Result of FASTA (omim) for
pF1KB5210
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5210, 328 aa
1>>>pF1KB5210 328 - 328 aa - 328 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1163+/-0.000371; mu= 16.9860+/- 0.023
mean_var=67.2251+/-14.134, 0's: 0 Z-trim(113.0): 15 B-trim: 1029 in 1/53
Lambda= 0.156426
statistics sampled from 22159 (22168) to 22159 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.26), width: 16
Scan time: 7.990
The best scores are: opt bits E(85289)
NP_006834 (OMIM: 182128) L-serine dehydratase/L-th ( 328) 2143 492.6 4.8e-139
XP_011522276 (OMIM: 606477) PREDICTED: serine race ( 340) 351 88.2 2.7e-17
XP_006721628 (OMIM: 606477) PREDICTED: serine race ( 340) 351 88.2 2.7e-17
XP_006721629 (OMIM: 606477) PREDICTED: serine race ( 340) 351 88.2 2.7e-17
NP_068766 (OMIM: 606477) serine racemase isoform a ( 340) 351 88.2 2.7e-17
NP_001291732 (OMIM: 606477) serine racemase isofor ( 191) 168 46.7 4.6e-05
>>NP_006834 (OMIM: 182128) L-serine dehydratase/L-threon (328 aa)
initn: 2143 init1: 2143 opt: 2143 Z-score: 2617.3 bits: 492.6 E(85289): 4.8e-139
Smith-Waterman score: 2143; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328)
10 20 30 40 50 60
pF1KB5 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 IFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
250 260 270 280 290 300
310 320
pF1KB5 IVCGGSNISLAQLRALKEQLGMTNRLPK
::::::::::::::::::::::::::::
NP_006 IVCGGSNISLAQLRALKEQLGMTNRLPK
310 320
>>XP_011522276 (OMIM: 606477) PREDICTED: serine racemase (340 aa)
initn: 308 init1: 123 opt: 351 Z-score: 431.5 bits: 88.2 E(85289): 2.7e-17
Smith-Waterman score: 362; 29.0% identity (60.3% similar) in 317 aa overlap (5-310:21-319)
10 20 30 40
pF1KB5 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG
. .:. ::. : :....: ....: . : .:::::::
XP_011 MCAQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRG
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 IGHFCKRWAKQGCAH----FVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLK
. . . .. . : :.:: :.: .:::. :.:: ::::.:.: ..
XP_011 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ
60 70 80 90 100 110
110 120 130 140 150
pF1KB5 NEGATVKVVGELLDEAFE-LAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEK
::.. : : ::. : .:: ..... : ... : ..: . :...:. :. : .
XP_011 AYGASI-VYCEPSDESRENVAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEV---LNQV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 P--GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKI
: :... :::::.: :.. .. . .: : : : .: . . . :::. .:
XP_011 PLVDALVVPVGGGGMLAGIAITVKALK-PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 TSVAKALGVKT-VGAQALKLFQE--HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAA
..: :::. .: .. .... ::. ....: : . . :.:.::. :..
XP_011 ETIAD--GVKSSIGLNTWPIIRDLVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVG
240 250 260 270 280
280 290 300 310 320
pF1KB5 LAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
.::: :. .: . .: . . :: .:.:..:
XP_011 VAAVLSQHFQTV-------SPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
290 300 310 320 330 340
>>XP_006721628 (OMIM: 606477) PREDICTED: serine racemase (340 aa)
initn: 308 init1: 123 opt: 351 Z-score: 431.5 bits: 88.2 E(85289): 2.7e-17
Smith-Waterman score: 362; 29.0% identity (60.3% similar) in 317 aa overlap (5-310:21-319)
10 20 30 40
pF1KB5 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG
. .:. ::. : :....: ....: . : .:::::::
XP_006 MCAQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRG
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 IGHFCKRWAKQGCAH----FVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLK
. . . .. . : :.:: :.: .:::. :.:: ::::.:.: ..
XP_006 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ
60 70 80 90 100 110
110 120 130 140 150
pF1KB5 NEGATVKVVGELLDEAFE-LAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEK
::.. : : ::. : .:: ..... : ... : ..: . :...:. :. : .
XP_006 AYGASI-VYCEPSDESRENVAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEV---LNQV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 P--GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKI
: :... :::::.: :.. .. . .: : : : .: . . . :::. .:
XP_006 PLVDALVVPVGGGGMLAGIAITVKALK-PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 TSVAKALGVKT-VGAQALKLFQE--HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAA
..: :::. .: .. .... ::. ....: : . . :.:.::. :..
XP_006 ETIAD--GVKSSIGLNTWPIIRDLVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVG
240 250 260 270 280
280 290 300 310 320
pF1KB5 LAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
.::: :. .: . .: . . :: .:.:..:
XP_006 VAAVLSQHFQTV-------SPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
290 300 310 320 330 340
>>XP_006721629 (OMIM: 606477) PREDICTED: serine racemase (340 aa)
initn: 308 init1: 123 opt: 351 Z-score: 431.5 bits: 88.2 E(85289): 2.7e-17
Smith-Waterman score: 362; 29.0% identity (60.3% similar) in 317 aa overlap (5-310:21-319)
10 20 30 40
pF1KB5 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG
. .:. ::. : :....: ....: . : .:::::::
XP_006 MCAQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRG
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 IGHFCKRWAKQGCAH----FVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLK
. . . .. . : :.:: :.: .:::. :.:: ::::.:.: ..
XP_006 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ
60 70 80 90 100 110
110 120 130 140 150
pF1KB5 NEGATVKVVGELLDEAFE-LAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEK
::.. : : ::. : .:: ..... : ... : ..: . :...:. :. : .
XP_006 AYGASI-VYCEPSDESRENVAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEV---LNQV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 P--GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKI
: :... :::::.: :.. .. . .: : : : .: . . . :::. .:
XP_006 PLVDALVVPVGGGGMLAGIAITVKALK-PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 TSVAKALGVKT-VGAQALKLFQE--HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAA
..: :::. .: .. .... ::. ....: : . . :.:.::. :..
XP_006 ETIAD--GVKSSIGLNTWPIIRDLVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVG
240 250 260 270 280
280 290 300 310 320
pF1KB5 LAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
.::: :. .: . .: . . :: .:.:..:
XP_006 VAAVLSQHFQTV-------SPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
290 300 310 320 330 340
>>NP_068766 (OMIM: 606477) serine racemase isoform a [Ho (340 aa)
initn: 308 init1: 123 opt: 351 Z-score: 431.5 bits: 88.2 E(85289): 2.7e-17
Smith-Waterman score: 362; 29.0% identity (60.3% similar) in 317 aa overlap (5-310:21-319)
10 20 30 40
pF1KB5 MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG
. .:. ::. : :....: ....: . : .:::::::
NP_068 MCAQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRG
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 IGHFCKRWAKQGCAH----FVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLK
. . . .. . : :.:: :.: .:::. :.:: ::::.:.: ..
NP_068 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ
60 70 80 90 100 110
110 120 130 140 150
pF1KB5 NEGATVKVVGELLDEAFE-LAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEK
::.. : : ::. : .:: ..... : ... : ..: . :...:. :. : .
NP_068 AYGASI-VYCEPSDESRENVAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEV---LNQV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 P--GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKI
: :... :::::.: :.. .. . .: : : : .: . . . :::. .:
NP_068 PLVDALVVPVGGGGMLAGIAITVKALK-PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 TSVAKALGVKT-VGAQALKLFQE--HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAA
..: :::. .: .. .... ::. ....: : . . :.:.::. :..
NP_068 ETIAD--GVKSSIGLNTWPIIRDLVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVG
240 250 260 270 280
280 290 300 310 320
pF1KB5 LAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
.::: :. .: . .: . . :: .:.:..:
NP_068 VAAVLSQHFQTV-------SPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
290 300 310 320 330 340
>>NP_001291732 (OMIM: 606477) serine racemase isoform b (191 aa)
initn: 116 init1: 56 opt: 168 Z-score: 211.9 bits: 46.7 E(85289): 4.6e-05
Smith-Waterman score: 168; 26.6% identity (58.7% similar) in 184 aa overlap (133-310:2-170)
110 120 130 140 150 160
pF1KB5 GATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKP--
. : ..: . :...:. :. : . :
NP_001 MVHPNQEPAVIAGQGTIALEV---LNQVPLV
10 20
170 180 190 200 210
pF1KB5 GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKITSV
:... :::::.: :.. .. . .: : : : .: . . . :::. .: ..
NP_001 DALVVPVGGGGMLAGIAITVKALK-PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETI
30 40 50 60 70 80
220 230 240 250 260 270
pF1KB5 AKALGVKT-VGAQALKLFQE--HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAA
: :::. .: .. .... ::. ....: : . . :.:.::. :...::
NP_001 AD--GVKSSIGLNTWPIIRDLVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVGVAA
90 100 110 120 130 140
280 290 300 310 320
pF1KB5 VYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
: :. .: . .: . . :: .:.:..:
NP_001 VLSQHFQTV-------SPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
150 160 170 180 190
328 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:28:15 2016 done: Sat Nov 5 06:28:16 2016
Total Scan time: 7.990 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]