Result of FASTA (omim) for
pF1KB5479
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5479, 486 aa
1>>>pF1KB5479 486 - 486 aa - 486 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7449+/-0.000346; mu= 16.4463+/- 0.022
mean_var=88.4509+/-17.493, 0's: 0 Z-trim(117.6): 98 B-trim: 290 in 1/51
Lambda= 0.136371
statistics sampled from 29597 (29710) to 29597 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.348), width: 16
Scan time: 10.480
The best scores are: opt bits E(85289)
NP_573419 (OMIM: 602711) amyloid beta A4 precursor ( 486) 3389 676.7 3.9e-194
NP_006042 (OMIM: 602711) amyloid beta A4 precursor ( 493) 3365 672.0 1e-192
NP_573420 (OMIM: 602711) amyloid beta A4 precursor ( 484) 3360 671.0 2e-192
NP_573418 (OMIM: 602711) amyloid beta A4 precursor ( 491) 3360 671.0 2e-192
XP_016863646 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1112 228.9 3.8e-59
XP_016863645 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1112 228.9 3.8e-59
XP_016863641 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1112 228.9 3.8e-59
XP_006714075 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1112 228.9 3.8e-59
XP_006714074 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59
XP_016863639 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59
XP_016863640 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59
XP_016863638 (OMIM: 104300,602710) PREDICTED: amyl ( 743) 1112 228.9 3.9e-59
XP_016863636 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59
XP_016863635 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59
XP_016863637 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59
XP_006714073 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59
XP_016863632 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59
XP_016863633 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59
XP_006714072 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_006714070 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_006714068 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_011511988 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_006714071 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_016863631 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59
XP_016863647 (OMIM: 104300,602710) PREDICTED: amyl ( 721) 1089 224.4 8.7e-58
NP_001317585 (OMIM: 104300,602710) amyloid beta A4 ( 737) 1089 224.4 8.8e-58
NP_001317587 (OMIM: 104300,602710) amyloid beta A4 ( 737) 1089 224.4 8.8e-58
XP_016863642 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58
XP_011511989 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58
XP_016863643 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58
NP_001159522 (OMIM: 104300,602710) amyloid beta A4 ( 758) 1089 224.4 9e-58
NP_004298 (OMIM: 104300,602710) amyloid beta A4 pr ( 759) 1089 224.4 9e-58
XP_016863634 (OMIM: 104300,602710) PREDICTED: amyl ( 759) 1089 224.4 9e-58
NP_775098 (OMIM: 104300,602710) amyloid beta A4 pr ( 736) 1072 221.0 9e-57
NP_001244249 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54
NP_001244250 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54
XP_011518342 (OMIM: 602709) PREDICTED: amyloid bet ( 451) 1021 210.8 6.4e-54
NP_001244255 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54
NP_001244254 (OMIM: 602709) amyloid beta A4 precur ( 475) 1021 210.8 6.7e-54
NP_001244248 (OMIM: 602709) amyloid beta A4 precur ( 490) 1021 210.9 6.8e-54
NP_001155 (OMIM: 602709) amyloid beta A4 precursor ( 710) 1021 211.0 9.1e-54
XP_006718275 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 1021 211.0 9.2e-54
XP_016873128 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 1021 211.0 9.2e-54
XP_006718278 (OMIM: 602709) PREDICTED: amyloid bet ( 802) 1021 211.0 1e-53
XP_016873131 (OMIM: 602709) PREDICTED: amyloid bet ( 449) 998 206.3 1.5e-52
NP_001244252 (OMIM: 602709) amyloid beta A4 precur ( 488) 998 206.3 1.6e-52
NP_663722 (OMIM: 602709) amyloid beta A4 precursor ( 708) 998 206.4 2.1e-52
XP_016873130 (OMIM: 602709) PREDICTED: amyloid bet ( 708) 998 206.4 2.1e-52
XP_006718277 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 998 206.4 2.1e-52
XP_016873129 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 998 206.4 2.1e-52
>>NP_573419 (OMIM: 602711) amyloid beta A4 precursor pro (486 aa)
initn: 3389 init1: 3389 opt: 3389 Z-score: 3606.4 bits: 676.7 E(85289): 3.9e-194
Smith-Waterman score: 3389; 100.0% identity (100.0% similar) in 486 aa overlap (1-486:1-486)
10 20 30 40 50 60
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP
430 440 450 460 470 480
pF1KB5 SLLHMP
::::::
NP_573 SLLHMP
>>NP_006042 (OMIM: 602711) amyloid beta A4 precursor pro (493 aa)
initn: 3375 init1: 1893 opt: 3365 Z-score: 3580.8 bits: 672.0 E(85289): 1e-192
Smith-Waterman score: 3365; 98.6% identity (98.6% similar) in 493 aa overlap (1-486:1-493)
10 20 30 40 50 60
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
130 140 150 160 170 180
190 200 210 220 230
pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD-------RDFAFVASDKDSCMLKCHVFCCD
:::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_006 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDSPISAPARDFAFVASDKDSCMLKCHVFCCD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 VPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 LYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEP
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 LWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 CLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFL
430 440 450 460 470 480
480
pF1KB5 DAFRLKPSLLHMP
:::::::::::::
NP_006 DAFRLKPSLLHMP
490
>>NP_573420 (OMIM: 602711) amyloid beta A4 precursor pro (484 aa)
initn: 1901 init1: 1901 opt: 3360 Z-score: 3575.6 bits: 671.0 E(85289): 2e-192
Smith-Waterman score: 3360; 99.6% identity (99.6% similar) in 486 aa overlap (1-486:1-484)
10 20 30 40 50 60
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA
:::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD--FAFVASDKDSCMLKCHVFCCDVPAKAIA
190 200 210 220 230
250 260 270 280 290 300
pF1KB5 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB5 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP
420 430 440 450 460 470
pF1KB5 SLLHMP
::::::
NP_573 SLLHMP
480
>>NP_573418 (OMIM: 602711) amyloid beta A4 precursor pro (491 aa)
initn: 3367 init1: 1893 opt: 3360 Z-score: 3575.5 bits: 671.0 E(85289): 2e-192
Smith-Waterman score: 3360; 98.8% identity (98.8% similar) in 491 aa overlap (1-486:1-491)
10 20 30 40 50 60
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
130 140 150 160 170 180
190 200 210 220 230
pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD-----RDFAFVASDKDSCMLKCHVFCCDVP
::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRPISAPARDFAFVASDKDSCMLKCHVFCCDVP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 AKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 AKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALY
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 MGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 MGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLW
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 QCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 QCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 VASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_573 VASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDA
430 440 450 460 470 480
480
pF1KB5 FRLKPSLLHMP
:::::::::::
NP_573 FRLKPSLLHMP
490
>>XP_016863646 (OMIM: 104300,602710) PREDICTED: amyloid (723 aa)
initn: 1259 init1: 661 opt: 1112 Z-score: 1182.9 bits: 228.9 E(85289): 3.8e-59
Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:263-723)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW
:.:.:::.... :::::... : ::::::
XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW
240 250 260 270 280 290
50 60 70 80 90
pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD
:.:.:.:::.::. .: . :. . : :... :.. .:..
XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL
300 310 320 330 340 350
100 110 120 130 140
pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::.:
XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ
360 370 380 390 400 410
150 160 170 180 190 200
pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR
:. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..::
XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR
420 430 440 450 460 470
210 220 230 240 250 260
pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI
.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER
480 490 500 510 520 530
270 280 290 300 310 320
pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :.
XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL
540 550 560 570 580 590
330 340 350 360 370 380
pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC
. ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.:
XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC
600 610 620 630 640
390 400 410 420 430 440
pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP
.:::.:.::..:::::::::..::::::: : .: :
XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P
650 660 670 680
450 460 470 480
pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : .: .: ::::.:..:... : . .::
XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
690 700 710 720
>>XP_016863645 (OMIM: 104300,602710) PREDICTED: amyloid (723 aa)
initn: 1259 init1: 661 opt: 1112 Z-score: 1182.9 bits: 228.9 E(85289): 3.8e-59
Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:263-723)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW
:.:.:::.... :::::... : ::::::
XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW
240 250 260 270 280 290
50 60 70 80 90
pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD
:.:.:.:::.::. .: . :. . : :... :.. .:..
XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL
300 310 320 330 340 350
100 110 120 130 140
pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::.:
XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ
360 370 380 390 400 410
150 160 170 180 190 200
pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR
:. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..::
XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR
420 430 440 450 460 470
210 220 230 240 250 260
pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI
.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER
480 490 500 510 520 530
270 280 290 300 310 320
pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :.
XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL
540 550 560 570 580 590
330 340 350 360 370 380
pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC
. ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.:
XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC
600 610 620 630 640
390 400 410 420 430 440
pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP
.:::.:.::..:::::::::..::::::: : .: :
XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P
650 660 670 680
450 460 470 480
pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : .: .: ::::.:..:... : . .::
XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
690 700 710 720
>>XP_016863641 (OMIM: 104300,602710) PREDICTED: amyloid (739 aa)
initn: 1260 init1: 661 opt: 1112 Z-score: 1182.8 bits: 228.9 E(85289): 3.8e-59
Smith-Waterman score: 1324; 43.0% identity (69.0% similar) in 491 aa overlap (16-486:277-739)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTY
. :.:.:::.... :::::... : ::::
XP_016 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTY
250 260 270 280 290 300
50 60 70 80 90
pF1KB5 YWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESS
:::.:.:.:::.::. .: . :. . : :... :.. .:..
XP_016 YWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGA
310 320 330 340 350 360
100 110 120 130 140
pF1KB5 LDRSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCI
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::
XP_016 TLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCI
370 380 390 400 410 420
150 160 170 180 190 200
pF1KB5 QQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSK
.::. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..
XP_016 RQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDN
430 440 450 460 470 480
210 220 230 240 250 260
pF1KB5 GRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPD
::.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_016 GRERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQ
490 500 510 520 530 540
270 280 290 300 310 320
pF1KB5 PISPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNA
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . ....
XP_016 ERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKED
550 560 570 580 590 600
330 340 350 360 370 380
pF1KB5 WVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSF
:. . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :
XP_016 WLSVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRF
610 620 630 640 650 660
390 400 410 420 430 440
pF1KB5 QCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPG
.: .:::.:.::..:::::::::..::::::: : .:
XP_016 ECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR-----------
670 680 690 700
450 460 470 480
pF1KB5 GPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : : .: .: ::::.:..:... : . .::
XP_016 -PPPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
710 720 730
>>XP_006714075 (OMIM: 104300,602710) PREDICTED: amyloid (739 aa)
initn: 1260 init1: 661 opt: 1112 Z-score: 1182.8 bits: 228.9 E(85289): 3.8e-59
Smith-Waterman score: 1324; 43.0% identity (69.0% similar) in 491 aa overlap (16-486:277-739)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTY
. :.:.:::.... :::::... : ::::
XP_006 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTY
250 260 270 280 290 300
50 60 70 80 90
pF1KB5 YWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESS
:::.:.:.:::.::. .: . :. . : :... :.. .:..
XP_006 YWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGA
310 320 330 340 350 360
100 110 120 130 140
pF1KB5 LDRSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCI
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::
XP_006 TLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCI
370 380 390 400 410 420
150 160 170 180 190 200
pF1KB5 QQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSK
.::. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..
XP_006 RQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDN
430 440 450 460 470 480
210 220 230 240 250 260
pF1KB5 GRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPD
::.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_006 GRERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQ
490 500 510 520 530 540
270 280 290 300 310 320
pF1KB5 PISPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNA
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . ....
XP_006 ERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKED
550 560 570 580 590 600
330 340 350 360 370 380
pF1KB5 WVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSF
:. . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :
XP_006 WLSVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRF
610 620 630 640 650 660
390 400 410 420 430 440
pF1KB5 QCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPG
.: .:::.:.::..:::::::::..::::::: : .:
XP_006 ECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR-----------
670 680 690 700
450 460 470 480
pF1KB5 GPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : : .: .: ::::.:..:... : . .::
XP_006 -PPPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
710 720 730
>>XP_006714074 (OMIM: 104300,602710) PREDICTED: amyloid (740 aa)
initn: 1259 init1: 661 opt: 1112 Z-score: 1182.7 bits: 228.9 E(85289): 3.9e-59
Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:280-740)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW
:.:.:::.... :::::... : ::::::
XP_006 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW
250 260 270 280 290 300
50 60 70 80 90
pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD
:.:.:.:::.::. .: . :. . : :... :.. .:..
XP_006 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL
310 320 330 340 350 360
100 110 120 130 140
pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::.:
XP_006 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ
370 380 390 400 410 420
150 160 170 180 190 200
pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR
:. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..::
XP_006 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR
430 440 450 460 470 480
210 220 230 240 250 260
pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI
.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_006 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER
490 500 510 520 530 540
270 280 290 300 310 320
pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :.
XP_006 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL
550 560 570 580 590 600
330 340 350 360 370 380
pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC
. ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.:
XP_006 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC
610 620 630 640 650 660
390 400 410 420 430 440
pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP
.:::.:.::..:::::::::..::::::: : .: :
XP_006 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P
670 680 690 700
450 460 470 480
pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : .: .: ::::.:..:... : . .::
XP_006 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
710 720 730 740
>>XP_016863639 (OMIM: 104300,602710) PREDICTED: amyloid (740 aa)
initn: 1259 init1: 661 opt: 1112 Z-score: 1182.7 bits: 228.9 E(85289): 3.9e-59
Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:280-740)
10 20 30 40
pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW
:.:.:::.... :::::... : ::::::
XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW
250 260 270 280 290 300
50 60 70 80 90
pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD
:.:.:.:::.::. .: . :. . : :... :.. .:..
XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL
310 320 330 340 350 360
100 110 120 130 140
pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ
: ::. .. .: . .: :::::::::::::. ::::::::::.::::::.:
XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ
370 380 390 400 410 420
150 160 170 180 190 200
pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR
:. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..::
XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR
430 440 450 460 470 480
210 220 230 240 250 260
pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI
.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : .
XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER
490 500 510 520 530 540
270 280 290 300 310 320
pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV
. :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :.
XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL
550 560 570 580 590 600
330 340 350 360 370 380
pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC
. ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.:
XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC
610 620 630 640 650 660
390 400 410 420 430 440
pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP
.:::.:.::..:::::::::..::::::: : .: :
XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P
670 680 690 700
450 460 470 480
pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
: : .: .: ::::.:..:... : . .::
XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
710 720 730 740
486 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:45:07 2016 done: Thu Nov 3 08:45:09 2016
Total Scan time: 10.480 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]