Result of FASTA (omim) for
pF1KB5120
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5120, 420 aa
1>>>pF1KB5120 420 - 420 aa - 420 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.1157+/-0.000614; mu= -28.1227+/- 0.037
mean_var=745.5672+/-171.495, 0's: 0 Z-trim(116.0): 1079 B-trim: 0 in 0/54
Lambda= 0.046971
statistics sampled from 25271 (26803) to 25271 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.314), width: 16
Scan time: 9.270
The best scores are: opt bits E(85289)
NP_001139628 (OMIM: 605004) glycogen synthase kina ( 420) 2798 205.7 1.8e-52
XP_006713674 (OMIM: 605004) PREDICTED: glycogen sy ( 387) 2463 182.9 1.2e-45
NP_063937 (OMIM: 606784) glycogen synthase kinase- ( 483) 2082 157.2 8.2e-38
XP_006713673 (OMIM: 605004) PREDICTED: glycogen sy ( 400) 2034 153.9 6.9e-37
NP_002084 (OMIM: 605004) glycogen synthase kinase- ( 433) 2034 153.9 7.2e-37
NP_002737 (OMIM: 601795) mitogen-activated protein ( 379) 612 57.5 6.7e-08
NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357) 606 57.0 8.6e-08
NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 597 56.3 1.2e-07
NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 594 56.2 1.4e-07
NP_002736 (OMIM: 176948) mitogen-activated protein ( 360) 596 56.4 1.4e-07
NP_620407 (OMIM: 176948) mitogen-activated protein ( 360) 596 56.4 1.4e-07
NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 576 55.0 3.4e-07
XP_016866355 (OMIM: 154235,614181) PREDICTED: seri ( 439) 575 55.0 4.2e-07
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 580 55.7 5e-07
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 580 55.7 5e-07
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 580 55.7 5e-07
NP_001229314 (OMIM: 154235,614181) serine/threonin ( 583) 575 55.2 5.1e-07
XP_011512924 (OMIM: 154235,614181) PREDICTED: seri ( 583) 575 55.2 5.1e-07
NP_005897 (OMIM: 154235,614181) serine/threonine-p ( 623) 575 55.2 5.3e-07
XP_016866353 (OMIM: 154235,614181) PREDICTED: seri ( 623) 575 55.2 5.3e-07
XP_011512922 (OMIM: 154235,614181) PREDICTED: seri ( 648) 575 55.2 5.5e-07
XP_016866352 (OMIM: 154235,614181) PREDICTED: seri ( 648) 575 55.2 5.5e-07
XP_011512921 (OMIM: 154235,614181) PREDICTED: seri ( 648) 575 55.2 5.5e-07
NP_001229886 (OMIM: 154235,614181) serine/threonin ( 648) 575 55.2 5.5e-07
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 563 54.1 6.3e-07
XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351) 560 53.9 7.4e-07
XP_016864300 (OMIM: 603442) PREDICTED: cyclin-depe ( 479) 559 54.0 9.5e-07
NP_003939 (OMIM: 603442) cyclin-dependent kinase-l ( 493) 559 54.0 9.7e-07
XP_016864299 (OMIM: 603442) PREDICTED: cyclin-depe ( 493) 559 54.0 9.7e-07
NP_002742 (OMIM: 602898) mitogen-activated protein ( 364) 554 53.5 1e-06
XP_006714469 (OMIM: 603442) PREDICTED: cyclin-depe ( 530) 559 54.1 1e-06
XP_016864298 (OMIM: 603442) PREDICTED: cyclin-depe ( 570) 559 54.1 1.1e-06
NP_001317653 (OMIM: 603442) cyclin-dependent kinas ( 570) 559 54.1 1.1e-06
NP_002960 (OMIM: 602399) mitogen-activated protein ( 367) 552 53.4 1.1e-06
NP_055735 (OMIM: 612325,612651) serine/threonine-p ( 632) 555 53.9 1.4e-06
XP_016865977 (OMIM: 612325,612651) PREDICTED: seri ( 632) 555 53.9 1.4e-06
NP_057597 (OMIM: 612325,612651) serine/threonine-p ( 632) 555 53.9 1.4e-06
XP_016865978 (OMIM: 612325,612651) PREDICTED: seri ( 632) 555 53.9 1.4e-06
XP_016865981 (OMIM: 612325,612651) PREDICTED: seri ( 632) 555 53.9 1.4e-06
XP_016865979 (OMIM: 612325,612651) PREDICTED: seri ( 632) 555 53.9 1.4e-06
XP_016865980 (OMIM: 612325,612651) PREDICTED: seri ( 632) 555 53.9 1.4e-06
XP_011512721 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_016865976 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_011512722 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_011512723 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_016865974 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_016865975 (OMIM: 612325,612651) PREDICTED: seri ( 639) 555 53.9 1.4e-06
XP_016870051 (OMIM: 610076) PREDICTED: cyclin-depe ( 329) 536 52.3 2.2e-06
NP_004187 (OMIM: 603441) cyclin-dependent kinase-l ( 358) 536 52.3 2.3e-06
XP_005268214 (OMIM: 603441) PREDICTED: cyclin-depe ( 358) 536 52.3 2.3e-06
>>NP_001139628 (OMIM: 605004) glycogen synthase kinase-3 (420 aa)
initn: 2798 init1: 2798 opt: 2798 Z-score: 1062.8 bits: 205.7 E(85289): 1.8e-52
Smith-Waterman score: 2798; 100.0% identity (100.0% similar) in 420 aa overlap (1-420:1-420)
10 20 30 40 50 60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
370 380 390 400 410 420
>>XP_006713674 (OMIM: 605004) PREDICTED: glycogen syntha (387 aa)
initn: 2486 init1: 2463 opt: 2463 Z-score: 940.6 bits: 182.9 E(85289): 1.2e-45
Smith-Waterman score: 2518; 92.1% identity (92.1% similar) in 420 aa overlap (1-420:1-387)
10 20 30 40 50 60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
::::: ::::::::::::::::::::::
XP_006 NFTTQ---------------------------------DANTGDRGQTNNAASASASNST
370 380
>>NP_063937 (OMIM: 606784) glycogen synthase kinase-3 al (483 aa)
initn: 2131 init1: 2065 opt: 2082 Z-score: 799.9 bits: 157.2 E(85289): 8.2e-38
Smith-Waterman score: 2082; 78.1% identity (90.8% similar) in 401 aa overlap (21-420:84-483)
10 20 30 40 50
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
..: :. .:..:::::::: ::::.:
NP_063 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
60 70 80 90 100 110
60 70 80 90 100 110
pF1KB5 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
:::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
NP_063 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
120 130 140 150 160 170
120 130 140 150 160 170
pF1KB5 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
:::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
NP_063 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
180 190 200 210 220 230
180 190 200 210 220 230
pF1KB5 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
:::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
NP_063 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
240 250 260 270 280 290
240 250 260 270 280 290
pF1KB5 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
300 310 320 330 340 350
300 310 320 330 340 350
pF1KB5 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL
:::::::::::::::. ::::::::::: ::::::..::.:::::::::::::: ...:
NP_063 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL
360 370 380 390 400 410
360 370 380 390 400
pF1KB5 PNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA-SDANTGDRGQTN
::.: : ::::.. ::: .: : .:::::: : :...: : .. : ... :.. :..
NP_063 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST
420 430 440 450 460 470
410 420
pF1KB5 NAASASASNST
.: . . .::.
NP_063 DA-TPTLTNSS
480
>>XP_006713673 (OMIM: 605004) PREDICTED: glycogen syntha (400 aa)
initn: 2449 init1: 2034 opt: 2034 Z-score: 783.3 bits: 153.9 E(85289): 6.9e-37
Smith-Waterman score: 2482; 89.4% identity (89.4% similar) in 433 aa overlap (1-420:1-400)
10 20 30 40 50 60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
250 260 270 280 290 300
310 320 330 340
pF1KB5 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
::: ::::::::::::::::::::::::::::::::::::::::::::
XP_006 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
:::::::::::::::::: :::::::::
XP_006 VKLPNGRDTPALFNFTTQ---------------------------------DANTGDRGQ
370 380
410 420
pF1KB5 TNNAASASASNST
:::::::::::::
XP_006 TNNAASASASNST
390 400
>>NP_002084 (OMIM: 605004) glycogen synthase kinase-3 be (433 aa)
initn: 2034 init1: 2034 opt: 2034 Z-score: 782.9 bits: 153.9 E(85289): 7.2e-37
Smith-Waterman score: 2762; 97.0% identity (97.0% similar) in 433 aa overlap (1-420:1-433)
10 20 30 40 50 60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
250 260 270 280 290 300
310 320 330 340
pF1KB5 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
::: ::::::::::::::::::::::::::::::::::::::::::::
NP_002 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
370 380 390 400 410 420
410 420
pF1KB5 TNNAASASASNST
:::::::::::::
NP_002 TNNAASASASNST
430
>>NP_002737 (OMIM: 601795) mitogen-activated protein kin (379 aa)
initn: 537 init1: 263 opt: 612 Z-score: 262.8 bits: 57.5 E(85289): 6.7e-08
Smith-Waterman score: 619; 33.9% identity (63.4% similar) in 372 aa overlap (43-385:17-372)
20 30 40 50 60
pF1KB5 SCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVS------------YTDTK
: : :: : :: ::. .
NP_002 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQ
10 20 30 40
70 80 90 100 110
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYF
::.:..:.: .: :::::. .. . . .: :.::. .. : :.. .: .
NP_002 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 FYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS
. .: : .:: .: : . .:.. . .: : .. ..::..:.: ::::
NP_002 LRASTLEAMRDVY--IVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHS
110 120 130 140 150
180 190 200 210 220
pF1KB5 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIF
.. :::.::.:::.. : ::.:::: :. .. : . . :. .:.:::::...
NP_002 ANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIML
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB5 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR---EMNP
.. ::.:::.::.::.:::.: ..::::: .::: .:. .::.:..:.. .:.
NP_002 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 -NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD
:: . ..:. :.:.: :.. .:. : .:.: ..:. :.: :: :: .... :
NP_002 RNYLQ-SLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD
280 290 300 310 320 330
350 360 370 380 390 400
pF1KB5 PNVKLPNGRDTPALFNFTTQELSSNPP--LATILIPPHARIQAAASTPTNATAASDANTG
:. . : ... : :.:. .::.. : : ... ::.:
NP_002 PTDE-PVAEE-P--FTFA-MELDDLPKERLKELIFQETARFQPGVLEAP
340 350 360 370
410 420
pF1KB5 DRGQTNNAASASASNST
>>NP_001035145 (OMIM: 601795) mitogen-activated protein (357 aa)
initn: 537 init1: 263 opt: 606 Z-score: 260.9 bits: 57.0 E(85289): 8.6e-08
Smith-Waterman score: 613; 34.7% identity (63.7% similar) in 331 aa overlap (43-346:17-336)
20 30 40 50 60
pF1KB5 SCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVS------------YTDTK
: : :: : :: ::. .
NP_001 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQ
10 20 30 40
70 80 90 100 110
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYF
::.:..:.: .: :::::. .. . . .: :.::. .. : :.. .: .
NP_001 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 FYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS
. .: : .:: .: : . .:.. . .: : .. ..::..:.: ::::
NP_001 LRASTLEAMRDVY--IVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHS
110 120 130 140 150
180 190 200 210 220
pF1KB5 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIF
.. :::.::.:::.. : ::.:::: :. .. : . . :. .:.:::::...
NP_001 ANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIML
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB5 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR---EMNP
.. ::.:::.::.::.:::.: ..::::: .::: .:. .::.:..:.. .:.
NP_001 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 -NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD
:: . ..:. :.:.: :.. .:. : .:.: ..:. :.: :: :: .... :
NP_001 RNYLQ-SLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD
280 290 300 310 320 330
350 360 370 380 390 400
pF1KB5 PNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDR
:
NP_001 PTDEVGQSPAAVGLGAGEQGGT
340 350
>>NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 iso (298 aa)
initn: 454 init1: 337 opt: 597 Z-score: 258.5 bits: 56.3 E(85289): 1.2e-07
Smith-Waterman score: 597; 34.2% identity (65.8% similar) in 304 aa overlap (55-346:3-292)
30 40 50 60 70 80
pF1KB5 SMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAI
.. .. ::.:..::::.:. .::.::.
NP_001 MENFQKVEKIGEGTYGVVYKARNKLTGEVVAL
10 20 30
90 100 110 120 130
pF1KB5 KKVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET
::. : . .. ::......:.: :::.: ... :.: : ::.... .
NP_001 KKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT--ENK----LYLVFEFLHQD
40 50 60 70 80
140 150 160 170 180 190
pF1KB5 VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKL
. . . : .:. .: :..::...::. :: . :::.::::::.. . :. ::
NP_001 LKKFMD--ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-KL
90 100 110 120 130 140
200 210 220 230 240 250
pF1KB5 CDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP
::: :. . : : .: . . .:::::...: :....:.:: ::..::.. .
NP_001 ADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRA
150 160 170 180 190 200
260 270 280 290 300 310
pF1KB5 IFPGDSGVDQLVEIIKVLGTPTR---EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE
.::::: .::: .:...:::: . . : :.: .::. . ..:: : .
NP_001 LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-PDYKP-SFPKWARQDFSKVV-PPLDED
210 220 230 240 250
320 330 340 350 360 370
pF1KB5 AIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPP
. .: :..:.: :. :.. : :: ::... :
NP_001 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
260 270 280 290
380 390 400 410 420
pF1KB5 LATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
>>NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 [Ho (305 aa)
initn: 537 init1: 370 opt: 594 Z-score: 257.3 bits: 56.2 E(85289): 1.4e-07
Smith-Waterman score: 594; 35.4% identity (67.0% similar) in 291 aa overlap (62-340:10-286)
40 50 60 70 80 90
pF1KB5 KDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK
::.:..::::.:: ..:.:::.::. :
NP_001 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDL
10 20 30
100 110 120 130 140
pF1KB5 RFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH
.... ::......: : ::::: .. :.: : ::.... . . .
NP_001 EMEGVPSTAIREISLLKELKHPNIVRLLDVVHN--ERK----LYLVFEFLSQDLKKYMD-
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB5 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK
: . ::. .: :..::...... :: . :::.::::::.. . ...:: ::: :.
NP_001 -STPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLAR
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB5 QLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG
. : : .: . . .:::::...:. ::...:.:: ::..::.. . .:::::
NP_001 AF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSE
160 170 180 190 200
270 280 290 300 310
pF1KB5 VDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR
.::: .:...::::... . .. :.: . .::. . .. : ::. : .
NP_001 IDQLFRIFRMLGTPSEDTWPGVTQL-PDY-KGSFPKWTRKGLEEIV-PNLEPEGRDLLMQ
210 220 230 240 250 260
320 330 340 350 360 370
pF1KB5 LLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIP
::.: :. :.: : :: .:
NP_001 LLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
270 280 290 300
>>NP_002736 (OMIM: 176948) mitogen-activated protein kin (360 aa)
initn: 504 init1: 263 opt: 596 Z-score: 257.2 bits: 56.4 E(85289): 1.4e-07
Smith-Waterman score: 596; 32.2% identity (64.0% similar) in 367 aa overlap (42-385:5-355)
20 30 40 50 60
pF1KB5 ESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPD--RPQ--EVS--YTDTKVIGNG
:. : ::. : : .:. ::. . ::.:
NP_002 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEG
10 20 30
70 80 90 100 110
pF1KB5 SFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYS-S
..:.: .: . :::::. .. . . .: :..:. .. : ::. . .. . .
NP_002 AYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB5 GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH
:. .:: .: : . .:.. . : : .. ..::..:.: :::: .. :
NP_002 IEQMKDVY--IVQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGLKYIHSANVLH
100 110 120 130 140
180 190 200 210 220 230
pF1KB5 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-------VSYICSRYYRAPELIFGAT
::.::.::::. : ::.:::: :. ..:. . :. .:.:::::.....
NP_002 RDLKPSNLLLNT-TCDLKICDFGLARV---ADPDHDHTGFLTEYVATRWYRAPEIMLNSK
150 160 170 180 190 200
240 250 260 270 280
pF1KB5 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM----NPNY
::.:::.::.::.:::.: ..::::: .::: .:. .::.:..:.. . ::
NP_002 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNY
210 220 230 240 250 260
290 300 310 320 330 340
pF1KB5 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV
...:. . ::...: : . .:. : ...: ..: :. .: :: .... ::.
NP_002 L-LSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB5 KLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQT
. : . ..: :.. ..: .. : ... ::.:
NP_002 E-PIA-EAPFKFDMELDDLPKEK-LKELIFEETARFQPGYRS
330 340 350 360
410 420
pF1KB5 NNAASASASNST
420 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 16:07:30 2016 done: Thu Nov 3 16:07:32 2016
Total Scan time: 9.270 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]