Result of FASTA (omim) for
pF1KB5828
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5828, 480 aa
1>>>pF1KB5828 480 - 480 aa - 480 aa
Library: /omim/omim.rfq.tfa
64236559 residues in 92054 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3921+/-0.00038; mu= -7.3977+/- 0.024
mean_var=392.2578+/-77.985, 0's: 0 Z-trim(125.0): 37 B-trim: 0 in 0/57
Lambda= 0.064757
statistics sampled from 49496 (49553) to 49496 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.802), E-opt: 0.2 (0.538), width: 16
Scan time: 5.660
The best scores are: opt bits E(92054)
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 3283 320.4 7.7e-87
XP_016865334 (OMIM: 606197) iroquois-class homeodo ( 449) 2996 293.5 8.6e-79
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 938 101.3 7e-21
XP_005256196 (OMIM: 612985) iroquois-class homeodo ( 529) 938 101.3 7.3e-21
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 607 70.4 1.4e-11
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 607 70.4 1.4e-11
XP_011512281 (OMIM: 606198) iroquois-class homeodo ( 471) 607 70.4 1.4e-11
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 604 70.1 1.7e-11
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 599 69.6 2.3e-11
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 564 66.4 2.4e-10
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 564 66.4 2.4e-10
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 564 66.4 2.4e-10
XP_024310147 (OMIM: 606198) iroquois-class homeodo ( 378) 551 65.0 4.4e-10
XP_011521111 (OMIM: 606195,611174) iroquois-class ( 413) 548 64.8 5.7e-10
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 501 60.5 1.5e-08
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 501 60.5 1.5e-08
XP_005256194 (OMIM: 606196) iroquois-class homeodo ( 445) 494 59.8 2e-08
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 494 59.8 2e-08
>>NP_077313 (OMIM: 606197) iroquois-class homeodomain pr (480 aa)
initn: 3283 init1: 3283 opt: 3283 Z-score: 1680.7 bits: 320.4 E(92054): 7.7e-87
Smith-Waterman score: 3283; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480)
10 20 30 40 50 60
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
430 440 450 460 470 480
>>XP_016865334 (OMIM: 606197) iroquois-class homeodomain (449 aa)
initn: 2992 init1: 2992 opt: 2996 Z-score: 1536.1 bits: 293.5 E(92054): 8.6e-79
Smith-Waterman score: 2996; 99.1% identity (99.1% similar) in 444 aa overlap (1-444:1-442)
10 20 30 40 50 60
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
::::::::::::::::: : ::
XP_016 GALNGDKASVRSSPTLPA--LWPRRRERRGS
430 440
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 759 init1: 592 opt: 938 Z-score: 496.4 bits: 101.3 E(92054): 7e-21
Smith-Waterman score: 1121; 45.2% identity (63.1% similar) in 526 aa overlap (1-480:1-501)
10 20 30 40 50
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS
:::::::: ::. :. ::::. ......:.: .. ::.::.. :. . ...:
NP_077 MSFPQLGY-QYIRPLYPS----ERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP
: : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : :
NP_077 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
:.:::::.:.:::.::::::::::::::::::::::::::::::::::::::::::::::
NP_077 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK
:::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: ..
NP_077 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG
180 190 200 210 220 230
240 250 260 270
pF1KB5 IDEHDGDQS-NEDDEDKA----EAPHAPAAP----SALARDQGS----PLAAADVLKPQD
.: : .. .::::. . : . : .. :: .:. :.. . .:
NP_077 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET
: :: . . :: : .: : :: .. :: ::::::::::
NP_077 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB5 ATSPDGAPKASPPPPAGHP-GAH-GPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL
:::::. :. ::: .: : :: .::: : .: : . .::: ::: :
NP_077 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFP
360 370 380 390 400 410
390 400 410 420 430
pF1KB5 AQ--GSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPE
. : :. :.:: .:: ::: . : .: :.: :.. . :. ::
NP_077 GPPPGPRLHPLSLLG-----SAP--PHLLG----LPGAAGHPAA-----AAAFARPAEPE
420 430 440 450
440 450 460 470 480
pF1KB5 --RDLVPRPDSPAQQLKSPFQPVRDNSLAPQE--GTPRILAALPSA
: . . ::. :::: ::. . .:.:: :.
NP_077 GGTDRCSALEVEKKLLKTAFQPVPRR---PQNHLDAALVLSALSSS
460 470 480 490 500
>>XP_005256196 (OMIM: 612985) iroquois-class homeodomain (529 aa)
initn: 759 init1: 592 opt: 938 Z-score: 496.1 bits: 101.3 E(92054): 7.3e-21
Smith-Waterman score: 1132; 45.6% identity (63.3% similar) in 518 aa overlap (1-474:1-490)
10 20 30 40 50
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS
:::::::: ::. : .::::. ......:.: .. ::.::.. :. . ...:
XP_005 MSFPQLGY-QYIRPLYP----SERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP
: : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : :
XP_005 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
:.:::::.:.:::.::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK
:::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: ..
XP_005 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG
180 190 200 210 220 230
240 250 260 270
pF1KB5 IDEHDGDQS-NEDDEDKA----EAPHAPAAP----SALARDQGS----PLAAADVLKPQD
.: : .. .::::. . : . : .. :: .:. :.. . .:
XP_005 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET
: :: . . :: : .: : :: .. :: ::::::::::
XP_005 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB5 ATSPDGAPKASPPPPAGHP-GAH-GPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL
:::::. :. ::: .: : :: .::: : .: : . .::: ::: :
XP_005 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFP
360 370 380 390 400 410
390 400 410 420 430
pF1KB5 AQ--GSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPE
. : :. :.:: .:: ::: . : .: :.: :.. . :. ::
XP_005 GPPPGPRLHPLSLLG-----SAP--PHLLG----LPGAAGHPAA-----AAAFARPAEPE
420 430 440 450
440 450 460 470 480
pF1KB5 --RDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
: . . ::. :::: :.. ::.:
XP_005 GGTDRCSALEVEKKLLKTAFQPV------PRRPRPRVLTPRAHPTVKPQHTHLQLDIILH
460 470 480 490 500 510
XP_005 CDTFLTIGPNPSRISPP
520
>>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa)
initn: 551 init1: 448 opt: 607 Z-score: 329.6 bits: 70.4 E(92054): 1.4e-11
Smith-Waterman score: 692; 37.3% identity (58.9% similar) in 445 aa overlap (17-402:4-422)
10 20 30 40 50
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS
: .: . :: :: . : .::. . : . ::. .:...: .
NP_150 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHT-----A
: .:: .: .... : :.:: . . : :. : . ::: :
NP_150 YPG--SAAFTAQAATGFGSPLQYSADAAA-AAAGF-------PSYMGAPYDAHTTGMTGA
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT
.:.:::. .: .::. :::::..:.::::::::::::::::::::::::::::::
NP_150 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT
100 110 120 130 140 150
180 190 200 210 220
pF1KB5 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE-
::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . :
NP_150 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED
160 170 180 190 200 210
230 240 250
pF1KB5 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH
:. .:.. .: ::.. ..:::....:
NP_150 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL
220 230 240 250 260 270
260 270 280 290 300
pF1KB5 APAAPSALARDQGSPLAA--ADVLKP--QDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA
:: : . .:::.. : .:.: . .: : ....:. . : ::::
NP_150 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------
280 290 300 310 320
310 320 330 340 350 360
pF1KB5 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG
: .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .:
NP_150 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL
330 340 350 360 370 380
370 380 390 400 410 420
pF1KB5 LYTCHI-GKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPG
:: . :...:. : ::. : .: ...:: : :
NP_150 YYTSPFYGNYTNYGNLNAALQGQGL-LRYNSAAAAPGEALHTAPKAASDAGKAGAHPLES
390 400 410 420 430 440
430 440 450 460 470 480
pF1KB5 ALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
NP_150 HYRSPGGGYEPKKDASEGCTVVGGGVQPYL
450 460 470
>>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 551 init1: 448 opt: 607 Z-score: 329.6 bits: 70.4 E(92054): 1.4e-11
Smith-Waterman score: 692; 37.3% identity (58.9% similar) in 445 aa overlap (17-402:4-422)
10 20 30 40 50
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS
: .: . :: :: . : .::. . : . ::. .:...: .
NP_001 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHT-----A
: .:: .: .... : :.:: . . : :. : . ::: :
NP_001 YPG--SAAFTAQAATGFGSPLQYSADAAA-AAAGF-------PSYMGAPYDAHTTGMTGA
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT
.:.:::. .: .::. :::::..:.::::::::::::::::::::::::::::::
NP_001 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT
100 110 120 130 140 150
180 190 200 210 220
pF1KB5 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE-
::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . :
NP_001 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED
160 170 180 190 200 210
230 240 250
pF1KB5 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH
:. .:.. .: ::.. ..:::....:
NP_001 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL
220 230 240 250 260 270
260 270 280 290 300
pF1KB5 APAAPSALARDQGSPLAA--ADVLKP--QDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA
:: : . .:::.. : .:.: . .: : ....:. . : ::::
NP_001 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------
280 290 300 310 320
310 320 330 340 350 360
pF1KB5 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG
: .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .:
NP_001 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL
330 340 350 360 370 380
370 380 390 400 410 420
pF1KB5 LYTCHI-GKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPG
:: . :...:. : ::. : .: ...:: : :
NP_001 YYTSPFYGNYTNYGNLNAALQGQGL-LRYNSAAAAPGEALHTAPKAASDAGKAGAHPLES
390 400 410 420 430 440
430 440 450 460 470 480
pF1KB5 ALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
NP_001 HYRSPGGGYEPKKDASEGCTVVGGGVQPYL
450 460 470
>>XP_011512281 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 551 init1: 448 opt: 607 Z-score: 329.6 bits: 70.4 E(92054): 1.4e-11
Smith-Waterman score: 692; 37.3% identity (58.9% similar) in 445 aa overlap (17-402:4-422)
10 20 30 40 50
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS
: .: . :: :: . : .::. . : . ::. .:...: .
XP_011 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHT-----A
: .:: .: .... : :.:: . . : :. : . ::: :
XP_011 YPG--SAAFTAQAATGFGSPLQYSADAAA-AAAGF-------PSYMGAPYDAHTTGMTGA
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT
.:.:::. .: .::. :::::..:.::::::::::::::::::::::::::::::
XP_011 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT
100 110 120 130 140 150
180 190 200 210 220
pF1KB5 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE-
::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . :
XP_011 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED
160 170 180 190 200 210
230 240 250
pF1KB5 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH
:. .:.. .: ::.. ..:::....:
XP_011 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL
220 230 240 250 260 270
260 270 280 290 300
pF1KB5 APAAPSALARDQGSPLAA--ADVLKP--QDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA
:: : . .:::.. : .:.: . .: : ....:. . : ::::
XP_011 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------
280 290 300 310 320
310 320 330 340 350 360
pF1KB5 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG
: .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .:
XP_011 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL
330 340 350 360 370 380
370 380 390 400 410 420
pF1KB5 LYTCHI-GKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPG
:: . :...:. : ::. : .: ...:: : :
XP_011 YYTSPFYGNYTNYGNLNAALQGQGL-LRYNSAAAAPGEALHTAPKAASDAGKAGAHPLES
390 400 410 420 430 440
430 440 450 460 470 480
pF1KB5 ALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
XP_011 HYRSPGGGYEPKKDASEGCTVVGGGVQPYL
450 460 470
>>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa)
initn: 504 init1: 463 opt: 604 Z-score: 328.0 bits: 70.1 E(92054): 1.7e-11
Smith-Waterman score: 701; 37.1% identity (55.0% similar) in 491 aa overlap (1-471:1-425)
10 20 30 40 50 60
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
::.:: :: : .:. . : . : .... :: : . ::: .....: .
NP_005 MSYPQ-GY-LYQPSASLALY---------SCPAYSTSVISG-PRTDELGRSSSGSAFSPY
10 20 30 40
70 80 90 100 110
pF1KB5 LGMYAAAGPYAGAPNYSAFLPYAAD------LSLFSQMGSQYELKDNPGVHPATFAAHTA
: : ..: .:.:.. : :.:: .. : .:: :. .::. .... :
NP_005 AGSTAFTAP---SPGYNSHLQYGADPAAAAAAAFSSYVGSPYD--HTPGM-AGSLGYH--
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 PAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: : :.. ::::. :::::..:.::::::::::::::::::::::::::::::::::
NP_005 PYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 STWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKID
::::::::::::::::.:: :.. .::.:: :.::..: :
NP_005 STWFANARRRLKKENKMTWTPRNR------------------SEDEEE--EENIDLEKND
170 180 190 200
240 250 260 270 280 290
pF1KB5 EHDGDQSNEDDEDKAEAPHAPAAPSALA----RDQGSPLAAADVLKPQDSPLGLAKEAPE
: : :. :: : :.:.: .: . : : :: : :. . . : . :: :
NP_005 E-DEPQKPEDKGDP-EGPEAGGAEQKAASGCERLQGPPTPAGKETEGSLSDSDF-KEPPS
210 220 230 240 250
300 310 320 330 340
pF1KB5 PGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATS--PDGAPKASPPPPAGH--PGAHGP
: :. .:: .: : : ::: . : ::: .: : ::. :: ::
NP_005 EGRLDALQGPPRTGG--PSPAG-PAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGP
260 270 280 290 300 310
350 360 370 380 390 400
pF1KB5 SAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHL
:. .. : : .. ..: . :. ::. . . . : :. ...:
NP_005 SV---IHSPPPPPPPAV----LAKPKLWS----LAEIATSSDKVKDGGGGNEGSP-----
320 330 340 350
410 420 430 440 450 460
pF1KB5 PAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPD----SPAQQLKSPFQPVRDN
:: : : :: ::.:..:: .:. : : : .:: : :
NP_005 -CPPCPGP---IAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTN
360 370 380 390 400 410
470 480
pF1KB5 --SLAPQEGTPRILAALPSA
:.. .: :
NP_005 YGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPY
420 430 440 450 460 470
>>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa)
initn: 565 init1: 457 opt: 599 Z-score: 325.5 bits: 69.6 E(92054): 2.3e-11
Smith-Waterman score: 708; 37.3% identity (55.1% similar) in 490 aa overlap (1-471:1-424)
10 20 30 40 50 60
pF1KB5 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
::.:: :: : .:. . : . : .... :: : . ::: .....: .
NP_001 MSYPQ-GY-LYQPSASLALY---------SCPAYSTSVISG-PRTDELGRSSSGSAFSPY
10 20 30 40
70 80 90 100 110
pF1KB5 LGMYAAAGPYAGAPNYSAFLPYAAD------LSLFSQMGSQYELKDNPGVHPATFAAHTA
: : ..: .:.:.. : :.:: .. : .:: :. .::. .... :
NP_001 AGSTAFTAP---SPGYNSHLQYGADPAAAAAAAFSSYVGSPYD--HTPGM-AGSLGYH--
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 PAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: : :.. ::::. :::::..:.::::::::::::::::::::::::::::::::::
NP_001 PYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 STWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKID
::::::::::::::::.:: :.. .::.:: :.::..: :
NP_001 STWFANARRRLKKENKMTWTPRNR------------------SEDEEE--EENIDLEKND
170 180 190 200
240 250 260 270 280 290
pF1KB5 EHDGDQSNEDDEDKAEAPHAPA---APSALARDQGSPLAAADVLKPQDSPLGLAKEAPEP
: : :. :: : :.:.: : : :. : :: : :. . . : . :: :
NP_001 E-DEPQKPEDKGDP-EGPEAGAEQKAASGCERLQGPPTPAGKETEGSLSDSDF-KEPPSE
210 220 230 240 250
300 310 320 330 340
pF1KB5 GSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATS--PDGAPKASPPPPAGH--PGAHGPS
: :. .:: .: : : ::: . : ::: .: : ::. :: :::
NP_001 GRLDALQGPPRTGG--PSPAG-PAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPS
260 270 280 290 300 310
350 360 370 380 390 400
pF1KB5 AGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLP
. .. : : .. ..: . :. ::. . . . : :. ...:
NP_001 V---IHSPPPPPPPAV----LAKPKLWS----LAEIATSSDKVKDGGGGNEGSP------
320 330 340 350
410 420 430 440 450 460
pF1KB5 APPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPD----SPAQQLKSPFQPVRDN-
:: : : :: ::.:..:: .:. : : : .:: : :
NP_001 CPPCPGP---IAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNY
360 370 380 390 400 410
470 480
pF1KB5 -SLAPQEGTPRILAALPSA
:.. .: :
NP_001 GSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYE
420 430 440 450 460 470
>>NP_057442 (OMIM: 606199) iroquois-class homeodomain pr (519 aa)
initn: 552 init1: 416 opt: 564 Z-score: 307.4 bits: 66.4 E(92054): 2.4e-10
Smith-Waterman score: 687; 36.4% identity (55.7% similar) in 508 aa overlap (1-422:1-502)
10 20 30 40 50
pF1KB5 MSFPQLGYP-----QYLSAAGPGAYGGERPG-VLAAAAAAAAAASSGRPGAAE---LGGG
::.::.::: :.: :.. . : : .:: .. ::.: . . : :. .
NP_057 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 AGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAA
...::.:. :::.:. .:. .. :... : : ...: .. ::. : . .:
NP_057 RHELNSAAALGVYG--GPYGGSQGYGNYVTYGSEASAFYSLNS-FDSKDGSGSAHGGLAP
70 80 90 100 110
120 130 140 150 160
pF1KB5 HTAPAYYPY----GQF---QYG--DPG-RPKNATRESTSTLKAWLNEHRKNPYPTKGEKI
.: ::::: ::. .:: : : : ::::::.::::::::.::::::::::::::
NP_057 -AAAAYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKI
120 130 140 150 160 170
170 180 190 200 210
pF1KB5 MLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--DQEDGALFGSDTEGDPEKAED
:::::::::::::::::::::::::::::.:: :.: :.. : . :: :.:..
NP_057 MLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEARE
180 190 200 210 220 230
220 230 240 250 260
pF1KB5 DEEIDLESIDIDKIDEHDGDQSNEDDED--KAEAP--------HA--------PAAPSAL
. . .. . .:.. . :. :: : .:: : :. ::::..
NP_057 EPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGP
240 250 260 270 280 290
270 280 290 300 310
pF1KB5 ARDQGSPL---------AAADV-LKPQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPH
... .. : :: : :. : : : .::: .: . . : .:
NP_057 VKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPA
300 310 320 330 340 350
320 330 340 350
pF1KB5 G-------KPKIWSLAETATSPDGAPKASPPP--PAGHPGAHGPSA-----GAPLQHPAF
: ::.:::::.:::. .: . :. .::.: .:: :.
NP_057 GASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSV
360 370 380 390 400 410
360 370 380 390
pF1KB5 -LPSHGLYTCH----IGKFSNWTNSAF---------------LAQGSLLN---MRSFLGV
:: : : . .. ::....: :.:.::. . ::.
NP_057 ALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGA
420 430 440 450 460 470
400 410 420 430 440 450
pF1KB5 GAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKS
:: . .: : :: : : : ::
NP_057 GA--NVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
480 490 500 510
480 residues in 1 query sequences
64236559 residues in 92054 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Aug 1 17:02:21 2019 done: Thu Aug 1 17:02:22 2019
Total Scan time: 5.660 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]