Result of FASTA (omim) for
pF1KB5438
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5438, 442 aa
1>>>pF1KB5438 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1855+/-0.000434; mu= 9.6015+/- 0.027
mean_var=139.6679+/-30.601, 0's: 0 Z-trim(114.9): 521 B-trim: 2447 in 2/49
Lambda= 0.108524
statistics sampled from 24385 (25003) to 24385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.293), width: 16
Scan time: 8.920
The best scores are: opt bits E(85289)
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 2951 473.9 3.8e-133
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 2951 473.9 3.8e-133
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 1184 197.2 6.9e-50
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 896 152.0 2.3e-36
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 896 152.1 2.5e-36
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 896 152.1 2.5e-36
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 896 152.1 2.5e-36
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 896 152.1 2.5e-36
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 742 128.0 5.1e-29
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 693 120.3 1e-26
NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419) 540 96.4 1.6e-19
NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 527 94.3 6.9e-19
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 527 94.3 6.9e-19
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 500 90.1 1.2e-17
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 500 90.1 1.3e-17
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 500 90.1 1.3e-17
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 489 88.3 3.3e-17
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 489 88.3 3.3e-17
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 489 88.3 3.6e-17
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 489 88.3 3.7e-17
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 489 88.4 3.8e-17
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 489 88.4 4.7e-17
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 489 88.5 4.9e-17
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 485 87.8 6.5e-17
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 485 87.8 6.5e-17
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 478 86.6 1.3e-16
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 471 85.5 2.2e-16
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 471 85.5 2.2e-16
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 471 85.5 2.3e-16
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 471 85.5 2.4e-16
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 471 85.5 2.5e-16
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 471 85.5 2.5e-16
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 472 85.7 2.6e-16
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 471 85.6 2.8e-16
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 471 85.6 2.8e-16
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 471 85.6 3e-16
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 471 85.6 3e-16
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 471 85.6 3.1e-16
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 471 85.6 3.1e-16
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 471 85.6 3.1e-16
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 471 85.6 3.1e-16
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 467 85.0 5.5e-16
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 458 83.6 1.3e-15
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 430 79.1 2.2e-14
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 415 76.8 1.3e-13
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 405 75.3 4e-13
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 403 74.9 4e-13
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 403 74.9 4e-13
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 403 74.9 4e-13
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 403 74.9 4e-13
>>NP_000786 (OMIM: 126450,159900) D(2) dopamine receptor (443 aa)
initn: 2336 init1: 2336 opt: 2951 Z-score: 2511.4 bits: 473.9 E(85289): 3.8e-133
Smith-Waterman score: 2951; 99.8% identity (99.8% similar) in 443 aa overlap (1-442:1-443)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
10 20 30 40 50 60
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_000 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
370 380 390 400 410 420
420 430 440
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
:::::::::::::::::::::::
NP_000 VNPIIYTTFNIEFRKAFLKILHC
430 440
>>XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) dop (443 aa)
initn: 2336 init1: 2336 opt: 2951 Z-score: 2511.4 bits: 473.9 E(85289): 3.8e-133
Smith-Waterman score: 2951; 99.8% identity (99.8% similar) in 443 aa overlap (1-442:1-443)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
10 20 30 40 50 60
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_016 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
370 380 390 400 410 420
420 430 440
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
:::::::::::::::::::::::
XP_016 VNPIIYTTFNIEFRKAFLKILHC
430 440
>>NP_057658 (OMIM: 126450,159900) D(2) dopamine receptor (414 aa)
initn: 2115 init1: 1184 opt: 1184 Z-score: 1016.7 bits: 197.2 E(85289): 6.9e-50
Smith-Waterman score: 2676; 93.2% identity (93.2% similar) in 443 aa overlap (1-442:1-414)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
10 20 30 40 50 60
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_057 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
: ::::::::::::::::::::::::::::::
NP_057 K-----------------------------EAARRAQELEMEMLSSTSPPERTRYSPIPP
250 260 270
300 310 320 330 340 350
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
340 350 360 370 380 390
420 430 440
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
:::::::::::::::::::::::
NP_057 VNPIIYTTFNIEFRKAFLKILHC
400 410
>>NP_387512 (OMIM: 126451,181500,190300) D(3) dopamine r (367 aa)
initn: 1276 init1: 295 opt: 896 Z-score: 773.7 bits: 152.0 E(85289): 2.3e-36
Smith-Waterman score: 1218; 52.9% identity (67.7% similar) in 427 aa overlap (23-442:19-367)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
:.. .. ::: ::: :: .::::: ::::::
NP_387 MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
10 20 30 40 50
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
.:.:::::::::.::::::::::::::::::::::: : :.:::: ::.::::::::::
NP_387 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
:::::::::::::::::.::. :. : :: :::..::. ::::.:..:::::::.:..
NP_387 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
: . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.
NP_387 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
: ..: .:: . . :. ::.. ::
NP_387 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
240 250
300 310 320 330 340 350
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSL
: : . : :. :..:. : . : ::.::
NP_387 YSI--------CQDTALGG-------PGFQERGGELKREEK--------------TRNSL
260 270 280
360 370 380 390 400 410
pF1KB5 KTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWL
. .:::::::.:::::.::.::::::.::.:: ::. :.. : :::: :::
NP_387 MPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWL
290 300 310 320 330
420 430 440
pF1KB5 GYVNSAVNPIIYTTFNIEFRKAFLKILHC
::::::.::.::::::::::::::::: :
NP_387 GYVNSALNPVIYTTFNIEFRKAFLKILSC
340 350 360
>>NP_000787 (OMIM: 126451,181500,190300) D(3) dopamine r (400 aa)
initn: 1196 init1: 295 opt: 896 Z-score: 773.2 bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
:.. .. ::: ::: :: .::::: ::::::
NP_000 MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
10 20 30 40 50
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
.:.:::::::::.::::::::::::::::::::::: : :.:::: ::.::::::::::
NP_000 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
:::::::::::::::::.::. :. : :: :::..::. ::::.:..:::::::.:..
NP_000 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
: . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.
NP_000 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
: ..: .:: . . :. ::.. ::
NP_000 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
240 250
300 310 320 330 340 350
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
: .. .: : :.. . ::. .. . : :: :. .:.. . ::. :
NP_000 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
260 270 280 290 300
360 370 380 390 400
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
::: .. : . .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_000 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
310 320 330 340 350 360
410 420 430 440
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
:::::::::.::.::::::::::::::::: :
NP_000 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
370 380 390 400
>>NP_001277738 (OMIM: 126451,181500,190300) D(3) dopamin (400 aa)
initn: 1196 init1: 295 opt: 896 Z-score: 773.2 bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
:.. .. ::: ::: :: .::::: ::::::
NP_001 MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
10 20 30 40 50
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
.:.:::::::::.::::::::::::::::::::::: : :.:::: ::.::::::::::
NP_001 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
:::::::::::::::::.::. :. : :: :::..::. ::::.:..:::::::.:..
NP_001 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
: . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.
NP_001 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
: ..: .:: . . :. ::.. ::
NP_001 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
240 250
300 310 320 330 340 350
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
: .. .: : :.. . ::. .. . : :: :. .:.. . ::. :
NP_001 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
260 270 280 290 300
360 370 380 390 400
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
::: .. : . .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_001 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
310 320 330 340 350 360
410 420 430 440
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
:::::::::.::.::::::::::::::::: :
NP_001 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
370 380 390 400
>>NP_001269492 (OMIM: 126451,181500,190300) D(3) dopamin (400 aa)
initn: 1196 init1: 295 opt: 896 Z-score: 773.2 bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
:.. .. ::: ::: :: .::::: ::::::
NP_001 MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
10 20 30 40 50
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
.:.:::::::::.::::::::::::::::::::::: : :.:::: ::.::::::::::
NP_001 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
:::::::::::::::::.::. :. : :: :::..::. ::::.:..:::::::.:..
NP_001 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
: . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.
NP_001 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
: ..: .:: . . :. ::.. ::
NP_001 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
240 250
300 310 320 330 340 350
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
: .. .: : :.. . ::. .. . : :: :. .:.. . ::. :
NP_001 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
260 270 280 290 300
360 370 380 390 400
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
::: .. : . .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_001 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
310 320 330 340 350 360
410 420 430 440
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
:::::::::.::.::::::::::::::::: :
NP_001 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
370 380 390 400
>>XP_016861318 (OMIM: 126451,181500,190300) PREDICTED: D (400 aa)
initn: 1196 init1: 295 opt: 896 Z-score: 773.2 bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)
10 20 30 40 50 60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
:.. .. ::: ::: :: .::::: ::::::
XP_016 MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
10 20 30 40 50
70 80 90 100 110
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
.:.:::::::::.::::::::::::::::::::::: : :.:::: ::.::::::::::
XP_016 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
:::::::::::::::::.::. :. : :: :::..::. ::::.:..:::::::.:..
XP_016 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
: . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.
XP_016 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
: ..: .:: . . :. ::.. ::
XP_016 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
240 250
300 310 320 330 340 350
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
: .. .: : :.. . ::. .. . : :: :. .:.. . ::. :
XP_016 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
260 270 280 290 300
360 370 380 390 400
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
::: .. : . .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
XP_016 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
310 320 330 340 350 360
410 420 430 440
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
:::::::::.::.::::::::::::::::: :
XP_016 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
370 380 390 400
>>NP_000672 (OMIM: 104210) alpha-2A adrenergic receptor (465 aa)
initn: 569 init1: 199 opt: 742 Z-score: 641.9 bits: 128.0 E(85289): 5.1e-29
Smith-Waterman score: 783; 33.6% identity (60.2% similar) in 455 aa overlap (22-442:28-457)
10 20 30 40
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSD---GKADRPHYNYYATLLT-----LLIA
.::.. : : :. .:: ::.
NP_000 MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIH
. ::::::: .:: .::.. : ..:::: ::.::::::.:. . :: : : :..
NP_000 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTI
:.:...:::..::.::..:::::.::: .... . :: . . ::. ..: :::.: .:
NP_000 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTP-RRIKAIIITVWVISAVI
130 140 150 160 170
170 180 190 200 210
pF1KB5 SCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYIKIYIVLR
: : :..... . .: : . . : :: . ::..: .. .:::..:: . .
NP_000 SFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAK
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQ
:: . ..:. : . :: :. .: :: : .: .. .:.
NP_000 RRTRVPPSRRGPDA----VAAPPGGTERRP------------NGLGP-ERSAGPGGAEAE
240 250 260 270 280
280 290 300 310 320 330
pF1KB5 ELEMEMLSSTSPPERTRYSPIPPSHHQ-LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPK
: .. .. . : .: : . : : . : : .: .::.. ..: . .
NP_000 PLPTQLNGAPGEP-----APAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKAR
290 300 310 320 330
340 350 360 370 380
pF1KB5 IAKIFEIQTMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGV
... ...: :. :.. :: . :..::. : .::.:.::
NP_000 ASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGV
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB5 FIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL
:..::.:::.:. :. :..: .:.. : :.:: ::..::.::: :: .::.:: :::
NP_000 FVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL
400 410 420 430 440 450
pF1KB5 HC
:
NP_000 -CRGDRKRIV
460
>>NP_000674 (OMIM: 104250) alpha-2C adrenergic receptor (462 aa)
initn: 680 init1: 187 opt: 693 Z-score: 600.5 bits: 120.3 E(85289): 1e-26
Smith-Waterman score: 705; 32.9% identity (63.1% similar) in 423 aa overlap (38-440:55-452)
10 20 30 40 50 60
pF1KB5 WYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQT
:... .::. : ::::: .:: .::..
NP_000 ERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRA
30 40 50 60 70 80
70 80 90 100 110 120
pF1KB5 TTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTASILNLCA
: ..:::: ::.::::::::. . :. . : :... : ....:::..::.::..:::
NP_000 PQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCA
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB5 ISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGL----NNADQNECI
::.::: .:.. . :: . . ::: . : ::..: .:: : : .: ..: .:
NP_000 ISLDRYWSVTQAVEYNLKRTP-RRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCG
150 160 170 180 190 200
190 200 210 220 230
pF1KB5 IANPAFVVYSSIV-SFYVPFIVTLLVYIKIYIVLRRRRKRVNTKR-----------SSRA
. . .. . :: . ::..: .. ::: .:: : . : . .. :: . .
NP_000 LNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENG
210 220 230 240 250 260
240 250 260 270 280
pF1KB5 FRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAA-RRAQELEMEMLSSTSPP
. : : .:.:. : . . ...: ..::: ..: ::. . . ....
NP_000 LGAAAGAGENGHCAPPP-----ADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGA
270 280 290 300 310
290 300 310 320 330 340
pF1KB5 ERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGK
. : . : .. : .. ::. . ..:.. . ...: ..
NP_000 D-----------GQGAGPGAAESGALTASRSPGPGGRLSRASS--RSVEFFL------SR
320 330 340 350
350 360 370 380 390 400
pF1KB5 TRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLY
: . ... :::..: .::. : .::.:.:::..::.:::... : : :..: :.
NP_000 RRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLF
360 370 380 390 400 410
410 420 430 440
pF1KB5 SAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
. : :.:: ::..::.:::.:: .::..: .::
NP_000 KFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
420 430 440 450 460
442 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:20:32 2016 done: Thu Nov 3 17:20:34 2016
Total Scan time: 8.920 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]