Result of FASTA (omim) for
pF1KB5854
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5854, 488 aa
1>>>pF1KB5854 488 - 488 aa - 488 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2669+/-0.000535; mu= 13.8070+/- 0.033
mean_var=195.0436+/-40.706, 0's: 0 Z-trim(113.2): 469 B-trim: 652 in 3/53
Lambda= 0.091835
statistics sampled from 21899 (22494) to 21899 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.264), width: 16
Scan time: 8.230
The best scores are: opt bits E(85289)
NP_000495 (OMIM: 227600,613872) coagulation factor ( 488) 3369 460.0 6.8e-129
NP_001299603 (OMIM: 227600,613872) coagulation fac ( 444) 2229 308.9 1.9e-83
NP_001299604 (OMIM: 227600,613872) coagulation fac ( 332) 2002 278.7 1.8e-74
XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 1101 159.5 2e-38
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 843 125.3 3.5e-28
NP_001300842 (OMIM: 122700,300746,300807,306900) c ( 423) 751 113.1 1.6e-24
NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 749 112.8 2.1e-24
XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 744 112.1 3.1e-24
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 709 107.4 7.3e-23
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 696 105.7 2.3e-22
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 681 103.9 1.1e-21
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 639 98.3 5e-20
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 639 98.3 5.1e-20
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 639 98.4 5.5e-20
NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 627 96.7 1.5e-19
NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 618 95.5 3.5e-19
XP_016876302 (OMIM: 176895,614024) PREDICTED: vita ( 334) 551 86.4 1.3e-16
NP_001243063 (OMIM: 176895,614024) vitamin K-depen ( 422) 551 86.6 1.5e-16
XP_016876301 (OMIM: 176895,614024) PREDICTED: vita ( 467) 551 86.6 1.6e-16
NP_940866 (OMIM: 615144) serine protease 55 isofor ( 352) 542 85.3 3.2e-16
NP_003882 (OMIM: 176895,614024) vitamin K-dependen ( 400) 541 85.2 3.7e-16
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 537 84.8 6.4e-16
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 537 84.9 6.6e-16
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 537 84.9 6.6e-16
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 532 84.3 1.2e-15
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 532 84.6 1.5e-15
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 532 84.6 1.5e-15
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 524 83.2 2.2e-15
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 521 82.6 2.5e-15
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 521 82.6 2.5e-15
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 521 82.8 3.1e-15
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 521 82.8 3.1e-15
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 521 82.8 3.1e-15
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 514 81.3 3.4e-15
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 521 83.0 3.5e-15
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 521 83.0 3.5e-15
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 510 81.2 6.9e-15
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 501 79.6 1.1e-14
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 501 79.6 1.2e-14
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 503 80.1 1.2e-14
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 502 79.9 1.2e-14
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 501 79.7 1.3e-14
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 503 80.2 1.3e-14
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 503 80.3 1.4e-14
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 503 80.3 1.4e-14
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 503 80.3 1.4e-14
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 499 79.5 1.6e-14
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 499 79.7 1.9e-14
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 498 79.5 2e-14
NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 495 78.8 2e-14
>>NP_000495 (OMIM: 227600,613872) coagulation factor X i (488 aa)
initn: 3369 init1: 3369 opt: 3369 Z-score: 2435.0 bits: 460.0 E(85289): 6.8e-129
Smith-Waterman score: 3369; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488)
10 20 30 40 50 60
pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
430 440 450 460 470 480
pF1KB5 VITSSPLK
::::::::
NP_000 VITSSPLK
>>NP_001299603 (OMIM: 227600,613872) coagulation factor (444 aa)
initn: 3022 init1: 2189 opt: 2229 Z-score: 1619.2 bits: 308.9 E(85289): 1.9e-83
Smith-Waterman score: 2938; 90.8% identity (91.0% similar) in 488 aa overlap (1-488:1-444)
10 20 30 40 50 60
pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
:::. ::::::::::::
NP_001 CELW--------------------------------------------PYPCGKQTLERR
130
190 200 210 220 230 240
pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
140 150 160 170 180 190
250 260 270 280 290 300
pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB5 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
380 390 400 410 420 430
pF1KB5 VITSSPLK
::::::::
NP_001 VITSSPLK
440
>>NP_001299604 (OMIM: 227600,613872) coagulation factor (332 aa)
initn: 2002 init1: 2002 opt: 2002 Z-score: 1458.0 bits: 278.7 E(85289): 1.8e-74
Smith-Waterman score: 2002; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285)
10 20 30 40 50 60
pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKGTGTRSRRRAVRRCT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
NP_001 RWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA
310 320 330
>>XP_011535776 (OMIM: 227500,608446,613878) PREDICTED: c (495 aa)
initn: 1252 init1: 459 opt: 1101 Z-score: 811.0 bits: 159.5 E(85289): 2e-38
Smith-Waterman score: 1154; 36.2% identity (61.7% similar) in 527 aa overlap (1-479:17-493)
10 20 30 40
pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSF
... :.:. : .: : : ..:. .:.:...: : :::.:
XP_011 MGNVNRQGQHCRDFIMVSQALRLLCLLLGLQGCL---AAVFVTQEEAHGVLHRRRRANAF
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 LEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDG
:::.. : ::::: :: ::.:::::.:.:...:. :: .:.::::: .::::: :.:::
XP_011 LEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQ
60 70 80 90 100 110
110 120 130
pF1KB5 LGEYTCTCLEGFEGKNCEL---------FTRK-------------LCSL-----------
: : : :: .:::.::: . :. :::
XP_011 LQSYICFCLPAFEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQ
120 130 140 150 160 170
140 150 160 170 180
pF1KB5 -----DNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSV
.:: :.:.: .. .. : : .::.: .: .: :: ::::: ::.:
XP_011 LICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR----
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB5 AQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDG
: ..:. : :::::. : :
XP_011 ------------------------------------NASKPQ-G-----RIVGGKVCPKG
240 250
250 260 270 280 290 300
pF1KB5 ECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEA
:::::.::. . . .::::... .....::::. . : .. . :... ...: :
XP_011 ECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQ
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB5 VHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIV
..: :: . .. : . :::.:::. :... .:.: ::::: ..: :: . ..:
XP_011 SRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLV
320 330 340 350 360 370
370 380 390 400 410
pF1KB5 SGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQ
::.:. ..: . .: .:.:: . ..: :...: ::. ::::::. ..:.:.
XP_011 SGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCK
380 390 400 410 420 430
420 430 440 450 460 470
pF1KB5 GDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKS
:::::::.:... :...:::::::.::: :..:.::.:. ...:... :... : .
XP_011 GDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLL
440 450 460 470 480 490
480
pF1KB5 HAPEVITSSPLK
.::
XP_011 RAPFP
>>XP_011535777 (OMIM: 227500,608446,613878) PREDICTED: c (433 aa)
initn: 999 init1: 330 opt: 843 Z-score: 626.9 bits: 125.3 E(85289): 3.5e-28
Smith-Waterman score: 896; 34.4% identity (58.8% similar) in 442 aa overlap (86-479:37-431)
60 70 80 90 100 110
pF1KB5 ECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEG
::::: .::::: :.::: : : : :: .
XP_011 QGQHCRDFIMVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA
10 20 30 40 50 60
120 130
pF1KB5 FEGKNCEL---------FTRK-------------LCSL----------------DNGDCD
:::.::: . :. ::: .:: :.
XP_011 FEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGCE
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB5 QFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSVAQATSSSGEAP
:.: .. .. : : .::.: .: .: :: ::::: ::.:
XP_011 QYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR---------------
130 140 150 160 170
200 210 220 230 240 250
pF1KB5 DSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINE
: ..:. : :::::. : ::::::.::. .
XP_011 -------------------------NASKPQ-G-----RIVGGKVCPKGECPWQVLLLVN
180 190 200
260 270 280 290 300 310
pF1KB5 ENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEAVHEVEVVIKHN
. .::::... .....::::. . : .. . :... ...: : ..: :: .
XP_011 GAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
210 220 230 240 250
320 330 340 350 360 370
pF1KB5 RFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGR
.. : . :::.:::. :... .:.: ::::: ..: :: . ..:::.:. ..:
XP_011 TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGA
260 270 280 290 300 310
380 390 400 410 420
pF1KB5 QSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRF
. .: .:.:: . ..: :...: ::. ::::::. ..:.:.:::::::.:..
XP_011 TALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 KDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPL
. :...:::::::.::: :..:.::.:. ...:... :... : . .::
XP_011 RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
380 390 400 410 420 430
pF1KB5 K
>>NP_001300842 (OMIM: 122700,300746,300807,306900) coagu (423 aa)
initn: 985 init1: 495 opt: 751 Z-score: 561.1 bits: 113.1 E(85289): 1.6e-24
Smith-Waterman score: 1095; 41.2% identity (66.2% similar) in 464 aa overlap (9-467:14-421)
10 20 30 40 50
pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL
:.. : : :: .: ..:. .:.::.:: : : :: :::. .:.:
NP_001 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
::::::: ::.::::::::....:.:::..: :
NP_001 ERECMEEKCSFEEAREVFENTERTTEFWKQYVD---------------------------
70 80 90
120 130 140 150 160 170
pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEE-QNSVVCSCARGYTLADNGKACIPTGPYPC
:.. :: :.:::.. .:.:::::..:: ::.: :.: :. :.::
NP_001 -------------VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC
100 110 120 130 140
180 190 200 210 220 230
pF1KB5 GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNL
: . ::.: ::. .: : : :. .. :: .:: : :: .. :..
NP_001 G-------RVSVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDF
150 160 170 180
240 250 260 270 280 290
pF1KB5 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN
::.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..:
NP_001 TRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHN
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB5 TEQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE
:. : : ..: .: :. .. . :. :::.:.: :... :.: :. .....
NP_001 IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK
. .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::.
NP_001 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEG
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB5 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRG
.:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. :
NP_001 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
370 380 390 400 410 420
480
pF1KB5 LPKAKSHAPEVITSSPLK
>>NP_000124 (OMIM: 122700,300746,300807,306900) coagulat (461 aa)
initn: 1211 init1: 495 opt: 749 Z-score: 559.3 bits: 112.8 E(85289): 2.1e-24
Smith-Waterman score: 1365; 46.3% identity (72.6% similar) in 464 aa overlap (9-467:14-459)
10 20 30 40 50
pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL
:.. : : :: .: ..:. .:.::.:: : : :: :::. .:.:
NP_000 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : :
NP_000 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEE-QNSVVCSCARGYTLADNGKACIPTGPYPC
::::::::: . :.. :: :.:::.. .:.:::::..:: ::.: :.: :. :.::
NP_000 FGFEGKNCELDV--TCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC
130 140 150 160 170
180 190 200 210 220 230
pF1KB5 GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNL
:. ::.: ::. .: : : :. .. :: .:: : :: .. :..
NP_000 GRV-------SVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDF
180 190 200 210 220
240 250 260 270 280 290
pF1KB5 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN
::.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..:
NP_000 TRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHN
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB5 TEQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE
:. : : ..: .: :. .. . :. :::.:.: :... :.: :. .....
NP_000 IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB5 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK
. .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::.
NP_000 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEG
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB5 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRG
.:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. :
NP_000 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
410 420 430 440 450 460
480
pF1KB5 LPKAKSHAPEVITSSPLK
>>XP_005262454 (OMIM: 122700,300746,300807,306900) PREDI (418 aa)
initn: 1062 init1: 495 opt: 744 Z-score: 556.2 bits: 112.1 E(85289): 3.1e-24
Smith-Waterman score: 1126; 41.9% identity (65.4% similar) in 463 aa overlap (9-467:14-416)
10 20 30 40 50
pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL
:.. : : :: .: ..:. .:.::.:: : : :: :::. .:.:
XP_005 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : :
XP_005 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCG
::::::::: :.:::
XP_005 FGFEGKNCELV--------------------------------------------PFPCG
130
180 190 200 210 220 230
pF1KB5 KQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLT
. ::.: ::. .: : : :. .. :: .:: : :: .. :..:
XP_005 RV-------SVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDFT
140 150 160 170 180
240 250 260 270 280 290
pF1KB5 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNT
:.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..:
XP_005 RVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNI
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB5 EQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAES
:. : : ..: .: :. .. . :. :::.:.: :... :.: :. ..... .
XP_005 EETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-N
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 TLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQ
.. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::.
XP_005 IFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGG
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB5 EDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGL
.:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. :
XP_005 RDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
370 380 390 400 410
480
pF1KB5 PKAKSHAPEVITSSPLK
>>NP_001254483 (OMIM: 227500,608446,613878) coagulation (382 aa)
initn: 999 init1: 330 opt: 709 Z-score: 531.5 bits: 107.4 E(85289): 7.3e-23
Smith-Waterman score: 964; 36.7% identity (63.3% similar) in 406 aa overlap (86-479:22-380)
60 70 80 90 100 110
pF1KB5 ECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEG
::::: .::::: :.::: : : : :: .
NP_001 MVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA
10 20 30 40 50
120 130 140 150 160 170
pF1KB5 FEGKNCELFT--RKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPC
:::.::: . .: .:: :.:.: .. .. : : .::.: .: .: :: :::
NP_001 FEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPC
60 70 80 90 100 110
180 190 200 210 220 230
pF1KB5 GK-QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNN
:: ::.: : ..:. :
NP_001 GKIPILEKR----------------------------------------NASKPQ-G---
120
240 250 260 270 280
pF1KB5 LTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---
:::::. : ::::::.::. . . .::::... .....::::. . : .. .
NP_001 --RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVL
130 140 150 160 170 180
290 300 310 320 330 340
pF1KB5 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW
:... ...: : ..: :: . .. : . :::.:::. :... .:.: ::::: .
NP_001 GEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTF
190 200 210 220 230 240
350 360 370 380 390 400
pF1KB5 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMF
.: :: . ..:::.:. ..: . .: .:.:: . ..: :...: ::. ::
NP_001 SERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMF
250 260 270 280 290 300
410 420 430 440 450 460
pF1KB5 CAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWID
::::. ..:.:.:::::::.:... :...:::::::.::: :..:.::.:. ...:..
NP_001 CAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ
310 320 330 340 350 360
470 480
pF1KB5 RSMKTRGLPKAKSHAPEVITSSPLK
. :... : . .::
NP_001 KLMRSEPRPGVLLRAPFP
370 380
>>XP_011535778 (OMIM: 227500,608446,613878) PREDICTED: c (364 aa)
initn: 807 init1: 330 opt: 696 Z-score: 522.4 bits: 105.7 E(85289): 2.3e-22
Smith-Waterman score: 778; 32.4% identity (59.5% similar) in 410 aa overlap (81-479:12-362)
60 70 80 90 100 110
pF1KB5 GHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTC
: . : .: .: . : :
XP_011 MAQGPEESPASWRRLKREASCWSSGSRMPGD--------LC
10 20 30
120 130 140 150 160
pF1KB5 TCL-EGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTG
. : . :. .: .: .:: :.:.: .. .. : : .::.: .: .: ::
XP_011 SALVPSSPDKDDQL----ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTV
40 50 60 70 80
170 180 190 200 210 220
pF1KB5 PYPCGK-QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPER
::::: ::.: : ..:.
XP_011 EYPCGKIPILEKR----------------------------------------NASKPQ-
90 100
230 240 250 260 270 280
pF1KB5 GDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVR
: :::::. : ::::::.::. . . .::::... .....::::. . : ..
XP_011 G-----RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNL
110 120 130 140 150 160
290 300 310 320 330 340
pF1KB5 V---GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLP
. :... ...: : ..: :: . .. : . :::.:::. :... .:.: :::
XP_011 IAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLP
170 180 190 200 210 220
350 360 370 380 390
pF1KB5 ERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIIT
:: ..: :: . ..:::.:. ..: . .: .:.:: . ..: :...: ::
XP_011 ERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNIT
230 240 250 260 270 280
400 410 420 430 440 450
pF1KB5 QNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFL
. ::::::. ..:.:.:::::::.:... :...:::::::.::: :..:.::.:. ..
XP_011 EYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYI
290 300 310 320 330 340
460 470 480
pF1KB5 KWIDRSMKTRGLPKAKSHAPEVITSSPLK
.:... :... : . .::
XP_011 EWLQKLMRSEPRPGVLLRAPFP
350 360
488 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:45:02 2016 done: Mon Nov 7 04:45:04 2016
Total Scan time: 8.230 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]