Result of FASTA (omim) for
pF1KB5730
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5730, 732 aa
1>>>pF1KB5730 732 - 732 aa - 732 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9818+/-0.000343; mu= 22.5587+/- 0.021
mean_var=76.1359+/-15.196, 0's: 0 Z-trim(115.9): 31 B-trim: 84 in 1/52
Lambda= 0.146987
statistics sampled from 26567 (26598) to 26567 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.312), width: 16
Scan time: 11.960
The best scores are: opt bits E(85289)
NP_000411 (OMIM: 110900,613883) kell blood group g ( 732) 4987 1067.3 0
XP_005250050 (OMIM: 110900,613883) PREDICTED: kell ( 744) 4980 1065.8 0
XP_005250051 (OMIM: 110900,613883) PREDICTED: kell ( 423) 2883 620.9 3.2e-177
XP_006710461 (OMIM: 145500,600423,613870) PREDICTE ( 753) 1253 275.5 5.4e-73
XP_011539175 (OMIM: 145500,600423,613870) PREDICTE ( 753) 1253 275.5 5.4e-73
XP_016856000 (OMIM: 145500,600423,613870) PREDICTE ( 753) 1253 275.5 5.4e-73
NP_001106819 (OMIM: 145500,600423,613870) endothel ( 754) 1253 275.5 5.4e-73
NP_001106818 (OMIM: 145500,600423,613870) endothel ( 758) 1253 275.5 5.5e-73
NP_001106820 (OMIM: 145500,600423,613870) endothel ( 767) 1253 275.5 5.5e-73
NP_001388 (OMIM: 145500,600423,613870) endothelin- ( 770) 1253 275.5 5.5e-73
XP_011539174 (OMIM: 145500,600423,613870) PREDICTE ( 778) 1253 275.5 5.6e-73
NP_001032401 (OMIM: 610145) endothelin-converting ( 736) 1185 261.1 1.2e-68
NP_001093591 (OMIM: 610145) endothelin-converting ( 765) 1185 261.1 1.2e-68
NP_001093590 (OMIM: 610145) endothelin-converting ( 811) 1185 261.1 1.3e-68
NP_055508 (OMIM: 610145) endothelin-converting enz ( 883) 1185 261.2 1.3e-68
NP_004817 (OMIM: 605896,615065) endothelin-convert ( 775) 733 165.3 8.7e-40
NP_001277716 (OMIM: 605896,615065) endothelin-conv ( 773) 667 151.3 1.4e-35
NP_001269683 (OMIM: 300550,307800) phosphate-regul ( 695) 496 115.0 1.1e-24
NP_000435 (OMIM: 300550,307800) phosphate-regulati ( 749) 496 115.0 1.1e-24
XP_011543835 (OMIM: 300550,307800) PREDICTED: phos ( 497) 405 95.5 5.4e-19
XP_016885068 (OMIM: 300550,307800) PREDICTED: phos ( 497) 405 95.5 5.4e-19
NP_009220 (OMIM: 120520,614692,617017,617018) nepr ( 750) 352 84.4 1.8e-15
XP_006713710 (OMIM: 120520,614692,617017,617018) P ( 750) 352 84.4 1.8e-15
NP_009218 (OMIM: 120520,614692,617017,617018) nepr ( 750) 352 84.4 1.8e-15
NP_009219 (OMIM: 120520,614692,617017,617018) nepr ( 750) 352 84.4 1.8e-15
XP_006713709 (OMIM: 120520,614692,617017,617018) P ( 750) 352 84.4 1.8e-15
XP_011511158 (OMIM: 120520,614692,617017,617018) P ( 750) 352 84.4 1.8e-15
XP_011511159 (OMIM: 120520,614692,617017,617018) P ( 750) 352 84.4 1.8e-15
NP_000893 (OMIM: 120520,614692,617017,617018) nepr ( 750) 352 84.4 1.8e-15
XP_011511157 (OMIM: 120520,614692,617017,617018) P ( 750) 352 84.4 1.8e-15
XP_011543838 (OMIM: 300550,307800) PREDICTED: phos ( 380) 296 72.3 4.1e-12
>>NP_000411 (OMIM: 110900,613883) kell blood group glyco (732 aa)
initn: 4987 init1: 4987 opt: 4987 Z-score: 5710.9 bits: 1067.3 E(85289): 0
Smith-Waterman score: 4987; 100.0% identity (100.0% similar) in 732 aa overlap (1-732:1-732)
10 20 30 40 50 60
pF1KB5 MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG
670 680 690 700 710 720
730
pF1KB5 ALLNPSSRCQLW
::::::::::::
NP_000 ALLNPSSRCQLW
730
>>XP_005250050 (OMIM: 110900,613883) PREDICTED: kell blo (744 aa)
initn: 4980 init1: 4980 opt: 4980 Z-score: 5702.8 bits: 1065.8 E(85289): 0
Smith-Waterman score: 4980; 100.0% identity (100.0% similar) in 731 aa overlap (2-732:14-744)
10 20 30 40
pF1KB5 MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRV
:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGEGSRNGTFRGQEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFAC
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 GRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 LRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQP
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 EFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 LEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWM
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 KCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 QDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 QHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFY
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 QLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQA
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSST
670 680 690 700 710 720
710 720 730
pF1KB5 PAFARYFRCARGALLNPSSRCQLW
::::::::::::::::::::::::
XP_005 PAFARYFRCARGALLNPSSRCQLW
730 740
>>XP_005250051 (OMIM: 110900,613883) PREDICTED: kell blo (423 aa)
initn: 2883 init1: 2883 opt: 2883 Z-score: 3302.8 bits: 620.9 E(85289): 3.2e-177
Smith-Waterman score: 2883; 100.0% identity (100.0% similar) in 423 aa overlap (310-732:1-423)
280 290 300 310 320 330
pF1KB5 SRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHD
::::::::::::::::::::::::::::::
XP_005 MAPAIDWLSCLQATFTPMSLSPSQSLVVHD
10 20 30
340 350 360 370 380 390
pF1KB5 VEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQP
40 50 60 70 80 90
400 410 420 430 440 450
pF1KB5 PMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPW
100 110 120 130 140 150
460 470 480 490 500 510
pF1KB5 MNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARI
160 170 180 190 200 210
520 530 540 550 560 570
pF1KB5 VQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIM
220 230 240 250 260 270
580 590 600 610 620 630
pF1KB5 AHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADV
280 290 300 310 320 330
640 650 660 670 680 690
pF1KB5 GGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHL
340 350 360 370 380 390
700 710 720 730
pF1KB5 RVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
:::::::::::::::::::::::::::::::::
XP_005 RVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
400 410 420
>>XP_006710461 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.4 bits: 275.5 E(85289): 5.4e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:35-753)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
XP_006 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
XP_006 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
70 80 90 100 110 120
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
XP_006 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
XP_006 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
XP_006 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
XP_006 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
XP_006 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
370 380 390 400 410
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
XP_006 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
XP_006 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
XP_006 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
XP_006 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
XP_006 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
660 670 680 690 700 710
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
XP_006 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>XP_011539175 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.4 bits: 275.5 E(85289): 5.4e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:35-753)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
XP_011 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
XP_011 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
70 80 90 100 110 120
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
XP_011 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
XP_011 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
XP_011 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
XP_011 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
XP_011 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
370 380 390 400 410
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
XP_011 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
XP_011 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
XP_011 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
XP_011 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
XP_011 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
660 670 680 690 700 710
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
XP_011 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>XP_016856000 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.4 bits: 275.5 E(85289): 5.4e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:35-753)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
XP_016 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
XP_016 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
70 80 90 100 110 120
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
XP_016 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
XP_016 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
XP_016 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
XP_016 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
XP_016 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
370 380 390 400 410
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
XP_016 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
XP_016 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
XP_016 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
XP_016 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
XP_016 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
660 670 680 690 700 710
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
XP_016 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>NP_001106819 (OMIM: 145500,600423,613870) endothelin-c (754 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.4 bits: 275.5 E(85289): 5.4e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:36-754)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
NP_001 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
NP_001 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
70 80 90 100 110 120
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
NP_001 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
NP_001 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
NP_001 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
NP_001 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
NP_001 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
370 380 390 400 410
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
NP_001 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
NP_001 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
NP_001 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
NP_001 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
NP_001 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
660 670 680 690 700 710
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
NP_001 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>NP_001106818 (OMIM: 145500,600423,613870) endothelin-c (758 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.4 bits: 275.5 E(85289): 5.5e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:40-758)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
NP_001 RNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
NP_001 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
70 80 90 100 110 120
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
NP_001 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
NP_001 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
NP_001 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
NP_001 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
NP_001 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
NP_001 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
NP_001 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
490 500 510 520 530
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
NP_001 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
NP_001 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
NP_001 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
660 670 680 690 700 710
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
NP_001 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>NP_001106820 (OMIM: 145500,600423,613870) endothelin-c (767 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.3 bits: 275.5 E(85289): 5.5e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:49-767)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
NP_001 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
NP_001 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
80 90 100 110 120 130
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
NP_001 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
NP_001 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
NP_001 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
NP_001 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
NP_001 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
380 390 400 410 420
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
NP_001 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
NP_001 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
NP_001 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
550 560 570 580 590 600
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
NP_001 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
NP_001 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
670 680 690 700 710 720
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
NP_001 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750 760
>>NP_001388 (OMIM: 145500,600423,613870) endothelin-conv (770 aa)
initn: 1230 init1: 225 opt: 1253 Z-score: 1431.3 bits: 275.5 E(85289): 5.5e-73
Smith-Waterman score: 1272; 31.5% identity (62.6% similar) in 730 aa overlap (35-732:52-770)
10 20 30 40 50
pF1KB5 DQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWA----VARR--VLTAILILGLL
: :.: :: : .: ::...: ::.
NP_001 KRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLV
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB5 LCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETN---
:...: . ..:. .: : . .:... . :.: . .: :: ::::.::: ..:
NP_001 ACLAALGI-QYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVP
90 100 110 120 130 140
120 130 140 150 160
pF1KB5 ------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPL
..:..: .:. ....:: ... . .:.:: .: .::. :: . ::
NP_001 DGHSRWGTFSNLWEHNQAIIKHLLE-NSTASVSEAERKAQVYYRACMNETRIEELRAKPL
150 160 170 180 190
170 180 190 200 210 220
pF1KB5 RQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPE
..::.:::: :.: :.. ::. ::... ..: ::: .:.. . .. :::.::
NP_001 MELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB5 FDVPLKQDQEQKIYAQ-IFREYLTYLNQLGTLLGG-DPSKVQEHSSLSISITSRLFQFLR
. .: .. .: . .. ::.:. ::: :::: : .. . . ... . : ..
NP_001 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITI
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB5 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMS
: :.:: . ... :: .:. .::::.:: :.. : :. .. :. .::.: :::...:
NP_001 PQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQIS
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB5 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW
:.. .: .:...:: .:: : ::..::.: ..:. :. :::
NP_001 TLINT---TDRCLLNNYMIWNLVRKTSSFLDQRFQDA----DEKFMEVMYGTKKTCLPRW
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB5 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNM
:: .: . . .:. .::. .:. ...: : ... :. :. : .: ::.:::..
NP_001 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
440 450 460 470 480 490
470 480 490 500 510 520
pF1KB5 AQDKVAQLQVEMGASEWALKPELARQEYNDIQ-LGSSFLQSVLSCVRSLRARIVQSFLQP
:..:. . .: .. . :. . .:: . . ...... .. :.. . :.
NP_001 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF-NFSWRVTADQLRK
500 510 520 530 540 550
530 540 550 560 570 580
pF1KB5 HPQH-RWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
:.. .:...: :::::: . . .:::::.:: ::. . :.:.:::. : ...::: :
NP_001 APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTH
560 570 580 590 600 610
590 600 610 620 630
pF1KB5 IFYQL---LLPGGCL-----ACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAA
: . : : . .:... :. ..:. . . .. : :. :: :
NP_001 AFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP-VNGRHTLGENIA
620 630 640 650 660 670
640 650 660 670 680 690
pF1KB5 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----D
: ::: : .::.. . .. .: ::.: :. .:.:: ..::: : .:..:: :
NP_001 DNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITD
680 690 700 710 720 730
700 710 720 730
pF1KB5 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
::: ..:: : ::.. :...::: :. .:: .:..:
NP_001 PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
740 750 760 770
732 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:06:24 2016 done: Sat Nov 5 15:06:25 2016
Total Scan time: 11.960 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]