Result of FASTA (omim) for
pF1KB5688
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5688, 695 aa
1>>>pF1KB5688 695 - 695 aa - 695 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7198+/-0.000424; mu= 4.5938+/- 0.027
mean_var=227.6717+/-44.827, 0's: 0 Z-trim(118.5): 78 B-trim: 458 in 3/59
Lambda= 0.085000
statistics sampled from 31361 (31453) to 31361 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.369), width: 16
Scan time: 12.260
The best scores are: opt bits E(85289)
NP_001135749 (OMIM: 104776) amyloid-like protein 2 ( 695) 4603 578.1 4e-164
NP_001315611 (OMIM: 104776) amyloid-like protein 2 ( 707) 3744 472.7 2.1e-132
NP_001315614 (OMIM: 104776) amyloid-like protein 2 ( 644) 3387 428.9 2.9e-119
NP_001315613 (OMIM: 104776) amyloid-like protein 2 ( 700) 2931 373.0 2.1e-102
NP_001135750 (OMIM: 104776) amyloid-like protein 2 ( 522) 2511 321.4 5.5e-87
NP_001135748 (OMIM: 104776) amyloid-like protein 2 ( 751) 2511 321.5 7.1e-87
NP_001230228 (OMIM: 104776) amyloid-like protein 2 ( 761) 2511 321.5 7.2e-87
NP_001191232 (OMIM: 104300,104760,605714) amyloid ( 677) 2244 288.8 4.8e-77
NP_001633 (OMIM: 104776) amyloid-like protein 2 is ( 763) 2092 270.2 2.1e-71
NP_958817 (OMIM: 104300,104760,605714) amyloid bet ( 695) 1916 248.6 6.2e-65
NP_001129603 (OMIM: 104300,104760,605714) amyloid ( 660) 1860 241.7 7e-63
NP_001315615 (OMIM: 104776) amyloid-like protein 2 ( 730) 1652 216.2 3.6e-55
NP_001129601 (OMIM: 104300,104760,605714) amyloid ( 639) 1629 213.3 2.3e-54
NP_001191231 (OMIM: 104300,104760,605714) amyloid ( 733) 1317 175.1 8.4e-43
NP_001191230 (OMIM: 104300,104760,605714) amyloid ( 752) 1287 171.4 1.1e-41
NP_001129488 (OMIM: 104300,104760,605714) amyloid ( 746) 989 134.9 1.1e-30
NP_958816 (OMIM: 104300,104760,605714) amyloid bet ( 751) 989 134.9 1.1e-30
NP_001129602 (OMIM: 104300,104760,605714) amyloid ( 714) 959 131.2 1.3e-29
NP_000475 (OMIM: 104300,104760,605714) amyloid bet ( 770) 959 131.2 1.4e-29
NP_001019978 (OMIM: 104775) amyloid-like protein 1 ( 651) 802 111.9 7.9e-24
NP_005157 (OMIM: 104775) amyloid-like protein 1 is ( 650) 798 111.4 1.1e-23
XP_016882227 (OMIM: 104775) PREDICTED: amyloid-lik ( 597) 705 100.0 2.8e-20
XP_016882226 (OMIM: 104775) PREDICTED: amyloid-lik ( 598) 704 99.9 3.1e-20
>>NP_001135749 (OMIM: 104776) amyloid-like protein 2 iso (695 aa)
initn: 4603 init1: 4603 opt: 4603 Z-score: 3067.5 bits: 578.1 E(85289): 4e-164
Smith-Waterman score: 4603; 100.0% identity (100.0% similar) in 695 aa overlap (1-695:1-695)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
610 620 630 640 650 660
670 680 690
pF1KB5 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::::::
NP_001 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
670 680 690
>>NP_001315611 (OMIM: 104776) amyloid-like protein 2 iso (707 aa)
initn: 3727 init1: 3727 opt: 3744 Z-score: 2498.1 bits: 472.7 E(85289): 2.1e-132
Smith-Waterman score: 4569; 98.3% identity (98.3% similar) in 707 aa overlap (1-695:1-707)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
490 500 510 520 530 540
550 560 570 580
pF1KB5 PPFHPFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVID
:::::::::::::::: ::::::::::::::::::::::::::::::::
NP_001 PPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVID
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 ETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML
610 620 630 640 650 660
650 660 670 680 690
pF1KB5 RKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
670 680 690 700
>>NP_001315614 (OMIM: 104776) amyloid-like protein 2 iso (644 aa)
initn: 3385 init1: 3385 opt: 3387 Z-score: 2262.1 bits: 428.9 E(85289): 2.9e-119
Smith-Waterman score: 4144; 92.7% identity (92.7% similar) in 695 aa overlap (1-695:1-644)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
:::::::::::::::::::::::::
NP_001 EERRNQSLSLLYKVPYVAQEIQEEI-----------------------------------
490 500
550 560 570 580 590 600
pF1KB5 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
510 520 530 540
610 620 630 640 650 660
pF1KB5 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
550 560 570 580 590 600
670 680 690
pF1KB5 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::::::
NP_001 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
610 620 630 640
>>NP_001315613 (OMIM: 104776) amyloid-like protein 2 iso (700 aa)
initn: 3370 init1: 2092 opt: 2931 Z-score: 1959.4 bits: 373.0 E(85289): 2.1e-102
Smith-Waterman score: 4021; 85.6% identity (85.8% similar) in 751 aa overlap (1-695:1-700)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
pF1KB5 EITHDVK-----------------------------------------------------
:::::::
NP_001 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
310 320 330 340 350 360
310 320 330 340 350 360
pF1KB5 ---VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
370 380 390 400 410 420
370 380 390 400 410 420
pF1KB5 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
430 440 450 460 470 480
430 440 450 460 470 480
pF1KB5 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB5 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
:::::::::::::::::::::
NP_001 NQSLSLLYKVPYVAQEIQEEI---------------------------------------
550 560
550 560 570 580 590 600
pF1KB5 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
570 580 590 600
610 620 630 640 650 660
pF1KB5 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
610 620 630 640 650 660
670 680 690
pF1KB5 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::
NP_001 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
670 680 690 700
>>NP_001135750 (OMIM: 104776) amyloid-like protein 2 iso (522 aa)
initn: 2511 init1: 2511 opt: 2511 Z-score: 1682.7 bits: 321.4 E(85289): 5.5e-87
Smith-Waterman score: 3051; 75.1% identity (75.1% similar) in 695 aa overlap (1-695:1-522)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
:::::::::::::::
NP_001 KQCKSRFVTPFKCLV---------------------------------------------
130
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
NP_001 ------------------------------------------------------------
310 320 330 340 350 360
pF1KB5 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --------PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
140 150 160 170 180
370 380 390 400 410 420
pF1KB5 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
190 200 210 220 230 240
430 440 450 460 470 480
pF1KB5 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
250 260 270 280 290 300
490 500 510 520 530 540
pF1KB5 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
310 320 330 340 350 360
550 560 570 580 590 600
pF1KB5 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
370 380 390 400 410 420
610 620 630 640 650 660
pF1KB5 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
430 440 450 460 470 480
670 680 690
pF1KB5 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::::::
NP_001 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
490 500 510 520
>>NP_001135748 (OMIM: 104776) amyloid-like protein 2 iso (751 aa)
initn: 4588 init1: 2510 opt: 2511 Z-score: 1680.6 bits: 321.5 E(85289): 7.1e-87
Smith-Waterman score: 4347; 92.2% identity (92.3% similar) in 727 aa overlap (25-695:25-751)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
pF1KB5 EITHDVK-----------------------------------------------------
:::::::
NP_001 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
310 320 330 340 350 360
310 320 330 340 350 360
pF1KB5 ---VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
370 380 390 400 410 420
370 380 390 400 410 420
pF1KB5 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
430 440 450 460 470 480
430 440 450 460 470 480
pF1KB5 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB5 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
550 560 570 580 590 600
550 560 570 580 590 600
pF1KB5 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
610 620 630 640 650 660
610 620 630 640 650 660
pF1KB5 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
670 680 690 700 710 720
670 680 690
pF1KB5 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::::::::::::::::::::::::::
NP_001 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
730 740 750
>>NP_001230228 (OMIM: 104776) amyloid-like protein 2 iso (761 aa)
initn: 4388 init1: 2510 opt: 2511 Z-score: 1680.5 bits: 321.5 E(85289): 7.2e-87
Smith-Waterman score: 4280; 92.0% identity (92.2% similar) in 716 aa overlap (36-695:46-761)
10 20 30 40 50 60
pF1KB5 TAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI
::::::::::::::::::::::::::::::
NP_001 SLCRLGPGRGRAFFKWRCLPASVDRGNPLWALAANAGTGFAVAEPQIAMFCGKLNMHVNI
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB5 QTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKS
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 RFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYG
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB5 MLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEAD
200 210 220 230 240 250
250 260 270 280 290 300
pF1KB5 LEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHD
260 270 280 290 300 310
pF1KB5 VK--------------------------------------------------------VP
:: .:
NP_001 VKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP
320 330 340 350 360 370
310 320 330 340 350 360
pF1KB5 PTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKA
380 390 400 410 420 430
370 380 390 400 410 420
pF1KB5 ERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPR
440 450 460 470 480 490
430 440 450 460 470 480
pF1KB5 PHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLS
500 510 520 530 540 550
490 500 510 520 530 540
pF1KB5 LLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPF
560 570 580 590 600 610
550 560 570 580 590 600
pF1KB5 PALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEE
620 630 640 650 660 670
610 620 630 640 650 660
pF1KB5 RESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTP
680 690 700 710 720 730
670 680 690
pF1KB5 EERHLNKMQNHGYENPTYKYLEQMQI
::::::::::::::::::::::::::
NP_001 EERHLNKMQNHGYENPTYKYLEQMQI
740 750 760
>>NP_001191232 (OMIM: 104300,104760,605714) amyloid beta (677 aa)
initn: 1470 init1: 1470 opt: 2244 Z-score: 1504.3 bits: 288.8 E(85289): 4.8e-77
Smith-Waterman score: 2244; 51.7% identity (76.8% similar) in 690 aa overlap (15-694:5-676)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
: ::::.. :: :: . .::: .::::::::::.::
NP_001 MLPGLALLLLAAWTARALEV-----PTDGNAGL---LAEPQIAMFCGRLN
10 20 30 40
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
NP_001 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
::::.. :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.: ..
NP_001 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
.:..::::::::.:.:.:.:.:::: .. .:.. . :::. . . :: : .
NP_001 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB5 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
.. :. :. .:. .: ::::.:.:.:: :. . :. : : ..
NP_001 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TMSDKEITHDVKVPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKK
: . . . . :.:: : : : :: :.:: .:.::::.::::::.:: .::.::..: .
NP_001 TTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMR
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 EWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRM
:::::: ::::::::.....::::: :..::.:::.:.:::::::.::::::::::::.
NP_001 EWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRL
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB5 ALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVM
:::::..:::. ::::..... :..:::::.::: ::..:..:: :::.::::..::::
NP_001 ALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM
400 410 420 430 440 450
480 490 500 510 520 530
pF1KB5 THLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSS
:::.:: :: ::::::::.:: ::.:::.:.:::::... :. :.. : :.:
NP_001 THLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP---RISY
460 470 480 490 500 510
540 550 560 570 580 590
pF1KB5 EESEEIPPFHPFHP-FPALPEN-EGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
.. .: . . :: : : : : .::. :..:. ... .: .
NP_001 GNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE-GSGLTNIKTEE
520 530 540 550 560 570
600 610 620 630 640 650
pF1KB5 VKEMIFNAE--RVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRK
..:. ..:: . .: : ..... . :: . ...:.:::.: .:.:::::::.::::.:
NP_001 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
580 590 600 610 620 630
660 670 680 690
pF1KB5 RQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
.:: .: ::.:::: .:::::::.:::..::::::::..::::
NP_001 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
640 650 660 670
>>NP_001633 (OMIM: 104776) amyloid-like protein 2 isofor (763 aa)
initn: 3712 init1: 2092 opt: 2092 Z-score: 1402.8 bits: 270.2 E(85289): 2.1e-71
Smith-Waterman score: 4199; 90.5% identity (90.6% similar) in 727 aa overlap (1-659:1-727)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
250 260 270 280 290 300
pF1KB5 EITHDVK-----------------------------------------------------
:::::::
NP_001 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
310 320 330 340 350 360
310 320 330 340 350 360
pF1KB5 ---VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
370 380 390 400 410 420
370 380 390 400 410 420
pF1KB5 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
430 440 450 460 470 480
430 440 450 460 470 480
pF1KB5 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB5 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
550 560 570 580 590 600
550 560 570 580 590
pF1KB5 PFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
:::::::::::: ::::::::::::::::::::::::::::::::::::
NP_001 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
610 620 630 640 650 660
600 610 620 630 640 650
pF1KB5 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ
670 680 690 700 710 720
660 670 680 690
pF1KB5 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
:::::::
NP_001 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
730 740 750 760
>>NP_958817 (OMIM: 104300,104760,605714) amyloid beta A4 (695 aa)
initn: 1541 init1: 1214 opt: 1916 Z-score: 1286.7 bits: 248.6 E(85289): 6.2e-65
Smith-Waterman score: 2230; 51.1% identity (75.6% similar) in 709 aa overlap (15-694:5-694)
10 20 30 40 50 60
pF1KB5 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
: ::::.. :: :: . .::: .::::::::::.::
NP_958 MLPGLALLLLAAWTARALEV-----PTDGNAGL---LAEPQIAMFCGRLN
10 20 30 40
70 80 90 100 110 120
pF1KB5 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
NP_958 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
::::.. :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.: ..
NP_958 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
.:..::::::::.:.:.:.:.:::: .. .:.. . :::. . . :: : .
NP_958 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB5 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
.. :. :. .:. .: ::::.:.:.:: :. . :. : : ..
NP_958 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TMSDKEITHDVKVPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKK
: . . . . :.:: : : : :: :.:: .:.::::.::::::.:: .::.::..: .
NP_958 TTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMR
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 EWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRM
:::::: ::::::::.....::::: :..::.:::.:.:::::::.::::::::::::.
NP_958 EWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRL
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB5 ALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVM
:::::..:::. ::::..... :..:::::.::: ::..:..:: :::.::::..::::
NP_958 ALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVM
400 410 420 430 440 450
480 490 500 510
pF1KB5 THLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------D
:::.:: :: ::::::::.:: ::.:::.:.:::::... :.: :
NP_958 THLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGND
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB5 QFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAE
. :..:: . :. :..: : ... :.: : :: ::: : . . :.
NP_958 ALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPA----AD
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB5 EKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLL
. . . .. :. .: .:: : . .. .: : ..... . :: . ...:.:::.
NP_958 RGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLM
580 590 600 610 620 630
640 650 660 670 680 690
pF1KB5 VIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLE
: .:.:::::::.::::.:.:: .: ::.:::: .:::::::.:::..::::::::..:
NP_958 VGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFE
640 650 660 670 680 690
pF1KB5 QMQI
:::
NP_958 QMQN
695 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 04:04:40 2016 done: Fri Nov 4 04:04:42 2016
Total Scan time: 12.260 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]