Result of FASTA (omim) for
pF1KB4902
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4902, 744 aa
1>>>pF1KB4902 744 - 744 aa - 744 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0478+/-0.000492; mu= 15.8514+/- 0.030
mean_var=80.2415+/-16.053, 0's: 0 Z-trim(109.2): 176 B-trim: 16 in 1/49
Lambda= 0.143178
statistics sampled from 17122 (17330) to 17122 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.548), E-opt: 0.2 (0.203), width: 16
Scan time: 8.420
The best scores are: opt bits E(85289)
NP_006169 (OMIM: 601633) vesicle-fusing ATPase [Ho ( 744) 4824 1007.1 0
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 540 122.2 8.2e-27
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 534 121.0 1.7e-26
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 472 108.1 7.5e-23
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 472 108.1 7.6e-23
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 463 106.2 2.5e-22
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 463 106.2 2.5e-22
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 463 106.2 3e-22
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 450 103.4 1.3e-21
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 450 103.5 1.8e-21
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 442 102.0 9.3e-21
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 442 102.0 1e-20
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 437 100.8 1.2e-20
XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 438 101.1 1.4e-20
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 433 100.0 2e-20
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 433 100.0 2.1e-20
XP_016863318 (OMIM: 613940,616577) PREDICTED: sper ( 765) 432 99.9 4.1e-20
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 432 99.9 4.3e-20
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 432 99.9 4.6e-20
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 432 99.9 4.6e-20
XP_011529980 (OMIM: 613940,616577) PREDICTED: sper ( 916) 432 100.0 4.7e-20
XP_016863314 (OMIM: 613940,616577) PREDICTED: sper ( 917) 432 100.0 4.7e-20
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 426 98.6 5.9e-20
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 417 96.7 2.2e-19
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 412 95.8 7.4e-19
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 412 95.8 7.5e-19
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 406 94.5 1.3e-18
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 406 94.5 1.4e-18
XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791) 405 94.3 2e-18
XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837) 405 94.4 2.1e-18
XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841) 405 94.4 2.1e-18
XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843) 405 94.4 2.1e-18
XP_011531230 (OMIM: 615347) PREDICTED: ATPase fami ( 849) 405 94.4 2.1e-18
XP_006712094 (OMIM: 615347) PREDICTED: ATPase fami (1067) 405 94.4 2.6e-18
XP_011531227 (OMIM: 615347) PREDICTED: ATPase fami (1079) 405 94.4 2.6e-18
XP_011531226 (OMIM: 615347) PREDICTED: ATPase fami (1083) 405 94.4 2.6e-18
XP_016863315 (OMIM: 613940,616577) PREDICTED: sper ( 859) 403 93.9 2.9e-18
NP_001229267 (OMIM: 615347) ATPase family AAA doma (1453) 405 94.5 3.4e-18
NP_060022 (OMIM: 615347) ATPase family AAA domain- (1458) 405 94.5 3.4e-18
XP_006712093 (OMIM: 615347) PREDICTED: ATPase fami (1460) 405 94.5 3.4e-18
XP_011531223 (OMIM: 615347) PREDICTED: ATPase fami (1467) 405 94.5 3.4e-18
XP_005264429 (OMIM: 615347) PREDICTED: ATPase fami (1472) 405 94.5 3.4e-18
XP_016859864 (OMIM: 615347) PREDICTED: ATPase fami (1492) 405 94.5 3.5e-18
XP_011531222 (OMIM: 615347) PREDICTED: ATPase fami (1497) 405 94.5 3.5e-18
XP_011531221 (OMIM: 615347) PREDICTED: ATPase fami (1506) 405 94.5 3.5e-18
XP_011531220 (OMIM: 615347) PREDICTED: ATPase fami (1511) 405 94.5 3.5e-18
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 390 91.3 2e-17
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 390 91.3 2.6e-17
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 390 91.4 2.8e-17
NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 378 88.8 1.1e-16
>>NP_006169 (OMIM: 601633) vesicle-fusing ATPase [Homo s (744 aa)
initn: 4824 init1: 4824 opt: 4824 Z-score: 5385.4 bits: 1007.1 E(85289): 0
Smith-Waterman score: 4824; 100.0% identity (100.0% similar) in 744 aa overlap (1-744:1-744)
10 20 30 40 50 60
pF1KB4 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 LASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 LEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 VVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 FSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQM
670 680 690 700 710 720
730 740
pF1KB4 DPEYRVRKFLALLREEGASPLDFD
::::::::::::::::::::::::
NP_006 DPEYRVRKFLALLREEGASPLDFD
730 740
>>NP_009057 (OMIM: 167320,601023,613954,616687) transiti (806 aa)
initn: 586 init1: 247 opt: 540 Z-score: 602.4 bits: 122.2 E(85289): 8.2e-27
Smith-Waterman score: 658; 34.4% identity (61.6% similar) in 425 aa overlap (242-652:227-629)
220 230 240 250 260 270
pF1KB4 DWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLAR
: . . .: : .::::::::: ::::.::
NP_009 SLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIAR
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB4 QIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEID
... .: ..:::::..: .::::.:.:: : .::. .. ::..::.:
NP_009 AVANETGAFFF-LINGPEIMSKLAGESESNLRKAFEEAEK--------NAPAIIFIDELD
260 270 280 290 300
340 350 360 370 380 390
pF1KB4 AICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEV
:: .: . : :. .:.:::. .::..: ...:.. ::::. :: :: : ::..
NP_009 AIAPKREKTHGE--VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDR
310 320 330 340 350 360
400 410 420 430 440 450
pF1KB4 KMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQST
...::.:: :::.::.::: :. :. :::....: ::.. ::.: .: :
NP_009 EVDIGIPDATGRLEILQIHTKNMK----LADDVDLEQVANETHGHVGADLAALCSEAALQ
370 380 390 400 410 420
460 470 480 490 500
pF1KB4 AMNRHIK-ASTKVE-VDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIK
:. ... . . : .: : .:: :: :: .: .. :. . . . . :
NP_009 AIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG
430 440 450 460 470 480
510 520 530 540 550 560
pF1KB4 WGDPVTRVLDDGELLVQQTKNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFP
: : : :. ::. ... :. :: .::. ::: ::: :: ::.: .
NP_009 LED-VKRELQ--ELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQAN
490 500 510 520 530
570 580 590 600 610
pF1KB4 FIKICSPDKM-IGFSETAKCQAMKKIFDDAYKSQLSCVVV-DDIERLLDY----VPIGPR
::.: .:. . . :.:. ...::: : .. ::. :... . . :
NP_009 FISIKGPELLTMWFGESEA--NVREIFDKARQAA-PCVLFFDELDSIAKARGGNIGDGGG
540 550 560 570 580 590
620 630 640 650 660 670
pF1KB4 FSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLL
.. :.. .:. . . ....:::.:.: :..
NP_009 AADRVINQILTEMDGMSTK-KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRV
600 610 620 630 640 650
680 690 700 710 720 730
pF1KB4 EALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEG
NP_009 AILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQ
660 670 680 690 700 710
>>NP_001304728 (OMIM: 613940,616577) spermatogenesis-ass (695 aa)
initn: 478 init1: 151 opt: 534 Z-score: 596.7 bits: 121.0 E(85289): 1.7e-26
Smith-Waterman score: 563; 29.9% identity (62.2% similar) in 442 aa overlap (146-567:279-691)
120 130 140 150 160 170
pF1KB4 KMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMD---PSILKGEPATGKRQKI
::..... .. : .:. .....
NP_001 STPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGNEQLTEEERL
250 260 270 280 290 300
180 190 200 210 220
pF1KB4 EVGLVVG---NSQVAFEKAENSSLNL--IGKAKTKENRQSIINPDWNFEKMGIGGLDKEF
. . .: :... . . .. .:. : : . ... : .. : ::::....
NP_001 -LKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDM------IGGLSSQL
310 320 330 340 350 360
230 240 250 260 270 280
pF1KB4 SDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNG
. : :. . . ::. ...: .:.::::::: :::..:: ... ..: .:.::
NP_001 KAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYV-SVING
370 380 390 400 410
290 300 310 320 330 340
pF1KB4 PEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVH
:::..:. ::.::..:..::.: .. ::..::.::.: .: .... :.
NP_001 PEIISKFYGETEAKLRQIFAEATLRHPS--------IIFIDELDALCPKR--EGAQNEVE
420 430 440 450 460
350 360 370 380 390 400
pF1KB4 DTVVNQLLSKIDGVEQL---NNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
:: .::. .::. . ...::.: :::: .: :: ::::.. ..:::.:. . ::
NP_001 KRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRL
470 480 490 500 510 520
410 420 430 440 450 460
pF1KB4 QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVE
.::. :. : : : .. .:: .... ::.:. : : :. : .: . ..
NP_001 DILQKLLRRV-PHLLTEA--ELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLP
530 540 550 560 570 580
470 480 490 500 510
pF1KB4 VDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGD-----PVTRVLD
:.. : ...: ::: .. :::.: . ... : . : ..:.: . :.
NP_001 -DVKVAGLVKITLKDFLQAM-NDIRP---SAMREIAIDVPN--VSWSDIGGLESIKLKLE
590 600 610 620 630
520 530 540 550 560 570
pF1KB4 DG-ELLVQQTKNSDRT---PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIG
.. : ... .. : : .::: ::: .:: .: .:.::.. :. :
NP_001 QAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKVGC
640 650 660 670 680 690
580 590 600 610 620 630
pF1KB4 FSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPP
>>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa)
initn: 403 init1: 206 opt: 472 Z-score: 531.2 bits: 108.1 E(85289): 7.5e-23
Smith-Waterman score: 524; 33.2% identity (65.1% similar) in 364 aa overlap (116-474:49-384)
90 100 110 120 130 140
pF1KB4 DKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLF
.. : .: ...:. ::. .: ....:
NP_001 KIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGE-VVRAMDKK--
20 30 40 50 60 70
150 160 170 180 190 200
pF1KB4 GLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENR
.::: . : .:. .. ..:... :. : .::. . .. .:. : :.
NP_001 KVLVK----VHP---EGKFVVDVDKNIDINDVTPNCRVAL-RNDSYTLHKILPNKVDPLV
80 90 100 110 120
210 220 230 240 250 260
pF1KB4 QSIIN---PDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPP
. .. :: ..: ::::::....: .... : ::. : .: . ::.::::::
NP_001 SLMMVEKVPDSTYEM--IGGLDKQIKEI-KEVIELPVKHPELFEALGIAQPKGVLLYGPP
130 140 150 160 170 180
270 280 290 300 310 320
pF1KB4 GCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGL
: ::::::: ... . .: .: :...:..::. .:.::. :.:. : :
NP_001 GTGKTLLARAVAHHTDCTFIRV-SGSELVQKFIGEGARMVRELFVMAREH-----APS--
190 200 210 220 230
330 340 350 360 370 380
pF1KB4 HIIIFDEIDAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLID
::..::::.: ..: :. .:.. :. :.. .::...:: : .:: :: ::: :..:
NP_001 -IIFMDEIDSIGSSRLEGGSGGDSEVQRTML-ELLNQLDGFEATKNIKVIMATNRIDILD
240 250 260 270 280 290
390 400 410 420 430 440
pF1KB4 EALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAE
:::::::.. :.:. :.:..::.::.::. .: :. ......: . ::::
NP_001 SALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMN----LTRGINLRKIAELMPGASGAE
300 310 320 330 340 350
450 460 470 480 490 500
pF1KB4 LEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYA
..:. : :. .. :. . .: :. .:
NP_001 VKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
360 370 380 390
510 520 530 540 550 560
pF1KB4 SYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEES
>>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa)
initn: 403 init1: 206 opt: 472 Z-score: 531.1 bits: 108.1 E(85289): 7.6e-23
Smith-Waterman score: 524; 33.2% identity (65.1% similar) in 364 aa overlap (116-474:57-392)
90 100 110 120 130 140
pF1KB4 DKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLF
.. : .: ...:. ::. .: ....:
NP_002 KIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGE-VVRAMDKK--
30 40 50 60 70 80
150 160 170 180 190 200
pF1KB4 GLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENR
.::: . : .:. .. ..:... :. : .::. . .. .:. : :.
NP_002 KVLVK----VHP---EGKFVVDVDKNIDINDVTPNCRVAL-RNDSYTLHKILPNKVDPLV
90 100 110 120 130
210 220 230 240 250 260
pF1KB4 QSIIN---PDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPP
. .. :: ..: ::::::....: .... : ::. : .: . ::.::::::
NP_002 SLMMVEKVPDSTYEM--IGGLDKQIKEI-KEVIELPVKHPELFEALGIAQPKGVLLYGPP
140 150 160 170 180 190
270 280 290 300 310 320
pF1KB4 GCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGL
: ::::::: ... . .: .: :...:..::. .:.::. :.:. : :
NP_002 GTGKTLLARAVAHHTDCTFIRV-SGSELVQKFIGEGARMVRELFVMAREH-----APS--
200 210 220 230 240
330 340 350 360 370 380
pF1KB4 HIIIFDEIDAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLID
::..::::.: ..: :. .:.. :. :.. .::...:: : .:: :: ::: :..:
NP_002 -IIFMDEIDSIGSSRLEGGSGGDSEVQRTML-ELLNQLDGFEATKNIKVIMATNRIDILD
250 260 270 280 290 300
390 400 410 420 430 440
pF1KB4 EALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAE
:::::::.. :.:. :.:..::.::.::. .: :. ......: . ::::
NP_002 SALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMN----LTRGINLRKIAELMPGASGAE
310 320 330 340 350
450 460 470 480 490 500
pF1KB4 LEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYA
..:. : :. .. :. . .: :. .:
NP_002 VKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
360 370 380 390 400
510 520 530 540 550 560
pF1KB4 SYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEES
>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa)
initn: 433 init1: 199 opt: 463 Z-score: 521.7 bits: 106.2 E(85289): 2.5e-22
Smith-Waterman score: 487; 36.9% identity (69.4% similar) in 255 aa overlap (220-471:114-350)
190 200 210 220 230 240
pF1KB4 NSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMG
:::::.....: ... . :: :.::
XP_016 HAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEI-KESVELPLTHPEYYEEMG
90 100 110 120 130 140
250 260 270 280 290 300
pF1KB4 CKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADA
: ::..:::::: ::::::. .... .: .:: : :...::.:.. .:.:: :
XP_016 IKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV-GSELIQKYLGDGPKLVRELFRVA
150 160 170 180 190 200
310 320 330 340 350 360
pF1KB4 EEEQRRLGANSGLHIIIFDEIDAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNI
::. : : :...:::::: .: .. .: .. :.. .::...:: .. ...
XP_016 EEH-----APS---IVFIDEIDAIGTKRYDSNSGGEREIQRTML-ELLNQLDGFDSRGDV
210 220 230 240 250
370 380 390 400 410 420
pF1KB4 LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIK
:: ::: . .: ::.::::.. :.:. ::::: . .:..:::.:: :. :: .
XP_016 KVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMT----LADDVTLD
260 270 280 290 300
430 440 450 460 470 480
pF1KB4 ELAVETKNFSGAELEGLVRAAQSTAM-NRHIKASTKVEVDMEKAESLQVTRGDFLASLEN
.: . ..:::..... : :. .:..:.... :..:..
XP_016 DLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNE---DFKKSKENVLYKKQEGTPEGL
310 320 330 340 350 360
490 500 510 520 530 540
pF1KB4 DIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPH
XP_016 YL
>>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa)
initn: 433 init1: 199 opt: 463 Z-score: 521.7 bits: 106.2 E(85289): 2.5e-22
Smith-Waterman score: 487; 36.9% identity (69.4% similar) in 255 aa overlap (220-471:114-350)
190 200 210 220 230 240
pF1KB4 NSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMG
:::::.....: ... . :: :.::
NP_001 HAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEI-KESVELPLTHPEYYEEMG
90 100 110 120 130 140
250 260 270 280 290 300
pF1KB4 CKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADA
: ::..:::::: ::::::. .... .: .:: : :...::.:.. .:.:: :
NP_001 IKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV-GSELIQKYLGDGPKLVRELFRVA
150 160 170 180 190 200
310 320 330 340 350 360
pF1KB4 EEEQRRLGANSGLHIIIFDEIDAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNI
::. : : :...:::::: .: .. .: .. :.. .::...:: .. ...
NP_001 EEH-----APS---IVFIDEIDAIGTKRYDSNSGGEREIQRTML-ELLNQLDGFDSRGDV
210 220 230 240 250
370 380 390 400 410 420
pF1KB4 LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIK
:: ::: . .: ::.::::.. :.:. ::::: . .:..:::.:: :. :: .
NP_001 KVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMT----LADDVTLD
260 270 280 290 300
430 440 450 460 470 480
pF1KB4 ELAVETKNFSGAELEGLVRAAQSTAM-NRHIKASTKVEVDMEKAESLQVTRGDFLASLEN
.: . ..:::..... : :. .:..:.... :..:..
NP_001 DLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNE---DFKKSKENVLYKKQEGTPEGL
310 320 330 340 350 360
490 500 510 520 530 540
pF1KB4 DIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPH
NP_001 YL
>>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa)
initn: 433 init1: 199 opt: 463 Z-score: 520.5 bits: 106.2 E(85289): 3e-22
Smith-Waterman score: 487; 36.9% identity (69.4% similar) in 255 aa overlap (220-471:187-423)
190 200 210 220 230 240
pF1KB4 NSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMG
:::::.....: ... . :: :.::
NP_002 HAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEI-KESVELPLTHPEYYEEMG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB4 CKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADA
: ::..:::::: ::::::. .... .: .:: : :...::.:.. .:.:: :
NP_002 IKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV-GSELIQKYLGDGPKLVRELFRVA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB4 EEEQRRLGANSGLHIIIFDEIDAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNI
::. : : :...:::::: .: .. .: .. :.. .::...:: .. ...
NP_002 EEH-----APS---IVFIDEIDAIGTKRYDSNSGGEREIQRTML-ELLNQLDGFDSRGDV
280 290 300 310 320
370 380 390 400 410 420
pF1KB4 LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIK
:: ::: . .: ::.::::.. :.:. ::::: . .:..:::.:: :. :: .
NP_002 KVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMT----LADDVTLD
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB4 ELAVETKNFSGAELEGLVRAAQSTAM-NRHIKASTKVEVDMEKAESLQVTRGDFLASLEN
.: . ..:::..... : :. .:..:.... :..:..
NP_002 DLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNE---DFKKSKENVLYKKQEGTPEGL
390 400 410 420 430
490 500 510 520 530 540
pF1KB4 DIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPH
NP_002 YL
440
>>XP_016876961 (OMIM: 602708) PREDICTED: 26S protease re (288 aa)
initn: 427 init1: 215 opt: 450 Z-score: 508.9 bits: 103.4 E(85289): 1.3e-21
Smith-Waterman score: 467; 37.1% identity (67.8% similar) in 264 aa overlap (220-472:34-281)
190 200 210 220 230 240
pF1KB4 NSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMG
::::.... .. :... . ::. ...:
XP_016 LTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIREL-REVIELPLTNPELFQRVG
10 20 30 40 50 60
250 260 270 280 290 300
pF1KB4 CKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADA
:: ::::::: ::::::: ....:. :::.. :..::.::: ::..: :
XP_016 IIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSS-IVDKYIGESARLIREMFNYA
70 80 90 100 110 120
310 320 330 340 350 360
pF1KB4 EEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTG--VHDTVVNQLLSKIDGVEQLNNI
...: ::..:::::: .: : . :. .. :.. .::...:: . :. .
XP_016 RDHQP--------CIIFMDEIDAIGGRRFSEGTSADREIQRTLM-ELLNQMDGFDTLHRV
130 140 150 160 170
370 380 390 400 410 420
pF1KB4 LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIK
.: ::::: .: ::::::::. :..: ::.:..::.::.::.. . : ...: .
XP_016 KMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKH----GEIDYE
180 190 200 210 220
430 440 450 460 470
pF1KB4 ELAVETKNFSGAELEGL--------VRAAQSTAMNRH-IKASTKVEVDMEKAESLQVTRG
.. . .:.::.:... .:: .. .... .:: :: .: .: ::
XP_016 AIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKV-ADSKKLESKLDYKP
230 240 250 260 270 280
480 490 500 510 520 530
pF1KB4 DFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVS
XP_016 V
>>NP_002797 (OMIM: 602708) 26S protease regulatory subun (403 aa)
initn: 427 init1: 215 opt: 450 Z-score: 506.6 bits: 103.5 E(85289): 1.8e-21
Smith-Waterman score: 467; 37.1% identity (67.8% similar) in 264 aa overlap (220-472:149-396)
190 200 210 220 230 240
pF1KB4 NSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMG
::::.... .. :... . ::. ...:
NP_002 LTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIREL-REVIELPLTNPELFQRVG
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB4 CKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADA
:: ::::::: ::::::: ....:. :::.. :..::.::: ::..: :
NP_002 IIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSS-IVDKYIGESARLIREMFNYA
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB4 EEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTG--VHDTVVNQLLSKIDGVEQLNNI
...: ::..:::::: .: : . :. .. :.. .::...:: . :. .
NP_002 RDHQP--------CIIFMDEIDAIGGRRFSEGTSADREIQRTLM-ELLNQMDGFDTLHRV
240 250 260 270 280
370 380 390 400 410 420
pF1KB4 LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIK
.: ::::: .: ::::::::. :..: ::.:..::.::.::.. . : ...: .
NP_002 KMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKH----GEIDYE
290 300 310 320 330 340
430 440 450 460 470
pF1KB4 ELAVETKNFSGAELEGL--------VRAAQSTAMNRH-IKASTKVEVDMEKAESLQVTRG
.. . .:.::.:... .:: .. .... .:: :: .: .: ::
NP_002 AIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKV-ADSKKLESKLDYKP
350 360 370 380 390 400
480 490 500 510 520 530
pF1KB4 DFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVS
NP_002 V
744 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 22:06:33 2016 done: Thu Nov 3 22:06:35 2016
Total Scan time: 8.420 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]