Result of FASTA (omim) for
pF1KB5162
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5162, 217 aa
1>>>pF1KB5162 217 - 217 aa - 217 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7825+/-0.000627; mu= -3.7210+/- 0.037
mean_var=448.4761+/-108.960, 0's: 0 Z-trim(114.7): 226 B-trim: 0 in 0/51
Lambda= 0.060563
statistics sampled from 24488 (24709) to 24488 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.29), width: 16
Scan time: 6.020
The best scores are: opt bits E(85289)
NP_002077 (OMIM: 108355) growth factor receptor-bo ( 217) 1519 147.1 2.2e-35
XP_016879518 (OMIM: 604330) PREDICTED: GRB2-relate ( 217) 930 95.6 6.7e-20
NP_006604 (OMIM: 604330) GRB2-related adapter prot ( 217) 930 95.6 6.7e-20
NP_987102 (OMIM: 108355) growth factor receptor-bo ( 176) 836 87.2 1.8e-17
NP_001278754 (OMIM: 604518) GRB2-related adapter p ( 330) 570 64.4 2.5e-10
NP_001278753 (OMIM: 604518) GRB2-related adapter p ( 330) 570 64.4 2.5e-10
NP_004801 (OMIM: 604518) GRB2-related adapter prot ( 330) 570 64.4 2.5e-10
NP_001317077 (OMIM: 604330) GRB2-related adapter p ( 205) 460 54.5 1.5e-07
NP_001278755 (OMIM: 604518) GRB2-related adapter p ( 258) 328 43.1 0.0005
XP_006724439 (OMIM: 604518) PREDICTED: GRB2-relate ( 258) 328 43.1 0.0005
XP_011539315 (OMIM: 164940) PREDICTED: tyrosine-pr ( 352) 327 43.2 0.00063
XP_011539314 (OMIM: 164940) PREDICTED: tyrosine-pr ( 410) 327 43.3 0.00068
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 327 43.5 0.00078
XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 327 43.5 0.00078
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 327 43.5 0.00078
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 327 43.5 0.00078
XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 327 43.5 0.00078
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 316 42.6 0.0015
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 320 43.4 0.0018
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 320 43.4 0.0018
NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043) 316 43.0 0.0022
NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058) 316 43.0 0.0022
NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064) 316 43.0 0.0022
NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079) 316 43.0 0.0022
NP_001317397 (OMIM: 153390,615758) tyrosine-protei ( 458) 308 41.8 0.0023
XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146) 316 43.1 0.0023
NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161) 316 43.1 0.0023
NP_005149 (OMIM: 164690) Abelson tyrosine-protein (1167) 316 43.1 0.0023
NP_009298 (OMIM: 164690) Abelson tyrosine-protein (1182) 316 43.1 0.0023
XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182) 316 43.1 0.0023
XP_011539756 (OMIM: 153390,615758) PREDICTED: tyro ( 516) 308 41.8 0.0024
XP_011539755 (OMIM: 153390,615758) PREDICTED: tyro ( 516) 308 41.8 0.0024
>>NP_002077 (OMIM: 108355) growth factor receptor-bound (217 aa)
initn: 1519 init1: 1519 opt: 1519 Z-score: 756.4 bits: 147.1 E(85289): 2.2e-35
Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
130 140 150 160 170 180
190 200 210
pF1KB5 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
:::::::::::::::::::::::::::::::::::::
NP_002 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
190 200 210
>>XP_016879518 (OMIM: 604330) PREDICTED: GRB2-related ad (217 aa)
initn: 934 init1: 724 opt: 930 Z-score: 478.3 bits: 95.6 E(85289): 6.7e-20
Smith-Waterman score: 930; 59.7% identity (85.6% similar) in 216 aa overlap (1-214:1-216)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..:::::
XP_016 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
. :.: : :::.: :. : ::::::::::.::.::.::..:..::::::::...:::::
XP_016 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
70 80 90 100 110 120
130 140 150 160 170
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR
: ::::::::::..:.:......:::::: : . ..: ..:: :::. :. ..:.::
XP_016 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
130 140 150 160 170 180
180 190 200 210
pF1KB5 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
:::.:.:.. ::.::.: :..:.:::.:: ::.
XP_016 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
190 200 210
>>NP_006604 (OMIM: 604330) GRB2-related adapter protein (217 aa)
initn: 934 init1: 724 opt: 930 Z-score: 478.3 bits: 95.6 E(85289): 6.7e-20
Smith-Waterman score: 930; 59.7% identity (85.6% similar) in 216 aa overlap (1-214:1-216)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..:::::
NP_006 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
. :.: : :::.: :. : ::::::::::.::.::.::..:..::::::::...:::::
NP_006 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
70 80 90 100 110 120
130 140 150 160 170
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR
: ::::::::::..:.:......:::::: : . ..: ..:: :::. :. ..:.::
NP_006 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
130 140 150 160 170 180
180 190 200 210
pF1KB5 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
:::.:.:.. ::.::.: :..:.:::.:: ::.
NP_006 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
190 200 210
>>NP_987102 (OMIM: 108355) growth factor receptor-bound (176 aa)
initn: 836 init1: 836 opt: 836 Z-score: 434.7 bits: 87.2 E(85289): 1.8e-17
Smith-Waterman score: 1152; 81.1% identity (81.1% similar) in 217 aa overlap (1-217:1-176)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHP-
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
::::::::::::::::::::
NP_987 ----------------------------------------FGNDVQHFKVLRDGAGKYFL
60 70
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
80 90 100 110 120 130
190 200 210
pF1KB5 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
:::::::::::::::::::::::::::::::::::::
NP_987 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
140 150 160 170
>>NP_001278754 (OMIM: 604518) GRB2-related adapter prote (330 aa)
initn: 784 init1: 328 opt: 570 Z-score: 306.5 bits: 64.4 E(85289): 2.5e-10
Smith-Waterman score: 570; 53.3% identity (84.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
:::.::.:: :...:::::. ::.::.:... ..:.::::....:..:::.:... :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
: . : .::..: .. : :.:: :.:.:::::.::. .:::::::.::. :.:::
NP_001 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
:. :: :::.::::.:..:.::..::::::
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>NP_001278753 (OMIM: 604518) GRB2-related adapter prote (330 aa)
initn: 784 init1: 328 opt: 570 Z-score: 306.5 bits: 64.4 E(85289): 2.5e-10
Smith-Waterman score: 570; 53.3% identity (84.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
:::.::.:: :...:::::. ::.::.:... ..:.::::....:..:::.:... :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
: . : .::..: .. : :.:: :.:.:::::.::. .:::::::.::. :.:::
NP_001 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
:. :: :::.::::.:..:.::..::::::
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>NP_004801 (OMIM: 604518) GRB2-related adapter protein (330 aa)
initn: 784 init1: 328 opt: 570 Z-score: 306.5 bits: 64.4 E(85289): 2.5e-10
Smith-Waterman score: 570; 53.3% identity (84.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
:::.::.:: :...:::::. ::.::.:... ..:.::::....:..:::.:... :
NP_004 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
: . : .::..: .. : :.:: :.:.:::::.::. .:::::::.::. :.:::
NP_004 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
:. :: :::.::::.:..:.::..::::::
NP_004 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>NP_001317077 (OMIM: 604330) GRB2-related adapter prote (205 aa)
initn: 460 init1: 460 opt: 460 Z-score: 256.6 bits: 54.5 E(85289): 1.5e-07
Smith-Waterman score: 460; 66.7% identity (85.9% similar) in 99 aa overlap (1-99:1-99)
10 20 30 40 50 60
pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..:::::
NP_001 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
. :.: : :::.: :. : ::::::::::.::.::.::
NP_001 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNHLGPALPRPSLTSQPRTPRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
NP_001 SASAVATSLRSWSAQTPTGGGAGPAGALASSHGVTCSPCTCEQPGGRSGQRAFLQELRSR
130 140 150 160 170 180
>>NP_001278755 (OMIM: 604518) GRB2-related adapter prote (258 aa)
initn: 539 init1: 328 opt: 328 Z-score: 193.3 bits: 43.1 E(85289): 0.0005
Smith-Waterman score: 328; 65.7% identity (90.0% similar) in 70 aa overlap (81-150:6-75)
60 70 80 90 100 110
pF1KB5 NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV
: :.:: :.:.:::::.::. .:::::::
NP_001 MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKV
10 20 30
120 130 140 150 160 170
pF1KB5 LRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQ
.::. :.::::. :: :::.::::.:..:.::..::::::
NP_001 MRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGG
40 50 60 70 80 90
180 190 200 210
pF1KB5 EDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NP_001 PHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHH
100 110 120 130 140 150
>>XP_006724439 (OMIM: 604518) PREDICTED: GRB2-related ad (258 aa)
initn: 539 init1: 328 opt: 328 Z-score: 193.3 bits: 43.1 E(85289): 0.0005
Smith-Waterman score: 328; 65.7% identity (90.0% similar) in 70 aa overlap (81-150:6-75)
60 70 80 90 100 110
pF1KB5 NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV
: :.:: :.:.:::::.::. .:::::::
XP_006 MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKV
10 20 30
120 130 140 150 160 170
pF1KB5 LRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQ
.::. :.::::. :: :::.::::.:..:.::..::::::
XP_006 MRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGG
40 50 60 70 80 90
180 190 200 210
pF1KB5 EDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
XP_006 PHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHH
100 110 120 130 140 150
217 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 16:14:17 2016 done: Thu Nov 3 16:14:18 2016
Total Scan time: 6.020 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]