KB6 VKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD :: . .:.:: :.. : ..:::. : . :. ... . :::..::. :.. ::.: XP_016 HKFPYRM-VPALPPKRMLGA-DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSG 70 80 90 100 110 120 360 370 380 390 400 410 pF1KB6 EKEWKTGKRKAE--RDELAGVMIFSTMEPEAP-DLDL---VEIEQKCEAVGKFTKAMD-- . :..:. ::. . . . . : :.. . : . ..: : : XP_016 SDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRA 130 140 150 160 170 180 420 430 440 450 pF1KB6 --------DGVKELLTVGQE--HWKRCTGPLPK-------EYQKIGKALQSLATVFS--- :.. .:: :.: : :::. . .. .::..:.. :. XP_016 ERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLA 190 200 210 220 230 240 460 470 480 490 500 pF1KB6 -SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECN--HEYKGFLGCFPDII ... ::. . ::.. : . . .. : ::: : . :... : . . XP_016 DKAAQQGKQEENDVV-EKLNLFLDLL-----QSYKDLCERHEKGVLHKHQRALHKYSLMK 250 260 270 280 290 300 510 520 530 540 550 560 pF1KB6 GTHKGAIEKVKESDKLVAT-SKITLQDK--QNMVKRVSIMSYALQAEMNHFHSNRIYDYN .: . .: ... :.:. :.. :.: : . : :. : . .: . . XP_016 RQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHV-YLPLTS 310 320 330 340 350 570 580 590 pF1KB6 SVIRLYLEQQVQFYETIAE---KLRQALSRFPVM ..: ....:.: .. ... :: :: XP_016 HILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 360 370 380 390 400 410 >>XP_016867573 (OMIM: 614905) PREDICTED: sorting nexin-8 (412 aa) initn: 142 init1: 90 opt: 197 Z-score: 171.3 bits: 41.2 E(85289): 0.0084 Smith-Waterman score: 200; 23.7% identity (52.6% similar) in 359 aa overlap (269-590:39-388) 240 250 260 270 280 290 pF1KB6 YGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLL ..::... . :: .::. : . : :: XP_016 LLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLL 10 20 30 40 50 60 300 310 320 330 340 350 pF1KB6 VKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD :: . .:.:: :.. : ..:::. : . :. ... . :::..::. :.. ::.: XP_016 HKFPYRM-VPALPPKRMLGA-DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSG 70 80 90 100 110 120 360 370 380 390 400 410 pF1KB6 EKEWKTGKRKAE--RDELAGVMIFSTMEPEAP-DLDL---VEIEQKCEAVGKFTKAMD-- . :..:. ::. . . . . : :.. . : . ..: : : XP_016 SDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRA 130 140 150 160 170 180 420 430 440 450 pF1KB6 --------DGVKELLTVGQE--HWKRCTGPLPK-------EYQKIGKALQSLATVFS--- :.. .:: :.: : :::. . .. .::..:.. :. XP_016 ERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLA 190 200 210 220 230 240 460 470 480 490 500 pF1KB6 -SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECN--HEYKGFLGCFPDII ... ::. . ::.. : . . .. : ::: : . :... : . . XP_016 DKAAQQGKQEENDVV-EKLNLFLDLL-----QSYKDLCERHEKGVLHKHQRALHKYSLMK 250 260 270 280 290 300 510 520 530 540 550 560 pF1KB6 GTHKGAIEKVKESDKLVAT-SKITLQDK--QNMVKRVSIMSYALQAEMNHFHSNRIYDYN .: . .: ... :.:. :.. :.: : . : :. : . .: . . XP_016 RQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHV-YLPLTS 310 320 330 340 350 570 580 590 pF1KB6 SVIRLYLEQQVQFYETIAE---KLRQALSRFPVM ..: ....:.: .. ... :: :: XP_016 HILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 360 370 380 390 400 410 >>XP_011513632 (OMIM: 614905) PREDICTED: sorting nexin-8 (451 aa) initn: 142 init1: 90 opt: 197 Z-score: 170.8 bits: 41.2 E(85289): 0.009 Smith-Waterman score: 200; 23.7% identity (52.6% similar) in 359 aa overlap (269-590:78-427) 240 250 260 270 280 290 pF1KB6 YGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLL ..::... . :: .::. : . : :: XP_011 LLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLL 50 60 70 80 90 100 300 310 320 330 340 350 pF1KB6 VKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD :: . .:.:: :.. : ..:::. : . :. ... . :::..::. :.. ::.: XP_011 HKFPYRM-VPALPPKRMLGA-DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSG 110 120 130 140 150 160 360 370 380 390 400 410 pF1KB6 EKEWKTGKRKAE--RDELAGVMIFSTMEPEAP-DLDL---VEIEQKCEAVGKFTKAMD-- . :..:. ::. . . . . : :.. . : . ..: : : XP_011 SDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRA 170 180 190 200 210 220 420 430 440 450 pF1KB6 --------DGVKELLTVGQE--HWKRCTGPLPK-------EYQKIGKALQSLATVFS--- :.. .:: :.: : :::. . .. .::..:.. :. XP_011 ERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLA 230 240 250 260 270 280 460 470 480 490 500 pF1KB6 -SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECN--HEYKGFLGCFPDII ... ::. . ::.. : . . .. : ::: : . :... : . . XP_011 DKAAQQGKQEENDVV-EKLNLFLDLL-----QSYKDLCERHEKGVLHKHQRALHKYSLMK 290 300 310 320 330 510 520 530 540 550 560 pF1KB6 GTHKGAIEKVKESDKLVAT-SKITLQDK--QNMVKRVSIMSYALQAEMNHFHSNRIYDYN .: . .: ... :.:. :.. :.: : . : :. : . .: . . XP_011 RQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHV-YLPLTS 340 350 360 370 380 390 570 580 590 pF1KB6 SVIRLYLEQQVQFYETIAE---KLRQALSRFPVM ..: ....:.: .. ... :: :: XP_011 HILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 400 410 420 430 440 450 >>XP_011513631 (OMIM: 614905) PREDICTED: sorting nexin-8 (457 aa) initn: 142 init1: 90 opt: 197 Z-score: 170.7 bits: 41.2 E(85289): 0.0091 Smith-Waterman score: 200; 23.7% identity (52.6% similar) in 359 aa overlap (269-590:84-433) 240 250 260 270 280 290 pF1KB6 YGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLL ..::... . :: .::. : . : :: XP_011 LLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLL 60 70 80 90 100 110 300 310 320 330 340 350 pF1KB6 VKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD :: . .:.:: :.. : ..:::. : . :. ... . :::..::. :.. ::.: XP_011 HKFPYRM-VPALPPKRMLGA-DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSG 120 130 140 150 160 170 360 370 380 390 400 410 pF1KB6 EKEWKTGKRKAE--RDELAGVMIFSTMEPEAP-DLDL---VEIEQKCEAVGKFTKAMD-- . :..:. ::. . . . . : :.. . : . ..: : : XP_011 SDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRA 180 190 200 210 220 230 420 430 440 450 pF1KB6 --------DGVKELLTVGQE--HWKRCTGPLPK-------EYQKIGKALQSLATVFS--- :.. .:: :.: : :::. . .. .::..:.. :. XP_011 ERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLA 240 250 260 270 280 290 460 470 480 490 500 pF1KB6 -SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECN--HEYKGFLGCFPDII ... ::. . ::.. : . . .. : ::: : . :... : . . XP_011 DKAAQQGKQEENDVV-EKLNLFLDLL-----QSYKDLCERHEKGVLHKHQRALHKYSLMK 300 310 320 330 340 510 520 530 540 550 560 pF1KB6 GTHKGAIEKVKESDKLVAT-SKITLQDK--QNMVKRVSIMSYALQAEMNHFHSNRIYDYN .: . .: ... :.:. :.. :.: : . : :. : . .: . . XP_011 RQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHV-YLPLTS 350 360 370 380 390 400 570 580 590 pF1KB6 SVIRLYLEQQVQFYETIAE---KLRQALSRFPVM ..: ....:.: .. ... :: :: XP_011 HILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 410 420 430 440 450 >>NP_037453 (OMIM: 614905) sorting nexin-8 [Homo sapiens (465 aa) initn: 142 init1: 90 opt: 197 Z-score: 170.6 bits: 41.2 E(85289): 0.0092 Smith-Waterman score: 200; 23.7% identity (52.6% similar) in 359 aa overlap (269-590:92-441) 240 250 260 270 280 290 pF1KB6 YGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLL ..::... . :: .::. : . : :: NP_037 LLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLL 70 80 90 100 110 120 300 310 320 330 340 350 pF1KB6 VKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD :: . .:.:: :.. : ..:::. : . :. ... . :::..::. :.. ::.: NP_037 HKFPYRM-VPALPPKRMLGA-DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSG 130 140 150 160 170 360 370 380 390 400 410 pF1KB6 EKEWKTGKRKAE--RDELAGVMIFSTMEPEAP-DLDL---VEIEQKCEAVGKFTKAMD-- . :..:. ::. . . . . : :.. . : . ..: : : NP_037 SDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRA 180 190 200 210 220 230 420 430 440 450 pF1KB6 --------DGVKELLTVGQE--HWKRCTGPLPK-------EYQKIGKALQSLATVFS--- :.. .:: :.: : :::. . .. .::..:.. :. NP_037 ERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLA 240 250 260 270 280 290 460 470 480 490 500 pF1KB6 -SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECN--HEYKGFLGCFPDII ... ::. . ::.. : . . .. : ::: : . :... : . . NP_037 DKAAQQGKQEENDVV-EKLNLFLDLL-----QSYKDLCERHEKGVLHKHQRALHKYSLMK 300 310 320 330 340 350 510 520 530 540 550 560 pF1KB6 GTHKGAIEKVKESDKLVAT-SKITLQDK--QNMVKRVSIMSYALQAEMNHFHSNRIYDYN .: . .: ... :.:. :.. :.: : . : :. : . .: . . NP_037 RQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHV-YLPLTS 360 370 380 390 400 410 570 580 590 pF1KB6 SVIRLYLEQQVQFYETIAE---KLRQALSRFPVM ..: ....:.: .. ... :: :: NP_037 HILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 420 430 440 450 460 595 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:35:02 2016 done: Sat Nov 5 13:35:04 2016 Total Scan time: 10.360 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]