Result of FASTA (omim) for
pF1KB5626
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5626, 462 aa
1>>>pF1KB5626 462 - 462 aa - 462 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4535+/-0.000372; mu= 8.1066+/- 0.023
mean_var=157.0888+/-30.685, 0's: 0 Z-trim(118.7): 141 B-trim: 37 in 2/57
Lambda= 0.102330
statistics sampled from 31729 (31888) to 31729 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.374), width: 16
Scan time: 10.380
The best scores are: opt bits E(85289)
NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, ( 462) 3043 461.2 2.6e-129
NP_001153476 (OMIM: 142445,603013) pro-neuregulin- ( 459) 2908 441.3 2.6e-123
XP_016868860 (OMIM: 142445,603013) PREDICTED: pro- ( 469) 2828 429.5 9.3e-120
NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, ( 640) 2790 424.0 5.8e-118
XP_016868861 (OMIM: 142445,603013) PREDICTED: pro- ( 466) 2693 409.6 9.3e-114
NP_001153480 (OMIM: 142445,603013) pro-neuregulin- ( 420) 2653 403.6 5.1e-112
NP_039251 (OMIM: 142445,603013) pro-neuregulin-1, ( 637) 2655 404.1 5.8e-112
NP_039250 (OMIM: 142445,603013) pro-neuregulin-1, ( 645) 2644 402.5 1.8e-111
XP_016868854 (OMIM: 142445,603013) PREDICTED: pro- ( 647) 2575 392.3 2.1e-108
XP_016868855 (OMIM: 142445,603013) PREDICTED: pro- ( 644) 2440 372.3 2.1e-102
XP_011542814 (OMIM: 142445,603013) PREDICTED: pro- ( 652) 2429 370.7 6.5e-102
NP_001153471 (OMIM: 142445,603013) pro-neuregulin- ( 624) 2427 370.4 7.7e-102
NP_001153468 (OMIM: 142445,603013) pro-neuregulin- ( 308) 1982 304.5 2.7e-82
NP_001309135 (OMIM: 142445,603013) pro-neuregulin- ( 522) 1838 283.4 1e-75
XP_016868859 (OMIM: 142445,603013) PREDICTED: pro- ( 486) 1729 267.3 6.7e-71
XP_005273543 (OMIM: 142445,603013) PREDICTED: pro- ( 695) 1731 267.7 7.1e-71
NP_001153467 (OMIM: 142445,603013) pro-neuregulin- ( 607) 1621 251.4 5e-66
NP_001309126 (OMIM: 142445,603013) pro-neuregulin- ( 483) 1594 247.3 6.6e-65
XP_005273544 (OMIM: 142445,603013) PREDICTED: pro- ( 692) 1596 247.8 7.1e-65
XP_016868856 (OMIM: 142445,603013) PREDICTED: pro- ( 618) 1592 247.1 9.8e-65
NP_001153473 (OMIM: 142445,603013) pro-neuregulin- ( 590) 1587 246.4 1.6e-64
XP_016868857 (OMIM: 142445,603013) PREDICTED: pro- ( 611) 1587 246.4 1.6e-64
NP_001309136 (OMIM: 142445,603013) pro-neuregulin- ( 483) 1583 245.7 2e-64
XP_016868858 (OMIM: 142445,603013) PREDICTED: pro- ( 491) 1583 245.7 2.1e-64
NP_001309134 (OMIM: 142445,603013) pro-neuregulin- ( 700) 1585 246.1 2.2e-64
NP_039252 (OMIM: 142445,603013) pro-neuregulin-1, ( 241) 1406 219.4 8.8e-57
NP_004486 (OMIM: 142445,603013) pro-neuregulin-1, ( 211) 1358 212.2 1.1e-54
XP_006716398 (OMIM: 142445,603013) PREDICTED: pro- ( 420) 1265 198.7 2.5e-50
NP_001309131 (OMIM: 142445,603013) pro-neuregulin- ( 382) 1120 177.3 6.4e-44
NP_001309130 (OMIM: 142445,603013) pro-neuregulin- ( 382) 1120 177.3 6.4e-44
NP_001153474 (OMIM: 142445,603013) pro-neuregulin- ( 194) 966 154.3 2.7e-37
NP_001153479 (OMIM: 142445,603013) pro-neuregulin- ( 177) 859 138.5 1.4e-32
NP_001153477 (OMIM: 142445,603013) pro-neuregulin- ( 207) 859 138.5 1.6e-32
NP_004874 (OMIM: 603818) pro-neuregulin-2, membran ( 850) 781 127.5 1.4e-28
NP_053584 (OMIM: 603818) pro-neuregulin-2, membran ( 844) 757 124.0 1.6e-27
NP_053586 (OMIM: 603818) pro-neuregulin-2, membran ( 852) 744 122.1 6.1e-27
NP_053585 (OMIM: 603818) pro-neuregulin-2, membran ( 858) 671 111.3 1.1e-23
NP_039256 (OMIM: 142445,603013) pro-neuregulin-1, ( 422) 644 107.1 9.9e-23
XP_005268590 (OMIM: 603818) PREDICTED: pro-neuregu ( 459) 600 100.6 9.5e-21
XP_016865553 (OMIM: 603818) PREDICTED: pro-neuregu ( 470) 598 100.3 1.2e-20
XP_016865554 (OMIM: 603818) PREDICTED: pro-neuregu ( 467) 594 99.7 1.8e-20
NP_001171864 (OMIM: 603818) pro-neuregulin-2, memb ( 784) 596 100.2 2.2e-20
NP_039253 (OMIM: 142445,603013) pro-neuregulin-1, ( 296) 347 63.1 1.2e-09
XP_006714873 (OMIM: 603818) PREDICTED: pro-neuregu ( 422) 230 45.9 0.00025
XP_011536015 (OMIM: 603818) PREDICTED: pro-neuregu ( 475) 230 46.0 0.00027
>>NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, memb (462 aa)
initn: 3043 init1: 3043 opt: 3043 Z-score: 2442.6 bits: 461.2 E(85289): 2.6e-129
Smith-Waterman score: 3043; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
370 380 390 400 410 420
430 440 450 460
pF1KB5 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
::::::::::::::::::::::::::::::::::::::::::
NP_039 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
430 440 450 460
>>NP_001153476 (OMIM: 142445,603013) pro-neuregulin-1, m (459 aa)
initn: 2969 init1: 1523 opt: 2908 Z-score: 2334.9 bits: 441.3 E(85289): 2.6e-123
Smith-Waterman score: 2908; 96.8% identity (97.4% similar) in 462 aa overlap (1-462:1-459)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
:::::::::::::::::::::::::::::::: ::: :: . : . . :::::::
NP_001 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ
190 200 210 220 230
250 260 270 280 290 300
pF1KB5 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
360 370 380 390 400 410
430 440 450 460
pF1KB5 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
::::::::::::::::::::::::::::::::::::::::::
NP_001 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
420 430 440 450
>>XP_016868860 (OMIM: 142445,603013) PREDICTED: pro-neur (469 aa)
initn: 2828 init1: 2828 opt: 2828 Z-score: 2271.0 bits: 429.5 E(85289): 9.3e-120
Smith-Waterman score: 2828; 98.0% identity (98.4% similar) in 441 aa overlap (22-462:29-469)
10 20 30 40 50
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKL
:: : . . ::::::::::::::::::::
XP_016 MEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
370 380 390 400 410 420
420 430 440 450 460
pF1KB5 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
430 440 450 460
>>NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, memb (640 aa)
initn: 2869 init1: 2790 opt: 2790 Z-score: 2238.8 bits: 424.0 E(85289): 5.8e-118
Smith-Waterman score: 2790; 99.8% identity (100.0% similar) in 424 aa overlap (1-424:1-424)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
370 380 390 400 410 420
430 440 450 460
pF1KB5 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
:::.
NP_039 SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLL
430 440 450 460 470 480
>>XP_016868861 (OMIM: 142445,603013) PREDICTED: pro-neur (466 aa)
initn: 2700 init1: 1523 opt: 2693 Z-score: 2163.3 bits: 409.6 E(85289): 9.3e-114
Smith-Waterman score: 2693; 94.6% identity (95.7% similar) in 441 aa overlap (22-462:29-466)
10 20 30 40 50
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKL
:: : . . ::::::::::::::::::::
XP_016 MEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
::::::::::::::::::::::::::::::::::::::: ::: :: . : . .
XP_016 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFY
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
360 370 380 390 400 410
420 430 440 450 460
pF1KB5 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
420 430 440 450 460
>>NP_001153480 (OMIM: 142445,603013) pro-neuregulin-1, m (420 aa)
initn: 2714 init1: 1406 opt: 2653 Z-score: 2132.0 bits: 403.6 E(85289): 5.1e-112
Smith-Waterman score: 2653; 96.5% identity (97.2% similar) in 423 aa overlap (1-423:1-420)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
:::::::::::::::::::::::::::::::: ::: :: . : . . :::::::
NP_001 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ
190 200 210 220 230
250 260 270 280 290 300
pF1KB5 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
360 370 380 390 400 410
430 440 450 460
pF1KB5 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
:::
NP_001 SER
420
>>NP_039251 (OMIM: 142445,603013) pro-neuregulin-1, memb (637 aa)
initn: 2740 init1: 1406 opt: 2655 Z-score: 2131.1 bits: 404.1 E(85289): 5.8e-112
Smith-Waterman score: 2655; 96.2% identity (97.2% similar) in 424 aa overlap (1-424:1-421)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
:::::::::::::::::::::::::::::::: ::: :: . : . . :::::::
NP_039 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ
190 200 210 220 230
250 260 270 280 290 300
pF1KB5 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
360 370 380 390 400 410
430 440 450 460
pF1KB5 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
:::.
NP_039 SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLL
420 430 440 450 460 470
>>NP_039250 (OMIM: 142445,603013) pro-neuregulin-1, memb (645 aa)
initn: 2688 init1: 1414 opt: 2644 Z-score: 2122.3 bits: 402.5 E(85289): 1.8e-111
Smith-Waterman score: 2644; 94.9% identity (96.3% similar) in 429 aa overlap (1-424:1-429)
10 20 30 40 50 60
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
130 140 150 160 170 180
190 200 210 220 230
pF1KB5 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKA
:::::::::::::::::::::::::::::::: ::: :: . : . .. .:
NP_039 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_039 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
370 380 390 400 410 420
420 430 440 450 460
pF1KB5 RDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
::::::::.
NP_039 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE
430 440 450 460 470 480
>>XP_016868854 (OMIM: 142445,603013) PREDICTED: pro-neur (647 aa)
initn: 2624 init1: 2575 opt: 2575 Z-score: 2067.2 bits: 392.3 E(85289): 2.1e-108
Smith-Waterman score: 2575; 97.5% identity (98.3% similar) in 403 aa overlap (22-424:29-431)
10 20 30 40 50
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKL
:: : . . ::::::::::::::::::::
XP_016 MEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
370 380 390 400 410 420
420 430 440 450 460
pF1KB5 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
::::::::::.
XP_016 SYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFME
430 440 450 460 470 480
>>XP_016868855 (OMIM: 142445,603013) PREDICTED: pro-neur (644 aa)
initn: 2471 init1: 1270 opt: 2440 Z-score: 1959.5 bits: 372.3 E(85289): 2.1e-102
Smith-Waterman score: 2440; 93.8% identity (95.3% similar) in 403 aa overlap (22-424:29-428)
10 20 30 40 50
pF1KB5 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKL
:: : . . ::::::::::::::::::::
XP_016 MEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTST
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE
::::::::::::::::::::::::::::::::::::::: ::: :: . : . .
XP_016 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFY
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPD
360 370 380 390 400 410
420 430 440 450 460
pF1KB5 SYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
::::::::::.
XP_016 SYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFME
420 430 440 450 460 470
462 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:44:08 2016 done: Thu Nov 3 17:44:09 2016
Total Scan time: 10.380 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]