Result of FASTA (omim) for
pF1KB5985
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5985, 521 aa
1>>>pF1KB5985 521 - 521 aa - 521 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6327+/-0.000317; mu= 18.0400+/- 0.020
mean_var=92.6274+/-17.931, 0's: 0 Z-trim(117.8): 18 B-trim: 0 in 0/53
Lambda= 0.133261
statistics sampled from 30145 (30163) to 30145 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.354), width: 16
Scan time: 10.170
The best scores are: opt bits E(85289)
NP_009185 (OMIM: 605610,613402,616267) bifunctiona ( 521) 3540 690.7 2.7e-198
NP_001182180 (OMIM: 208920,606350) aprataxin isofo ( 292) 229 54.0 7.4e-07
NP_778239 (OMIM: 208920,606350) aprataxin isoform ( 306) 229 54.0 7.7e-07
XP_016870325 (OMIM: 208920,606350) PREDICTED: apra ( 308) 229 54.0 7.7e-07
XP_016870324 (OMIM: 208920,606350) PREDICTED: apra ( 315) 229 54.0 7.8e-07
XP_016870323 (OMIM: 208920,606350) PREDICTED: apra ( 325) 229 54.0 8e-07
XP_016870322 (OMIM: 208920,606350) PREDICTED: apra ( 338) 229 54.0 8.3e-07
XP_006716854 (OMIM: 208920,606350) PREDICTED: apra ( 342) 229 54.0 8.3e-07
NP_778243 (OMIM: 208920,606350) aprataxin isoform ( 342) 229 54.0 8.3e-07
NP_001182178 (OMIM: 208920,606350) aprataxin isofo ( 342) 229 54.0 8.3e-07
NP_001182177 (OMIM: 208920,606350) aprataxin isofo ( 356) 229 54.0 8.6e-07
XP_016870321 (OMIM: 208920,606350) PREDICTED: apra ( 369) 229 54.0 8.8e-07
XP_016870320 (OMIM: 208920,606350) PREDICTED: apra ( 423) 229 54.1 9.8e-07
NP_001182181 (OMIM: 208920,606350) aprataxin isofo ( 284) 187 45.9 0.0002
>>NP_009185 (OMIM: 605610,613402,616267) bifunctional po (521 aa)
initn: 3540 init1: 3540 opt: 3540 Z-score: 3680.9 bits: 690.7 E(85289): 2.7e-198
Smith-Waterman score: 3540; 100.0% identity (100.0% similar) in 521 aa overlap (1-521:1-521)
10 20 30 40 50 60
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 EKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRAL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 IDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 IDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMY
430 440 450 460 470 480
490 500 510 520
pF1KB5 GYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
:::::::::::::::::::::::::::::::::::::::::
NP_009 GYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
490 500 510 520
>>NP_001182180 (OMIM: 208920,606350) aprataxin isoform g (292 aa)
initn: 220 init1: 220 opt: 229 Z-score: 244.1 bits: 54.0 E(85289): 7.4e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:6-141)
10 20 30 40 50 60
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
:: . : :: .:.:.:::: :..::.:::: ::.: :. .
NP_001 MMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQVQLKAECNKG
10 20 30 40 50
70 80 90 100 110
pF1KB5 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TRTPESQPDTP
: :::.::::.. . . : .: :..:..:: :.: ...:: ...: .
NP_001 YVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 PGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITT
:.. .::: . .::
NP_001 RKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKIS
120 130 140 150 160 170
>>NP_778239 (OMIM: 208920,606350) aprataxin isoform b [H (306 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.8 bits: 54.0 E(85289): 7.7e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:20-155)
10 20 30 40 50
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQV
:: . : :: .:.:.:::: :..::.:::: ::
NP_778 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 ELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TR
.: :. . : :::.::::.. . . : .: :..:..:: :.: ...:: ..
NP_778 QLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGF
.: . :.. .::: . .::
NP_778 NPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAE
NP_778 HWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLK
180 190 200 210 220 230
>>XP_016870325 (OMIM: 208920,606350) PREDICTED: aprataxi (308 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.8 bits: 54.0 E(85289): 7.7e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:20-155)
10 20 30 40 50
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQV
:: . : :: .:.:.:::: :..::.:::: ::
XP_016 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 ELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TR
.: :. . : :::.::::.. . . : .: :..:..:: :.: ...:: ..
XP_016 QLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGF
.: . :.. .::: . .::
XP_016 NPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAE
XP_016 HWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLK
180 190 200 210 220 230
>>XP_016870324 (OMIM: 208920,606350) PREDICTED: aprataxi (315 aa)
initn: 241 init1: 220 opt: 229 Z-score: 243.6 bits: 54.0 E(85289): 7.8e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:20-155)
10 20 30 40 50
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQV
:: . : :: .:.:.:::: :..::.:::: ::
XP_016 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 ELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TR
.: :. . : :::.::::.. . . : .: :..:..:: :.: ...:: ..
XP_016 QLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGF
.: . :.. .::: . .::
XP_016 NPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAE
XP_016 HWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLK
180 190 200 210 220 230
>>XP_016870323 (OMIM: 208920,606350) PREDICTED: aprataxi (325 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.4 bits: 54.0 E(85289): 8e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:20-155)
10 20 30 40 50
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQV
:: . : :: .:.:.:::: :..::.:::: ::
XP_016 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 ELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TR
.: :. . : :::.::::.. . . : .: :..:..:: :.: ...:: ..
XP_016 QLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGF
.: . :.. .::: . .::
XP_016 NPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAE
XP_016 HWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLK
180 190 200 210 220 230
>>XP_016870322 (OMIM: 208920,606350) PREDICTED: aprataxi (338 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.2 bits: 54.0 E(85289): 8.3e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:20-155)
10 20 30 40 50
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQV
:: . : :: .:.:.:::: :..::.:::: ::
XP_016 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 ELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TR
.: :. . : :::.::::.. . . : .: :..:..:: :.: ...:: ..
XP_016 QLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGF
.: . :.. .::: . .::
XP_016 NPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAE
XP_016 HWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLK
180 190 200 210 220 230
>>XP_006716854 (OMIM: 208920,606350) PREDICTED: aprataxi (342 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.2 bits: 54.0 E(85289): 8.3e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:6-141)
10 20 30 40 50 60
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
:: . : :: .:.:.:::: :..::.:::: ::.: :. .
XP_006 MMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQVQLKAECNKG
10 20 30 40 50
70 80 90 100 110
pF1KB5 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TRTPESQPDTP
: :::.::::.. . . : .: :..:..:: :.: ...:: ...: .
XP_006 YVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 PGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITT
:.. .::: . .::
XP_006 RKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKIS
120 130 140 150 160 170
>>NP_778243 (OMIM: 208920,606350) aprataxin isoform a [H (342 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.2 bits: 54.0 E(85289): 8.3e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:6-141)
10 20 30 40 50 60
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
:: . : :: .:.:.:::: :..::.:::: ::.: :. .
NP_778 MMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQVQLKAECNKG
10 20 30 40 50
70 80 90 100 110
pF1KB5 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TRTPESQPDTP
: :::.::::.. . . : .: :..:..:: :.: ...:: ...: .
NP_778 YVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 PGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITT
:.. .::: . .::
NP_778 RKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKIS
120 130 140 150 160 170
>>NP_001182178 (OMIM: 208920,606350) aprataxin isoform a (342 aa)
initn: 220 init1: 220 opt: 229 Z-score: 243.2 bits: 54.0 E(85289): 8.3e-07
Smith-Waterman score: 229; 34.3% identity (58.4% similar) in 137 aa overlap (11-146:6-141)
10 20 30 40 50 60
pF1KB5 MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
:: . : :: .:.:.:::: :..::.:::: ::.: :. .
NP_001 MMRVCWLVRQDSRHQRIRLPHL-EAVVIGRGPETKITDKKCSRQQVQLKAECNKG
10 20 30 40 50
70 80 90 100 110
pF1KB5 TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEE-TRTPESQPDTP
: :::.::::.. . . : .: :..:..:: :.: ...:: ...: .
NP_001 YVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 PGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITT
:.. .::: . .::
NP_001 RKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKIS
120 130 140 150 160 170
521 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:43:18 2016 done: Fri Nov 4 21:43:20 2016
Total Scan time: 10.170 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]