Result of FASTA (omim) for
pF1KB5867
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5867, 462 aa
1>>>pF1KB5867 462 - 462 aa - 462 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.9389+/-0.000349; mu= -8.9583+/- 0.022
mean_var=273.4046+/-56.341, 0's: 0 Z-trim(123.3): 25 B-trim: 41 in 1/56
Lambda= 0.077566
statistics sampled from 42908 (42933) to 42908 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.503), width: 16
Scan time: 8.690
The best scores are: opt bits E(85289)
XP_006710760 (OMIM: 608069) PREDICTED: ERBB recept ( 462) 3200 371.1 3.5e-102
NP_061821 (OMIM: 608069) ERBB receptor feedback in ( 462) 3200 371.1 3.5e-102
XP_005263534 (OMIM: 608069) PREDICTED: ERBB recept ( 411) 2862 333.3 7.7e-91
XP_011539898 (OMIM: 608069) PREDICTED: ERBB recept ( 387) 2711 316.4 9e-86
XP_005269332 (OMIM: 606994) PREDICTED: activated C ( 741) 481 66.9 2.1e-10
XP_005269331 (OMIM: 606994) PREDICTED: activated C ( 816) 481 67.0 2.2e-10
XP_011510623 (OMIM: 606994) PREDICTED: activated C ( 979) 481 67.0 2.6e-10
NP_005772 (OMIM: 606994) activated CDC42 kinase 1 (1038) 481 67.0 2.7e-10
NP_001294975 (OMIM: 606994) activated CDC42 kinase (1040) 481 67.0 2.7e-10
XP_016860999 (OMIM: 606994) PREDICTED: activated C (1055) 481 67.0 2.8e-10
XP_011510622 (OMIM: 606994) PREDICTED: activated C (1055) 481 67.0 2.8e-10
XP_005269327 (OMIM: 606994) PREDICTED: activated C (1055) 481 67.0 2.8e-10
XP_016860998 (OMIM: 606994) PREDICTED: activated C (1069) 481 67.0 2.8e-10
XP_016860997 (OMIM: 606994) PREDICTED: activated C (1072) 481 67.0 2.8e-10
XP_011510620 (OMIM: 606994) PREDICTED: activated C (1085) 481 67.0 2.8e-10
NP_001010938 (OMIM: 606994) activated CDC42 kinase (1086) 481 67.0 2.8e-10
XP_005269325 (OMIM: 606994) PREDICTED: activated C (1118) 481 67.0 2.9e-10
XP_011510619 (OMIM: 606994) PREDICTED: activated C (1219) 481 67.1 3.1e-10
>>XP_006710760 (OMIM: 608069) PREDICTED: ERBB receptor f (462 aa)
initn: 3200 init1: 3200 opt: 3200 Z-score: 1955.5 bits: 371.1 E(85289): 3.5e-102
Smith-Waterman score: 3200; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462)
10 20 30 40 50 60
pF1KB5 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
370 380 390 400 410 420
430 440 450 460
pF1KB5 AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
::::::::::::::::::::::::::::::::::::::::::
XP_006 AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
430 440 450 460
>>NP_061821 (OMIM: 608069) ERBB receptor feedback inhibi (462 aa)
initn: 3200 init1: 3200 opt: 3200 Z-score: 1955.5 bits: 371.1 E(85289): 3.5e-102
Smith-Waterman score: 3200; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462)
10 20 30 40 50 60
pF1KB5 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
370 380 390 400 410 420
430 440 450 460
pF1KB5 AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
::::::::::::::::::::::::::::::::::::::::::
NP_061 AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
430 440 450 460
>>XP_005263534 (OMIM: 608069) PREDICTED: ERBB receptor f (411 aa)
initn: 2862 init1: 2862 opt: 2862 Z-score: 1751.8 bits: 333.3 E(85289): 7.7e-91
Smith-Waterman score: 2862; 100.0% identity (100.0% similar) in 411 aa overlap (52-462:1-411)
30 40 50 60 70 80
pF1KB5 NGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSAQERLIPLGHASKSAPMNGHCF
::::::::::::::::::::::::::::::
XP_005 MAYSLNSSAQERLIPLGHASKSAPMNGHCF
10 20 30
90 100 110 120 130 140
pF1KB5 AENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFP
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB5 CAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSF
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB5 RGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPA
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB5 IRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB5 REPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILP
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB5 IIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDS
340 350 360 370 380 390
450 460
pF1KB5 KTKMDLGGHVKRKHLSYVVSP
:::::::::::::::::::::
XP_005 KTKMDLGGHVKRKHLSYVVSP
400 410
>>XP_011539898 (OMIM: 608069) PREDICTED: ERBB receptor f (387 aa)
initn: 2711 init1: 2711 opt: 2711 Z-score: 1660.9 bits: 316.4 E(85289): 9e-86
Smith-Waterman score: 2711; 100.0% identity (100.0% similar) in 387 aa overlap (76-462:1-387)
50 60 70 80 90 100
pF1KB5 NIDPITMAYSLNSSAQERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGP
::::::::::::::::::::::::::::::
XP_011 MNGHCFAENGPSQKSSLPPLLIPPSENLGP
10 20 30
110 120 130 140 150 160
pF1KB5 HEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLD
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 DTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYV
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 SDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 RVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGV
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 MPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLD
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 KYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
340 350 360 370 380
>>XP_005269332 (OMIM: 606994) PREDICTED: activated CDC42 (741 aa)
initn: 669 init1: 222 opt: 481 Z-score: 308.0 bits: 66.9 E(85289): 2.1e-10
Smith-Waterman score: 636; 38.9% identity (57.9% similar) in 321 aa overlap (127-427:304-590)
100 110 120 130 140 150
pF1KB5 IPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPL
::: .: . : . .:. . .:::::
XP_005 FGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPP
280 290 300 310 320 330
160 170 180 190 200 210
pF1KB5 PISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT--
: . .. :. : :. . .::: ::. : :: :::.
XP_005 PAYDDVAQDEDDFEICSI----------NSTL--VGAGVPAGPS---QGQTNYAFVPEQA
340 350 360 370
220 230 240 250 260
pF1KB5 -PAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCI
: : .. :.:: : . . . :. :. ..:::: ::
XP_005 RPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------
380 390 400 410 420
270 280 290 300 310 320
pF1KB5 HRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLS
::..: :::.:::::::::::..: . : : .: . ::.::::::::
XP_005 PSPSPGGD-DKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLS
430 440 450 460 470 480
330 340 350 360 370
pF1KB5 PSNSRTPSP------KSLPSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKV
:..:::::: . :: :.. .:: ::::: ::::.. ...: . ...
XP_005 PQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----
490 500 510 520 530 540
380 390 400 410 420 430
pF1KB5 PCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSAT
::::::...:::::::::::::::: ::..:..:.:::. . . :::
XP_005 PCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPS
550 560 570 580 590
440 450 460
pF1KB5 EKPDSKTKMDLGGHVKRKHLSYVVSP
XP_005 TPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRP
600 610 620 630 640 650
>>XP_005269331 (OMIM: 606994) PREDICTED: activated CDC42 (816 aa)
initn: 669 init1: 222 opt: 481 Z-score: 307.3 bits: 67.0 E(85289): 2.2e-10
Smith-Waterman score: 636; 38.9% identity (57.9% similar) in 321 aa overlap (127-427:379-665)
100 110 120 130 140 150
pF1KB5 IPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPL
::: .: . : . .:. . .:::::
XP_005 FGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPP
350 360 370 380 390 400
160 170 180 190 200 210
pF1KB5 PISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT--
: . .. :. : :. . .::: ::. : :: :::.
XP_005 PAYDDVAQDEDDFEICSI----------NSTL--VGAGVPAGPS---QGQTNYAFVPEQA
410 420 430 440 450
220 230 240 250 260
pF1KB5 -PAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCI
: : .. :.:: : . . . :. :. ..:::: ::
XP_005 RPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------
460 470 480 490 500
270 280 290 300 310 320
pF1KB5 HRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLS
::..: :::.:::::::::::..: . : : .: . ::.::::::::
XP_005 PSPSPGGD-DKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLS
510 520 530 540 550 560
330 340 350 360 370
pF1KB5 PSNSRTPSP------KSLPSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKV
:..:::::: . :: :.. .:: ::::: ::::.. ...: . ...
XP_005 PQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----
570 580 590 600 610
380 390 400 410 420 430
pF1KB5 PCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSAT
::::::...:::::::::::::::: ::..:..:.:::. . . :::
XP_005 PCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPS
620 630 640 650 660 670
440 450 460
pF1KB5 EKPDSKTKMDLGGHVKRKHLSYVVSP
XP_005 TPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRP
680 690 700 710 720 730
>>XP_011510623 (OMIM: 606994) PREDICTED: activated CDC42 (979 aa)
initn: 669 init1: 222 opt: 481 Z-score: 306.1 bits: 67.0 E(85289): 2.6e-10
Smith-Waterman score: 636; 38.9% identity (57.9% similar) in 321 aa overlap (127-427:542-828)
100 110 120 130 140 150
pF1KB5 IPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPL
::: .: . : . .:. . .:::::
XP_011 FGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPP
520 530 540 550 560 570
160 170 180 190 200 210
pF1KB5 PISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT--
: . .. :. : :. . .::: ::. : :: :::.
XP_011 PAYDDVAQDEDDFEICSI----------NSTL--VGAGVPAGPS---QGQTNYAFVPEQA
580 590 600 610
220 230 240 250 260
pF1KB5 -PAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCI
: : .. :.:: : . . . :. :. ..:::: ::
XP_011 RPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------
620 630 640 650 660
270 280 290 300 310 320
pF1KB5 HRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLS
::..: :::.:::::::::::..: . : : .: . ::.::::::::
XP_011 PSPSPGGD-DKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLS
670 680 690 700 710 720
330 340 350 360 370
pF1KB5 PSNSRTPSP------KSLPSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKV
:..:::::: . :: :.. .:: ::::: ::::.. ...: . ...
XP_011 PQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----
730 740 750 760 770 780
380 390 400 410 420 430
pF1KB5 PCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSAT
::::::...:::::::::::::::: ::..:..:.:::. . . :::
XP_011 PCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPS
790 800 810 820 830
440 450 460
pF1KB5 EKPDSKTKMDLGGHVKRKHLSYVVSP
XP_011 TPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRP
840 850 860 870 880 890
>>NP_005772 (OMIM: 606994) activated CDC42 kinase 1 isof (1038 aa)
initn: 669 init1: 222 opt: 481 Z-score: 305.7 bits: 67.0 E(85289): 2.7e-10
Smith-Waterman score: 665; 33.1% identity (56.1% similar) in 483 aa overlap (2-427:445-889)
10 20 30
pF1KB5 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRK
:.::..::.: ::...:.:.:.. .. :.
NP_005 VIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRH
420 430 440 450 460 470
40 50 60 70 80
pF1KB5 TYWSSRSEFKNNFLN--IDPITMAYSLNSSAQERLIPLGHASKSA---------PMNGHC
:. ... . .:. .:: . :.. :... :: ..: . :...
NP_005 C-WGFPDRIDELYLGNPMDPPDL-LSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSD-
480 490 500 510 520 530
90 100 110
pF1KB5 FAENG---PSQKSSL----PPLLIPPSE---------NLGPHEEDQVV-----CG--FKK
: . : :. .: : .: .. .: :. :: :. . .
NP_005 FKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQ
540 550 560 570 580 590
120 130 140 150 160 170
pF1KB5 LTVNGVCA---STPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFL
:.... :. ::: .: . : . .:. . .::::: : . .. :. : :. .
NP_005 LAMDA-CSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSI
600 610 620 630 640 650
180 190 200 210 220 230
pF1KB5 TSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT---PAVSAADLSYVSDQNGG
.::: ::. : :: :::. : : .. :.::
NP_005 ----------NSTLVG--AGVPAGPS---QGQTNYAFVPEQARPPPPLEDNLFLPPQGGG
660 670 680 690
240 250 260 270 280
pF1KB5 VPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRV
: . . . :. :. ..:::: :: ::..: :::.:::::
NP_005 KPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------PSPSPGGD-DKPQVPPRV
700 710 720 730 740
290 300 310 320 330
pF1KB5 PIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLSPSNSRTPSP------KSL
::::::..: . : : .: . ::.:::::::::..:::::: . :
NP_005 PIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPL
750 760 770 780 790 800
340 350 360 370 380 390
pF1KB5 PSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHY
: :.. .:: ::::: ::::.. ...: . ... ::::::...:::::::::
NP_005 PPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----PCILPIVRDGKKVSSTHY
810 820 830 840 850
400 410 420 430 440 450
pF1KB5 YLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRK
::::::: ::..:..:.:::. . . :::
NP_005 YLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAA
860 870 880 890 900 910
460
pF1KB5 HLSYVVSP
NP_005 LDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQ
920 930 940 950 960 970
>>NP_001294975 (OMIM: 606994) activated CDC42 kinase 1 i (1040 aa)
initn: 669 init1: 222 opt: 481 Z-score: 305.7 bits: 67.0 E(85289): 2.7e-10
Smith-Waterman score: 665; 33.1% identity (56.1% similar) in 483 aa overlap (2-427:477-921)
10 20 30
pF1KB5 MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRK
:.::..::.: ::...:.:.:.. .. :.
NP_001 VIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRH
450 460 470 480 490 500
40 50 60 70 80
pF1KB5 TYWSSRSEFKNNFLN--IDPITMAYSLNSSAQERLIPLGHASKSA---------PMNGHC
:. ... . .:. .:: . :.. :... :: ..: . :...
NP_001 C-WGFPDRIDELYLGNPMDPPDL-LSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSD-
510 520 530 540 550 560
90 100 110
pF1KB5 FAENG---PSQKSSL----PPLLIPPSE---------NLGPHEEDQVV-----CG--FKK
: . : :. .: : .: .. .: :. :: :. . .
NP_001 FKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQ
570 580 590 600 610 620
120 130 140 150 160 170
pF1KB5 LTVNGVCA---STPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFL
:.... :. ::: .: . : . .:. . .::::: : . .. :. : :. .
NP_001 LAMDA-CSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSI
630 640 650 660 670 680
180 190 200 210 220 230
pF1KB5 TSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT---PAVSAADLSYVSDQNGG
.::: ::. : :: :::. : : .. :.::
NP_001 ----------NSTLVG--AGVPAGPS---QGQTNYAFVPEQARPPPPLEDNLFLPPQGGG
690 700 710 720
240 250 260 270 280
pF1KB5 VPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRV
: . . . :. :. ..:::: :: ::..: :::.:::::
NP_001 KPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------PSPSPGGD-DKPQVPPRV
730 740 750 760 770
290 300 310 320 330
pF1KB5 PIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLSPSNSRTPSP------KSL
::::::..: . : : .: . ::.:::::::::..:::::: . :
NP_001 PIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPL
780 790 800 810 820 830
340 350 360 370 380 390
pF1KB5 PSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHY
: :.. .:: ::::: ::::.. ...: . ... ::::::...:::::::::
NP_001 PPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----PCILPIVRDGKKVSSTHY
840 850 860 870 880 890
400 410 420 430 440 450
pF1KB5 YLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRK
::::::: ::..:..:.:::. . . :::
NP_001 YLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAA
900 910 920 930 940
460
pF1KB5 HLSYVVSP
NP_001 LDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMVEQLFGLGLRPR
950 960 970 980 990 1000
>>XP_016860999 (OMIM: 606994) PREDICTED: activated CDC42 (1055 aa)
initn: 669 init1: 222 opt: 481 Z-score: 305.6 bits: 67.0 E(85289): 2.8e-10
Smith-Waterman score: 636; 38.9% identity (57.9% similar) in 321 aa overlap (127-427:650-936)
100 110 120 130 140 150
pF1KB5 IPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPL
::: .: . : . .:. . .:::::
XP_016 FGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPP
620 630 640 650 660 670
160 170 180 190 200 210
pF1KB5 PISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDT--
: . .. :. : :. . .::: ::. : :: :::.
XP_016 PAYDDVAQDEDDFEICSI----------NSTL--VGAGVPAGPS---QGQTNYAFVPEQA
680 690 700 710 720
220 230 240 250 260
pF1KB5 -PAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLR----RSHSGPAGSFNKPAIRISNCCI
: : .. :.:: : . . . :. :. ..:::: ::
XP_016 RPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGS---PA--------
730 740 750 760 770
270 280 290 300 310 320
pF1KB5 HRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSA---EVTSSTYSDEDRPPKVPPREPLS
::..: :::.:::::::::::..: . : : .: . ::.::::::::
XP_016 PSPSPGGD-DKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLS
780 790 800 810 820 830
330 340 350 360 370
pF1KB5 PSNSRTPSP------KSLPSYLNG----VMPPTQSFAPDPKYVSSKALQRQNSEGSASKV
:..:::::: . :: :.. .:: ::::: ::::.. ...: . ...
XP_016 PQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG----
840 850 860 870 880
380 390 400 410 420 430
pF1KB5 PCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSAT
::::::...:::::::::::::::: ::..:..:.:::. . . :::
XP_016 PCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPE---EPTPLPVPLLLPPPS
890 900 910 920 930 940
440 450 460
pF1KB5 EKPDSKTKMDLGGHVKRKHLSYVVSP
XP_016 TPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRP
950 960 970 980 990 1000
462 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:34:48 2016 done: Sat Nov 5 10:34:50 2016
Total Scan time: 8.690 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]