Result of FASTA (ccds) for
pF1KB5356
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5356, 448 aa
1>>>pF1KB5356 448 - 448 aa - 448 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7129+/-0.000803; mu= 16.6642+/- 0.048
mean_var=83.8769+/-16.984, 0's: 0 Z-trim(109.3): 14 B-trim: 364 in 1/52
Lambda= 0.140040
statistics sampled from 10800 (10810) to 10800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.332), width: 16
Scan time: 2.840
The best scores are: opt bits E(32554)
CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1 ( 448) 2979 611.5 5.5e-175
CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1 ( 447) 2961 607.9 6.8e-174
CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14 ( 463) 1309 274.1 2.1e-73
CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14 ( 467) 1309 274.1 2.1e-73
>>CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1 (448 aa)
initn: 2979 init1: 2979 opt: 2979 Z-score: 3255.1 bits: 611.5 E(32554): 5.5e-175
Smith-Waterman score: 2979; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448)
10 20 30 40 50 60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
370 380 390 400 410 420
430 440
pF1KB5 TFGLIFYFSTDNLVRPFMDTLASHQLYI
::::::::::::::::::::::::::::
CCDS15 TFGLIFYFSTDNLVRPFMDTLASHQLYI
430 440
>>CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1 (447 aa)
initn: 2164 init1: 2164 opt: 2961 Z-score: 3235.4 bits: 607.9 E(32554): 6.8e-174
Smith-Waterman score: 2961; 99.8% identity (99.8% similar) in 448 aa overlap (1-448:1-447)
10 20 30 40 50 60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
CCDS44 TVGMAKLDPSSQGALQLPYDPEME-DSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
310 320 330 340 350
370 380 390 400 410 420
pF1KB5 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
360 370 380 390 400 410
430 440
pF1KB5 TFGLIFYFSTDNLVRPFMDTLASHQLYI
::::::::::::::::::::::::::::
CCDS44 TFGLIFYFSTDNLVRPFMDTLASHQLYI
420 430 440
>>CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14 (463 aa)
initn: 1828 init1: 1291 opt: 1309 Z-score: 1431.4 bits: 274.1 E(32554): 2.1e-73
Smith-Waterman score: 1821; 65.3% identity (79.3% similar) in 464 aa overlap (24-448:3-463)
10 20 30 40 50 60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
: :.: : .. : ::.. . ...:.: :..
CCDS98 MTELPAPLSYFQNAQMSEDNHLSN---TNDNRERQEHND
10 20 30
70 80 90 100
pF1KB5 DRYVCSGVP---GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVATI
: . : ::: : .:::::::::::::::::::::::.::::::
CCDS98 RRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI
40 50 60 70 80 90
110 120 130 140 150 160
pF1KB5 KSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYK
::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::::
CCDS98 KSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYK
100 110 120 130 140 150
170 180 190 200 210 220
pF1KB5 FIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLV
::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. :::::::
CCDS98 VIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLR
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB5 LQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNE
::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::::
CCDS98 LQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNE
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 PIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPE-MEEDSYDSFGEPS---YPEVF
.::::::::.::: :.::. :: .: .. :. : :..: :. .: . . : .
CCDS98 TLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEW
280 290 300 310 320 330
350 360 370 380
pF1KB5 EPPLTGYPG------------EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAATG
: .. : .:: :. ::::::::::::::::::::::.::.
CCDS98 EAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATA
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB5 SGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTL
:::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.:::: :
CCDS98 SGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQL
400 410 420 430 440 450
pF1KB5 ASHQLYI
: ::.::
CCDS98 AFHQFYI
460
>>CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14 (467 aa)
initn: 1864 init1: 1291 opt: 1309 Z-score: 1431.3 bits: 274.1 E(32554): 2.1e-73
Smith-Waterman score: 1841; 65.7% identity (79.4% similar) in 466 aa overlap (24-448:3-467)
10 20 30 40 50 60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
: :.: : .. : ::.. . :::..... .:
CCDS98 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHN
10 20 30
70 80 90 100
pF1KB5 DRYVCSGVP-----GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVA
:: : : ::: : .:::::::::::::::::::::::.::::
CCDS98 DRRSL-GHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVA
40 50 60 70 80 90
110 120 130 140 150 160
pF1KB5 TIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRC
::::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::
CCDS98 TIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRC
100 110 120 130 140 150
170 180 190 200 210 220
pF1KB5 YKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGP
:: ::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. ::::::
CCDS98 YKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGP
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB5 LVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQER
: ::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::
CCDS98 LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQER
220 230 240 250 260 270
290 300 310 320 330
pF1KB5 NEPIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPE-MEEDSYDSFGEPS---YPE
:: .::::::::.::: :.::. :: .: .. :. : :..: :. .: . . :
CCDS98 NETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSE
280 290 300 310 320 330
340 350 360 370
pF1KB5 VFEPPLTGYPG------------EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAA
.: .. : .:: :. ::::::::::::::::::::::.:
CCDS98 EWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASA
340 350 360 370 380 390
380 390 400 410 420 430
pF1KB5 TGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMD
:.:::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.::::
CCDS98 TASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMD
400 410 420 430 440 450
440
pF1KB5 TLASHQLYI
:: ::.::
CCDS98 QLAFHQFYI
460
448 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:48:57 2016 done: Fri Nov 4 21:48:58 2016
Total Scan time: 2.840 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]