Result of FASTA (omim) for
pF1KB5797
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5797, 834 aa
1>>>pF1KB5797 834 - 834 aa - 834 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.8266+/-0.000428; mu= 0.3890+/- 0.027
mean_var=273.8466+/-59.562, 0's: 0 Z-trim(119.0): 35 B-trim: 1799 in 1/58
Lambda= 0.077503
statistics sampled from 32419 (32454) to 32419 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.381), width: 16
Scan time: 10.540
The best scores are: opt bits E(85289)
NP_006394 (OMIM: 602265) enhancer of filamentation ( 834) 5656 646.6 1.3e-184
NP_001135865 (OMIM: 602265) enhancer of filamentat ( 834) 5634 644.2 7.3e-184
NP_001257962 (OMIM: 602265) enhancer of filamentat ( 685) 4605 529.0 2.7e-149
XP_016879387 (OMIM: 602941) PREDICTED: breast canc ( 886) 1169 144.9 1.5e-33
NP_001164188 (OMIM: 602941) breast cancer anti-est ( 888) 1093 136.4 5.4e-31
NP_892011 (OMIM: 602265) enhancer of filamentation ( 174) 1062 132.4 1.7e-30
XP_011521777 (OMIM: 602941) PREDICTED: breast canc ( 841) 989 124.8 1.6e-27
XP_005256317 (OMIM: 602941) PREDICTED: breast canc ( 841) 989 124.8 1.6e-27
NP_001164190 (OMIM: 602941) breast cancer anti-est ( 868) 989 124.8 1.7e-27
XP_005256316 (OMIM: 602941) PREDICTED: breast canc ( 870) 989 124.8 1.7e-27
NP_055382 (OMIM: 602941) breast cancer anti-estrog ( 870) 989 124.8 1.7e-27
NP_001164189 (OMIM: 602941) breast cancer anti-est ( 870) 989 124.8 1.7e-27
NP_001164187 (OMIM: 602941) breast cancer anti-est ( 888) 989 124.8 1.7e-27
NP_001164186 (OMIM: 602941) breast cancer anti-est ( 888) 989 124.8 1.7e-27
XP_005256315 (OMIM: 602941) PREDICTED: breast canc ( 896) 989 124.8 1.7e-27
NP_001164185 (OMIM: 602941) breast cancer anti-est ( 916) 989 124.8 1.7e-27
XP_016879386 (OMIM: 602941) PREDICTED: breast canc ( 916) 989 124.8 1.7e-27
XP_016879388 (OMIM: 602941) PREDICTED: breast canc ( 823) 946 120.0 4.5e-26
NP_001164191 (OMIM: 602941) breast cancer anti-est ( 722) 936 118.8 8.8e-26
NP_001164192 (OMIM: 602941) breast cancer anti-est ( 660) 931 118.2 1.2e-25
NP_001264103 (OMIM: 609906) embryonal Fyn-associat ( 392) 383 56.8 2.3e-07
NP_115835 (OMIM: 609906) embryonal Fyn-associated ( 468) 383 56.8 2.6e-07
NP_005855 (OMIM: 609906) embryonal Fyn-associated ( 561) 383 56.9 3e-07
XP_005267313 (OMIM: 609906) PREDICTED: embryonal F ( 531) 381 56.6 3.3e-07
>>NP_006394 (OMIM: 602265) enhancer of filamentation 1 i (834 aa)
initn: 5656 init1: 5656 opt: 5656 Z-score: 3435.2 bits: 646.6 E(85289): 1.3e-184
Smith-Waterman score: 5656; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:1-834)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 YDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 HPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 LHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 DAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 KALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 LEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 SLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSS
730 740 750 760 770 780
790 800 810 820 830
pF1KB5 NQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
790 800 810 820 830
>>NP_001135865 (OMIM: 602265) enhancer of filamentation (834 aa)
initn: 5632 init1: 5632 opt: 5634 Z-score: 3421.9 bits: 644.2 E(85289): 7.3e-184
Smith-Waterman score: 5634; 99.6% identity (99.8% similar) in 834 aa overlap (1-834:1-834)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
: .::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWTRNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 YDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 HPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 LHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 DAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 KALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 LEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 SLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSS
730 740 750 760 770 780
790 800 810 820 830
pF1KB5 NQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
790 800 810 820 830
>>NP_001257962 (OMIM: 602265) enhancer of filamentation (685 aa)
initn: 4605 init1: 4605 opt: 4605 Z-score: 2801.3 bits: 529.0 E(85289): 2.7e-149
Smith-Waterman score: 4605; 100.0% identity (100.0% similar) in 682 aa overlap (153-834:4-685)
130 140 150 160 170 180
pF1KB5 GHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIPPS
::::::::::::::::::::::::::::::
NP_001 MKYKVITPVRTGHGYVYEYPSRYQKDVYDIPPS
10 20 30
190 200 210 220 230 240
pF1KB5 HTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKDYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKDYD
40 50 60 70 80 90
250 260 270 280 290 300
pF1KB5 FPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHP
100 110 120 130 140 150
310 320 330 340 350 360
pF1KB5 PPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRDLV
160 170 180 190 200 210
370 380 390 400 410 420
pF1KB5 DGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEM
220 230 240 250 260 270
430 440 450 460 470 480
pF1KB5 GVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILH
280 290 300 310 320 330
490 500 510 520 530 540
pF1KB5 NKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDA
340 350 360 370 380 390
550 560 570 580 590 600
pF1KB5 KQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKA
400 410 420 430 440 450
610 620 630 640 650 660
pF1KB5 LPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLE
460 470 480 490 500 510
670 680 690 700 710 720
pF1KB5 HHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFISL
520 530 540 550 560 570
730 740 750 760 770 780
pF1KB5 LNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQ
580 590 600 610 620 630
790 800 810 820 830
pF1KB5 LCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
640 650 660 670 680
>>XP_016879387 (OMIM: 602941) PREDICTED: breast cancer a (886 aa)
initn: 1370 init1: 504 opt: 1169 Z-score: 723.4 bits: 144.9 E(85289): 1.5e-33
Smith-Waterman score: 1616; 37.6% identity (58.4% similar) in 936 aa overlap (5-832:51-884)
10 20 30
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIE
:..:.:::::: : .::.::::::.::.:
XP_016 GPGPQGTGQPCSCGHWAEGQGGPPEPAGGPNVLAKALYDNVAESPDELSFRKGDIMTVLE
30 40 50 60 70 80
40 50 60 70 80
pF1KB5 QNTGGLEGWWLCSLHGRQGIVPGNRVKLLIG--------PMQETASSHEQPASGL-----
:.: ::.::::::::::::::::::.:.:.: : .. :: ::
XP_016 QDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAP
90 100 110 120 130 140
90
pF1KB5 --------MQQTF---------------GQQKLYQVPNPQA-------------------
. .:. .:: :::::.:.
XP_016 PASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPH
150 160 170 180 190 200
100 110 120 130 140 150
pF1KB5 ----APRDTIYQVPPSYQN--QGIYQVPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGK
.: .:::::. . : ::::: . : . ...::::::.. :: ::. :
XP_016 HPFPSPATDLYQVPPGPGGPAQDIYQVPPSAG-MGHDIYQVPPSMDTRSWEGTKPP---A
210 220 230 240 250
160 170 180 190
pF1KB5 KVITPVRTGHGYVYEYPSRYQ--------------KDVYDIPP------SHTTQGVYDIP
::..:.:.:.::::: . : .:.::.:: :. : ::: :
XP_016 KVVVPTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTP
260 270 280 290 300 310
200 210 220 230
pF1KB5 PSSAKGPVFSVPVGEIKPQGVYDIPPT--KG--------VYAIPPSACRDEAG---LREK
: ..::: :. : :::.::. :: :: .:::. .: :::.
XP_016 PMAVKGPNGRDPLLE-----VYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREE
320 330 340 350 360 370
240 250 260 270 280 290
pF1KB5 DYDFPPPMRQAGRPD-LRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLS
:: :: . .: : : : :: . :: .:.. :.: : : ..
XP_016 TYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPA-EDVY-----DVP----PPAPDLYDVP
380 390 400 410 420
300 310 320 330 340 350
pF1KB5 PNHPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERD-GVYDVPLHNPPDAKG
:. : : ::::: . . :: : :. : ::: :: :: .
XP_016 PGLRRPGPGT-------LYDVPR--ERVLPP----EVADGGVVDSGVYAVP---PPAERE
430 440 450 460
360 370 380 390 400 410
pF1KB5 SRDLVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQ
. ..: .::: ::::::::..:.:: :.:... :. ..:.: : :::
XP_016 AP--AEG-KRLSASSTGSTRSSQSASSLE------VAGPGREP---LELEVAVEALARLQ
470 480 490 500 510
420 430 440 450 460 470
pF1KB5 QALEMGVSSLMALV-----TTDWRCYGY-MERHINEIRTAVDKVELFLKEYLHFVKGAVA
:.. :. :. :. : .:: . .: ......:: :. ..: :.:...::.
XP_016 QGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVG
520 530 540 550 560 570
480 490 500 510 520 530
pF1KB5 NAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRF
::: . :: :..:.::..:: :: : .. :. . .::::.
XP_016 NAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGR--------GGSGATLEDLDRL
580 590 600 610 620
540 550 560 570 580 590
pF1KB5 VMVAKTVPDDAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHP
: ...::.:::::.. .. :: ::: .. :::. ::. :::
XP_016 VACSRAVPEDAKQLASFLHGNASLLFRRTKAT---APGPEG---------GGT----LHP
630 640 650 660
600 610 620 630 640
pF1KB5 G--DHKAQAHNKALP--PGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKEL
. :. .. ... :: : ......:: .. ..:: .::.::::::::
XP_016 NPTDKTSSIQSRPLPSPPKFTSQDSPD-GQYENSEGGWMEDYDYVHLQ------------
670 680 690 700 710
650 660 670 680 690 700
pF1KB5 LEKENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSL-PTTNSGVSAQDRQ
:.::. ::::...:...:...: :.: : : ..:.. .:::
XP_016 ------------------LKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQ
720 730 740 750
710 720 730 740 750 760
pF1KB5 LLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQ
:: :: .:::... .: ::.::.:. :.. :::.:::::::::::::::::::::::.::
XP_016 LLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQ
760 770 780 790 800 810
770 780 790 800 810 820
pF1KB5 VTAQDIRNKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKR
. : :.:..: . :: ::. :. :: .:: :::.::: .: :.::..: .:....: :.:
XP_016 AKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRR
820 830 840 850 860 870
830
pF1KB5 SLLEMATF
: ..:
XP_016 VLGQLAAA
880
>>NP_001164188 (OMIM: 602941) breast cancer anti-estroge (888 aa)
initn: 1622 init1: 504 opt: 1093 Z-score: 677.5 bits: 136.4 E(85289): 5.4e-31
Smith-Waterman score: 1725; 39.2% identity (61.5% similar) in 916 aa overlap (23-832:23-886)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
.::::::.::.::.: ::.::::::::::::::::::.
NP_001 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50 60
70 80
pF1KB5 KLLIG--------PMQETASSHEQPASGL-------------MQQTF-------------
:.:.: : .. :: :: . .:.
NP_001 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
70 80 90 100 110 120
90 100 110
pF1KB5 --GQQKLYQVPNPQA-----------------------APRDTIYQVPPSYQN--QGIYQ
.:: :::::.:. .: .:::::. . : :::
NP_001 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
130 140 150 160 170 180
120 130 140 150 160 170
pF1KB5 VPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYD
:: . : . ...::::::.. :: ::. : ::..:.:.:.::::: .. ..: ::
NP_001 VPPSAG-MGHDIYQVPPSMDTRSWEGTKPP---AKVVVPTRVGQGYVYE-AAQPEQDEYD
190 200 210 220 230
180 190 200 210 220
pF1KB5 IPPSHTT----QGVYDIPPSSAKGP------VFSVPVGEIK-PQGVYDIPPTKGVYAIPP
:: : : .::.:: . : :...: .: :.: : : :: .::
NP_001 IP-RHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNG-RD--PLLEVYDVPP
240 250 260 270 280 290
230 240 250 260 270 280
pF1KB5 SACRDEAGLREKDYDFPPPMRQAGRPDLRPEGV--YDIPPTCTK--PAGKDLHVKYNCDI
:. : :: ... . .: :: :: ::.::. .: : : :. . . :.
NP_001 SV---EKGLPPSNHHAVSKCQGNARARLRLWGVWVYDVPPSVSKDVPDGPLLR-EETYDV
300 310 320 330 340
290 300 310 320 330
pF1KB5 PGA---AEPV--ARRHQSLS---PNHPPPQLGQSVGSQN-DAYDVPRGVQFLEPPAETSE
: : :.: :: :. :. :: . .: : :::: : :. :. .
NP_001 PPAFAKAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPG---LRRPGPGTL
350 360 370 380 390 400
340 350 360 370 380
pF1KB5 KANPQER--------DGVYDVPLHN-PPDAKGSRDLVDGINRLSFSSTGSTRSNMSTSST
:.:: :: : .. :: :. :. .::: ::::::::..:.::
NP_001 YDVPRERVLPPEVADGGVVDSGVYAVPPPAE--REAPAEGKRLSASSTGSTRSSQSASSL
410 420 430 440 450 460
390 400 410 420 430 440
pF1KB5 SSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALV-----TTDWRCYGY
:.:... :. ..:.: : ::::.. :. :. :. : .:: .
NP_001 EV------AGPGREP---LELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSE
470 480 490 500 510
450 460 470 480 490
pF1KB5 -MERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQIL
.: ......:: :. ..: :.:...::.::: . :: :..:.::..:: :: :
NP_001 PQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTL
520 530 540 550 560 570
500 510 520 530 540 550
pF1KB5 SQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRP
.. :. . .::::.: ...::.:::::.. .. :: :::
NP_001 VAHGQALDAGR--------GGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRR
580 590 600 610 620
560 570 580 590 600 610
pF1KB5 GPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPG--DHKAQAHNKALP--PGLSKEQAPDC
.. :::. ::. :::. :. .. ... :: : ......::
NP_001 TKAT---APGPEG---------GGT----LHPNPTDKTSSIQSRPLPSPPKFTSQDSPD-
630 640 650 660
620 630 640 650 660 670
pF1KB5 SSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLEQE
.. ..:: .::.::::::::::::::. ::::::: .: .:.: ::: .::.::. ::::
NP_001 GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQE
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB5 ITKPVENDISKWKPSQSL-PTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVS
...:...:...: :.: : : ..:.. .::::: :: .:::... .: ::.::.:. :.
NP_001 VSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVA
730 740 750 760 770 780
740 750 760 770 780 790
pF1KB5 SAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVMAT
. :::.:::::::::::::::::::::::.::. : :.:..: . :: ::. :. :: .:
NP_001 TNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATT
790 800 810 820 830 840
800 810 820 830
pF1KB5 KMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
: :::.::: .: :.::..: .:....: :.: : ..:
NP_001 KAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
850 860 870 880
>>NP_892011 (OMIM: 602265) enhancer of filamentation 1 i (174 aa)
initn: 1062 init1: 1062 opt: 1062 Z-score: 668.4 bits: 132.4 E(85289): 1.7e-30
Smith-Waterman score: 1062; 100.0% identity (100.0% similar) in 154 aa overlap (1-154:1-154)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_892 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIP
::::::::::::::::::::::::::::::::::
NP_892 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQTSL
130 140 150 160 170
190 200 210 220 230 240
pF1KB5 PSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKD
>>XP_011521777 (OMIM: 602941) PREDICTED: breast cancer a (841 aa)
initn: 1500 init1: 504 opt: 989 Z-score: 615.0 bits: 124.8 E(85289): 1.6e-27
Smith-Waterman score: 1692; 39.0% identity (60.4% similar) in 911 aa overlap (30-832:1-839)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
.::.::.: ::.::::::::::::::::::.
XP_011 MTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30
70 80
pF1KB5 KLLIG--------PMQETASSHEQPASGL-------------MQQTF-------------
:.:.: : .. :: :: . .:.
XP_011 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
40 50 60 70 80 90
90 100 110
pF1KB5 --GQQKLYQVPNPQA-----------------------APRDTIYQVPPSYQN--QGIYQ
.:: :::::.:. .: .:::::. . : :::
XP_011 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB5 VPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQ-----
:: . : ...::::::.. :: ::. : ::..:.:.:.::::: . :
XP_011 VPPSAGMG-HDIYQVPPSMDTRSWEGTKPP---AKVVVPTRVGQGYVYEAAQPEQDEYDI
160 170 180 190 200
180 190 200 210
pF1KB5 ---------KDVYDIPP------SHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPP
.:.::.:: :. : ::: :: ..::: :. : :::.::
XP_011 PRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLE-----VYDVPP
210 220 230 240 250 260
220 230 240 250 260
pF1KB5 T--KG--------VYAIPPSACRDEAG---LREKDYDFPPPMRQAGRPD-LRPEGVYDIP
. :: :: .:::. .: :::. :: :: . .: : : : :
XP_011 SVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAP
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB5 PTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQ
: . :: .:.. :.: : : .. :. : : ::::: .
XP_011 PPDSPPA-EDVY-----DVP----PPAPDLYDVPPGLRRPGPGT-------LYDVPR--E
330 340 350 360
330 340 350 360 370 380
pF1KB5 FLEPPAETSEKANPQERD-GVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTS
. :: : :. : ::: :: :: . . ..: .::: ::::::::..:.:
XP_011 RVLPP----EVADGGVVDSGVYAVP---PPAEREAP--AEG-KRLSASSTGSTRSSQSAS
370 380 390 400 410
390 400 410 420 430
pF1KB5 STSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALV-----TTDWRCY
: :.:... :. ..:.: : ::::.. :. :. :. : .::
XP_011 SLEV------AGPGREP---LELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSP
420 430 440 450 460
440 450 460 470 480 490
pF1KB5 GY-MERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQ
. .: ......:: :. ..: :.:...::.::: . :: :..:.::..:: ::
XP_011 SEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQ
470 480 490 500 510 520
500 510 520 530 540 550
pF1KB5 ILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALF
: .. :. . . .::::.: ...::.:::::.. .. :: ::
XP_011 TLVAHGQALDA--------GRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLF
530 540 550 560 570
560 570 580 590 600 610
pF1KB5 RPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPG--DHKAQAHNKALP--PGLSKEQAP
: .. :::. ::. :::. :. .. ... :: : ......:
XP_011 RRTKAT---APGPEG---------GGT----LHPNPTDKTSSIQSRPLPSPPKFTSQDSP
580 590 600 610 620
620 630 640 650 660 670
pF1KB5 DCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLE
: .. ..:: .::.::::::::::::::. ::::::: .: .:.: ::: .::.::. ::
XP_011 D-GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLE
630 640 650 660 670
680 690 700 710 720 730
pF1KB5 QEITKPVENDISKWKPSQSL-PTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSC
::...:...:...: :.: : : ..:.. .::::: :: .:::... .: ::.::.:.
XP_011 QEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTA
680 690 700 710 720 730
740 750 760 770 780 790
pF1KB5 VSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVM
:.. :::.:::::::::::::::::::::::.::. : :.:..: . :: ::. :. ::
XP_011 VATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVA
740 750 760 770 780 790
800 810 820 830
pF1KB5 ATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
.:: :::.::: .: :.::..: .:....: :.: : ..:
XP_011 TTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
800 810 820 830 840
>>XP_005256317 (OMIM: 602941) PREDICTED: breast cancer a (841 aa)
initn: 1500 init1: 504 opt: 989 Z-score: 615.0 bits: 124.8 E(85289): 1.6e-27
Smith-Waterman score: 1692; 39.0% identity (60.4% similar) in 911 aa overlap (30-832:1-839)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
.::.::.: ::.::::::::::::::::::.
XP_005 MTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30
70 80
pF1KB5 KLLIG--------PMQETASSHEQPASGL-------------MQQTF-------------
:.:.: : .. :: :: . .:.
XP_005 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
40 50 60 70 80 90
90 100 110
pF1KB5 --GQQKLYQVPNPQA-----------------------APRDTIYQVPPSYQN--QGIYQ
.:: :::::.:. .: .:::::. . : :::
XP_005 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB5 VPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQ-----
:: . : ...::::::.. :: ::. : ::..:.:.:.::::: . :
XP_005 VPPSAGMG-HDIYQVPPSMDTRSWEGTKPP---AKVVVPTRVGQGYVYEAAQPEQDEYDI
160 170 180 190 200
180 190 200 210
pF1KB5 ---------KDVYDIPP------SHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPP
.:.::.:: :. : ::: :: ..::: :. : :::.::
XP_005 PRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLE-----VYDVPP
210 220 230 240 250 260
220 230 240 250 260
pF1KB5 T--KG--------VYAIPPSACRDEAG---LREKDYDFPPPMRQAGRPD-LRPEGVYDIP
. :: :: .:::. .: :::. :: :: . .: : : : :
XP_005 SVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAP
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB5 PTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQ
: . :: .:.. :.: : : .. :. : : ::::: .
XP_005 PPDSPPA-EDVY-----DVP----PPAPDLYDVPPGLRRPGPGT-------LYDVPR--E
330 340 350 360
330 340 350 360 370 380
pF1KB5 FLEPPAETSEKANPQERD-GVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTS
. :: : :. : ::: :: :: . . ..: .::: ::::::::..:.:
XP_005 RVLPP----EVADGGVVDSGVYAVP---PPAEREAP--AEG-KRLSASSTGSTRSSQSAS
370 380 390 400 410
390 400 410 420 430
pF1KB5 STSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALV-----TTDWRCY
: :.:... :. ..:.: : ::::.. :. :. :. : .::
XP_005 SLEV------AGPGREP---LELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSP
420 430 440 450 460
440 450 460 470 480 490
pF1KB5 GY-MERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQ
. .: ......:: :. ..: :.:...::.::: . :: :..:.::..:: ::
XP_005 SEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQ
470 480 490 500 510 520
500 510 520 530 540 550
pF1KB5 ILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALF
: .. :. . . .::::.: ...::.:::::.. .. :: ::
XP_005 TLVAHGQALDA--------GRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLF
530 540 550 560 570
560 570 580 590 600 610
pF1KB5 RPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPG--DHKAQAHNKALP--PGLSKEQAP
: .. :::. ::. :::. :. .. ... :: : ......:
XP_005 RRTKAT---APGPEG---------GGT----LHPNPTDKTSSIQSRPLPSPPKFTSQDSP
580 590 600 610 620
620 630 640 650 660 670
pF1KB5 DCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLE
: .. ..:: .::.::::::::::::::. ::::::: .: .:.: ::: .::.::. ::
XP_005 D-GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLE
630 640 650 660 670
680 690 700 710 720 730
pF1KB5 QEITKPVENDISKWKPSQSL-PTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSC
::...:...:...: :.: : : ..:.. .::::: :: .:::... .: ::.::.:.
XP_005 QEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTA
680 690 700 710 720 730
740 750 760 770 780 790
pF1KB5 VSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVM
:.. :::.:::::::::::::::::::::::.::. : :.:..: . :: ::. :. ::
XP_005 VATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVA
740 750 760 770 780 790
800 810 820 830
pF1KB5 ATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
.:: :::.::: .: :.::..: .:....: :.: : ..:
XP_005 TTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
800 810 820 830 840
>>NP_001164190 (OMIM: 602941) breast cancer anti-estroge (868 aa)
initn: 1617 init1: 504 opt: 989 Z-score: 614.8 bits: 124.8 E(85289): 1.7e-27
Smith-Waterman score: 1808; 39.7% identity (61.1% similar) in 936 aa overlap (5-832:3-866)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
:..:.:::::: : .::.::::::.::.::.: ::.::::::::::::::::::.
NP_001 MENVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50
70 80
pF1KB5 KLLIG--------PMQETASSHEQPASGL-------------MQQTF-------------
:.:.: : .. :: :: . .:.
NP_001 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
60 70 80 90 100 110
90 100 110
pF1KB5 --GQQKLYQVPNPQA-----------------------APRDTIYQVPPSYQN--QGIYQ
.:: :::::.:. .: .:::::. . : :::
NP_001 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
120 130 140 150 160 170
120 130 140 150 160 170
pF1KB5 VPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQ-----
:: . : . ...::::::.. :: ::. : ::..:.:.:.::::: . :
NP_001 VPPSAG-MGHDIYQVPPSMDTRSWEGTKPP---AKVVVPTRVGQGYVYEAAQPEQDEYDI
180 190 200 210 220 230
180 190 200 210
pF1KB5 ---------KDVYDIPP------SHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPP
.:.::.:: :. : ::: :: ..::: :. : :::.::
NP_001 PRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLE-----VYDVPP
240 250 260 270 280
220 230 240 250 260
pF1KB5 T--KG--------VYAIPPSACRDEAG---LREKDYDFPPPMRQAGRPD-LRPEGVYDIP
. :: :: .:::. .: :::. :: :: . .: : : : :
NP_001 SVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAP
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB5 PTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQ
: . :: .:.. :.: : : .. :. : : ::::: .
NP_001 PPDSPPA-EDVY-----DVP----PPAPDLYDVPPGLRRPGPGT-------LYDVPR--E
350 360 370 380 390
330 340 350 360 370 380
pF1KB5 FLEPPAETSEKANPQERD-GVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTS
. :: : :. : ::: :: :: . . ..: .::: ::::::::..:.:
NP_001 RVLPP----EVADGGVVDSGVYAVP---PPAEREAP--AEG-KRLSASSTGSTRSSQSAS
400 410 420 430 440
390 400 410 420 430
pF1KB5 STSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALV-----TTDWRCY
: :.:... :. ..:.: : ::::.. :. :. :. : .::
NP_001 SLE------VAGPGREP---LELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSP
450 460 470 480 490
440 450 460 470 480 490
pF1KB5 GY-MERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQ
. .: ......:: :. ..: :.:...::.::: . :: :..:.::..:: ::
NP_001 SEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQ
500 510 520 530 540 550
500 510 520 530 540 550
pF1KB5 ILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALF
: .. :. . .::::.: ...::.:::::.. .. :: ::
NP_001 TLVAHGQALDAGR--------GGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLF
560 570 580 590 600
560 570 580 590 600 610
pF1KB5 RPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPG--DHKAQAHNKALP--PGLSKEQAP
: .. :::. ::. :::. :. .. ... :: : ......:
NP_001 RRTKAT---APGPEG---------GGT----LHPNPTDKTSSIQSRPLPSPPKFTSQDSP
610 620 630 640
620 630 640 650 660 670
pF1KB5 DCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLE
: .. ..:: .::.::::::::::::::. ::::::: .: .:.: ::: .::.::. ::
NP_001 D-GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLE
650 660 670 680 690 700
680 690 700 710 720 730
pF1KB5 QEITKPVENDISKWKPSQSL-PTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSC
::...:...:...: :.: : : ..:.. .::::: :: .:::... .: ::.::.:.
NP_001 QEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTA
710 720 730 740 750 760
740 750 760 770 780 790
pF1KB5 VSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVM
:.. :::.:::::::::::::::::::::::.::. : :.:..: . :: ::. :. ::
NP_001 VATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVA
770 780 790 800 810 820
800 810 820 830
pF1KB5 ATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
.:: :::.::: .: :.::..: .:....: :.: : ..:
NP_001 TTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
830 840 850 860
>>XP_005256316 (OMIM: 602941) PREDICTED: breast cancer a (870 aa)
initn: 1628 init1: 504 opt: 989 Z-score: 614.8 bits: 124.8 E(85289): 1.7e-27
Smith-Waterman score: 1808; 39.7% identity (61.1% similar) in 936 aa overlap (5-832:5-868)
10 20 30 40 50 60
pF1KB5 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
:..:.:::::: : .::.::::::.::.::.: ::.::::::::::::::::::.
XP_005 MQGKNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
10 20 30 40 50 60
70 80
pF1KB5 KLLIG--------PMQETASSHEQPASGL-------------MQQTF-------------
:.:.: : .. :: :: . .:.
XP_005 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
70 80 90 100 110 120
90 100 110
pF1KB5 --GQQKLYQVPNPQA-----------------------APRDTIYQVPPSYQN--QGIYQ
.:: :::::.:. .: .:::::. . : :::
XP_005 SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
130 140 150 160 170 180
120 130 140 150 160 170
pF1KB5 VPTGHGTQEQEVYQVPPSVQ-RSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQ-----
:: . : . ...::::::.. :: ::. : ::..:.:.:.::::: . :
XP_005 VPPSAG-MGHDIYQVPPSMDTRSWEGTKPP---AKVVVPTRVGQGYVYEAAQPEQDEYDI
190 200 210 220 230
180 190 200 210
pF1KB5 ---------KDVYDIPP------SHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPP
.:.::.:: :. : ::: :: ..::: :. : :::.::
XP_005 PRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLE-----VYDVPP
240 250 260 270 280 290
220 230 240 250 260
pF1KB5 T--KG--------VYAIPPSACRDEAG---LREKDYDFPPPMRQAGRPD-LRPEGVYDIP
. :: :: .:::. .: :::. :: :: . .: : : : :
XP_005 SVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAP
300 310 320 330 340 350
270 280 290 300 310 320
pF1KB5 PTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQ
: . :: .:.. :.: : : .. :. : : ::::: .
XP_005 PPDSPPA-EDVY-----DVP----PPAPDLYDVPPGLRRPGPGT-------LYDVPR--E
360 370 380 390
330 340 350 360 370 380
pF1KB5 FLEPPAETSEKANPQERD-GVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTS
. :: : :. : ::: :: :: . . ..: .::: ::::::::..:.:
XP_005 RVLPP----EVADGGVVDSGVYAVP---PPAEREAP--AEG-KRLSASSTGSTRSSQSAS
400 410 420 430 440
390 400 410 420 430
pF1KB5 STSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALV-----TTDWRCY
: :.:... :. ..:.: : ::::.. :. :. :. : .::
XP_005 SLE------VAGPGREP---LELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSP
450 460 470 480 490
440 450 460 470 480 490
pF1KB5 GY-MERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQ
. .: ......:: :. ..: :.:...::.::: . :: :..:.::..:: ::
XP_005 SEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQ
500 510 520 530 540 550
500 510 520 530 540 550
pF1KB5 ILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALF
: .. :. . .::::.: ...::.:::::.. .. :: ::
XP_005 TLVAHGQALDAGR--------GGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLF
560 570 580 590 600
560 570 580 590 600 610
pF1KB5 RPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPG--DHKAQAHNKALP--PGLSKEQAP
: .. :::. ::. :::. :. .. ... :: : ......:
XP_005 RRTKAT---APGPEG---------GGT----LHPNPTDKTSSIQSRPLPSPPKFTSQDSP
610 620 630 640
620 630 640 650 660 670
pF1KB5 DCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLE
: .. ..:: .::.::::::::::::::. ::::::: .: .:.: ::: .::.::. ::
XP_005 D-GQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLE
650 660 670 680 690 700
680 690 700 710 720 730
pF1KB5 QEITKPVENDISKWKPSQSL-PTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSC
::...:...:...: :.: : : ..:.. .::::: :: .:::... .: ::.::.:.
XP_005 QEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTA
710 720 730 740 750 760
740 750 760 770 780 790
pF1KB5 VSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVM
:.. :::.:::::::::::::::::::::::.::. : :.:..: . :: ::. :. ::
XP_005 VATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVA
770 780 790 800 810 820
800 810 820 830
pF1KB5 ATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
.:: :::.::: .: :.::..: .:....: :.: : ..:
XP_005 TTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
830 840 850 860 870
834 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:51:02 2016 done: Sat Nov 5 07:51:04 2016
Total Scan time: 10.540 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]